Jie Chen

发表

Maturation Inhibitor with Improved Potency, Anti-viral Spectrum and Gag Polymorphic

N. Meanwell, Zeyu Lin, M. Krystal, 2016 .

Identification and Characterization of BMS-955176, a Second-Generation HIV-1 Maturation Inhibitor with Improved Potency, Antiviral Spectrum, and Gag Polymorphic Coverage

N. Meanwell, Zeyu Lin, M. Krystal, 2016, Antimicrobial Agents and Chemotherapy.

Discovery of BMS-955176, a Second Generation HIV-1 Maturation Inhibitor with Broad Spectrum Antiviral Activity.

B. Beno, N. Meanwell, Zeyu Lin, 2016, ACS medicinal chemistry letters.

[6,7]‐Heterocycle‐Fused 14‐Hydroxymorphinan Derivatives: Design, Synthesis, and Opioid Receptor Activity

A. Zhang, Xin Xie, Jie Chen, 2009, ChemMedChem.

Palladium-catalyzed amination of 3-bromo-4-fluoro-acetophenone

Yong-Jin Wu, Huan He, Jie Chen, 2002 .

(R)-2-(4-Phenylbutyl)dihydrobenzofuran derivatives as melatoninergic agents.

S. Bertenshaw, C. D. Mahle, K. Takaki, 2005, Bioorganic & medicinal chemistry letters.

Discovery of a Potent Acyclic, Tripeptidic, Acyl Sulfonamide Inhibitor of Hepatitis C Virus NS3 Protease as a Back-up to Asunaprevir with the Potential for Once-Daily Dosing.

L. Mueller, K. Kish, H. Klei, 2016, Journal of medicinal chemistry.

(S,E)-N-[1-(3-heteroarylphenyl)ethyl]-3-(2-fluorophenyl)acrylamides: synthesis and KCNQ2 potassium channel opener activity.

S. Dworetzky, Ronald J. Knox, Joanne Natale, 2005, Bioorganic & medicinal chemistry letters.

Synthesis and SAR Study of Opioid Receptor Ligands: Mono‐ and Bis‐Indolomorphinans

A. Zhang, Xin Xie, Jie Chen, 2009, Chemical biology & drug design.

Synthesis and opioid receptor activity of indolopropellanes.

A. Zhang, Xin Xie, Jie Chen, 2009, Bioorganic & medicinal chemistry letters.

N-[2-[2-(4-Phenylbutyl)benzofuran-4-yl]cyclopropylmethyl]acetamide: an orally bioavailable melatonin receptor agonist.

Jie Chen, C. D. Mahle, K. Takaki, 2004, Bioorganic & medicinal chemistry letters.

Design and synthesis of benzoxazole derivatives as novel melatoninergic ligands.

C. D. Mahle, K. Takaki, Cen Xu, 2004, Bioorganic & medicinal chemistry letters.

Discovery and early clinical evaluation of BMS-605339, a potent and orally efficacious tripeptidic acylsulfonamide NS3 protease inhibitor for the treatment of hepatitis C virus infection.

A. Good, H. Klei, A. Cocuzza, 2014, Journal of medicinal chemistry.

Facile and efficient synthesis and herbicidal activity determination of novel 1,2,4-triazolo[4,3-a]pyridin-3(2H)-one derivatives via microwave irradiation.

Zhi‐Wen Zhai, Jianquan Weng, Xinghai Liu, 2015, Bioorganic & medicinal chemistry letters.

Synthesis, crystal structure, herbicidal activities and 3D-QSAR study of some novel 1,2,4-triazolo[4,3-a]pyridine derivatives.

Jianquan Weng, Xinghai Liu, Jie Chen, 2015, Pest management science.

Synthesis, Structure and Antifungal Activity of New 3-[(5-Aryl-1,3,4-oxadiazol-2-yl)methyl]benzo[d]thiazol-2(3H)-ones

Jianquan Weng, Xinghai Liu, Jie Chen, 2012, Molecules.

Synthesis and structure-activity relationship of novel benzoxazole derivatives as melatonin receptor agonists.

C. D. Mahle, K. Takaki, Cen Xu, 2004, Bioorganic & medicinal chemistry letters.

Design, Synthesis, and Bioassay of Novel Compounds of Isolongifolenone Oxime Derivatives

Haitang Xu, Jie Chen, Li-qun Shen, 2016 .

Design and synthesis of 5-chloro-2-hydroxy-3-triazolylbenzoic acids as HIV integrase inhibitors

Chengchu Zeng, Liming Hu, W. Liu, 2015, Medicinal Chemistry Research.

The discovery of asunaprevir (BMS-650032), an orally efficacious NS3 protease inhibitor for the treatment of hepatitis C virus infection.

Qi Gao, Huabin Sun, Hong Shi, 2014, Journal of medicinal chemistry.

Structure elucidation of nigricanoside A through enantioselective total synthesis

Peng Fu, J. MacMillan, J. Ready, 2015, Chemical science.

Efficiency of the Urushibara Nickel Catalyzed Atmospheric Hydrogenation in the Synthesis of Aniline Derivatives.

