D. Breckenridge

发表

Structure-guided discovery of a novel, potent, and orally bioavailable 3,5-dimethylisoxazole aryl-benzimidazole BET bromodomain inhibitor.

R. Neve, R. Mackman, Xiaowu Chen, 2019, Bioorganic & Medicinal Chemistry.

Structure-guided discovery of a novel, potent, and orally bioavailable 3,5-dimethylisoxazole aryl-benzimidazole BET bromodomain inhibitor.

R. Neve, R. Mackman, Xiaowu Chen, 2019, Bioorganic & medicinal chemistry.

and from Mitochondria c Fragmentation and Release of Cytochrome Fas-Mediated Apoptotic Membrane Caspase-Resistant BAP 31 Inhibits

G. Shore, A. Ducret, D. Breckenridge, 2000 .

Caspase-Resistant BAP31 Inhibits Fas-Mediated Apoptotic Membrane Fragmentation and Release of Cytochrome cfrom Mitochondria

G. Shore, A. Ducret, D. Breckenridge, 2000, Molecular and Cellular Biology.

Peptide-based urinary monitoring of fibrotic nonalcoholic steatohepatitis by mass-barcoded activity-based sensors

Mehar K Cheema, W. Winckler, S. Bhatia, 2021, Science Translational Medicine.

ASK1 Inhibitor Halts Progression of Diabetic Nephropathy in Nos3-Deficient Mice

D. Nikolic-Paterson, F. Ma, G. Tesch, 2015, Diabetes.

An apoptosis signal‐regulating kinase 1 inhibitor reduces cardiomyocyte apoptosis and infarct size in a rat ischemia‐reperfusion model

R. Kloner, W. Dai, J. Shryock, 2012, Journal of cardiovascular pharmacology.

Inhibitor of apoptosis signal-regulating kinase 1 protects against acetaminophen-induced liver injury.

H. Jaeschke, A. Ramachandran, A. Farhood, 2015, Toxicology and applied pharmacology.

Combinations of an acetyl CoA carboxylase inhibitor with hepatic lipid modulating agents do not augment antifibrotic efficacy in preclinical models of NASH and fibrosis

Saritha Kusam, J. Trevaskis, M. Toteva, 2022, Hepatology communications.

Acetyl-CoA carboxylase inhibition disrupts metabolic reprogramming during hepatic stellate cell activation.

I. Mikaelian, B. Marchand, Saili Yi, 2020, Journal of hepatology.

Inhibition of Apoptosis Signal–Regulating Kinase 1 Reduces Myocardial Ischemia–Reperfusion Injury in the Mouse

N. Voelkel, A. Abbate, S. Toldo, 2012, Journal of the American Heart Association.

ASK1 inhibitor treatment suppresses p38/JNK signalling with reduced kidney inflammation and fibrosis in rat crescentic glomerulonephritis

D. Nikolic-Paterson, F. Ma, G. Tesch, 2018, Journal of cellular and molecular medicine.

The Non-Steroidal FXR Agonist Cilofexor Improves Portal Hypertension and Reduces Hepatic Fibrosis in a Rat NASH Model

M. Trauner, P. Schwabl, C. Kremoser, 2021, Biomedicines.

Selonsertib Enhances Kidney Protection Beyond Standard of Care in a Hypertensive, Secondary Glomerulosclerosis CKD Model

A. Fogo, Shawn S Badal, Hai-chun Yang, 2022, Kidney360.

Regulation of apoptosis by endoplasmic reticulum pathways

G. Shore, M. Germain, Gordon C Shore, 2003, Oncogene.

Regulation of mitochondrial membrane permeabilization by BCL-2 family proteins and caspases.

D. Xue, D. Breckenridge, 2004, Current opinion in cell biology.

Single-Cell Transcriptomics Uncovers Zonation of Function in the Mesenchyme during Liver Fibrosis

C. Ponting, S. Teichmann, J. Marioni, 2019, Cell reports.

U1 small nuclear RNA and spliceosomal introns in Euglena gracilis.

M. N. Schnare, S. Greenwood, D. Breckenridge, 1999, Proceedings of the National Academy of Sciences of the United States of America.

