L. Miesel

发表

Screening for Antibacterial Inhibitors of the UDP-3-O-(R-3-Hydroxymyristoyl)- N-Acetylglucosamine Deacetylase (LpxC) Using a High-Throughput Mass Spectrometry Assay

F. Monsma, A. Malikzay, D. Daubaras, 2010, Journal of biomolecular screening.

Broadening the Spectrum of β-Lactam Antibiotics through Inhibition of Signal Peptidase Type I

J. Phillips, A. Therien, P. Beaulieu, 2012, Antimicrobial Agents and Chemotherapy.

Effects of Mutations in Ribosomal Protein L16 on Susceptibility and Accumulation of Evernimicin

P. Mann, P. McNicholas, R. Hare, 2001, Antimicrobial Agents and Chemotherapy.

Binding affinities and geometries of various metal ligands in peptide deformylase inhibitors.

P. Weber, T. Fischmann, A. Cooper, 2002, Biophysical chemistry.

Structure activity relationship of N-1 substituted 1,5-naphthyrid-2-one analogs of oxabicyclooctane-linked novel bacterial topoisomerase inhibitors as broad-spectrum antibacterial agents (Part-9).

Akinori Nishimura, P. Meinke, D. Olsen, 2022, Bioorganic & medicinal chemistry letters.

Preclinical development of Ramizol, an antibiotic belonging to a new class, for the treatment of Clostridium difficile colitis

Ramiz A. Boulos, C. Prestidge, Shasha Rao, 2016, The Journal of Antibiotics.

Rezafungin treatment in mouse models of invasive candidiasis and aspergillosis: Insights on the PK/PD pharmacometrics of rezafungin efficacy

L. Miesel, Kun Lin, V. Ong, 2019, Pharmacology research & perspectives.

Efficacy of Rezafungin in Prophylactic Mouse Models of Invasive Candidiasis, Aspergillosis, and Pneumocystis Pneumonia

M. Cushion, L. Miesel, Santiago R. Lopez, 2020, Antimicrobial Agents and Chemotherapy.

Microbial genetics: Genetic strategies for antibacterial drug discovery

J. Greene, Lynn Miesel, Jonathan Greene, 2003, Nature Reviews Genetics.

A high-throughput assay for the adenylation reaction of bacterial DNA ligase.

B. Feld, R. Palermo, J. Pichardo, 2007, Analytical biochemistry.

Structure of the Bacterial Deacetylase LpxC Bound to the Nucleotide Reaction Product Reveals Mechanisms of Oxyanion Stabilization and Proton Transfer

Sujata Sharma, D. Klein, K. Lumb, 2013, The Journal of Biological Chemistry.

Barriers to the Formation of Inversion Rearrangements in Salmonella

L. Miesel, 2011 .

Potent LpxC Inhibitors with In Vitro Activity against Multidrug-Resistant Pseudomonas aeruginosa

F. Cohen, A. Jubb, M. Hackel, 2019, Antimicrobial Agents and Chemotherapy.

Efficacy of CD101, a Novel Echinocandin, in Mouse Models of Aspergillosis and Azole-Resistant Disseminated Candidiasis

K. Bartizal, L. Miesel, V. Ong, 2016 .

In Vitro and In Vivo Characterization of the Novel Oxabicyclooctane-Linked Bacterial Topoisomerase Inhibitor AM-8722, a Selective, Potent Inhibitor of Bacterial DNA Gyrase

Akinori Nishimura, Jin Wu, C. Garlisi, 2016, Antimicrobial Agents and Chemotherapy.

Screening strategies for discovery of antibacterial natural products

Sheo B. Singh, K. Young, L. Miesel, 2011, Expert review of anti-infective therapy.

Isolation and structure elucidation of two novel deformylase inhibitors produced by Streptomyces sp.

P. Shipkova, A. Hruza, J. Terracciano, 2001 .

Rearrangements of the Bacterial Chromosome : Formation and Applications

T. Galitski, J. Roth, J. Lawrence, 1999 .

Chemical genetic identification of peptidoglycan inhibitors potentiating carbapenem activity against methicillin-resistant Staphylococcus aureus.

