A. Regueiro-Ren

发表

Mechanistic Studies and Modeling Reveal the Origin of Differential Inhibition of Gag Polymorphic Viruses by HIV-1 Maturation Inhibitors

N. Meanwell, Hong Yang, Zeyu Lin, 2016, PLoS pathogens.

Maturation Inhibitor with Improved Potency, Anti-viral Spectrum and Gag Polymorphic

N. Meanwell, Zeyu Lin, M. Krystal, 2016 .

Identification and Characterization of BMS-955176, a Second-Generation HIV-1 Maturation Inhibitor with Improved Potency, Antiviral Spectrum, and Gag Polymorphic Coverage

N. Meanwell, Zeyu Lin, M. Krystal, 2016, Antimicrobial Agents and Chemotherapy.

Inhibitors of human immunodeficiency virus type 1 (HIV-1) attachment. 12. Structure-activity relationships associated with 4-fluoro-6-azaindole derivatives leading to the identification of 1-(4-benzoylpiperazin-1-yl)-2-(4-fluoro-7-[1,2,3]triazol-1-yl-1h-pyrrolo[2,3-c]pyridin-3-yl)ethane-1,2-dione (B

N. Meanwell, D. Langley, R. Colonno, 2013, Journal of medicinal chemistry.

Discovery of BMS-955176, a Second Generation HIV-1 Maturation Inhibitor with Broad Spectrum Antiviral Activity.

B. Beno, N. Meanwell, Zeyu Lin, 2016, ACS medicinal chemistry letters.

Resistance profile of the HIV-1 maturation inhibitor GSK3532795 in vitro and in a clinical study

Samit R. Joshi, B. Beno, M. Krystal, 2019, PloS one.

Structural and Thermal Characterization of Halogenated Azidopyridines: Under-Reported Synthons for Medicinal Chemistry.

Darpandeep Aulakh, Amy A Sarjeant, P. Cheng, 2021, Organic letters.

Drug-Induced Phospholipidosis: Prediction, Detection, and Mitigation Strategies

U. Hanumegowda, A. Regueiro-Ren, 2013 .

SAR and pH stability of cyano-substituted epothilones.

Soong-Hoon Kim, Kenneth J. Leavitt, C. Fairchild, 2002, Organic letters.

Cyclic sulfoxides and sulfones in drug design

A. Regueiro-Ren, 2020 .

Novel semi-synthetic nocathiacin antibiotics: synthesis and antibacterial activity of bis- and mono-O-alkylated derivatives.

M. Pucci, T. Connolly, Xiaofan Zheng, 2004, Bioorganic & medicinal chemistry letters.

Microbial transformations of betulinic and betulonic acids

F. Rinaldi, Zhiwei Guo, A. Goswami, 2015 .

Chemical conversion of nocathiacin I to nocathiacin II and a lactone analogue of glycothiohexide alpha.

J. Leet, M. Pucci, T. Connolly, 2005, Journal of natural products.

Mild method for cleavage of dehydroalanine units: highly efficient conversion of nocathiacin I to nocathiacin IV.

A. Regueiro-Ren, Y. Ueda, 2002, The Journal of organic chemistry.

Novel Semi‐Synthetic Nocathiacin Antibiotics: Synthesis and Antibacterial Activity of Bis‐ and Mono‐O‐alkylated Derivatives

A. Regueiro-Ren, 2004 .

Mild Method for Cleavage of Dehydroalanine Units: Highly Efficient Conversion of Nocathiacin I (Ia) to Nocathiacin IV (Ib).

A. Regueiro-Ren, Y. Ueda, 2003 .

Identification of Monosaccharide Derivatives as Potent, Selective, and Orally Bioavailable Inhibitors of Human and Mouse Galectin-3.

B. Beno, A. Mathur, Chunjian Liu, 2022, Journal of medicinal chemistry.

Synthesis and biological activity of novel epothilone aziridines.

C. Fairchild, R. Borzilleri, F. Lee, 2001, Organic letters.

An efficient one-pot synthesis of 3-glyoxylic acids of electron-deficient substituted azaindoles by ionic liquid imidazolium chloroaluminate-promoted Friedel–Crafts acylation

A. Good, K. Yeung, Michelle E. Farkas, 2008 .

Inhibitors of HIV-1 attachment: The discovery and structure-activity relationships of tetrahydroisoquinolines as replacements for the piperazine benzamide in the 3-glyoxylyl 6-azaindole pharmacophore.

L. Hamann, N. Meanwell, Tao Wang, 2016, Bioorganic & medicinal chemistry letters.

Discovery and preclinical characterization of the cyclopropylindolobenzazepine BMS-791325, a potent allosteric inhibitor of the hepatitis C virus NS5B polymerase.

