S. Venkatraman

发表

Metal Complexes of Marine Peptide Metabolites: A Novel Ag4 Cluster

Chris P. Miller, P. Wipf, Steven J. Geib, 1994 .

Potent aza-peptide derived inhibitors of HCV NS3 protease.

N. Shih, S. Venkatraman, Wanli Wu, 2009, Bioorganic & medicinal chemistry letters.

Novel Quinoline-Based P2-P4 Macrocyclic Derivatives As Pan-Genotypic HCV NS3/4a Protease Inhibitors.

Charles L. Jayne, M. Rudd, P. Coleman, 2014, ACS medicinal chemistry letters.

5-Benzothiazole substituted pyrimidine derivatives as HCV replication (replicase) inhibitors.

X. Tong, M. Maccoss, R. Reynolds, 2012, Bioorganic & medicinal chemistry letters.

I. Novel HCV NS5B polymerase inhibitors: discovery of indole 2-carboxylic acids with C3-heterocycles.

B. Feld, R. Palermo, J. Duca, 2011, Bioorganic & medicinal chemistry letters.

Ultra-performance liquid chromatography/tandem mass spectrometric determination of diastereomers of SCH 503034 in monkey plasma.

Walter A. Korfmacher, R. Morrison, F. G. Njoroge, 2007, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

On the mechanism of the Skraup-Doebner-Von Miller quinoline synthesis.

S. Denmark, S. Venkatraman, 2006, The Journal of organic chemistry.

Discovery of MK-8831, A Novel Spiro-Proline Macrocycle as a Pan-Genotypic HCV-NS3/4a Protease Inhibitor.

Rebecca T. Ruck, Yongxin Han, J. Howe, 2016, ACS medicinal chemistry letters.

Structure-activity relationship (SAR) development and discovery of potent indole-based inhibitors of the hepatitis C virus (HCV) NS5B polymerase.

B. Feld, J. Duca, F. G. Njoroge, 2012, Journal of medicinal chemistry.

A novel class of highly potent irreversible hepatitis C virus NS5B polymerase inhibitors.

B. Feld, J. Duca, F. G. Njoroge, 2012, Journal of medicinal chemistry.

Design and Synthesis of P2-P4 Macrocycles Containing a Unique Spirocyclic Proline: A New Class of HCV NS3/4A Inhibitors.

J. Howe, Zhuyan Guo, I. Davies, 2016, ACS medicinal chemistry letters.

Discovery of boceprevir, a direct-acting NS3/4A protease inhibitor for treatment of chronic hepatitis C infections.

S. Venkatraman, 2012, Trends in pharmacological sciences.

Development of boceprevir: a first‐in‐class direct antiviral treatment for chronic hepatitis C infection

D. Hazuda, M. Burroughs, A. Howe, 2013, Annals of the New York Academy of Sciences.

Discovery of Boceprevir, a Ketoamide-Derived HCV NS3 Protease Inhibitor, for Treatment of Genotype 1 Infections

S. Venkatraman, 2019, Topics in Medicinal Chemistry.

Discovery of Boceprevir and Narlaprevir: Ketoamide-Derived HCV NS3 Serine Protease Inhibitors for the Treatment of Chronic Hepatitis C

S. Venkatraman, 2017 .

Discovery of SCH 900188: A Potent Hepatitis C Virus NS5B Polymerase Inhibitor Prodrug As a Development Candidate.

F. G. Njoroge, K. Cheng, S. Agrawal, 2014, ACS medicinal chemistry letters.

Discovery of Boceprevir and Narlaprevir: A Case Study for Role of Structure‐Based Drug Design

A. Prongay, George F. Njoroge, S. Venkatraman, 2012 .

Potent ketoamide inhibitors of HCV NS3 protease derived from quaternized P1 groups.

V. Madison, F. G. Njoroge, Melissa L. Blackman, 2010, Bioorganic & medicinal chemistry letters.

Cyclic sulfones as novel P3-caps for hepatitis C virus NS3/4A (HCV NS3/4A) protease inhibitors: synthesis and evaluation of inhibitors with improved potency and pharmacokinetic profiles.

