J. Hutt

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Aerobiology and Inhalation Exposure to Biological Select Agents and Toxins

D. Reed, C. Roy, J. Hutt, 2010, Veterinary pathology.

Autophagy protects against active tuberculosis by suppressing bacterial burden and inflammation

V. Deretic, N. Dupont, K. Dobos, 2012, Proceedings of the National Academy of Sciences.

Gestational Exposure of Mice to Secondhand Cigarette Smoke Causes Bronchopulmonary Dysplasia Blocked by the Nicotinic Receptor Antagonist Mecamylamine

Kevin R. Smith, R. Langley, K. Harrod, 2013, Environmental health perspectives.

Intranasal Vaccination Induces Protective Immunity against Intranasal Infection with Virulent Francisella tularensis Biovar A

Terry H Wu, J. Hutt, C. Lyons, 2005, Infection and Immunity.

Expression and function of CCAAT/enhancer binding proteinβ (C/EBPβ) LAP and LIP isoforms in mouse mammary gland, tumors and cultured mammary epithelial cells

L. R. Dearth, A. Gigliotti, J. Dewille, 2001 .

Muc1 knockout potentiates murine lung carcinogenesis involving an epiregulin-mediated EGFR activation feedback loop

S. Leng, S. Belinsky, M. Tessema, 2017, Carcinogenesis.

Carcinogen exposure differentially modulates RAR-beta promoter hypermethylation, an early and frequent event in mouse lung carcinogenesis.

S. Belinsky, W. Palmisano, J. Hutt, 2003, Carcinogenesis.

Carcinogenic Responses of the Respiratory Tract

F. Hahn, J. Hutt, 2010 .

Comparative Oncology of Lung Tumors

A. Gigliotti, F. Hahn, J. Hutt, 2007, Toxicologic pathology.

The regulation of CCAAT/enhancer binding protein delta expression by activated stat3 /

J. Hutt, 2002 .

A Review of the Histopathology of Cigarette Smoke–Induced Lung Cancer in Rats and Mice

J. Mauderly, A. Gigliotti, F. Hahn, 2007, International journal of toxicology.

Ribavirin, human convalescent plasma and anti-beta3 integrin antibody inhibit infection by Sin Nombre virus in the deer mouse model.

B. Hjelle, J. Hutt, R. Medina, 2007, The Journal of general virology.

Current use of animal models of disease for nonclinical safety testing

D. Blanset, S. Morgan, J. Hutt, 2020 .

The pathogenesis of acute pulmonary viral and bacterial infections: investigations in animal models.

Terry H Wu, J. Hutt, C. Lyons, 2010, Annual review of pathology.

Local and systemic tolerability of a 2′O-methoxyethyl antisense oligonucleotide targeting interleukin-4 receptor-α delivery by inhalation in mouse and monkey

J. McDonald, A. Gigliotti, M. Reed, 2014, Inhalation toxicology.

Transcriptional Regulation of C/EBPδ in G0 Growth-Arrested Mouse Mammary Epithelial Cells

J. O’Rourke, J. Dewille, J. Hutt, 1999 .

Immunization with a Recombinant, Pseudomonas fluorescens-Expressed, Mutant Form of Bacillus anthracis-Derived Protective Antigen Protects Rabbits from Anthrax Infection

M. Valderas, M. Reed, P. Kuehl, 2015, PloS one.

Clinical and pathologic features of cynomolgus macaques (Macaca fascicularis) infected with aerosolized Yersinia pestis.

C. Gennings, A. Gigliotti, J. Hutt, 2008, Comparative medicine.

Lethal factor, but not edema factor, is required to cause fatal anthrax in cynomolgus macaques after pulmonary spore challenge.

T. Brasel, J. Hutt, C. Lyons, 2014, The American journal of pathology.

Resonance Raman spectroscopic studies of adriamycin and copper(II)-adriamycin and copper(II)-adriamycin-DNA complexes.

P. Dutta, J. Hutt, 1986, Biochemistry.

Role of muscarinic receptors in the regulation of immune and inflammatory responses

F. Hahn, M. Sopori, S. Razani-Boroujerdi, 2008, Journal of Neuroimmunology.

C-Reactive Protein-Mediated Suppression of Nephrotoxic Nephritis: Role of Macrophages, Complement, and Fc Receptors

L. Marnell, C. Mold, J. Verbeek, 2006 .

Assessment of toxicity and biodistribution of recombinant AAV8 vector–mediated immunomodulatory gene therapy in mice with Pompe disease

Songtao Li, D. Bali, D. Koeberl, 2014, Molecular therapy. Methods & clinical development.

Antibodies Contribute to Effective Vaccination against Respiratory Infection by Type A Francisella tularensis Strains

Terry H Wu, J. Hutt, C. Lyons, 2011, Infection and Immunity.

