S. Lin

发表

Piperazine-based CCR5 antagonists as HIV-1 inhibitors. I: 2(S)-methyl piperazine as a key pharmacophore element.

S. Mccombie, J. Tagat, J. Liu, 2001, Bioorganic & medicinal chemistry letters.

Synthesis and structure-activity relationships of new second-generation taxoids.

M. Miller, X. Geng, I. Ojima, 1999, Bioorganic & medicinal chemistry letters.

Antitumour activity of novel taxanes that act at the same time as cytotoxic agents and P-glycoprotein inhibitors

A. Riva, G. Scambia, C. Ferlini, 2000, British Journal of Cancer.

Recent advances in the medicinal chemistry of taxoids with novel beta-amino acid side chains.

I. Ojima, Songnian Lin, T. Wang, 1999, Current medicinal chemistry.

Syntheses and biological activity of C-3'-difluoromethyl-taxoids.

G. Scambia, C. Ferlini, I. Ojima, 2000, Bioorganic & medicinal chemistry.

Piperazine-based CCR5 antagonists as HIV-1 inhibitors. II. Discovery of 1-[(2,4-dimethyl-3-pyridinyl)carbonyl]-4- methyl-4-[3(S)-methyl-4-[1(S)-[4-(trifluoromethyl)phenyl]ethyl]-1-piperazinyl]- piperidine N1-oxide (Sch-350634), an orally bioavailable, potent CCR5 antagonist.

B. Neustadt, K. Cox, M. Murray, 2001, Journal of medicinal chemistry.

Potent inhibitors of the HIV-1 protease with good oral bioavailabilities.

S. Vasavanonda, H. Sham, T. Robins, 1995, Biochemical and biophysical research communications.

A common pharmacophore for cytotoxic natural products that stabilize microtubules.

S. Kuduk, S. Chakravarty, S. Danishefsky, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Inhibition of 4-hydroxyphenylpyruvate dioxygenase by sethoxydim, a potent inhibitor of acetyl-coenzyme A carboxylase.

D. Yang, S. Lin, 1999, Bioorganic & medicinal chemistry letters.

Discovery of a potent, non-triketone type inhibitor of 4-hydroxyphenylpyruvate dioxygenase.

T. Lin, S. Lin, Y. L. Lin, 2000, Bioorganic & medicinal chemistry letters.

SAR studies of 2-o-substituted-benzoyl- and 2-alkanoyl-cyclohexane-1,3-diones as inhibitors of 4-hydroxyphenylpyruvate dioxygenase.

S. Lin, Y. L. Lin, D. Yang, 2000, Bioorganic & medicinal chemistry letters.

A novel, picomolar inhibitor of human immunodeficiency virus type 1 protease.

A. Molla, S. Vasavanonda, N. Lyons, 1996, Journal of medicinal chemistry.

Synthesis of highly potent second-generation taxoids through effective kinetic resolution coupling of racemic beta-lactams with baccatins.

E. Pollina, X. Geng, I. Ojima, 2000, Chirality.

Novel azacyclic ureas that are potent inhibitors of HIV-1 protease.

A. Molla, S. Vasavanonda, D. Norbeck, 1996, Biochemical and Biophysical Research Communications - BBRC.