J. Hartley

发表

In vitro cytotoxicity of GC sequence directed alkylating agents related to distamycin.

M. D’Incalci, M. Wyatt, M. Lee, 1993, Journal of medicinal chemistry.

Association of DNA strand breaks with accelerated terminal differentiation in mouse epidermal cells exposed to tumor promoters.

L. Zwelling, S. Yuspa, N. Gibson, 1985, Cancer research.

DNA sequence selectivity of guanine-N7 alkylation by three antitumor chloroethylating agents.

W. Mattes, J. Hartley, N. Gibson, 1986, Cancer research.

The effect of AT and GC sequence specific minor groove-binding agents on restriction endonuclease activity.

R. Souhami, M. Lee, S. Forrow, 1995, Chemico-biological interactions.

Dendritic cells in the lung: what is their relevance to asthma?

A. Semper, J. Hartley, 1996, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

GC-rich regions in genomes as targets for DNA alkylation.

W. Mattes, J. Hartley, K. Kohn, 1988, Carcinogenesis.

DNA repair in cisplatin-sensitive and resistant human cell lines measured in specific genes by quantitative polymerase chain reaction.

J. Masters, B. Köberle, J. Hartley, 1996, Biochemical pharmacology.

In vitro isoflavone supplementation reduces hydrogen peroxide-induced DNA damage in sperm.

J. Woodside, J. Hartley, A. Leathem, 2002, Teratogenesis, carcinogenesis, and mutagenesis.

Effect of phytoestrogen and antioxidant supplementation on oxidative DNA damage assessed using the comet assay.

A. Leathem, J. Woodside, J. Hartley, 2001, Mutation research.

Combined effects of streptozotocin and mitozolomide against four human cell lines of the Mer+ phenotype.

D. Barnes, N. Gibson, L. Erickson, 1986, Cancer research.

The use of alpha-DNA as an internal standard in the detection and quantitation of DNA damage in specific genes using Southern blotting.

R. Souhami, A. Sunters, J. Hartley, 1996, Nucleic acids research.

PCR-based assays for strand-specific measurement of DNA damage and repair. II. Single-strand ligation-PCR.

J. Hartley, S. McAdam, K. Grimaldi, 1999, Methods in molecular biology.

PCR-based methods for detecting DNA damage and its repair at the subgene and single nucleotide levels in cells.

J. Hartley, K. Grimaldi, 2002, Methods in molecular biology.

Alteration in the choice of DNA repair pathway with increasing sequence selective DNA alkylation in the minor groove.

P. McHugh, M. Lee, J. Hartley, 2000, Chemistry & biology.

DNA sequence specificity of antitumor agents. Oncogenes as possible targets for cancer therapy.

J. Lown,, W. Mattes, J. Hartley, 1988, Acta oncologica.

DNA sequence specificity of guanine N7-alkylations for a series of structurally related triazenes.

N. Gibson, W. Mattes, J. Hartley, 1988, Carcinogenesis.

DNA damage and sequence specificity of DNA binding of the new anti-cancer agent 1,4-bis(2'-chloroethyl)-1,4-diazabicyclo-[2.2.1] heptane dimaleate (Dabis maleate)

M. Broggini, M. D’Incalci, W. Mattes, 1990, British Journal of Cancer.

Mechanisms of DNA Sequence Selective Modifications by Alkylating Agents

J. Hartley, 1990 .

Mechanism of DNA strand breakage by piperidine at sites of N7-alkylguanines.

W. Mattes, J. Hartley, K. Kohn, 1986, Biochimica et biophysica acta.

Identification of specific DNA lesions induced by three classes of chloroethylating agents: chloroethylnitrosoureas, chloroethylmethanesulfonates and chloroethylimidazotetrazines.

N. Gibson, W. Mattes, J. Hartley, 1985, Pharmacology & therapeutics.

Mechanisms of DNA sequence selective alkylation of guanine-N7 positions by nitrogen mustards.