Zhong-Xing Jiang, Jie Chen, Huaibin Zhang, 2001 .

Synthesis and biological activities of novel chiral fluorinated β‐carboline derivatives

Jie Chen, Xiao-Bo Huang, Jinchang Ding, 2008 .

Design, synthesis and biological evaluation of novel tetrahydroisoquinoline quaternary derivatives as peripheral κ-opioid receptor agonists.

Ting Guo, Dechuan Wang, Ling He, 2016, Bioorganic & medicinal chemistry.

OHMEFENTANYL——A NEW AGONIST FOR μ-OPIATE RECEPTOR

Heng Xu, Jie Chen, Z. Chi, 1985 .

N‐{2‐[2‐(4‐Phenylbutyl)benzofuran‐4‐yl]cyclopropylmethyl}acetamide: An Orally Bioavailable Melatonin Receptor Agonist.

C. D. Mahle, K. Takaki, J. Knipe, 2005 .

Design, Synthesis and Insecticidal Activity of 1-Methyl-3-(5-aryl-4,5-dihydroisoxazol-3-yl)-1H-pyrazole-5-carboxamides

Xinghai Liu, Chengrong Ding, Tao Jiang, 2019, HETEROCYCLES.

Design, Synthesis, and SAR of C-3 Benzoic Acid, C-17 Triterpenoid Derivatives. Identification of the HIV-1 Maturation Inhibitor 4-((1 R,3a S,5a R,5b R,7a R,11a S,11b R,13a R,13b R)-3a-((2-(1,1-Dioxidothiomorpholino)ethyl)amino)-5a,5b,8,8,11a-pentamethyl-1-(prop-1-en-2-yl)-2,3,3a,4,5,5a,5b,6,7,7a,8,1

B. Beno, N. Meanwell, V. Arora, 2018, Journal of medicinal chemistry.

The design, synthesis and structure-activity relationships associated with C28 amine-based betulinic acid derivatives as inhibitors of HIV-1 maturation.

N. Meanwell, Zeyu Lin, M. Krystal, 2018, Bioorganic & medicinal chemistry letters.

Discovery of (S,E)-3-(2-fluorophenyl)-N-(1-(3-(pyridin-3-yloxy)phenyl)ethyl)-acrylamide as a potent and efficacious KCNQ2 (Kv7.2) opener for the treatment of neuropathic pain.

V. Gribkoff, Ping Chen, S. Dworetzky, 2013, Bioorganic & medicinal chemistry letters.

Synthesis and KCNQ2 opener activity of N-(1-benzo[1,3]dioxol-5-yl-ethyl, N-[1-(2,3-dihydro-benzofuran-5-yl)-ethyl, and N-[1-(2,3-dihydro-1H-indol-5-yl)-ethyl acrylamides.

Qi Gao, Jie Chen, Huan He, 2004, Bioorganic & medicinal chemistry letters.

(S)-N-[1-(4-cyclopropylmethyl-3,4-dihydro-2H-benzo[1,4]oxazin-6-yl)-ethyl]-3-(2-fluoro-phenyl)-acrylamide is a potent and efficacious KCNQ2 opener which inhibits induced hyperexcitability of rat hippocampal neurons.

Qi Gao, Jie Chen, Huan He, 2004, Bioorganic & medicinal chemistry letters.

Novel stilbene analogues containing thiazole moiety: Synthesis, biological evaluation and docking study

Xing-Hai Liu, Jianquan Weng, Qirong Lu, 2019, Journal of Molecular Structure.

Synthesis and herbicidal activity of new pyrazole ketone derivatives

Jianquan Weng, Xinghai Liu, Jie Chen, 2020 .

Inhibitors of HIV-1 maturation: Development of structure-activity relationship for C-28 amides based on C-3 benzoic acid-modified triterpenoids.

N. Meanwell, M. Krystal, Tricia L. Protack, 2016, Bioorganic & medicinal chemistry letters.

The Discovery of GSK3640254, a Next-Generation Inhibitor of HIV-1 Maturation.

A. Mathur, N. Meanwell, Zeyu Lin, 2022, Journal of medicinal chemistry.

Synthesis, Structure-Activity Relationships, and In Vivo Evaluation of Novel C-17 Amine Derivatives Based on GSK3640254 as HIV-1 Maturation Inhibitors with Broad Spectrum Activity.

N. Meanwell, Zeyu Lin, M. Krystal, 2022, Journal of Medicinal Chemistry.

Synthesis and Structure−Activity Relationship of Acrylamides as KCNQ2 Potassium Channel Openers

V. Gribkoff, S. Dworetzky, Joanne Natale, 2004 .

Discovery of new indole-based acylsulfonamide Nav1.7 inhibitors.

N. Meanwell, J. Herrington, R. Pieschl, 2019, Bioorganic & medicinal chemistry letters.

Discovery and early clinical evaluation of BMS-605339, a potent and orally efficacious tripeptidic acylsulfonamide NS3 protease inhibitor for the treatment of hepatitis C virus infection.

A. Good, H. Klei, A. Cocuzza, 2014, Journal of medicinal chemistry.