BID-dependent and BID-independent pathways for BAX insertion into mitochondria

S. Korsmeyer, A. Gross, I. Goping, 2000, Cell Death and Differentiation.

Caspase cleavage product of BAP31 induces mitochondrial fission through endoplasmic reticulum calcium signals, enhancing cytochrome c release to the cytosol

G. Shore, R. Marcellus, D. Breckenridge, 2003, The Journal of cell biology.

Uncleaved BAP31 in Association with A4 Protein at the Endoplasmic Reticulum Is an Inhibitor of Fas-initiated Release of Cytochromec from Mitochondria*

P. Clemons, G. Shore, Bing Wang, 2003, The Journal of Biological Chemistry.

Combination of an FXR agonist and an ACC inhibitor increases anti-fibrotic efficacy in rodent models of NASH

I. Mikaelian, A. Ray, D. Newstrom, 2018 .

The procaspase-8 isoform, procaspase-8L, recruited to the BAP31 complex at the endoplasmic reticulum

M. Nguyen, M. Reth, G. Shore, 2002, Proceedings of the National Academy of Sciences of the United States of America.

ASK1 contributes to fibrosis and dysfunction in models of kidney disease

Melanie H. Wong, S. Wise, D. French, 2018, The Journal of clinical investigation.

Pharmacokinetics, Safety, and Tolerability of Selonsertib, an Apoptosis Signal-Regulating Kinase 1 (ASK1) Inhibitor, Following First-in-Human Single and Multiple Ascending Doses in Healthy Subjects

A. Mathias, Saili Yi, C. Nelson, 2020, Clinical Pharmacokinetics.

efficacy of an Ask1 Inhibitor to Reduce Fibrosis and Steatosis in a Murine Model of Nash is Associated with Normalization of Lipids and Hepatic Gene Expression and a Reduction in Serum Biomarkers of Inflammation and Fibrosis : 1359

S. Watkins, Z. Goodman, D. French, 2015 .

Regulation of apoptosis by E1A and Myc oncoproteins.

G. Shore, D. Breckenridge, 2000, Critical reviews in eukaryotic gene expression.

Caenorhabditis elegans drp-1 and fis-2 regulate distinct cell-death execution pathways downstream of ced-3 and independent of ced-9.

S. Mitani, L. Staehelin, B. Kang, 2008, Molecular cell.

ASK1-dependent endothelial cell activation is critical in ovarian cancer growth and metastasis.

Ming-zhu Yin, Xia Li, W. Min, 2017, JCI insight.

ASK 1-dependent endothelial cell activation is critical in ovarian cancer growth and metastasis

Ming-zhu Yin, Xia Li, W. Min, 2017 .

Loss of TRIM33 causes resistance to BET bromodomain inhibitors through MYC- and TGF-β–dependent mechanisms

B. Turk, J. Schlessinger, Peng Yue, 2016, Proceedings of the National Academy of Sciences.

Reduction of Liver Steatosis and Fibrosis with an Ask1 Inhibitor in a Murine Model of Nash is Accompanied by Improvements in Cholesterol, Bile Acid and Lipid Metabolism

S. Watkins, D. Tumas, G. Budas, 2016 .

Bcl-2 Proteins EGL-1 and CED-9 Do Not Regulate Mitochondrial Fission or Fusion in Caenorhabditis elegans

B. Kang, D. Xue, D. Breckenridge, 2009, Current Biology.

The resident endoplasmic reticulum protein, BAP31, associates with gamma-actin and myosin B heavy chain.

G. Shore, A. Ducret, D. Breckenridge, 2003, European journal of biochemistry.

Bcl-2 Proteins EGL-1 and CED-9 Do Not Regulate Mitochondrial Fission or Fusion in Caenorhabditis elegans

D. Xue, D. Breckenridge, B. Kang, 2009, Current Biology.

Caspase cleavage product of BAP31 induces mitochondrial fission through endoplasmic reticulum calcium signals, enhancing cytochrome c release to the cytosol

G. Shore, R. Marcellus, D. Breckenridge, 2003, The Journal of cell biology.

N-terminal bromodomain of human BRD2 with N-((4-(3-(N-cyclopentylsulfamoyl)-4-methylphenyl)-3-methylisoxazol-5-yl)methyl)acetamide inhibitor

R. Neve, R. Mackman, K. Babaoglu, 2019 .