Chong-Hwan Chang, M. Witmer, B. Beno, 2014, Journal of medicinal chemistry.

Identification of a broad-spectrum azasordarin with improved pharmacokinetic properties.

C. Mazzucco, A. Marinier, M. Serrano-Wu, 2003, Bioorganic & medicinal chemistry letters.

Improving physical properties via C-H oxidation: chemical and enzymatic approaches.

Raghunath O. Ramabhadran, K. Houk, Zhiwei Guo, 2014, Angewandte Chemie.

Synthesis, Structure-Activity Relationships, and In Vivo Evaluation of Novel Tetrahydropyran-Based Thiodisaccharide Mimics as Galectin-3 Inhibitors.

B. Beno, Amit Kumar, K. Ghosh, 2021, Journal of medicinal chemistry.

Amination of Nitro-Substituted Heteroarenes by Nucleophilic Substitution of Hydrogen.

Darpandeep Aulakh, M. Davies, B. Ellsworth, 2022, Organic letters.

GSK3640254 Is a Novel HIV-1 Maturation Inhibitor with an Optimized Virology Profile

N. Meanwell, Zeyu Lin, Joseph L. Cantone, 2021, Antimicrobial Agents and Chemotherapy.

Design, Synthesis, and SAR of C-3 Benzoic Acid, C-17 Triterpenoid Derivatives. Identification of the HIV-1 Maturation Inhibitor 4-((1 R,3a S,5a R,5b R,7a R,11a S,11b R,13a R,13b R)-3a-((2-(1,1-Dioxidothiomorpholino)ethyl)amino)-5a,5b,8,8,11a-pentamethyl-1-(prop-1-en-2-yl)-2,3,3a,4,5,5a,5b,6,7,7a,8,1

B. Beno, N. Meanwell, V. Arora, 2018, Journal of medicinal chemistry.

Inhibitors of human immunodeficiency virus type 1 (HIV-1) attachment 13. Synthesis and profiling of a novel amminium prodrug of the HIV-1 attachment inhibitor BMS-585248.

Michael Sinz, Dawn Parker, Kim A Johnson, 2013, Journal of medicinal chemistry.

Mild deprotection of 2-(trimethylsilyl)ethyl esters

M. Serrano-Wu, D. Laurent, A. Regueiro-Ren, 2001 .

Phospholipidosis as a function of basicity, lipophilicity, and volume of distribution of compounds.

J. Corradi, R. Yordanova, S. Adams, 2010, Chemical research in toxicology.

The design, synthesis and structure-activity relationships associated with C28 amine-based betulinic acid derivatives as inhibitors of HIV-1 maturation.

N. Meanwell, Zeyu Lin, M. Krystal, 2018, Bioorganic & medicinal chemistry letters.

Discovery and Development of HIV‐1 Entry Inhibitors That Target gp120

N. Meanwell, K. Yeung, J. Kadow, 2011 .

Highly Efficient Semisynthesis of Biologically Active Epothilone Derivatives

W. Humphreys, Soong-Hoon Kim, R. Borzilleri, 2001 .

Second Generation Inhibitors of HIV-1 Maturation.

N. Meanwell, I. Dicker, U. Hanumegowda, 2019, ACS medicinal chemistry letters.

Design and exploration of C-3 benzoic acid bioisosteres and alkyl replacements in the context of GSK3532795 (BMS-955176) that exhibit broad spectrum HIV-1 maturation inhibition.

B. Beno, N. Meanwell, M. Krystal, 2021, Bioorganic & medicinal chemistry letters.

Inhibitors of HIV-1 maturation: Development of structure-activity relationship for C-28 amides based on C-3 benzoic acid-modified triterpenoids.

N. Meanwell, M. Krystal, Tricia L. Protack, 2016, Bioorganic & medicinal chemistry letters.

The Discovery of GSK3640254, a Next-Generation Inhibitor of HIV-1 Maturation.

A. Mathur, N. Meanwell, Zeyu Lin, 2022, Journal of medicinal chemistry.

Synthesis, Structure-Activity Relationships, and In Vivo Evaluation of Novel C-17 Amine Derivatives Based on GSK3640254 as HIV-1 Maturation Inhibitors with Broad Spectrum Activity.

N. Meanwell, Zeyu Lin, M. Krystal, 2022, Journal of Medicinal Chemistry.

C-3 benzoic acid derivatives of C-3 deoxybetulinic acid and deoxybetulin as HIV-1 maturation inhibitors.

B. Beno, N. Meanwell, Zeyu Lin, 2016, Bioorganic & medicinal chemistry.

Synthesis of Bicyclo[1.1.0]butanes from Iodo-Bicyclo[1.1.1]pentanes.

Maximilian D Palkowitz, Darpandeep Aulakh, B. Ellsworth, 2023, Organic Letters.