D. Tschaen

发表

Process Chemistry in Antiviral Research

Hongming Li, M. McLaughlin, Y. Zhong, 2016, Topics in Current Chemistry.

Synthesis of vaniprevir (MK-7009): lactamization to prepare a 20-membered [corrected] macrocycle.

Paul N. Devine, D. Tellers, D. Zewge, 2011, The Journal of organic chemistry.

Practical Synthesis of A Macrocyclic HCV Protease Inhibitor: A High-Yielding Macrolactam Formation

Paul N. Devine, D. Tellers, D. Zewge, 2014 .

Nine-Step Stereoselective Synthesis of Islatravir from Deoxyribose.

Christopher C. Nawrat, Hongming Li, M. McLaughlin, 2020, Organic letters.

Synthesis of Islatravir Enabled by a Catalytic, Enantioselective Alkynylation of a Ketone.

Christopher C. Nawrat, K. Maloney, A. Fryszkowska, 2020, Organic letters.

Asymmetric Synthesis of Letermovir Using a Novel Phase-Transfer-Catalyzed Aza-Michael Reaction

G. Humphrey, S. M. Dalby, Z. Song, 2016 .

Oxidation of Primary Alcohols to Carboxylic Acids with Sodium Chlorite Catalyzed by TEMPO and Bleach

P. Reider, E. Grabowski, Z. Song, 1999 .

Stereoselective synthesis of 2-aryloxy acids from lactamide derived esters of racemic α-halo carboxylic acids

Paul N. Devine, R. Heid, D. Tschaen, 1996 .

Synthesis of the GPR40 Partial Agonist MK-8666 through a Kinetically Controlled Dynamic Enzymatic Ketone Reduction.

Nicholas J Agard, L. Tan, Eric Ashley, 2016, Organic letters.

Asymmetric Biosynthesis of Key Aromatic Intermediates in the Synthesis of an Endothelin Receptor Antagonist

Paul N. Devine, M. Chartrain, R. Greasham, 2001 .

The Application of Asymmetric Bioreductions to the Production of Chiral Pharmaceutical Drugs

M. Chartrain, J. Armstrong, R. Greasham, 1996, Annals of the New York Academy of Sciences.

Asymmetric bioreduction of a β-tetralone to its corresponding (S)-alcohol by the yeast Trichosporon capitatum MY 1890

M. Chartrain, R. Greasham, V. Pecore, 1996 .

Asymmetric synthesis of highly functionalized tetrahydropyran DPP-4 inhibitor.

Jeremy P. Scott, Feng Xu, Michael J. Zacuto, 2014, Organic letters.

Asymmetric reduction of keto oxime ethers using oxazaborolidine reagents. The enantioselective synthesis of cyclic amino alcohols

P. Reider, R. Tillyer, D. Tschaen, 1995 .

A Mild Cu(I)-Catalyzed Oxidative Aromatization of Indolines to Indoles.

I. Mangion, M. McLaughlin, Yizhou Liu, 2016, The Journal of organic chemistry.

Ullmann diaryl ether synthesis: rate acceleration by 2,2,6,6-tetramethylheptane-3,5-dione.

R. Volante, P. Reider, Z. Song, 2002, Organic letters.

Oxidation of Primary Alcohols to Carboxylic Acids with Sodium Chlorite Catalyzed by TEMPO and Bleach: 4‐Methoxyphenylacetic Acid

Z. Song, D. Tschaen, E. Mano, 2005 .

A novel chromium trioxide catalyzed oxidation of primary alcohols to the carboxylic acids

P. Reider, E. Grabowski, Z. Song, 1998 .

Efficient Synthesis of α-Chloro Ketones via Reaction of Organometallic Reagents with N-Methoxy-N-Methylchloroacetamide

R. Tillyer, L. Frey, D. Tschaen, 1996 .

Practical synthesis of a neuropeptide Y antagonist via stereoselective addition to a ketene.

K. Maeda, R. Volante, Yuhei Yamamoto, 2005, The Journal of organic chemistry.

Asymmetric Synthesis of MK-0499

D. Cai, L. Frey, S. Karady, 1995 .

Efficient Synthesis of Losartan, A Nonpeptide Angiotensin II Receptor Antagonist

James R. Moore, P. Reider, Y. Lo, 1994 .

Methods for the Synthesis of 5,6,7,8-Tetrahydro-1,8-naphthyridine Fragments for αVβ3 Integrin Antagonists

L. Tan, D. Zewge, M. Palucki, 2004 .

Practical Asymmetric Synthesis of an Endothelin Receptor Antagonist

Paul N. Devine, R. Volante, P. Reider, 1999 .

