M. Marder

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Anticonvulsant profile of 2-ethylthio-7-methyl-4-(4-methylphenyl)pyrazolo[1,5-a][1,3,5]triazine

A. Fierro, L. Cuca, Martín Estrada, 2014 .

6-Bromoflavone, a high affinity ligand for the central benzodiazepine receptors is a member of a family of active flavonoids.

H. Viola, B. Cassels, P. Waterman, 1996, Biochemical and biophysical research communications.

Antitumor activity of some natural flavonoids and synthetic derivatives on various human and murine cancer cell lines.

L. Roguin, M. Marder, M. Cárdenas, 2006, Bioorganic & medicinal chemistry.

Central nervous system depressant action of flavonoid glycosides.

Sebastian P Fernandez, G. Johnston, A. Paladini, 2006, European journal of pharmacology.

Opioid receptors are involved in the sedative and antinociceptive effects of hesperidin as well as in its potentiation with benzodiazepines.

A. Paladini, M. Marder, C. Wasowski, 2008, European journal of pharmacology.

Natural flavonoids inhibit the plasma membrane Ca2+-ATPase.

I. Mangialavori, M. Ferreira-Gomes, J. Rossi, 2019, Biochemical pharmacology.

Antiproliferative activity of various flavonoids and related compounds: additive effect of interferon-alpha2b.

L. Roguin, M. Marder, V. Blank, 2004, Bioorganic & medicinal chemistry letters.

Synergistic interaction between hesperidin, a natural flavonoid, and diazepam.

Sebastian P Fernandez, A. Paladini, M. Marder, 2005, European journal of pharmacology.

Chronic Intraperitoneal and Oral Treatments with Hesperidin Induce Central Nervous System Effects in Mice

M. Marder, C. Wasowski, L. Loscalzo, 2012, Phytotherapy research : PTR.

Hesperidin induces antinociceptive effect in mice and its aglicone, hesperetin, binds to μ-opioid receptor and inhibits GIRK1/2 currents

M. Chebib, M. Marder, C. Wasowski, 2011, Pharmacology Biochemistry and Behavior.

Hesperidin, a flavonoid glycoside with sedative effect, decreases brain pERK1/2 levels in mice

J. Medina, H. Viola, Sebastian P Fernandez, 2009, Pharmacology Biochemistry and Behavior.

6,3'-dibromoflavone and 6-nitro-3'-bromoflavone: new additions to the 6,3'-disubstituted flavone family of high-affinity ligands of the brain benzodiazepine binding site with agonistic properties.

J. Medina, H. Viola, O. Giorgi, 2000, Biochemical and biophysical research communications.

6-Methyl-3'-bromoflavone, a high-affinity ligand for the benzodiazepine binding site of the GABA(A) receptor with some antagonistic properties.

L. Izquierdo, J. Medina, H. Viola, 1999, Biochemical and biophysical research communications.

6-Bromo-3′-nitroflavone, a new high affinity benzodiazepine receptor agonist recognizes two populations of cerebral cortical binding sites

J. Medina, H. Viola, A. Paladini, 1997 .

Chalcone derivatives: synthesis, in vitro and in vivo evaluation of their anti-anxiety, anti-depression and analgesic effects

C. Paván, S. Gobec, M. Jukič, 2019, Heliyon.

Novel sulfamides and sulfamates derived from amino esters: Synthetic studies and anticonvulsant activity.

Maria L. Villalba, Andrea V. Enrique, L. Gavernet, 2016, European journal of pharmacology.