Scientific and Regulatory Policy Committee Points to Consider: Nonclinical Research and Development of In Vivo Gene Therapy Products, Emphasizing Adeno-Associated Virus Vectors

L. Kattenhorn, B. Bolon, L. Whiteley, 2021, Toxicologic pathology.

C-reactive protein-mediated suppression of nephrotoxic nephritis: role of macrophages, complement, and Fcgamma receptors.

L. Marnell, C. Mold, T. D. Du Clos, 2007, Journal of immunology.

Biological microdosimetry based on radiation cytotoxicity data.

B. Scott, J. Hutt, C. Potter, 2013, Radiation protection dosimetry.

Opinion on the Use of Animal Models in Nonclinical Safety Assessment: Pros and Cons

R. Sura, S. Morgan, J. Hutt, 2021, Toxicologic pathology.

Oncostatin M Induces Growth Arrest of Mammary Epithelium via a CCAAT/enhancer-binding Protein δ-dependent Pathway1Supported in part by NIH Grant RR00136CA (to J. A. H.) and NIH Grants CA 57607 and P30CA16058 from the National Cancer Institute (to J. W. D.).1

J. Dewille, J. Hutt, 2002 .

Oncostatin M Induces Growth Arrest of Mammary Epithelium via a CCAAT / enhancer-binding Protein-dependent Pathway 1

J. Dewille, J. Hutt, 2002 .

Intrapleural administration of an AAVrh.10 vector coding for human α1-antitrypsin for the treatment of α1-antitrypsin deficiency.

R. Crystal, N. Hackett, Yihharn Hwang, 2013, Human gene therapy. Clinical development.

Cowpox virus inhibits human dendritic cell immune function by nonlethal, nonproductive infection.

J. Rushton, D. Pickup, H. Chand, 2011, Virology.

Infrared and resonance Raman spectroscopic studies of 1-hydroxy-9,10-anthraquinone and its metal complexes

P. Dutta, J. Hutt, 1987 .

Gene Promoter Hypermethylation in Mouse Lung Tumors

S. Belinsky, J. Hutt, Brian R. Vuillemenot, 2006, Molecular Cancer Research.

Capsule synthesis by Bacillus anthracis is required for dissemination in murine inhalation anthrax

T. Koehler, Yahua Chen, J. Hutt, 2005, The EMBO journal.

C-Reactive Protein-Mediated Suppression of Nephrotoxic Nephritis: Role of Macrophages, Complement, and Fcγ Receptors1

L. Marnell, C. Mold, T. D. Du Clos, 2007, The Journal of Immunology.

Aberrant Promoter Hypermethylation of the Death-Associated Protein Kinase Gene Is Early and Frequent in Murine Lung Tumors Induced by Cigarette Smoke and Tobacco Carcinogens

S. Belinsky, T. Devereux, J. Hutt, 2004, Cancer Research.

Preclinical efficacy and safety of KCNH2‐G628S gene therapy for postoperative atrial fibrillation

B. Rajeshkumar, J. Hutt, Zhao Liu, 2017, The Journal of thoracic and cardiovascular surgery.

The SARS-CoV ferret model in an infection–challenge study

Qianjun Li, D. Kelvin, C. Jonsson, 2008, Virology.

Granuloma Formation Induced by Low-Dose Chronic Silica Inhalation is Associated with an Anti-Apoptotic Response in Lewis Rats

R. Langley, N. Mishra, M. Sopori, 2010, Journal of toxicology and environmental health. Part A.

The Natural History of Pneumonic Tularemia in Female Fischer 344 Rats after Inhalational Exposure to Aerosolized Francisella tularensis Subspecies tularensis Strain SCHU S4.

J. Hutt, J. Lovchik, A. Dekonenko, 2017, The American journal of pathology.

Preclinical evaluation of a recombinant adeno-associated virus vector expressing human alpha-1 antitrypsin made using a recombinant herpes simplex virus production method.

T. Flotte, G. Ye, J. Chulay, 2011, Human gene therapy.

Identification of an Attenuated Substrain of Francisella tularensis SCHU S4 by Phenotypic and Genotypic Analyses

Fangfang Xia, T. Modise, E. Barry, 2021, Pathogens.

Learning and modeling biosignatures from tissue images

Robert Veroff, Paul Helman, Vikas Hamine, 2007, Comput. Biol. Medicine.

Murine Model of Pulmonary Anthrax: Kinetics of Dissemination, Histopathology, and Mouse Strain Susceptibility

E. Wang, J. Hutt, C. Lyons, 2004, Infection and Immunity.

Expression of either Lethal Toxin or Edema Toxin by Bacillus anthracis Is Sufficient for Virulence in a Rabbit Model of Inhalational Anthrax

T. Koehler, J. Hutt, C. Lyons, 2012, Infection and Immunity.

Prevention and reversal of nephritis in MRL/lpr mice with a single injection of C-reactive protein.

