R. Kerns

发表

Susceptibility studies of piperazinyl-cross-linked fluoroquinolone dimers against test strains of Gram-positive and Gram-negative bacteria.

M. Rybak, Chrissy M. Cheung, R. Kerns, 2006, Diagnostic microbiology and infectious disease.

Ciprofloxacin Dimers Target Gyrase in Streptococcus pneumoniae

K. Gould, L. Fisher, Xiaohui Pan, 2004, Antimicrobial Agents and Chemotherapy.

Piperazinyl-linked fluoroquinolone dimers possessing potent antibacterial activity against drug-resistant strains of Staphylococcus aureus.

G. Kaatz, M. Rybak, R. Kerns, 2003, Bioorganic & medicinal chemistry letters.

Diversity-oriented chemical modification of heparin: Identification of charge-reduced N-acyl heparin derivatives having increased selectivity for heparin-binding proteins.

Liusheng Huang, R. Kerns, 2006, Bioorganic & medicinal chemistry.

Bactericidal activity and target preference of a piperazinyl-cross-linked ciprofloxacin dimer with Staphylococcus aureus and Escherichia coli.

Xilin Zhao, K. Drlica, R. Kerns, 2006, The Journal of antimicrobial chemotherapy.

Use of Gyrase Resistance Mutants To Guide Selection of 8-Methoxy-Quinazoline-2,4-Diones

K. Drlica, M. Malik, N. German, 2008, Antimicrobial Agents and Chemotherapy.

Novel Approach for Comparing the Abilities of Quinolones To Restrict the Emergence of Resistant Mutants during Quinolone Exposure

K. Drlica, K. Chavda, M. Malik, 2009, Antimicrobial Agents and Chemotherapy.

Separation of hydroxyl protected heparin derived disaccharides using reversed-phase high-performance liquid chromatography.

R. Linhardt, R. Kerns, 1995, Journal of chromatography. A.

Semi-synthetic heparin derivatives: chemical modifications of heparin beyond chain length, sulfate substitution pattern and N-sulfo/N-acetyl groups.

R. Kerns, C. Fernández, Christopher M. Hattan, 2006, Carbohydrate research.

Synthesis, separation, and characterization of amphiphilic sulfated oligosaccharides enabled by reversed-phase ion pairing LC and LC-MS methods.

Amanda M. Fenner, R. Kerns, 2011, Carbohydrate research.

Metabolic effects of a mitochondrial‐targeted coenzyme Q analog in high fat fed obese mice

K. Rahmouni, D. Guo, W. Sivitz, 2017, Pharmacology research & perspectives.

A Novel Triphenylphosphonium Carrier to Target Mitochondria without Uncoupling Oxidative Phosphorylation.

W. Sivitz, B. Fink, R. Kerns, 2021, Journal of medicinal chemistry.

ENZYMATIC PREPARATION OF HEPARIN DISACCHARIDES AS BUILDING BLOCKS IN GLYCOSAMINOGLYCAN SYNTHESIS

R. Linhardt, Yeong Shik Kim, R. Kerns, 2001, Preparative biochemistry & biotechnology.

Regio and stereoselective conversion of Δ4-uronic acids to l-Ido- and d-glucopyranosiduronic acids

R. Linhardt, R. Kerns, H. Bazin, 1997 .

Effect of mitoquinone on liver metabolism and steatosis in obese and diabetic rats

Liping Yu, W. Sivitz, B. Fink, 2021, Pharmacology research & perspectives.

N-Arylacyl O-sulfonated aminoglycosides as novel inhibitors of human neutrophil elastase, cathepsin G and proteinase 3.

Amanda M. Fenner, R. Kerns, I. Crăciun, 2016, Glycobiology.

Lethal synergy involving bicyclomycin: an approach for reviving old antibiotics.

J. Berger, Liping Li, Xilin Zhao, 2014, The Journal of antimicrobial chemotherapy.

Structural differences between paroxetine and femoxetine responsible for differential inhibition of Staphylococcus aureus efflux pumps.

