H. Samanta

发表

Maturation Inhibitor with Improved Potency, Anti-viral Spectrum and Gag Polymorphic

N. Meanwell, Zeyu Lin, M. Krystal, 2016 .

Identification and Characterization of BMS-955176, a Second-Generation HIV-1 Maturation Inhibitor with Improved Potency, Antiviral Spectrum, and Gag Polymorphic Coverage

N. Meanwell, Zeyu Lin, M. Krystal, 2016, Antimicrobial Agents and Chemotherapy.

Discovery of BMS-955176, a Second Generation HIV-1 Maturation Inhibitor with Broad Spectrum Antiviral Activity.

B. Beno, N. Meanwell, Zeyu Lin, 2016, ACS medicinal chemistry letters.

Biochemical Analysis of HIV-1 Integrase Variants Resistant to Strand Transfer Inhibitors*

Zeyu Lin, M. Krystal, B. Terry, 2008, Journal of Biological Chemistry.

High level expression of human tissue-type plasminogen activator gene in mouse C127 cell.

Y. J. Kim, H. Samanta, 1991, Journal of biotechnology.

Deionization of formamide with Biorad AG501-X(D).

H. Samanta, D. Engel, 1987, Journal of biochemical and biophysical methods.

INTERFERON ACTION: CLONING OF cDNA SEGMENTS COMPLEMENTARY TO MESSENGER RNAs INDUCED BY INTERFERONS

P. Lengyel, J. Dougherty, M. Brawner, 1982 .

Interferon action: transcriptional control of a gene specifying a 56,000-Da protein in Ehrlich ascites tumor cells.

P. Lengyel, D. A. Engel, M. Brawner, 1985, Virology.

Interferons as gene activators. Indications for repeated gene duplication during the evolution of a cluster of interferon-activatable genes on murine chromosome 1.

P. Lengyel, J. Snoddy, D. Choubey, 1989, The Journal of biological chemistry.

DOUBLE‐STRANDED RNA AND THE ENZYMOLOGY OF INTERFERON ACTION *

P. Lengyel, J. Dougherty, P. Farrell, 1980, Annals of the New York Academy of Sciences.

INTERFERON ACTION: (A) INTERFERONS AS INDUCERS OF mRNA AND PROTEIN SYNTHESIS (B) CROSS-LINKING OF MOUSE-BETA INTERFERON TO CELL SURFACE RECEPTORS

P. Lengyel, O. Yoshie, H. Samanta, 1983 .

Interferons as gene activators. Cloning of the 5' terminus and the control segment of an interferon activated gene.

P. Lengyel, M. Garcia-Blanco, D. A. Engel, 1986, The Journal of biological chemistry.

Expression of hepatitis B virus surface antigen containing the pre-S region in mammalian cell culture system.

H. Samanta, B. Youn, 1989, Vaccine.

Chromosomal location of mouse gene 202 which is induced by interferons and specifies a 56.5 kD protein.

P. Lengyel, F. Ruddle, H. Samanta, 1984, Journal of interferon research.

Establishment of transfected cell lines producing testicular angiotensin-converting enzyme. Structural relationship between its secreted and cellular forms.

G. Sen, I. Sen, H. Samanta, 1991, The Journal of biological chemistry.

Genotypic and phenotypic analysis of human immunodeficiency virus type 1 isolates from patients on prolonged stavudine therapy.

Hui Li, R. E. Anderson, R. Colonno, 1994, The Journal of infectious diseases.

Purification and characterization of pre-S-containing hepatitis B surface antigens produced in recombinant mammalian cell culture.

H. Samanta, B. Youn, 1989, Vaccine.

Interferon, double-stranded RNA, and RNA degradation: activation of an endonuclease by (2'-5')An.

P. Lengyel, H. Samanta, E. Slattery, 1979, Proceedings of the National Academy of Sciences of the United States of America.

Interferon, double-stranded RNA, and RNA degradation. Isolation of homogeneous pppA(2'p5'A)n-1 synthetase from Ehrlich ascites tumor cells.

P. Lengyel, J. Dougherty, P. Farrell, 1980, The Journal of biological chemistry.

Interferons, double-stranded RNA, and RNA degradation. Isolation and characterization of homogeneous human (2'-5')(a)n synthetase.

