Y. Shirasaki

发表

DY-9760e, a novel calmodulin antagonist, reduces brain damage induced by transient focal cerebral ischemia.

Toshiyuki Sato, T. Sato, Y. Morishima, 1999, European journal of pharmacology.

Serum S-100b protein as a biomarker for the assessment of neuroprotectants

Toshiyuki Sato, Y. Shirasaki, Naoko Edo, 2004, Brain Research.

DY-9760e, a calmodulin antagonist, reduces brain damage after permanent focal cerebral ischemia in cats.

Y. Kitano, M. Sugimura, Y. Shirasaki, 2005, Biological & pharmaceutical bulletin.

Inhibition of nitric oxide production and protein tyrosine nitration contribute to neuroprotection by a novel calmodulin antagonist, DY-9760e, in the rat microsphere embolism.

K. Fukunaga, S. Moriguchi, J. Kasahara, 2005, Biological & pharmaceutical bulletin.

DY-9760e, a novel calmodulin inhibitor, exhibits cardioprotective effects in the ischemic heart.

K. Fukunaga, N. Shioda, S. Moriguchi, 2006, Cardiovascular drug reviews.

Cytoprotective effect of 3-[2-[4-(3-chloro-2-methylphenyl)-1-piperazinyl]ethyl]-5,6-dimethoxy-1-(4-imidazolylmethyl)-1H-indazole dihydrochloride 3.5 hydrate (DY-9760e) against ischemia/reperfusion-induced injury in rat heart involves inhibition of fodrin breakdown and protein tyrosine nitration.

K. Fukunaga, Y. Takada, J. Kasahara, 2005, Journal of pharmacological sciences.

Generation of constitutively active calcineurin by calpain contributes to delayed neuronal death following mouse brain ischemia

K. Fukunaga, N. Shioda, S. Moriguchi, 2006, Journal of neurochemistry.

Calmodulin and calmodulin-dependent kinase II mediate neuronal cell death induced by depolarization

H. Takano, Y. Morishima, Y. Shirasaki, 2003, Brain Research.

DY-9760e, a novel calmodulin antagonist with cytoprotective action.

K. Fukunaga, E. Miyamoto, T. Sato, 1997, European journal of pharmacology.

Phenylephrine-Induced Cardiomyocyte Injury Is Triggered by Superoxide Generation through Uncoupled Endothelial Nitric-Oxide Synthase and Ameliorated by 3-[2-[4-(3-Chloro-2-methylphenyl)-1-piperazinyl]ethyl]-5,6-dimethoxyindazole (DY-9836), a Novel Calmodulin Antagonist

K. Fukunaga, Z. Qin, N. Shioda, 2009, Molecular Pharmacology.

Phenylephrine-induced cardiomyocyte injury is triggered by superoxide generation through uncoupled eNOS and ameliorated by DY9836, a novel calmodulin antagonist

K. Fukunaga, Z. Qin, N. Shioda, 2008 .

3-[2-[4-(3-Chloro-2-methylphenyl)-1-piperazinyl]ethyl]-5,6-dimethoxy-1-(4-imidazolylmethyl)-1H-indazole Dihydrochloride 3.5 Hydrate (DY-9760e), a Novel Calmodulin Antagonist, Reduces Brain Edema through the Inhibition of Enhanced Blood-Brain Barrier Permeability after Transient Focal Ischemia

Toshiyuki Sato, Y. Morishima, Y. Shirasaki, 2003, Journal of Pharmacology and Experimental Therapeutics.

Inhibition of Dystrophin Breakdown and Endothelial Nitric-Oxide Synthase Uncoupling Accounts for Cytoprotection by 3-[2-[4-(3-Chloro-2-methylphenyl)-1-piperazinyl]ethyl]-5,6-dimethoxy-1-(4-imidazolylmethyl)-1H-indazole Dihydrochloride 3.5 Hydrate (DY-9760e) in Left Ventricular Hypertrophied Mice

K. Fukunaga, H. Hasegawa, H. Kanai, 2010, Journal of Pharmacology and Experimental Therapeutics.

DY-9760e inhibits endothelin-1-induced cardiomyocyte hypertrophy through inhibition of CaMKII and ERK activities.