G. Kaatz, P. Wei, R. Kerns, 2004, Bioorganic & medicinal chemistry letters.

Bioenergetic Effects of Mitochondrial-Targeted Coenzyme Q Analogs in Endothelial Cells

W. Sivitz, B. Fink, M. Yorek, 2012, Journal of Pharmacology and Experimental Therapeutics.

Effect of mitoquinone (Mito-Q) on neuropathic endpoints in an obese and type 2 diabetic rat model

W. Sivitz, B. Fink, E. Davidson, 2020, Free radical research.

Effect of N-1/C-8 Ring Fusion and C-7 Ring Structure on Fluoroquinolone Lethality

Kevin R. Marks, K. Drlica, M. Malik, 2010, Antimicrobial Agents and Chemotherapy.

Novel N-1 substituted fluoroquinolones inhibit human topoisomerase I activity and exhibit anti-proliferative activity

D. Murry, C. Flory, H. Hiasa, 2018, Investigational New Drugs.

Synthesis and evaluation of 1-cyclopropyl-2-thioalkyl-8-methoxy fluoroquinolones.

Kevin R. Marks, K. Drlica, H. Hiasa, 2011, Bioorganic & medicinal chemistry letters.

Efficient Synthesis of the 2-amino-6-chloro-4-cyclopropyl-7-fluoro-5-methoxy-pyrido[1,2-c]pyrimidine-1,3-dione core ring system.

N. German, R. Kerns, J. Rosen, 2009, Tetrahedron letters.

Different protein-binding selectivities for N-acyl heparin derivatives having N-phenylacetyl and heterocycle analogs of N-phenylacetyl substituted in place of N-sulfo groups.

Liusheng Huang, R. Kerns, C. Fernández, 2007, Bioorganic & medicinal chemistry letters.

Semisynthetic Heparin Derivatives: Chemical Modifications of Heparin Beyond Chain Length, Sulfate Substitution Pattern and N-Sulfo/N-Acetyl Groups

R. Kerns, C. Fernández, Christopher M. Hattan, 2006 .

Synthetic Methods to Incorporate α-Linked 2-Amino-2-deoxy-D-glucopyranoside and 2-Amino-2-deoxy-D-galactopyranoside Residues into Glycoconjugate Structures

P. Wei, R. Kerns, 2013 .

Extended applications and potential limitations of ring-fused 2,3-oxazolidinone thioglycosides in glycoconjugate synthesis

K. Benakli, Yu-Zeng Liang, R. Kerns, 2003 .

Variability in the carbazole assay for N-desulfonated/N-acylated heparin derivatives.

R. Kerns, Christopher M. Hattan, 2007, Carbohydrate research.

Lethality of Quinolones against Mycobacterium smegmatis in the Presence or Absence of Chloramphenicol

J. Domagala, Xilin Zhao, K. Drlica, 2005, Antimicrobial Agents and Chemotherapy.

Interactions between Quinolones and Bacillus anthracis Gyrase and the Basis of Drug Resistance

N. Osheroff, C. Turnbough, R. Kerns, 2017, Biochemistry.

Mechanism of Quinolone Action and Resistance

N. Osheroff, R. Kerns, Katie J. Aldred, 2014, Biochemistry.

Fluoroquinolone and Quinazolinedione Activities against Wild-Type and Gyrase Mutant Strains of Mycobacterium smegmatis

Kevin R. Marks, Xilin Zhao, K. Drlica, 2011, Antimicrobial Agents and Chemotherapy.

Quinolones: Action and Resistance Updated

Xilin Zhao, K. Drlica, H. Hiasa, 2009, Current topics in medicinal chemistry.

Synthesis and evaluation of fluoroquinolone derivatives as substrate-based inhibitors of bacterial efflux pumps.

G. Kaatz, P. Wei, N. German, 2008, European journal of medicinal chemistry.

Structural features of piperazinyl-linked ciprofloxacin dimers required for activity against drug-resistant strains of Staphylococcus aureus.

G. Kaatz, M. Rybak, R. Kerns, 2003, Bioorganic & medicinal chemistry letters.

Crystal structure and stability of gyrase–fluoroquinolone cleaved complexes from Mycobacterium tuberculosis

J. Berger, T. R. Blower, R. Kerns, 2016, Proceedings of the National Academy of Sciences.

Quinolone-Mediated Bacterial Death

Xilin Zhao, Xilin Zhao, K. Drlica, 2007, Antimicrobial Agents and Chemotherapy.

