T. Hammonds

发表

Increased sensitivity to quinolone antibacterials can be engineered in human topoisomerase IIalpha by selective mutagenesis.

S. Foster, A. Maxwell, T. Hammonds, 2000, Journal of molecular biology.

Identification of a novel orally bioavailable ERK5 inhibitor with selectivity over p38α and BRD4.

M. Noble, J. Endicott, S. Cook, 2019, European journal of medicinal chemistry.

Molecular basis of USP7 inhibition by selective small-molecule inhibitors

Elizabeth C. Townsend, Claire Heride, D. Komander, 2017, Nature.

Fluorescence-based incision assay for human XPF–ERCC1 activity identifies important elements of DNA junction recognition

N. McDonald, J. Lally, S. Mouilleron, 2012, Nucleic acids research.

Deletion of the deISGylating enzyme USP 18 enhances 1 tumour cell antigenicity and radiosensitivity 2 3

A. Damianou, P. Borrow, V. Cerundolo, 2020 .

Use of a Rapid Throughput In Vivo Screen To Investigate Inhibitors of Eukaryotic Topoisomerase II Enzymes

J. Jenkins, A. Maxwell, T. Hammonds, 1998, Antimicrobial Agents and Chemotherapy.

Studies to show that with podophyllotoxin the early replicative stages of herpes simplex virus type 1 depend upon functional cytoplasmic microtubules.

W. Irving, S. Denyer, T. Hammonds, 1996, Journal of medical microbiology.

Deep analysis of the USP18-dependent ISGylome and proteome unveils important roles for USP18 in tumour cell antigenicity and radiosensitivity

Andreas C. Damianou, A. Damianou, P. Borrow, 2020, bioRxiv.

High-Throughput Screening and Hit Validation of Extracellular-Related Kinase 5 (ERK5) Inhibitors.

I. Hardcastle, R. Griffin, B. Golding, 2016, ACS combinatorial science.

Patient-derived explants (PDEs) as a powerful preclinical platform for anti-cancer drug and biomarker discovery

C. Pritchard, L. Howells, M. MacFarlane, 2020, British Journal of Cancer.

Antitumor polycyclic acridines. 7. Synthesis and biological properties of DNA affinic tetra- and pentacyclic acridines.

M. Stevens, J. Stanslas, M F Stevens, 2000, Journal of medicinal chemistry.

Identification of 3-aminothieno[2,3-b]pyridine-2-carboxamides and 4-aminobenzothieno[3,2-d]pyrimidines as LIMK1 inhibitors

Jonathan B. Baell, Michael F. Olson, J. Baell, 2011 .

LIM kinase inhibitors disrupt mitotic microtubule organization and impair tumor cell proliferation

U. McDermott, M. Garnett, O. Rath, 2015, Oncotarget.

Dynamic Telomerase Gene Suppression via Network Effects of GSK3 Inhibition

Alan E. Bilsland, Katrina Stevenson, Jon Roffey, 2009, PloS one.

Academic-Pharma drug discovery alliances: seeking ways to eliminate the valley of death.

T. Hammonds, 2015, Future medicinal chemistry.

Deletion of the deISGylating enzyme USP18 enhances tumour cell antigenicity and radiosensitivity

Andreas C. Damianou, A. Damianou, P. Borrow, 2020, British Journal of Cancer.

Addressing the Right Targets in Oncology

C. Dillon, T. Hammonds, J. Roffey, 2015, Journal of biomolecular screening.

Isolation of a small molecule inhibitor of DNA base excision repair

M. Sternberg, P. Freemont, G. Dianov, 2005, Nucleic acids research.

Discovery, Development, and SAR of Aminothiazoles as LIMK Inhibitors with Cellular Anti-Invasive Properties.

M. Olson, D. Crighton, S. Boyd, 2015, Journal of medicinal chemistry.

Evaluating and comparing immunostaining and computational methods for spatial profiling of drug response in patient-derived explants

C. Pritchard, L. Howells, J. Pringle, 2020, Laboratory Investigation.

The N-terminal domain of human topoisomerase IIalpha is a DNA-dependent ATPase.

A. Maxwell, D. Roper, T. Hammonds, 1998, Biochemistry.

The DNA Dependence of the ATPase Activity of Human DNA Topoisomerase IIα*

A. Maxwell, T. Hammonds, 1997, The Journal of Biological Chemistry.

Antitumor Polycyclic Acridines. Part 7. Synthesis and Biological Properties of DNA Affinic Tetra- and Pentacyclic Acridines.

Malcolm F. G. Stevens, M. Stevens, J. Stanslas, 2000 .

USP28 deletion and small-molecule inhibition destabilizes c-MYC and elicits regression of squamous cell lung carcinoma

Andreas C. Damianou, A. Damianou, Claire Heride, 2020, bioRxiv.

The deubiquitylase USP9X controls ribosomal stalling

Claire Heride, D. Komander, A. Behrens, 2020, bioRxiv.