Photo-oxidative cleavage of a furan-azetidinone carbon-carbon bond: a synthesis of 4-acetoxyazetidinone

R. Reamer, D. Tschaen, J. Lynch, 1993 .

Effects of triethylamine in asymmetric reduction using oxazaborolidine reagents

A. W. Douglas, D. Cai, Y. She, 1993 .

The oxazaborolidine-borane reduction of ketones: Identification and reactivity of transient intermediates

A. W. Douglas, R. Reamer, D. Tschaen, 1996 .

Synthesis of PAF antagonist MK-287

A. Thompson, R. Reamer, D. Tschaen, 1992 .

Conversion of a silylated hemiacetal into an α-bromoether using trimethylsilylbromide. Synthesis of platelet activating factor antagonist L-659,989.

A. Thompson, D. Tschaen, T. Verhoeven, 1990 .

Stereochemistry of the glyoxylate N-sulfonylimine ene reaction

S. Weinreb, D. Tschaen, 1982 .

Stereocontrolled synthesis of trisubstituted cyclopropanes: expedient, atom-economical, asymmetric syntheses of (+)-Bicifadine and DOV21947.

E. Corley, Feng Xu, S. Karady, 2006, Organic Letters.

Total Synthesis of (+)-Actinobolin.

R. Garigipati, S. Weinreb, D. Tschaen, 1986 .

Stereoselective total syntheses of the antitumor antibiotics (+)-actinobolin and (-)-bactobolin from a common bridged lactone intermediate

R. Garigipati, S. Weinreb, D. Tschaen, 1990 .

Total synthesis of (+)-actinobolin

R. Garigipati, S. Weinreb, D. Tschaen, 1985 .

Stereochemical studies of thermal intermolecular and intramolecular N-sulfonylimine ene reactions

S. Weinreb, E. Turos, D. Tschaen, 1984 .

Highly efficient synthesis of HIV NNRTI doravirine.

T. Itoh, I. Mangion, B. Sherry, 2015, Organic letters.

Chlorination/cyclodehydration of amino alcohols with SOCl2: an old reaction revisited.

E. Corley, Feng Xu, R. Reamer, 2008, The Journal of organic chemistry.

Asymmetric synthesis of a potent, aminopiperidine-fused imidazopyridine dipeptidyl peptidase IV inhibitor.

E. Corley, Feng Xu, G. Humphrey, 2010, The Journal of organic chemistry.

Stereoselective Conjugate Addition Reactions of α,β-Unsaturated tert-Butyl Esters with Aryllithium Reagents†

A. Caillé, P. Reider, E. Grabowski, 1998 .

Enantioselective preparation of ring-fused 1-fluorocyclopropane-1-carboxylate derivatives: en route to mGluR 2 receptor agonist MGS0028.

R. Volante, Z. Song, D. Tschaen, 2004, Organic letters.

Stereoselective synthesis of 2-aryloxy esters: An asymmetric approach to fluoxetine, tomoxetine and nisoxetine

Paul N. Devine, R. Heid, D. Tschaen, 1997 .

Enantioselective 1,4-addition of aryllithium reagents to α,β-unsaturated tert-butyl esters in the presence of chiral additives

P. Reider, E. Grabowski, R. Tillyer, 1998 .

Highly selective cascade couplings for the syntheses of functionalized piperidinones and bispidines.

E. Corley, Feng Xu, D. Tschaen, 2007, Organic letters.

A Practical, One-Pot Preparation of Diisopinocampheylchloroborane

D. Tschaen, T. Verhoeven, Pamela M. Simpson, 1991 .

An Improved Procedure for Aromatic Cyanation

D. Tschaen, T. Verhoeven, Richard A Desmond, 1994 .

An efficient synthesis of 4-benzoyloxyazetidinone: an important carbapenem intermediate

R. Volante, D. Tschaen, J. Lynch, 1988 .

Mechanism of an acid chloride-imine reaction by low-temperature FT-IR: .beta.-lactam formation occurs exclusively through a ketene intermediate

R. Volante, D. Tschaen, J. Lynch, 1989 .

Photooxidative Cleavage of a Furanazetidinone Carbon-Carbon Bond: A Synthesis of 4-Acetoxyazetidinone.

R. Volante, R. Reamer, D. Tschaen, 1994 .

Efficient synthesis of NK(1) receptor antagonist aprepitant using a crystallization-induced diastereoselective transformation.

Jing Li, Paul N Devine, Paul N. Devine, 2003, Journal of the American Chemical Society.

Synthesis of a muscarinic receptor antagonist via a diastereoselective Michael reaction, selective deoxyfluorination and aromatic metal-halogen exchange reaction.

J. Song, D. Zewge, I. Houpis, 2001, The Journal of organic chemistry.

Practical synthesis of a potent indolocarbazole-based, DNA topoisomerase inhibitor

K. Rossen, T. Nemoto, A. Kamatani, 2001 .

An improved method for chiral oxazaborolidine-catalyzed reduction of 4-chromanone analogs and MK-0499

A. W. Douglas, D. Cai, D. Tschaen, 1994 .

Effects of Triethylamine in Asymmetric Reduction Using Oxazaborolidine Reagents.