Vancomycin derivatives that inhibit peptidoglycan biosynthesis without binding D-Ala-D-Ala.

Zhong Chen, M. Ge, D. Kahne, 1999, Science.

The Role of Hydrophobic Substituents in the Biological Activityof Glycopeptide Antibiotics

J. Carbeck, D. Kahne, S. Fukuzawa, 2000 .

Role of the Water–Metal Ion Bridge in Quinolone Interactions with Escherichia coli Gyrase

R. Kerns, H. Schwanz, Katie J. Aldred, 2023, International journal of molecular sciences.

Bacterial Type II Topoisomerases and Target-Mediated Drug Resistance

N. Osheroff, R. Kerns, E. Gibson, 2018 .

Fluoroquinolone interactions with Mycobacterium tuberculosis gyrase: Enhancing drug activity against wild-type and resistant gyrase

N. Osheroff, J. Berger, T. R. Blower, 2016, Proceedings of the National Academy of Sciences.

Activity of quinolone CP-115,955 against bacterial and human type II topoisomerases is mediated by different interactions.

N. Osheroff, C. Turnbough, R. Kerns, 2015, Biochemistry.

Overcoming target-mediated quinolone resistance in topoisomerase IV by introducing metal-ion-independent drug-enzyme interactions.

N. Osheroff, C. Turnbough, R. Kerns, 2013, ACS chemical biology.

Topoisomerase IV-quinolone interactions are mediated through a water-metal ion bridge: mechanistic basis of quinolone resistance

N. Osheroff, C. Turnbough, R. Kerns, 2013, Nucleic acids research.

Design, synthesis, and evaluation of novel N-1 fluoroquinolone derivatives: Probing for binding contact with the active site tyrosine of gyrase.

H. Hiasa, R. Kerns, Chaitanya A. Kulkarni, 2018, Bioorganic & medicinal chemistry letters.

Drug interactions with Bacillus anthracis topoisomerase IV: biochemical basis for quinolone action and resistance.

N. Osheroff, C. Turnbough, R. Kerns, 2012, Biochemistry.

Synthesis of the Bis-Tetrahydropyrano[2,3-b:2′,3′-e] Piperazine Ring System: A New Tricyclic Heterocycle from D-Glucosamine

R. Linhardt, T. Toida, R. Kerns, 1996 .

A Mitochondrial-Targeted Coenzyme Q Analog Prevents Weight Gain and Ameliorates Hepatic Dysfunction in High-Fat–Fed Mice

K. Rahmouni, D. Guo, J. Grobe, 2014, The Journal of Pharmacology and Experimental Therapeutics.

Selective N-Sulfation of Glucosamine Derivatives using Phenyl Chlorosulfate in Non-Aqueous Solvent

R. Linhardt, R. Kerns, 1996 .

Fluoroquinolone Resistance: Mechanisms, Restrictive Dosing, and Anti-Mutant Screening Strategies for New Compounds

Xilin Zhao, K. Drlica, T. Salz, 2012 .

Synthesis and evaluation of PSSRI-based inhibitors of Staphylococcus aureus multidrug efflux pumps.

G. Kaatz, N. German, R. Kerns, 2008, Bioorganic & medicinal chemistry letters.

Bypassing Fluoroquinolone Resistance with Quinazolinediones: Studies of Drug–Gyrase–DNA Complexes Having Implications for Drug Design

J. Berger, K. Drlica, R. Kerns, 2014, ACS chemical biology.

Oxazolidinone protected 2-amino-2-deoxy-D-glucose derivatives as versatile intermediates in stereoselective oligosaccharide synthesis and the formation of alpha-linked glycosides.

K. Benakli, R. Kerns, C. Zha, 2001, Journal of the American Chemical Society.

Chemoselective deprotection and functional group interconversion of ring-fused 2N,3O-oxazolidinones of N-acetyl-d-glucosamine

P. Wei, R. Kerns, 2005 .

Factors affecting stereocontrol during glycosidation of 2,3-oxazolidinone-protected 1-tolylthio-N-acetyl-D-glucosamine.

P. Wei, R. Kerns, 2005, The Journal of organic chemistry.

Identification of an ethyl 5,6-dihydropyrazolo[1,5-c]quinazoline-1-carboxylate as a catalytic inhibitor of DNA gyrase.

