R. Bonnert

发表

Design driven HtL: The discovery and synthesis of new high efficacy β₂-agonists.

G. Pairaudeau, A. Bailey, E. Cadogan, 2011, Bioorganic & medicinal chemistry letters.

QSAR and the rational design of long-acting dual D2-receptor/beta 2-adrenoceptor agonists.

R. Austin, P. Barton, A. Davis, 2003, Journal of medicinal chemistry.

Substituted indole-1-acetic acids as potent and selective CRTh2 antagonists-discovery of AZD1981.

S. Teague, S. Thom, A. Cook, 2011, Bioorganic & medicinal chemistry letters.

AZD3199: A potent and selective β2-adrenergic receptor agonist with rapid onset of action

R. Austin, G. Pairaudeau, D. Nicholls, 2011, ATS 2011.

The In Vivo Profile Of AZD3199: A Novel, Fast Acting B2-Agonist With A Long Duration Of Action

G. Pairaudeau, D. Nicholls, S. Connolly, 2011, ATS 2011.

From ATP to AZD6140: the discovery of an orally active reversible P2Y12 receptor antagonist for the prevention of thrombosis.

P. Leeson, B. Springthorpe, P. Barton, 2007, Bioorganic & medicinal chemistry letters.

A new synthesis of substituted dienes and its application to an alkylated taxane model system

P. R. Jenkins, R. Bonnert, 1987 .

Discovery of AZD3199, An Inhaled Ultralong Acting β2 Receptor Agonist with Rapid Onset of Action.

G. Pairaudeau, A. Bailey, E. Cadogan, 2014, ACS medicinal chemistry letters.

The discovery of AZD 3199 A new inhaled ultra-long acting 2 receptor agonist with rapid onset of action

David, A. Bailey, E. Cadogan, 2014 .

Characteristics of AZD9708, a novel, selective β2-adrenoceptor agonist with rapid onset and long duration of action.

R. Austin, E. Cadogan, D. Nicholls, 2012, Pulmonary pharmacology & therapeutics.

Evaluation of a series of bicyclic CXCR2 antagonists.

R. Austin, R. Jewell, M. Christie, 2008, Bioorganic & medicinal chemistry letters.

SAR studies on thiazolo[4,5-d]pyrimidine based CXCR2 antagonists involving a novel tandem displacement reaction.

R. Austin, R. Jewell, M. Christie, 2007, Bioorganic & medicinal chemistry letters.

Discovery and evaluation of a novel monocyclic series of CXCR2 antagonists.

R. Austin, D. Nicholls, A. Cook, 2015, Bioorganic & medicinal chemistry letters.

Discovery of potent CRTh2 (DP2) receptor antagonists.

S. Teague, R. Weaver, S. Paine, 2006, Bioorganic & medicinal chemistry letters.

Switching between agonists and antagonists at CRTh2 in a series of highly potent and selective biaryl phenoxyacetic acids.

A. Davis, G. Pairaudeau, S. Thom, 2011, Bioorganic & medicinal chemistry letters.

A novel one-pot method for the preparation of pyrazoles by 1,3-dipolar cycloadditions of diazo compounds generated in situ.

V. Aggarwal, R. Bonnert, J. de Vicente, 2003, The Journal of organic chemistry.

Fused mesoionic heterocycles: synthesis of [1,2,3]triazolo[1,5-a]quinoline, [1,2,3]triazolo[1,5-a]quinazoline, [1,2,3]triazolo[1,5-a]quinoxaline and [1,2,3]triazolo[5,1-c]benzotriazine derivatives

D. Donald, R. Bonnert, P. Cage, 2002 .

Dual D2-receptor and beta2-adrenoceptor agonists for the treatment of airway diseases. 1. Discovery and biological evaluation of some 7-(2-aminoethyl)-4-hydroxybenzothiazol-2(3H)-one analogues.

R C Brown, A M Davis, W. T. Simpson, 1998, Journal of medicinal chemistry.

Diastereoselective synthesis of cyclopropane amino acids using diazo compounds generated in situ.

R. Cox, M. Walter, V. Aggarwal, 2003, The Journal of organic chemistry.

Catalytic cyclopropanation of alkenes using diazo compounds generated in situ. A novel route to 2-arylcyclopropylamines.

V. Aggarwal, R. Bonnert, J. de Vicente, 2001, Organic letters.

The first example of a Robinson annulation on a carbohydrate derivative

P. R. Jenkins, R. Bonnert, 1987 .

A simple, user-friendly process for the homologation of aldehydes using tosylhydrazone salts

I. Holmes, V. Aggarwal, B. Pelotier, 2000 .

Zwitterionic CRTh2 antagonists.

S. Thom, A. Cook, S. Paine, 2011, Journal of medicinal chemistry.

Synthesis of strychnine via the Wieland-Gumlich aldehyde

N. Vicker, P. Magnus, R. Bonnert, 1992 .

Robinson annulation on a carbohydrate derivative

P. R. Jenkins, N. Lawrence, R. Bonnert, 1991 .

Silicon-directed diene synthesis

Paul R. Jenkins, N. J. Lawrence, Paul A. Brown, 1991 .

Stereoselective reductive hydroxymethylation of an annulated sugar derivative via radical cyclisation

Paul R. Jenkins, N. J. Lawrence, Roger V. Bonnert, 1992 .

The Diels-Alder reaction of dienes with a cis-1-methyl group

P. R. Jenkins, R. Bonnert, 1987 .

A silicon directed diene synthesis

P. R. Jenkins, R. Bonnert, M. Selim, 1987 .

A synthesis of an alkylated taxane model system

P. R. Jenkins, R. Bonnert, 1989 .

Synthesis and evaluation of 8-oxoadenine derivatives as potent Toll-like receptor 7 agonists with high water solubility.

Tomoaki Nakamura, T. Mcinally, H. Wada, 2013, Bioorganic & medicinal chemistry letters.

Synthesis and biological evaluation of 8-oxoadenine derivatives as toll-like receptor 7 agonists introducing the antedrug concept.

Tomoaki Nakamura, A. Kurimoto, T. Mcinally, 2010, Journal of medicinal chemistry.

NMR identification of an S-linked glucuronide of a triazole thione formed in vitro.

R. Lewis, Iain J Martin, R. Bonnert, 2003, Drug metabolism and disposition: the biological fate of chemicals.

A Novel One‐Pot Method for the Preparation of Pyrazoles by 1,3‐Dipolar Cycloadditions of Diazo Compounds Generated in situ.

V. Aggarwal, R. Bonnert, J. Vicente, 2003 .