P. Lengyel, J. Dougherty, R. Broeze, 1981, The Journal of biological chemistry.

Interferon action: Two (2′-5′) (A)n synthetases specified by distinct mRNAs in Ehrlich ascites tumor cells treated with interferon

P. Lengyel, G. Laurent, P. Sehgal, 1983, Cell.

Synthesis of (2'-5')(A)n from ATP. Characteristics of the reaction catalyzed by (2'-5')(A)n synthetase purified from mouse Ehrlich ascites tumor cells treated with interferon.

P. Lengyel, J. Dougherty, H. Samanta, 1980, The Journal of biological chemistry.

Enzymatic synthesis of (2'-5')-linked oligoadenylates on a preparative scale.

P. Lengyel, H. Samanta, 1986, Methods in enzymology.

Changes to the HIV Long Terminal Repeat and to HIV Integrase Differentially Impact HIV Integrase Assembly, Activity, and the Binding of Strand Transfer Inhibitors*

D. Langley, M. Krystal, M. A. Walker, 2007, Journal of Biological Chemistry.

Heterocycle amide isosteres: An approach to overcoming resistance for HIV-1 integrase strand transfer inhibitors.

N. Meanwell, D. Langley, Zeyu Lin, 2019, Bioorganic & medicinal chemistry letters.

Cloning, sequencing, and expression of two murine 2'-5'-oligoadenylate synthetases. Structure-function relationships.

R. Kumar, J. Kusari, G. Sen, 1991, The Journal of biological chemistry.

Characterization of siamycin I, a human immunodeficiency virus fusion inhibitor

R. Colonno, A. Patick, R. White, 1996, Antimicrobial agents and chemotherapy.

Clinical HIV-1 isolates remain sensitive to stavudine following prolonged therapy.

R. Colonno, R. Rose, H. Samanta, 1998, AIDS.

Characterization of a Mutant HIV-1 Reverse Transcriptase Resistant to (+)-(5S)-4,5,6,7-tetrahydro-5-methyl-6-(3-methyl-2-butenyl)-imidazo[4,5,1-jk][1,4]benzodiazepin-2(1H)-thione (TIBO R82150)

R. Colonno, A. Patick, R. Rose, 1994 .

Design, Synthesis, and SAR of C-3 Benzoic Acid, C-17 Triterpenoid Derivatives. Identification of the HIV-1 Maturation Inhibitor 4-((1 R,3a S,5a R,5b R,7a R,11a S,11b R,13a R,13b R)-3a-((2-(1,1-Dioxidothiomorpholino)ethyl)amino)-5a,5b,8,8,11a-pentamethyl-1-(prop-1-en-2-yl)-2,3,3a,4,5,5a,5b,6,7,7a,8,1

B. Beno, N. Meanwell, V. Arora, 2018, Journal of medicinal chemistry.

Identification of cell surface receptors for murine macrophage inflammatory protein-1 alpha.

H. Broxmeyer, H. Broxmeyer, M. Fraser, 1991, Journal of immunology.

Triketoacid inhibitors of HIV-integrase: a new chemotype useful for probing the integrase pharmacophore.

N. Meanwell, Zeyu Lin, Carol Deminie, 2006, Bioorganic & medicinal chemistry letters.

Benzyl amide-ketoacid inhibitors of HIV-integrase.

N. Meanwell, Zeyu Lin, M. Krystal, 2007, Bioorganic & Medicinal Chemistry Letters.

Exploration of the diketoacid integrase inhibitor chemotype leading to the discovery of the anilide-ketoacids chemotype.

N. Meanwell, Zeyu Lin, Carol Deminie, 2006, Bioorganic & medicinal chemistry letters.

The terminal (catalytic) adenosine of the HIV LTR controls the kinetics of binding and dissociation of HIV integrase strand transfer inhibitors.

D. Langley, Zeyu Lin, M. Krystal, 2008, Biochemistry.

C-3 benzoic acid derivatives of C-3 deoxybetulinic acid and deoxybetulin as HIV-1 maturation inhibitors.

B. Beno, N. Meanwell, Zeyu Lin, 2016, Bioorganic & medicinal chemistry.

Structural Analysis of the Native and Drug Resistant HIV-1 Proteinases Complexed With an Aminodiol Inhibitor

Alexander Wlodawer, Jukka Kervinen, Pin-Fang Lin, 1996, Protein & Peptide Letters.

C-3 benzoic acid derivatives of C-3 deoxybetulinic acid and deoxybetulin as HIV-1 maturation inhibitors.

B. Beno, N. Meanwell, Zeyu Lin, 2016, Bioorganic & medicinal chemistry.