X. Tong, A. McPhail, A. Arasappan, 2010, Journal of medicinal chemistry.

FROM AZIRIDINES TO OXAZOLINES AND THIAZOLINES : THE HETEROCYCLIC ROUTE TO THIANGAZOLE

P. Wipf, S. Venkatraman, 2004 .

Optimization of potency and pharmacokinetics of tricyclic indole derived inhibitors of HCV NS5B polymerase. Identification of ester prodrugs with improved oral pharmacokinetics.

J. Duca, F. G. Njoroge, S. Agrawal, 2014, Bioorganic & medicinal chemistry.

Synthesis of new 4,5-dihydrofuranoindoles and their evaluation as HCV NS5B polymerase inhibitors.

José Duca, J. Duca, F. G. Njoroge, 2012, Organic letters.

2-TRIMETHYLSILYLETHANESULFONYL CHLORIDE (SES-CI) : (ETHANESULFONYL CHLORIDE, 2-(TRIMETHYLSILYL)-)

P. Wipf, S. Weinreb, S. Venkatraman, 1998 .

SCH 503034, a Mechanism-Based Inhibitor of Hepatitis C Virus NS3 Protease, Suppresses Polyprotein Maturation and Enhances the Antiviral Activity of Alpha Interferon in Replicon Cells

N. Butkiewicz, F. Gheyas, X. Tong, 2006, Antimicrobial Agents and Chemotherapy.

Transmetalation reactions of organosamarium reagents. Chlorosilane-accelerated copper-catalyzed conjugate additions

P. Wipf, S. Venkatraman, 1993 .

A New Thiazole Synthesis by Cyclocondensation of Thioamides and Alkynyl(Aryl)Iodonium Reagents.

P. Wipf, S. Venkatraman, 1996, The Journal of organic chemistry.

P2-P4 macrocyclic inhibitors of hepatitis C virus NS3-4A serine protease.

V. Madison, A. Arasappan, F. G. Njoroge, 2006, Bioorganic & medicinal chemistry letters.

An improved protocol for azole synthesis with PEG-supported Burgess reagent

P. Wipf, S. Venkatraman, 1996 .

Synthesis and Reactions of Oxazoles

S. Venkatraman, D. Palmer, 2003 .

Stereoselective Synthesis of β-Substituted β-Amino Sulfones and Sulfonamides via Addition of Sulfonyl Anions to Chiral N-Sulfinyl Imines

A. McPhail, A. Arasappan, T. Chan, 2006 .

TOTAL SYNTHESIS OF (-)-THIANGAZOLE AND STRUCTURALLY RELATED POLYAZOLES

P. Wipf, S. Venkatraman, 1995 .

Thiolysis of oxazolines: A new, selective method for the direct conversion of peptide oxazolines into thiazolines

Chris P. Miller, P. Wipf, S. Venkatraman, 1995 .

Total Synthesis of (-)-Muscoride A.

P. Wipf, S. Venkatraman, 1996, The Journal of organic chemistry.

Application of ruthenium induced cyclization for construction of strained biaryl ether macrocyclic compounds

F. G. Njoroge, V. Girijavallabhan, S. Venkatraman, 2002 .

Discovery of an irreversible HCV NS5B polymerase inhibitor.

J. Gesell, J. Duca, F. G. Njoroge, 2013, Bioorganic & medicinal chemistry letters.

The introduction of P4 substituted 1-methylcyclohexyl groups into Boceprevir: a change in direction in the search for a second generation HCV NS3 protease inhibitor.

Zhuyan Guo, Frank Bennett, X. Tong, 2010, Bioorganic & medicinal chemistry letters.

Discovery of potent sulfonamide P4-capped ketoamide second generation inhibitors of hepatitis C virus NS3 serine protease with favorable pharmacokinetic profiles in preclinical species.