Terry Roemer, Sang Ho Lee, Katherine Young, 2009, Chemistry & biology.

NADH Dehydrogenase Defects Confer Isoniazid Resistance and Conditional Lethality in Mycobacterium smegmatis

T. Weisbrod, W. Jacobs, J. Marcinkeviciene, 1998, Journal of bacteriology.

Construction of chromosomal rearrangements in Salmonella by transduction: inversions of non-permissive segments are not lethal.

A. Segall, J. Roth, L. Miesel, 1994, Genetics.

Peptidase Type I Antibiotics through Inhibition of Signal-Lactam β Broadening the Spectrum of

Alexandre Caron, Mihai Petcu, Kenneth E. Wilson, 2012 .

Structure activity relationship of C-2 ether substituted 1,5-naphthyridine analogs of oxabicyclooctane-linked novel bacterial topoisomerase inhibitors as broad-spectrum antibacterial agents (Part-5).

Akinori Nishimura, Jin Wu, P. Meinke, 2015, Bioorganic & medicinal chemistry letters.

Hydroxy tricyclic 1,5-naphthyridinone oxabicyclooctane-linked novel bacterial topoisomerase inhibitors as broad-spectrum antibacterial agents-SAR of RHS moiety (Part-3).

R. Nargund, Akinori Nishimura, Jin Wu, 2015, Bioorganic & medicinal chemistry letters.

Tricyclic 1,5-naphthyridinone oxabicyclooctane-linked novel bacterial topoisomerase inhibitors as broad-spectrum antibacterial agents-SAR of left-hand-side moiety (Part-2).

Leo A. Joyce, E. Sherer, R. Nargund, 2015, Bioorganic & medicinal chemistry letters.

Oxabicyclooctane-linked novel bacterial topoisomerase inhibitors as broad spectrum antibacterial agents.

Sangita Patel, Jin Wu, P. Meinke, 2014, ACS medicinal chemistry letters.

Salmonella recD mutations increase recombination in a short sequence transduction assay

J. Roth, L. Miesel, 1994, Journal of bacteriology.

C1–C2-linker substituted 1,5-naphthyridine analogues of oxabicyclooctane-linked NBTIs as broad-spectrum antibacterial agents (part 7)

Akinori Nishimura, Jin Wu, Xuanjia Peng, 2015 .

Structure activity relationship of pyridoxazinone substituted RHS analogs of oxabicyclooctane-linked 1,5-naphthyridinyl novel bacterial topoisomerase inhibitors as broad-spectrum antibacterial agents (Part-6).

Akinori Nishimura, Jin Wu, Xuanjia Peng, 2015, Bioorganic & medicinal chemistry letters.

Evidence that SbcB and RecF pathway functions contribute to RecBCD-dependent transductional recombination

J. Roth, L. Miesel, John R. Roth, 1996, Journal of bacteriology.

Pharmacological Basis of CD101 Efficacy: Exposure Shape Matters

Paul G. Ambrose, D. Andes, S. Bhavnani, 2017, Antimicrobial Agents and Chemotherapy.

Kibdelomycin Is a Potent and Selective Agent against Toxigenic Clostridium difficile

D. Gerding, D. Hecht, D. Olsen, 2014, Antimicrobial Agents and Chemotherapy.

FDA Public Workshop Summary: Advancing Animal Models for Antibacterial Drug Development

B. Diep, T. Walsh, T. Guina, 2020, Antimicrobial Agents and Chemotherapy.

Mechanisms for isoniazid action and resistance.

J C Sacchettini, J. Sacchettini, W. Jacobs, 2008, Novartis Foundation symposium.

Hydroxy tricyclic 1,5-naphthyridinone oxabicyclooctane-linked novel bacterial topoisomerase inhibitors as broad-spectrum antibacterial agents-SAR of RHS moiety (Part-3).

R. Nargund, Akinori Nishimura, Jin Wu, 2015, Bioorganic & medicinal chemistry letters.