K. Fukunaga, Z. Qin, N. Shioda, 2009, Cardiovascular therapeutics.

Microsphere embolism‐induced endothelial nitric oxide synthase expression mediates disruption of the blood–brain barrier in rat brain

K. Fukunaga, F. Han, Y. Shirasaki, 2006, Journal of neurochemistry.

Effect of physical restraint on glucose tolerance in cynomolgus monkeys

Y. Shirasaki, Toshiaki Hayashi, Naoya Yoshioka, 2013, Journal of medical primatology.

The neuroprotective effect of a novel calmodulin antagonist, 3-[2-[4-(3-chloro-2-methylphenyl)-1-piperazinyl]ethyl]-5,6-dimethoxy-1-(4-imidazolylmethyl)-1h-indazole dihydrochloride 3.5 hydrate, in transient forebrain ischemia

K. Fukunaga, T. Kawano, M. Morioka, 2003, Neuroscience.

Bromocriptine, an ergot alkaloid, inhibits excitatory amino acid release mediated by glutamate transporter reversal.

Toshiyuki Sato, M. Sugimura, Y. Shirasaki, 2010, European journal of pharmacology.

Endothelium removal augments vasodilation by sodium nitroprusside and sodium nitrite.

C. Su, Y. Shirasaki, YasufumiShirasaki, 1985, European journal of pharmacology.

Comparison of the effect of edoxaban, a direct factor Xa inhibitor, with a direct thrombin inhibitor, melagatran, and heparin on intracerebral hemorrhage induced by collagenase in rats.

T. Shibano, Y. Morishima, Y. Shirasaki, 2014, Thrombosis research.

A study of the properties of chlorine dioxide gas as a fumigant

Y. Shirasaki, Toshiaki Hayashi, A. Matsuura, 2016, Experimental animals.

Endothelial modulation of vascular relaxation to nitrovasodilators in aging and hypertension.

C. Su, G. A. Nickols, T. J. Lee, 1986, The Journal of pharmacology and experimental therapeutics.

5 Hydrate ( DY-9760 e ) , a Novel Calmodulin Antagonist , Reduces Brain Edema through the Inhibition of Enhanced Blood-Brain Barrier Permeability after Transient Focal Ischemia

Toshiyuki Sato, Y. Morishima, Y. Shirasaki, 2003 .

3-[2-[4-(3-Chloro-2-methylphenylmethyl)-1-piperazinyl]ethyl]-5,6-dimethoxy-1-(4-imidazolylmethyl)-1H-indazole Dihydro-chloride 3.5 Hydrate (DY-9760e) Is Neuroprotective in Rat Microsphere Embolism: Role of the Cross-Talk between Calpain and Caspase-3 through Calpastatin

K. Fukunaga, F. Han, Y. Shirasaki, 2006, Journal of Pharmacology and Experimental Therapeutics.

1 H-indazole Dihydro-chloride 3 . 5 Hydrate ( DY-9760 e ) Is Neuroprotective in Rat Microsphere Embolism : Role of the Cross-Talk between Calpain and Caspase-3 through Calpastatin

K. Fukunaga, F. Han, Y. Shirasaki, 2006 .

Endothelial regulation of cyclic GMP and vascular responses in hypertension.

G. A. Nickols, T. J. Lee, Y. Shirasaki, 1988, The Journal of pharmacology and experimental therapeutics.

The Protective Effect of DY9760e, a Novel Calmodulin Antagonist, on Rat Permanent Middle Cerebral Artery Occlusion

A. Tamura, M. Aoki, K. Takagi, 1999 .

[The effect of an antihypertensive drug budralazine on cerebrovascular lesions in salt-loaded SHR].

