D. Beattie

发表

A physical properties based approach for the exploration of a 4-hydroxybenzothiazolone series of beta2-adrenoceptor agonists as inhaled long-acting bronchodilators.

B. Cuenoud, R. Taylor, S. Charlton, 2010, Bioorganic & medicinal chemistry letters.

The identification of indacaterol as an ultralong-acting inhaled beta2-adrenoceptor agonist.

J. Fozard, B. Faller, D. Wyss, 2010, Journal of medicinal chemistry.

Synthesis and biological properties of novel glucocorticoid androstene C-17 furoate esters.

J. Fozard, Deborah Hynx, Keith Butler, 2004, Bioorganic & medicinal chemistry.

Design of non-peptide CCK2 and NK1 peptidomimetics using 1-(2-nitrophenyl)thiosemicarbazide as a novel common scaffold.

R. Wrigglesworth, C. Snell, J. Wood, 2001, Bioorganic & medicinal chemistry letters.

Synthesis and fungicidal activity of novel pimprinine analogues.

Qiong Chen, Guangfu Yang, Yucheng Gu, 2012, European journal of medicinal chemistry.

Synthesis and antifungal activity of 3-(1,3,4-oxadiazol-5-yl)-indoles and 3-(1,3,4-oxadiazol-5-yl)methyl-indoles.

Qiong Chen, Guangfu Yang, Yucheng Gu, 2013, European journal of medicinal chemistry.

2-Nitrophenylcarbamoyl-(S)-prolyl-(S)-3-(2-naphthyl)alanyl-N-benzyl-N - methylamide (SDZ NKT 343), a potent human NK1 tachykinin receptor antagonist with good oral analgesic activity in chronic pain models.

S. Ko, L. Urbán, M. Lemaire, 1998, Journal of medicinal chemistry.

Synthesis and antifungal activity of novel indole-replaced streptochlorin analogues.

Guangfu Yang, Yucheng Gu, J. Clough, 2017, European journal of medicinal chemistry.

The discovery of 3-(1-aminoethylidene)quinoline-2, 4(1H,3H)-dione derivatives as novel PSII electron transport inhibitors

Yong-hong Li, D. Beattie, Ziwen Wang, 2013, Molecular Diversity.

Design, synthesis and fungicidal activity of novel sclerotiorin derivatives.

Shao-Wei Huang, Guangfu Yang, Yucheng Gu, 2012 .

Synthesis and antifungal activity of novel sclerotiorin analogues.

Shao-Wei Huang, Guangfu Yang, Yucheng Gu, 2012, Journal of agricultural and food chemistry.

Synthesis and evaluation of two series of 4'-aza-carbocyclic nucleosides as adenosine A2A receptor agonists.

J. Fozard, S. Charlton, P. Gedeck, 2010, Bioorganic & medicinal chemistry letters.

AZD7648 is a potent and selective DNA-PK inhibitor that enhances radiation, chemotherapy and olaparib activity

M. O’Connor, S. Fawell, B. Davies, 2019, Nature Communications.

The discovery of 7-methyl-2-[(7-methyl[1,2,4]triazolo[1,5-a]pyridin-6-yl)amino]-9-(tetrahydro-2H-pyran-4-yl)-7,9-dihydro-8H-purin-8-one (AZD7648), a potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor.

B. Davies, M. Vázquez‐Chantada, G. Lamont, 2019, Journal of medicinal chemistry.

5,6,7,8-Tetrahydroquinolines. 5. Antiulcer and antisecretory activity of 5,6,7,8-tetrahydroquinolinethioureas and related heterocycles.

R. Crossley, D. Hill, D. Beattie, 1977, Journal of medicinal chemistry.

Discovery of Clinical Candidate AZD0095, a Selective Inhibitor of Monocarboxylate Transporter 4 (MCT4) for Oncology.

G. Lamont, D. Buttar, S. Critchlow, 2022, Journal of medicinal chemistry.

Design, synthesis, and biological activities of arylmethylamine substituted chlorotriazine and methylthiotriazine compounds.

Yucheng Gu, Yuxiu Liu, D. Beattie, 2011, Journal of agricultural and food chemistry.

An investigation into the structure-activity relationships associated with the systematic modification of the β(2)-adrenoceptor agonist indacaterol.

J. Fozard, B. Cuenoud, S. Charlton, 2012, Bioorganic & medicinal chemistry letters.

Potent and orally bioavailable non-peptide antagonists at the human bradykinin B(1) receptor based on a 2-alkylamino-5-sulfamoylbenzamide core.

P. McIntyre, S. Bevan, T. Ritchie, 2004, Journal of medicinal chemistry.

The identification of 7-[(R)-2-((1S,2S)-2-benzyloxycyclopentylamino)-1-hydroxyethyl]-4-hydroxybenzothiazolone as an inhaled long-acting β2-adrenoceptor agonist.

J. Fozard, S. Charlton, M. Gosling, 2014, Bioorganic & medicinal chemistry letters.

The discovery of 3-(1-aminoethylidene)quinoline-2, 4(1H,3H)-dione derivatives as novel PSII electron transport inhibitors

Yucheng Gu, Yuxiu Liu, Yong-hong Li, 2013, Molecular Diversity.

5,6,7,8-TETRAHYDROQUINOLINES. 4. ANTIULCER AND ANTISECRETORY ACTIVITY OF 5,6,7,8-TETRAHYDROQUINOLINENITRILES AND -THIOAMIDES

R. Crossley, D. Hill, D. Beattie, 1977 .

5,6,7,8-Tetrahydroguinolines. 4. Antiulcer and antisecretory activity of 5,6,7,8-tetrahydroquinolinenitriles and -thioamides.

R. Crossley, D. Hill, D. Beattie, 1977, Journal of medicinal chemistry.

The gastric antisecretory activity of 3-methyl-5,6,7,8-tetrahydroquinoline-8-thiocarboxamide hydrochloride (tiquinamide).

D. Beattie, G. Dixon, B. J. Alps, 1979, Arzneimittel-Forschung.

Optimization of hERG and Pharmacokinetic Properties for Basic Dihydro-8H-purin-8-one Inhibitors of DNA-PK.

B. Davies, M. Vázquez‐Chantada, G. Lamont, 2022, ACS medicinal chemistry letters.

Development of autotaxin inhibitors: A series of tetrazole cinnamides.

S. Rieffel, M. Dowling, M. Faller, 2020, Bioorganic & medicinal chemistry letters.