K. Kohn, W. Mattes, J. Hartley, 1987, Nucleic acids research.

GC base sequence recognition by oligo(imidazolecarboxamide) and C-terminus-modified analogues of distamycin deduced from circular dichroism, proton nuclear magnetic resonance, and methidiumpropylethylenediaminetetraacetate-iron(II) footprinting studies.

J. Hartley, M. Wyatt, Moses Lee, 1993, Biochemistry.

Structure-activity relationship of a series of nitrogen mustard- and pyrrole-containing minor groove-binding agents related to distamycin.

R. Souhami, M. Wyatt, M. Lee, 1994, Anti-cancer drug design.

DNA sequence selectivity of guanine-N7 alkylation by nitrogen mustards.

W. Mattes, J. Hartley, K. Kohn, 1986, Nucleic acids research.

A filter incubation method for the determination of potentially crosslinkable sites in DNA in mammalian cells.

K. Kohn, M. D’Incalci, L. Szmigiero, 1985, Analytical biochemistry.

DNA damage by anticancer agents and its repair: mapping in cells at the subgene level with quantitative polymerase chain reaction.

R. Souhami, J. Bingham, J. Hartley, 1994, Analytical biochemistry.

Differential cytotoxicity and DNA-damaging effects produced in human cells of the Mer+ and Mer- phenotypes by a series of alkyltriazenylimidazoles.

N. Gibson, J. Hartley, K. Vaughan, 1986, Carcinogenesis.

Phase I study of TP300 in patients with advanced solid tumors with pharmacokinetic, pharmacogenetic and pharmacodynamic analyses

C. Twelves, I. Macpherson, T. Evans, 2012, BMC Cancer.

DNA reactivity and in vitro cytotoxicity of the novel antitumor agent 1,5,2,4-dioxadithiepane-2,2,4,4-tetraoxide (NSC-348948) in human embryo cells.

N. Gibson, J. Hartley, K. Kohn, 1986, Cancer research.

N2,N4,N6-tri(hydroxymethyl)-N2,N4,N6-trimethylmelamine (trimelamol) is an efficient DNA cross-linking agent in vitro.

J. Hartley, D. Thurston, R. Saunders, 1991, Biochemical pharmacology.

Differential cytotoxicity and DNA-damaging effects produced in human cells of the Mer+ and Mer- phenotypes by a series of 1-aryl-3-alkyltriazenes.

N. Gibson, J. Hartley, K. Vaughan, 1986, Cancer research.

DNA damage and cytotoxicity of 2-chloroethyl (methylsulfonyl)methanesulfonate (NSC 338947) produced in human colon carcinoma cells with or without methylating agent pretreatment.

N. Gibson, J. Hartley, 1986, Cancer research.

Feasibility of preoperative chemotherapy for locally advanced, operable colon cancer: the pilot phase of a randomised controlled trial

Jacob G. Scott, H. J. Pearson, C. Fuller, 2012 .

Design, synthesis, and biological evaluation of DNA sequence and minor groove selective alkylating agents.

M. Lee, A. L. Rhodes, S. Forrow, 1993, Anti-cancer drug design.

DNA damage by anti-cancer agents resolved at the nucleotide level of a single copy gene: evidence for a novel binding site for cisplatin in cells.

R. Souhami, J. Hartley, S. McAdam, 1994, Nucleic acids research.

Phase I trial combining gemcitabine and treosulfan in advanced cutaneous and uveal melanoma patients

I. Cree, V. Spanswick, P. Corrie, 2005, British Journal of Cancer.

2-Chloroethyl (methylsulfonyl)methanesulfonate (NSC-338947), a more selective DNA alkylating agent than the chloroethylnitrosoureas.

N. Gibson, J. Strong, J. Hartley, 1986, Cancer research.

The role of base excision repair in the repair of DNA adducts formed by a series of nitrogen mustard-containing analogues of distamycin of increasing binding site size.

P. McHugh, M. Lee, J. Hartley, 1999, Anti-cancer drug design.