Opportunities, obstacles and current challenges of flavonoids for luminal and triple-negative breast cancer therapy

M. F. Troncoso, M. T. Elola, M. Marder, 2022, European Journal of Medicinal Chemistry Reports.

Neuroactive flavonoid glycosides from Tilia petiolaris DC. extracts

M. Marder, C. Wasowski, L. Loscalzo, 2009, Phytotherapy research : PTR.

In vitro binding affinities of a series of flavonoids for μ-opioid receptors. Antinociceptive effect of the synthetic flavonoid 3,3-dibromoflavanone in mice

M. Marder, C. Wasowski, L. Loscalzo, 2013, Neuropharmacology.

Longitudinal evaluation of a novel BChE PET tracer as an early in vivo biomarker in the brain of a mouse model for Alzheimer disease

M. Sastre, J. Llop, P. Ramos-Cabrer, 2021, Theranostics.

Detection of benzodiazepine receptor ligands in small libraries of flavone derivatives synthesized by solution phase combinatorial chemistry.

J H Medina, J. Medina, H. Viola, 1998, Biochemical and biophysical research communications.

6,3'-Dinitroflavone, a novel high affinity ligand for the benzodiazepine receptor with potent anxiolytic properties

J. Medina, H. Viola, P. Waterman, 1995 .

2’-Hydroxy-4’,5’-dimethyl-4-dimethylaminochalcone, a novel fluorescent flavonoid with capacity to detect aluminium in cells and modulate Alzheimer’s disease targets

Laureano L. Sabatier, M. Ferreira-Gomes, L. Gavernet, 2021 .

Flavonoids and the Central Nervous System: from Forgotten Factors to Potent Anxiolytic Compounds

J. Medina, H. Viola, A. Paladini, 1999, The Journal of pharmacy and pharmacology.

6-Methylapigenin and hesperidin: new valeriana flavonoids with activity on the CNS

J. Medina, H. Viola, A. Paladini, 2003, Pharmacology Biochemistry and Behavior.

Isolation and identification of 6-methylapigenin, a competitive ligand for the brain GABA(A) receptors, from Valeriana wallichii.

J. Medina, H. Viola, A. Paladini, 2002, Planta medica.

Sedative and sleep-enhancing properties of linarin, a flavonoid-isolated from Valeriana officinalis

A. Paladini, M. Marder, C. Wasowski, 2004, Pharmacology Biochemistry and Behavior.

Neuroactive flavonoids: new ligands for the Benzodiazepine receptors.

J. Medina, H. Viola, D. Calvo, 1998, Phytomedicine : international journal of phytotherapy and phytopharmacology.

Biological Evaluation of Valeriana Extracts from Argentina with Potent Cholinesterase Inhibition for the Treatment of Neurodegenerative Disorders and Their Comorbidities—The Case of Valeriana carnosa Sm. (Caprifoliaceae) Studied in Mice

S. Gobec, D. Knez, M. Wagner, 2023, Pharmaceuticals.

GABA(A)-receptor ligands of flavonoid structure.

A. Paladini, M. Marder, 2002, Current topics in medicinal chemistry.

The anxiolytic-like effects of Aloysia polystachya (Griseb.) Moldenke (Verbenaceae) in mice.

M. L. Kennedy, J. Tortoriello, M. Marder, 2006, Journal of ethnopharmacology.

Flavonoids as GABAA receptor ligands: the whole story?

M. Marder, C. Wasowski, 2012, Journal of experimental pharmacology.

Cirsiliol and caffeic acid ethyl ester, isolated from Salvia guaranitica, are competitive ligands for the central benzodiazepine receptors.

J. Medina, H. Viola, P. Waterman, 1996, Phytomedicine : international journal of phytotherapy and phytopharmacology.

Synthesis and anticonvulsant activity of bioisosteres of trimethadione, N-derivative-1,2,3-oxathiazolidine-4-one-2,2-dioxides from α-hydroxyamides.

Laureano L. Sabatier, Luis E Bruno-Blanch, Andrea V. Enrique, 2013, Bioorganic & medicinal chemistry.

Overview—Flavonoids: A New Family of Benzodiazepine Receptor Ligands

J. Medina, H. Viola, Jorge H. Medina, 1997, Neurochemical Research.

N,N'-dicyclohexylsulfamide and N,N'-diphenethylsulfamide are anticonvulsant sulfamides with affinity for the benzodiazepine binding site of the GABA(A) receptor and anxiolytic activity in mice.