H. Hiasa, R. Kerns, Pratiksha Chheda, 2020, Bioorganic & medicinal chemistry.

Capillary electrophoresis for monitoring chemical reactions: sulfation and synthetic manipulation of sulfated carbohydrates.

R. Linhardt, R. Kerns, I. Vlahov, 1995, Carbohydrate research.

Fluoroquinolone-Gyrase-DNA Complexes

Kevin R. Marks, J. Berger, Xilin Zhao, 2014, The Journal of Biological Chemistry.

Small molecule SWELL1 complex induction improves glycemic control and nonalcoholic fatty liver disease in murine Type 2 diabetes

E. Taylor, Chen Kang, R. Sah, 2021, Nature Communications.

Promising Antimalarials targeting Apicoplast DNA Polymerase from Plasmodium falciparum

R. Honzatko, Supreet Kaur, J. M. Beck, 2022, bioRxiv.

Induction of Mycobacterial Resistance to Quinolone Class Antimicrobials

B. Kreiswirth, Xilin Zhao, K. Drlica, 2012, Antimicrobial Agents and Chemotherapy.

Probing structural requirements for human topoisomerase I inhibition by a novel N1-Biphenyl fluoroquinolone.

H. Hiasa, Justine L Delgado, R. Kerns, 2019, European journal of medicinal chemistry.

The C7-aminomethylpyrrolidine group rescues the activity of a thio-fluoroquinolone.

H. Hiasa, R. Kerns, Tyrell R. Towle, 2019, Biochimie.

Suppression of gyrase-mediated resistance by C7 aryl fluoroquinolones

Xilin Zhao, K. Drlica, H. Hiasa, 2016, Nucleic acids research.

Comparison of In Vitro Activities of Fluoroquinolone-Like 2,4- and 1,3-Diones

K. Drlica, H. Hiasa, R. Kerns, 2010, Antimicrobial Agents and Chemotherapy.

Selective inhibition of bacterial and human topoisomerases by N-arylacyl O-sulfonated aminoglycoside derivatives.

Amanda M. Fenner, H. Hiasa, R. Kerns, 2013, ACS medicinal chemistry letters.

Bacillus anthracis GrlAV96A Topoisomerase IV, a Quinolone Resistance Mutation That Does Not Affect the Water-Metal Ion Bridge

N. Osheroff, C. Turnbough, R. Kerns, 2014, Antimicrobial Agents and Chemotherapy.

Role of the Water–Metal Ion Bridge in Mediating Interactions between Quinolones and Escherichia coli Topoisomerase IV

N. Osheroff, K. Neuman, M. Strub, 2014, Biochemistry.

Suppression of human T cell activation by derivatives of glycerol monolaurate

J. Houtman, R. Kerns, Phuong M. Tran, 2021, Scientific Reports.

Fluoroquinolones stimulate the DNA cleavage activity of topoisomerase IV by promoting the binding of Mg(2+) to the second metal binding site.

H. Hiasa, R. Kerns, Tyrell R. Towle, 2016, Biochimica et biophysica acta.

IV: A Quinolone Resistance Mutation that Does Not Affect the

N. Osheroff, R. Kerns, L. Charles, 2014 .

Regio and Stereoselective Conversion of Δ4-Uronic Acids to L-Ido- and D-Glucopyranosiduronic Acids.

R. Linhardt, R. Kerns, H. Bazin, 1997 .

Chemical probes of a trisubstituted pyrrole to identify its protein target(s) in Plasmodium sporozoites.

P. Bhanot, R. Kerns, Tyrell R. Towle, 2013, Bioorganic & medicinal chemistry letters.

Heparin and Heparin Oligosaccharides: Preparation, Analysis, Applications and Biological Activities

R. Linhardt, R. Kerns, I. Vlahov, 1997 .

Quinolones: Action and Resistance Updated

Xilin Zhao, K. Drlica, H. Hiasa, 2009, Current Topics in Medicinal Chemistry.

Effect of a mitochondrial‐targeted coenzyme Q analog on pancreatic β‐cell function and energetics in high fat fed obese mice

Joseph A. Promes, W. Sivitz, B. Fink, 2018, Pharmacology research & perspectives.