R. Doll, Zhuyan Guo, A. Arasappan, 2010, Bioorganic & medicinal chemistry.

Practical and efficient method for amino acid derivatives containing β-quaternary center: application toward synthesis of hepatitis C virus NS3 serine protease inhibitors

A. Arasappan, F. G. Njoroge, T. Meng, 2007 .

Discovery of (1R,5S)-N-[3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]- 3-[2(S)-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]- 6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2(S)-carboxamide (SCH 503034), a selective, potent, orally bioavailable hepatitis C virus NS3 protease inhibitor:

Weiying Yang, Zhuyan Guo, Andrea Hart, 2006, Journal of medicinal chemistry.

Novel inhibitors of hepatitis C NS3-NS4A serine protease derived from 2-aza-bicyclo[2.2.1]heptane-3-carboxylic acid.

F. G. Njoroge, A. Prongay, J. Pichardo, 2006, Bioorganic & medicinal chemistry letters.

A new synthesis of α-methylserine by nucleophilic ring-opening of N-sulfonyl aziridines☆

Chris P. Miller, P. Wipf, S. Venkatraman, 1995 .

2‐Trimethylsilylethanesulfonyl Chloride (SES‐Cl)

P. Wipf, S. Weinreb, S. Venkatraman, 2003 .

Macrocyclic inhibitors of HCV NS3 protease

F. G. Njoroge, F George Njoroge, Srikanth Venkatraman, 2009, Expert opinion on therapeutic patents.

Structure-activity relationship (SAR) optimization of 6-(indol-2-yl)pyridine-3-sulfonamides: identification of potent, selective, and orally bioavailable small molecules targeting hepatitis C (HCV) NS4B.

Ramesh Kakarla, Guangming Chen, Song Huang, 2014, Journal of medicinal chemistry.

Intervention of Hepatitis C Replication through NS3‐4A, the Protease Inhibitor Boceprevir

F. G. Njoroge, S. Venkatraman, F. Njoroge, 2011 .

Discovery of novel P3 sulfonamide-capped inhibitors of HCV NS3 protease. Inhibitors with improved cellular potencies.

X. Tong, A. Arasappan, K. Cheng, 2009, Bioorganic & medicinal chemistry.

Discovery of Chromane Propionic Acid Analogues as Selective Agonists of GPR120 with in Vivo Activity in Rodents.

Charles L. Jayne, F. Ujjainwalla, T. Akiyama, 2017, ACS medicinal chemistry letters.

Discovery of the HCV NS3/4A protease inhibitor (1R,5S)-N-[3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3- [2(S)-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]- 6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2(S)-carboxamide (Sch 503034) II. Key steps in structure-based optimization.

Zhuyan Guo, Frank Bennett, Rong-Sheng Yang, 2007, Journal of medicinal chemistry.

Impact of naturally occurring variants of HCV protease on the binding of different classes of protease inhibitors.

X. Tong, P. Qiu, Zhuyan Guo, 2006, Biochemistry.

Computational Study of the Effects of Mutations A156T, D168V, and D168Q on the Binding of HCV Protease Inhibitors.

X. Tong, T. Fischmann, Zhuyan Guo, 2006, Journal of chemical theory and computation.

Potent inhibitors of HCV-NS3 protease derived from boronic acids.

A. Prongay, V. Girijavallabhan, S. Venkatraman, 2009, Bioorganic & medicinal chemistry letters.

The Discovery and Development of Boceprevir: A Novel, First-generation Inhibitor of the Hepatitis C Virus NS3/4A Serine Protease

A. Howe, S. Venkatraman, 2013, Journal of clinical and translational hepatology.

The Discovery and Development of Boceprevir : A Novel , First-generation Inhibitor of the Hepatitis C Virus NS 3 / 4 A Serine Protease

A. Howe, S. Venkatraman, 2013 .

Discovery of Narlaprevir (SCH 900518): A Potent, Second Generation HCV NS3 Serine Protease Inhibitor.

Weiying Yang, Frank Bennett, Jesse Wong, 2010, ACS medicinal chemistry letters.

From Aziridines to Oxazolines and Thiazolines: The Heterocyclic Route to Thiangazole

P. Wipf, S. Venkatraman, 1997 .

Novel Inhibitors of Hepatitis C NS3—NS4A Serine Protease Derived from 2-Aza-bicyclo[2.2.1]heptane-3-carboxylic Acid.