A. W. Douglas, D. Cai, R. Reamer, 2010 .

A stereoselective aldol reaction via diisopinocampheyl boron-enolate in preparation of chromane carboxylate with quaternary carbon

D. Zewge, R. Volante, P. Reider, 2003 .

Conversion of a Silylated Hemiacetal into an α-Bromo Ether Using Trimethylsilylbromide. Synthesis of Platelet Activating Factor Antagonist L-659,989.

A. Thompson, D. Tschaen, T. Verhoeven, 1992 .

Synthesis of PAF Antagonist MK-287.

A. Thompson, R. Reamer, D. Tschaen, 2010 .

Why are benzimidazoles efficiently acylated with esters? Identification of a tetrahedral hemiacetal alkoxide intermediate

K. Maeda, J. Dannenberg, Ross A. Miller, 2005 .

A Publication of Reliable Methods for the Preparation of Organic Compounds

Z. Song, D. Tschaen, E. Mano, 2016 .

A Practical Synthesis of 2-Butyl-4(5)-chloro-5(4)-hydroxymethyl- 1H-imidazole

L. Frey, D. Tschaen, T. Verhoeven, 1993 .

Stereocontrolled Synthesis of Trisubstituted Cyclopropanes: Expedient, Atom‐Economical, Asymmetric Syntheses of (+)‐Bicifadine and DOV21947.

E. Corley, Feng Xu, S. Karady, 2006 .

Stereoselective Total Syntheses of the Antitumor Antibiotics (+)-Actinobolin and (-)-Bactobolin from a Common Bridged Lactone Intermediate.

R. Garigipati, S. Weinreb, D. Tschaen, 1990 .

Chlorination/cyclodehydration of amino alcohols with SOCl2: an old reaction revisited.

E. Corley, Feng Xu, R. Reamer, 2008, The Journal of organic chemistry.

Highly Chemoselective Trichloroacetimidate-Mediated Alkylation of Ascomycin: A Convergent, Practical Synthesis of the Immunosuppressant L-733,725.

Yulan Li, D. Mathre, P. Reider, 1999, The Journal of organic chemistry.

syn-2,3-Disubstituted-2,3-dihydro-1,4-benzoxathiin rings: preparation from quinone ketals and 2-mercaptoethanols☆

Jimmy O. DaSilva, E. Corley, Feng Xu, 2004 .

A kinase-cGAS cascade to synthesize a therapeutic STING activator

Steven P. Miller, Paul N. Devine, Matthew L. Maddess, 2022, Nature.

Practical synthesis of a potent hepatitis C virus RNA replication inhibitor.

R. Volante, E. Grabowski, Feng Xu, 2004, The Journal of organic chemistry.

Merck’s Reaction Review Policy: An Exercise in Process Safety

Rebecca T. Ruck, I. Raheem, G. Humphrey, 2013 .

Enhanced O-dealkylation activity of SiCl4/LiI with catalytic amount of BF3

D. Zewge, D. Tschaen, S. Weissman, 2004 .

The Practical Enantioselective Reduction of Prochiral Ketones

D. Mathre, D. Tschaen, I. Shinkai, 1997 .

Practical asymmetric synthesis of aprepitant, a potent human NK-1 receptor antagonist, via a stereoselective Lewis acid-catalyzed trans acetalization reaction.

P. Reider, E. Grabowski, Guojie Ho, 2002, The Journal of organic chemistry.

Practical asymmetric synthesis of a selective endothelin A receptor (ETA) antagonist.

H. Satō, T. Nemoto, R. Volante, 2001, Organic Letters.

Efficient Synthesis of a Highly Selective NPY-5 Receptor Antagonist: A Drug Candidate for the Treatment of Obesity

K. Maeda, N. Nonoyama, T. Itoh, 2006 .

The plasma corticosteroid profile in the adjuvant induced arthritic rat model

J. Belliveau, G. P. O'Leary, D. Tschaen, 1982, FEBS letters.

Asymmetric Reduction of Keto Oxime Ethers Using Oxazaborolidine Reagents. The Enantioselective Synthesis of Cyclic Amino Alcohols.

P. Reider, R. Tillyer, D. Tschaen, 1995 .

Synthesis of Islatravir Enabled by a Catalytic, Enantioselective Alkynylation of a Ketone.

Christopher C. Nawrat, K. Maloney, A. Fryszkowska, 2020, Organic letters.

An efficient asymmetric synthesis of an estrogen receptor modulator by sulfoxide-directed borane reduction.

D. Zewge, D. Mathre, R. Volante, 2004, Proceedings of the National Academy of Sciences of the United States of America.