M. Bradley

发表

A physical properties based approach for the exploration of a 4-hydroxybenzothiazolone series of beta2-adrenoceptor agonists as inhaled long-acting bronchodilators.

B. Cuenoud, R. Taylor, S. Charlton, 2010, Bioorganic & medicinal chemistry letters.

Investigating the molecular mechanisms through which FTY 720P causes persistent S 1 P 1 receptor internalisation 1

M. Dowling, S. Charlton, A. Sattikar, 2014 .

The identification of indacaterol as an ultralong-acting inhaled beta2-adrenoceptor agonist.

J. Fozard, B. Faller, D. Wyss, 2010, Journal of medicinal chemistry.

Long Receptor Residence Time of C26 Contributes to Super Agonist Activity at the Human β2 Adrenoceptor

S. Charlton, A. Sattikar, D. Sykes, 2016, Molecular Pharmacology.

Potent and Efficacious Inhibition of CXCR2 Signaling by Biparatopic Nanobodies Combining Two Distinct Modes of Action

S. Charlton, T. Laeremans, B. Dombrecht, 2015, Molecular Pharmacology.

Fevipiprant (QAW039), a Slowly Dissociating CRTh2 Antagonist with the Potential for Improved Clinical Efficacy

S. Watson, S. Charlton, D. Sykes, 2016, Molecular Pharmacology.

Fevipiprant ( QAW 039 ) , a Slowly Dissociating CRTh 2 Antagonist with the Potential for Improved Clinical Efficacy s

S. Watson, S. Charlton, D. Sykes, 2016 .

Functional desensitization of the b 2 adrenoceptor is not dependent on agonist efﬁcacy

S. Charlton, M. Bradley, E. Rosethorne, 2015 .

F1000Prime recommendation of Formation and dissociation of M1 muscarinic receptor dimers seen by total internal reflection fluorescence imaging of single molecules.

S. Charlton, M. Bradley, 2010 .

Title : Long Receptor Residence Time of C 26 Contributes to Super Agonist Activity at the Human β 2 Adrenoceptor

S. Charlton, A. Sattikar, D. Sykes, 2016 .

The in vitro metabolism of sphingosine-1-phosphate: identification; inhibition and pharmacological implications.

M. Dowling, S. Charlton, M. Bradley, 2011, European journal of pharmacology.

Functional desensitization of the β2 adrenoceptor is not dependent on agonist efficacy

S. Charlton, M. Bradley, E. Rosethorne, 2015, Pharmacology research & perspectives.

The discovery of potent, orally bioavailable pyrazolo and triazolopyrimidine CXCR2 receptor antagonists.

D. O'connor, S. Watson, S. Charlton, 2014, Bioorganic & medicinal chemistry letters.

An investigation into the structure-activity relationships associated with the systematic modification of the β(2)-adrenoceptor agonist indacaterol.

J. Fozard, B. Cuenoud, S. Charlton, 2012, Bioorganic & medicinal chemistry letters.

The identification of 7-[(R)-2-((1S,2S)-2-benzyloxycyclopentylamino)-1-hydroxyethyl]-4-hydroxybenzothiazolone as an inhaled long-acting β2-adrenoceptor agonist.

J. Fozard, S. Charlton, M. Gosling, 2014, Bioorganic & medicinal chemistry letters.