F. G. Njoroge, A. Prongay, J. Pichardo, 2006 .

Discovery of SCH446211 (SCH6): a new ketoamide inhibitor of the HCV NS3 serine protease and HCV subgenomic RNA replication.

S. Tamura, S. Kemp, M. Lim-Wilby, 2006, Journal of medicinal chemistry.

Second-generation highly potent and selective inhibitors of the hepatitis C virus NS3 serine protease.

Weiying Yang, Frank Bennett, X. Tong, 2009, Journal of medicinal chemistry.

Discovery of novel tricyclic indole derived inhibitors of HCV NS5B RNA dependent RNA polymerase.

J. Duca, F. G. Njoroge, S. Agrawal, 2013, Bioorganic & medicinal chemistry.

Design, Synthesis, and Evaluation of Novel and Selective G-protein Coupled Receptor 120 (GPR120) Spirocyclic Agonists.

A. Crespo, E. Tozzo, F. Ujjainwalla, 2017, ACS medicinal chemistry letters.

Hepatitis C virus NS3-4A serine protease inhibitors: SAR of P'2 moiety with improved potency.

S. Tamura, N. Yao, B. Malcolm, 2005, Bioorganic & medicinal chemistry letters.

Toward the back-up of boceprevir (SCH 503034): discovery of new extended P4-capped ketoamide inhibitors of hepatitis C virus NS3 serine protease with improved potency and pharmacokinetic profiles.

Zhuyan Guo, Frank Bennett, Sumei Ruan, 2009, Journal of medicinal chemistry.

Toward second generation hepatitis C virus NS3 serine protease inhibitors: discovery of novel P4 modified analogues with improved potency and pharmacokinetic profile.

Frank Bennett, X. Tong, A. Arasappan, 2009, Journal of medicinal chemistry.

Synthesis and SAR of geminal substitutions at the C5' carbosugar position of pyrimidine-derived HCV inhibitors.

X. Tong, M. Maccoss, N. Bansal, 2012, Bioorganic & medicinal chemistry letters.

Synthesis and SAR of pyridothiazole substituted pyrimidine derived HCV replication inhibitors.

X. Tong, M. Maccoss, N. Bansal, 2012, Bioorganic & medicinal chemistry letters.

Interferon in Replicon Cells Enhances the Antiviral Activity of Alpha Suppresses Polyprotein Maturation and of Hepatitis C Virus NS 3 Protease , SCH 503034 , a Mechanism-Based Inhibitor

F. Gheyas, X. Tong, C. Jiang, 2005 .

Macrocyclic inhibitors of HCV NS3-4A protease: design and structure activity relationship.

F. G. Njoroge, S. Venkatraman, 2007, Current Topics in Medicinal Chemistry.

Discovery and structure-activity relationship of P1-P3 ketoamide derived macrocyclic inhibitors of hepatitis C virus NS3 protease.

Andrea Hart, Robert Chase, Sony Agrawal, 2009, Journal of medicinal chemistry.

Design, synthesis, and evaluation of oxygen-containing macrocyclic peptidomimetics as inhibitors of HCV NS3 protease.

X. Tong, Melissa L. Blackman, J. Pichardo, 2009, Journal of medicinal chemistry.

Application of ring-closing metathesis for the synthesis of macrocyclic peptidomimetics as inhibitors of HCV NS3 protease.

Melissa L. Blackman, A. Prongay, V. Girijavallabhan, 2007, Organic Letters.

Stereoselective Synthesis of β‐Substituted β‐Amino Sulfones and Sulfonamides via Addition of Sulfonyl Anions to Chiral N‐Sulfinyl Imines.

A. McPhail, A. Arasappan, T. Chan, 2006 .

Stereoselective synthesis of beta-substituted beta-amino sulfones and sulfonamides via addition of sulfonyl anions to chiral N-sulfinyl imines.

A. McPhail, A. Arasappan, T. Chan, 2006, Organic letters.

II. Novel HCV NS5B polymerase inhibitors: discovery of indole C2 acyl sulfonamides.

Frank Bennett, Charles A Lesburg, Sony Agrawal, 2011, Bioorganic & medicinal chemistry letters.