S. Tanaka, F. Sekiguchi, S. Shibamura, 1989, Nihon yakurigaku zasshi. Folia pharmacologica Japonica.

Inhibition of neuronal nitric oxide synthase activity by 3-[2-[4-(3-chloro-2-methylphenyl)- 1-piperazinyl]ethyl]-5, 6-dimethoxy-1-(4-imidazolylmethyl)-1H-indazole dihydrochloride 3.5 hydrate (DY-9760e), a novel neuroprotective agent, in vitro and in cultured neuroblastoma cells in situ.

K. Fukunaga, E. Miyamoto, M. Ohmitsu, 2000, Biochemical pharmacology.

Protective effect of DY-9760e, a calmodulin antagonist, against neuronal cell death.

H. Takano, Y. Morishima, M. Sugimura, 2004, Biological & pharmaceutical bulletin.

Validation studies on blood collection from the jugular vein of conscious mice.

M. Kikuchi, Y. Shirasaki, Toshiaki Hayashi, 2012, Journal of the American Association for Laboratory Animal Science : JAALAS.

Reduced membrane-associated protein kinase C(β) immunoreactivity in the hippocampus of reserpinized rat brain

T. Miyatake, K. Yanagisawa, Y. Shirasaki, 1993, Neuroscience Letters.

β-Amyloid Induces Neuronal Apoptosis Via a Mechanism that Involves the c-Jun N-Terminal Kinase Pathway and the Induction of Fas Ligand

M. Greenberg, R. Flavell, Y. Gotoh, 2001, The Journal of Neuroscience.

Imbalance between CaM kinase II and calcineurin activities impairs caffeine-induced calcium release in hypertrophic cardiomyocytes.

K. Fukunaga, Z. Qin, N. Shioda, 2007, Biochemical pharmacology.

Protein kinase C subspecies in hippocampus and striatum of reserpinized rat brain

T. Miyatake, K. Yanagisawa, Y. Shirasaki, 1994, Brain Research.

Post-ischemic administration of DY-9760e, a novel calmodulin antagonist, reduced infarct volume in the permanent focal ischemia model of spontaneously hypertensive rat

K. Sano, Toshiyuki Sato, Y. Shirasaki, 2001, Neurological research.

CaMKIIδB Mediates Aberrant NCX1 Expression and the Imbalance of NCX1/SERCA in Transverse Aortic Constriction-Induced Failing Heart

K. Fukunaga, N. Shioda, F. Han, 2011, PloS one.

The post-ischemic administration of 3-[2-[4-(3-chloro-2-methylphenyl)-1-piperazinyl]ethyl]-5,6-dimethoxy-1-(4-imidazolylmethyl)-1H-indazole dihydrochloride 3.5 hydrate (DY-9760e), a novel calmodulin antagonist, prevents delayed neuronal death in gerbil hippocampus.

K. Fukunaga, J. Hamada, M. Morioka, 2004, Journal of pharmacological sciences.

Degradation of PEP-19, a calmodulin-binding protein, by calpain is implicated in neuronal cell death induced by intracellular Ca2+ overload

T. Nabeshima, M. Makino, Y. Morishima, 2008, Neuroscience.

Aortic cholesterol esterase and other lysosomal enzyme activities in DOCA-salt, renal and spontaneous hypertension in the rat.

T. Tomita, Y. Takiguchi, E. Hayashi, 1981, Atherosclerosis.

DY-9760e, a Novel Calmodulin Antagonist, Reduces Infarction after Permanent Focal Cerebral Ischemia in Rats

Toshiyuki Sato, Y. Shirasaki, H. Takamori, 2004, Pharmacology.

Involvement of calmodulin in neuronal cell death

M. Makino, Y. Morishima, Y. Shirasaki, 2006, Brain Research.

Altered endothelial modulation of vascular tone in aging and hypertension.

T. J. Lee, Y. Shirasaki, G. Nickols, 1987, Blood vessels.