Maria L. Villalba, Andrea V. Enrique, L. Bruno‐Blanch, 2012, Biochemical pharmacology.

A synthetic bioisoster of trimethadione and phenytoin elicits anticonvulsant effect, protects the brain oxidative damage produced by seizures and exerts antidepressant action in mice

L. Bruno‐Blanch, I. Mangialavori, M. Marder, 2014, European Neuropsychopharmacology.

6-Chloro-3′-nitroflavone is a Potent Ligand for the Benzodiazepine Binding Site of the GABAA Receptor Devoid of Intrinsic Activity

J. Medina, H. Viola, J. Goutman, 2000, Pharmacology Biochemistry and Behavior.

Stereoselective Activity of 1-Propargyl-4-styrylpiperidine-like Analogues That Can Discriminate between Monoamine Oxidase Isoforms A and B

Janez Konc, J. Kos, I. Mangialavori, 2020, Journal of medicinal chemistry.

Anxioselective properties of 6,3'-dinitroflavone, a high-affinity benzodiazepine receptor ligand.

I. Izquierdo, J. Medina, H. Viola, 1996, European journal of pharmacology.

Reaction of 2,6-dinitroanisole with cyclohexylamine in toluene–octanol binary solvents. Further support for the ‘dimer nucleophile mechanism’ in aromatic nucleophilic substitution

N. Nudelman, M. Marder, A. Gurevich, 1993 .

Anticonvulsant and anxiolytic-like effects of compounds isolated from Polygala sabulosa (Polygalaceae) in rodents: in vitro and in vivo interactions with benzodiazepine binding sites

M. Duzzioni, A. Hoeller, B. G. Mendes, 2008, Psychopharmacology.

6,3'-Dinitroflavone is a low efficacy modulator of GABA(A) receptors.

W. Sieghart, S. Huck, A. Paladini, 2008, European journal of pharmacology.

2′-Nitroflavone induces apoptosis and modulates mitogen-activated protein kinase pathways in human leukaemia cells

L. Roguin, M. Marder, V. Blank, 2012, Anti-cancer drugs.

In vitro induction of apoptosis and in vivo effects of a flavone nitroderivative in murine mammary adenocarcinoma cells

E. Zotta, L. Roguin, M. Marder, 2009, International journal of cancer.

2'-Nitroflavone induces cell cycle arrest and apoptosis in HeLa human cervical carcinoma cells.

L. Roguin, M. Marder, V. Blank, 2008, Cancer letters.

Molecular modeling and QSAR analysis of the interaction of flavone derivatives with the benzodiazepine binding site of the GABA(A) receptor complex.

J H Medina, J. Medina, H. Viola, 2001, Bioorganic & medicinal chemistry.

Pharmacological Characterization of 6-Bromo-3′-nitroflavone, a Synthetic Flavonoid with High Affinity for the Benzodiazepine Receptors

J. Medina, H. Viola, P. Ardenghi, 1998, Pharmacology Biochemistry and Behavior.

Central nervous system activities of two diterpenes isolated from Aloysia virgata.

M. Marder, C. Wasowski, 2011, Phytomedicine : international journal of phytotherapy and phytopharmacology.

Multitarget 2′-hydroxychalcones as potential drugs for the treatment of neurodegenerative disorders and their comorbidities

S. Gobec, D. Knez, S. Žakelj, 2021, Neuropharmacology.

Neurobehavioral evaluation and phytochemical characterization of a series of argentine valerian species

M. Wagner, H. Bach, M. Marder, 2020, Heliyon.

Sedative and hypnotic properties of Salvia guaranitica St. Hil. and of its active principle, Cirsiliol.

J. Medina, H. Viola, A. Paladini, 1997, Phytomedicine : international journal of phytotherapy and phytopharmacology.

Antiproliferative Activity of Various Flavonoids and Related Compounds: Additive Effect of Interferon‐α2b.

L. Roguin, M. Marder, V. Blank, 2004 .