M. Yabuki

发表

Species differences in intestinal metabolic activities of cytochrome P450 isoforms between cynomolgus monkeys and humans.

Y. Mizuki, S. Komuro, H. Nishimuta, 2011, Drug metabolism and pharmacokinetics.

Pharmacokinetics of a Novel N-Methyl-D-aspartate Receptor Antagonist ( SM-18400 ) : Identification of an N-Acetylated Metabolite and Pre-clinical Assessment of N-Acetylation Polymorphism

I. Nakatsuka, M. Yabuki, M. Kataoka, 2022 .

Dehydroepiandrosterone sulfate, a useful endogenous probe for evaluation of drug-drug interaction on hepatic organic anion transporting polypeptide (OATP) in cynomolgus monkeys.

I. Tamai, Takao Watanabe, Masaki Watanabe, 2015, Drug metabolism and pharmacokinetics.

A new methodology for simultaneous quantification of total-Aβ, Aβx-38, Aβx-40, and Aβx-42 by column-switching LC/MS/MS

Ken-ichi Watanabe, Shiro Watanabe, T. Nakagawa, 2012, Analytical and Bioanalytical Chemistry.

Microsoft Word-11623028-file00

Toru Usui, S. Komuro, M. Yabuki, 2009 .

Doxorubicin: an antagonist of muscarinic receptors in guinea pig heart.

T. Akera, K. Temma, A. Chugun, 1992, European journal of pharmacology.

Absorption, Distribution and Excretion of SM-10888 in Rats

A. Yoshitake, I. Nakatsuka, M. Yabuki, 1993 .

Metabolism of a tetrahydroaminoacridine derivative (SM-10888) in rat: structural analysis of an N-glucuronide of SM-10888 and an O-glucuronide of hydroxylated SM-10888 by FAB-MS/MS.

A. Yoshitake, I. Nakatsuka, M. Yabuki, 1993, Xenobiotica; the fate of foreign compounds in biological systems.

Characterization of human cytochrome P450 enzymes involved in the in vitro metabolism of perospirone.

S. Komuro, M. Yabuki, H. Kanamaru, 2005, Biopharmaceutics & drug disposition.

Local thrombus formation in the site of intravenous injection of chlorpromazine: possible colloid-osmotic lysis of the local endothelial cells.

H. Kaneko, M. Yabuki, H. Nishibe, 2000, Biological & pharmaceutical bulletin.

Species differences in hepatic and intestinal metabolic activities for 43 human cytochrome P450 substrates between humans and rats or dogs

Masashi Yabuki, T. Nakagawa, Haruka Nishimuta, 2013, Xenobiotica; the fate of foreign compounds in biological systems.

Evaluation of the Potential for Drug-Induced Liver Injury Based on in Vitro Covalent Binding to Human Liver Proteins

Masashi Yabuki, Setsuko Komuro, Masashi Mise, 2009, Drug Metabolism and Disposition.

Prediction of the Intestinal First-Pass Metabolism of CYP3A Substrates in Humans Using Cynomolgus Monkeys

Y. Mizuki, S. Komuro, Kimihiko Sato, 2010, Drug Metabolism and Disposition.

Pharmacokinetics of a novelN-methyl-D-aspartate receptor antagonist (SM-18400): Identification of anN-acetylated metabolite and pre-clinical assessment ofN-acetylation polymorphism

I. Nakatsuka, T. Shimizudani, M. Yabuki, 2010, European Journal of Drug Metabolism and Pharmacokinetics.

Pharmacokinetics of miriplatin in experimental dog models of hepatic or renal impairment

S. Komuro, M. Yabuki, Hiroyuki Asano, 2011, European Journal of Drug Metabolism and Pharmacokinetics.

Tissue Distribution and Pharmacological Potential of SM‐16896, a Novel Oestrogen‐bisphosphonate Hybrid Compound *

I. Nakatsuka, T. Katsumata, H. Harada, 2000, The Journal of pharmacy and pharmacology.

Blonanserin, a novel atypical antipsychotic agent not actively transported as substrate by P-glycoprotein

A. Taguchi, Tomoko Inoue, T. Katsumata, 2012, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

Novel cleavage of the 1,2,4-oxadiazole ring in rat metabolism of SM-6586, a dihydropyridine calcium antagonist.

A. Yoshitake, I. Nakatsuka, M. Yabuki, 1993, Drug metabolism and disposition: the biological fate of chemicals.

The new acyl‐CoA cholesterol acyltransferase inhibitor SMP‐797 does not interact with statins via OATP1B1 in human cryopreserved hepatocytes and oocytes expressing systems

S. Komuro, M. Yabuki, Atsushi Kitamura, 2007, Biopharmaceutics & drug disposition.

Liver uptake of biguanides in rats.

Y. Sogame, S. Komuro, M. Yabuki, 2011, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

Characterization of the enzymes involved in the in vitro metabolism of amrubicin hydrochloride

S. Komuro, M. Yabuki, H. Kanamaru, 2005, Xenobiotica; the fate of foreign compounds in biological systems.

Transport of biguanides by human organic cation transporter OCT2.

M. Takano, Y. Sogame, S. Komuro, 2013, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

Translational research into species differences of endocrine toxicity via steroidogenesis inhibition by SMP-028--for human safety in clinical study.

T. Kunimatsu, K. Kikuchi, M. Yabuki, 2014, Toxicology and applied pharmacology.

Time-dependent inhibition (TDI) of CYP1A2 by a CYP3A4-mediated reactive metabolite: proposal for a novel mechanism of irreversible TDI by a non-suicide substrate

Takao Watanabe, Kimihiko Sato, M. Yabuki, 2018, Xenobiotica; the fate of foreign compounds in biological systems.

Significance of Reductive Metabolism in Human Intestine and Quantitative Prediction of Intestinal First-Pass Metabolism by Cytosolic Reductive Enzymes

T. Nakagawa, N. Nomura, M. Yabuki, 2013, Drug Metabolism and Disposition.

Pharmacokinetics Characterization of Liposomal Amphotericin B: Investigation of Clearance Process and Drug Interaction Potential

S. Komuro, M. Yabuki, Satoki Imai, 2009, Arzneimittelforschung.

Prediction of the intestinal first-pass metabolism of CYP3A and UGT substrates in humans from in vitro data.

S. Komuro, Kimihiko Sato, M. Yabuki, 2011, Drug metabolism and pharmacokinetics.

Metabolism of 4-[1-(2-fluoro-4-biphenylyl)ethyl]-2-methylaminothiazole (SM-8849) in rats

I. Nakatsuka, M. Yabuki, J. Shimakura, 2010, European Journal of Drug Metabolism and Pharmacokinetics.

A comparison of uptake of metformin and phenformin mediated by hOCT1 in human hepatocytes

Y. Sogame, S. Komuro, M. Yabuki, 2009, Biopharmaceutics & drug disposition.