R. Brys

发表

Discovery of the S1P2 Antagonist GLPG2938 (1-[2-Ethoxy-6-(trifluoromethyl)-4-pyridyl]-3-[[5-methyl-6-[1-methyl-3-(trifluoromethyl)pyrazol-4-yl]pyridazin-3-yl]methyl]urea), a Preclinical Candidate for the Treatment of Idiopathic Pulmonary Fibrosis.

T. Christophe, C. Menet, B. Allart, 2021, Journal of medicinal chemistry.

A multiparameter approach to monitor disease activity in collagen-induced arthritis

G. Verbruggen, D. Elewaut, M. Drennan, 2010, Arthritis research & therapy.

Three classes of mammalian transcription activation domain stimulate transcription in Schizosaccharomyces pombe

G. Braus, G. Albrecht, D. Huylebroeck, 1997, The EMBO journal.

Discovery, Structure-Activity Relationship, and Binding Mode of an Imidazo[1,2-a]pyridine Series of Autotaxin Inhibitors.

J. Steyaert, N. Triballeau, K. Conrath, 2017, Journal of medicinal chemistry.

Discovery and optimization of an azetidine chemical series as a free fatty acid receptor 2 (FFA2) antagonist: from hit to clinic.

L. Nelles, S. Dupont, N. Triballeau, 2014, Journal of medicinal chemistry.

Discovery of 9-cyclopropylethynyl-2-((S)-1-[1,4]dioxan-2-ylmethoxy)-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one (GLPG1205), a Unique GPR84 Negative Allosteric Modulator Undergoing Evaluation in a Phase II Clinical Trial.

L. Nelles, G. Milligan, S. Dupont, 2020, Journal of medicinal chemistry.

The Medium-Chain Fatty Acid Receptor GPR84 Mediates Myeloid Cell Infiltration Promoting Steatohepatitis and Fibrosis

T. Luedde, F. Tacke, C. Trautwein, 2020, Journal of clinical medicine.

Identical cis-acting elements and related trans-acting factors control activity of nonviral promoter in Schizosaccharomyces pombe and mammalian cells.

L. Nelles, D. Huylebroeck, J. Remacle, 1998, DNA and cell biology.

Triazolopyridines as selective JAK1 inhibitors: from hit identification to GLPG0634.

L. Nelles, R. Geney, E. M. van der Aar, 2014, Journal of medicinal chemistry.

Preclinical Characterization of GLPG0634, a Selective Inhibitor of JAK1, for the Treatment of Inflammatory Diseases

L. Nelles, B. Smets, K. Conrath, 2013, The Journal of Immunology.

Oct-1 is involved in the transcriptional repression of the von willebrand factor gene promoter.

D. Huylebroeck, N. Janel, J. Remacle, 1998, Blood.

Oct-1 is involved in the transcriptional repression of the von willebrand factor gene promoter.

D. Huylebroeck, N. Janel, J. Remacle, 1998, Blood.

Neutralization of IL-17C Reduces Skin Inflammation in Mouse Models of Psoriasis and Atopic Dermatitis.

S. Dupont, P. Fallon, K. Eyerich, 2018, The Journal of investigative dermatology.

Selective Inhibitor of JAK 1 , for the Preclinical Characterization of GLPG 0634 , a Feyen and

Vandeghinste, B. Smets, K. Conrath, 2013 .

Pharmacological profile and efficacy of GLPG1690, a novel ATX inhibitor for COPD treatment

S. Dupont, N. Desroy, R. Blanqué, 2015 .

[Icterus due to oxyphenisatine].

R. Brys, L. Botelberge, R. de Keyser, 1972, Tijdschrift voor gastro-enterologie.

Discovery of 2-[[2-Ethyl-6-[4-[2-(3-hydroxyazetidin-1-yl)-2-oxoethyl]piperazin-1-yl]-8-methylimidazo[1,2-a]pyridin-3-yl]methylamino]-4-(4-fluorophenyl)thiazole-5-carbonitrile (GLPG1690), a First-in-Class Autotaxin Inhibitor Undergoing Clinical Evaluation for the Treatment of Idiopathic Pulmonary Fib

N. Triballeau, M. Lamers, B. Hrvačić, 2017, Journal of medicinal chemistry.

Adenoviral vectors expressing siRNAs for discovery and validation of gene function.

F. Michiels, M. Lambrecht, G. Arts, 2003, Genome research.

Arrayed adenoviral expression libraries for functional screening

Helmuth van Es, Ing Ren Tsang, F. Michiels, 2002, Nature Biotechnology.

Corrigendum: Arrayed adenoviral expression libraries for functional screening

Helmuth van Es, Ing Ren Tsang, F. Michiels, 2003, Nature Biotechnology.

The alpha7 nicotinic acetylcholine receptor on fibroblast-like synoviocytes and in synovial tissue from rheumatoid arthritis patients: a possible role for a key neurotransmitter in synovial inflammation.

E. P. van der Zanden, W. D. de Jonge, P. Tak, 2009, Arthritis and rheumatism.

Some tips and tricks in reading cervical spine radiographs in trauma patients.

S. Pans, R. Brys, E. Geusens, 2005, JBR-BTR : organe de la Societe royale belge de radiologie (SRBR) = orgaan van de Koninklijke Belgische Vereniging voor Radiologie.

A metastatic tumor to the heart.

L. Jordaens, R. Brys, R. de Keyser, 1983, Acta Cardiologica.

Discovery and development of ASK1 inhibitors.

K. Gibson, R. Brys, D. Amantini, 2020, Progress in medicinal chemistry.

IRAK4 inhibition dampens pathogenic processes driving inflammatory skin diseases

S. Dupont, P. Fallon, K. Eyerich, 2023, Science Translational Medicine.

A novel expression cloning method to isolate mammalian transcription factors in Schizosaccharomyces pombe.

L. Nelles, D. Huylebroeck, J. Remacle, 1998, Nucleic acids research.

Discovery and Optimization of Orally Bioavailable Phthalazone and Cinnolone Carboxylic Acid Derivatives as S1P2 Antagonists against Fibrotic Diseases.

N. Triballeau, Denis Bucher, T. Christophe, 2021, Journal of medicinal chemistry.

Strong reversal of the lung fibrosis disease signature by autotaxin inhibitor GLPG1690 in a mouse model for IPF

S. Dupont, M. Ongenaert, R. Blanqué, 2016 .

Reconstitution of the human 5-HT(1D) receptor-G-protein coupling: evidence for constitutive activity and multiple receptor conformations.

M. Jurzak, J. Leysen, M. P. Castelli, 2000, Molecular pharmacology.

Discovery of a series of imidazopyrazine small molecule inhibitors of the kinase MAPKAPK5, that show activity using in vitro and in vivo models of rheumatoid arthritis.

V. Birault, Joelle Le, G. Dixon, 2012, Bioorganic & medicinal chemistry letters.