L. Marnell, C. Mold, T. D. Du Clos, 2006, Arthritis and rheumatism.

Reversal of ongoing proteinuria in autoimmune mice by treatment with C-reactive protein.

L. Marnell, C. Mold, T. D. Du Clos, 2005, Arthritis and rheumatism.

Radiobiological studies using gamma and x rays.

B. Scott, J. Hutt, C. Potter, 2013 .

Signal Transducer and Activator of Transcription 3 Activates CCAAT Enhancer-binding Protein d Gene Transcription in G 0 Growth-arrested Mouse Mammary Epithelial Cells and in Involuting Mouse Mammary Gland*

J. O’Rourke, J. Dewille, J. Hutt, 2000 .

Safety and biodistribution assessment of sc-rAAV2.5IL-1Ra administered via intra-articular injection in a mono-iodoacetate-induced osteoarthritis rat model

J. Grieger, R. Samulski, J. Seagrave, 2016, Molecular therapy. Methods & clinical development.

Life-span inhalation exposure to mainstream cigarette smoke induces lung cancer in B6C3F1 mice through genetic and epigenetic pathways.

J. Mauderly, S. Belinsky, A. Gigliotti, 2005, Carcinogenesis.

Nicotine Primarily Suppresses Lung Th2 but Not Goblet Cell and Muscle Cell Responses to Allergens1

Y. Tesfaigzi, R. Langley, K. C. Kim, 2008, The Journal of Immunology.

Cigarette smoke suppresses Th1 cytokine production and increases RSV expression in a neonatal model.

J. McDonald, K. Harrod, J. Hutt, 2006, American journal of physiology. Lung cellular and molecular physiology.

Chromatin remodeling by the histone methyltransferase EZH2 drives lung pre-malignancy and is a target for cancer prevention

S. Belinsky, S. Amin, D. Desai, 2021, Clinical Epigenetics.

Scientific and Regulatory Policy Committee Points to Consider: Data Visualization for Clinical and Anatomic Pathologists

Brian Knight, Martin Lamb, Julie Hutt, 2018, Toxicologic pathology.

Toxin-Deficient Mutants of Bacillus anthracis Are Lethal in a Murine Model for Pulmonary Anthrax

T. Koehler, J. Hutt, C. Lyons, 2006, Infection and Immunity.

Expression and function of CCAAT/enhancer binding proteinbeta (C/EBPbeta) LAP and LIP isoforms in mouse mammary gland, tumors and cultured mammary epithelial cells.

L. R. Dearth, A. Gigliotti, J. Dewille, 2001, Journal of cellular biochemistry.

Vaccination of Fischer 344 rats against pulmonary infections by Francisella tularensis type A strains.

J. Hutt, C. Lyons, G. Statom, 2009, Vaccine.

HIV gp120 Induces Mucus Formation in Human Bronchial Epithelial Cells through CXCR4/α7-Nicotinic Acetylcholine Receptors

S. Buch, C. Feghali-Bostwick, J. McIntosh, 2013, PloS one.

The toxicity of microcystin LR in mice following 7 days of inhalation exposure.

L. Fleming, E. Barr, S. Boggs, 2005, Toxicon : official journal of the International Society on Toxinology.

Signal Transducer and Activator of Transcription 3 Activates CCAAT Enhancer-binding Protein δ Gene Transcription in G0Growth-arrested Mouse Mammary Epithelial Cells and in Involuting Mouse Mammary Gland*

J. O’Rourke, J. Dewille, J. Hutt, 2000, The Journal of Biological Chemistry.

CCAAT/Enhancer-binding Protein δ Regulates Mammary Epithelial Cell G0 Growth Arrest and Apoptosis*

G. C. Newbound, J. O’Rourke, J. Dewille, 1999, The Journal of Biological Chemistry.

Oncostatin M induces growth arrest of mammary epithelium via a CCAAT/enhancer-binding protein delta-dependent pathway.

J. Dewille, J. Hutt, 2002, Molecular cancer therapeutics.

Signal transducer and activator of transcription 3 activates CCAAT enhancer-binding protein delta gene transcription in G0 growth-arrested mouse mammary epithelial cells and in involuting mouse mammary gland.

J. O’Rourke, J. Dewille, J. Hutt, 2000, The Journal of biological chemistry.

Transcriptional regulation of C/EBPdelta in G(0) growth-arrested mouse mammary epithelial cells.

J. O’Rourke, J. Dewille, J. Hutt, 1999, Biochemical and biophysical research communications.

Preclinical safety and biodistribution assessment of Ad‐KCNH2‐G628S administered via atrial painting in New Zealand white rabbits

Gensheng Wang, S. Kaminsky, Guodong Wu, 2023, Basic & clinical pharmacology & toxicology.