D. Ikeda

发表

Apolipoprotein E3 (apoE3) safeguards pig proximal tubular LLC-PK1 cells against reduction in SGLT1 activity induced by gentamicin C.

M. Kawada, K. Takamoto, D. Ikeda, 2005, Biochimica et biophysica acta.

Leucinostatin A inhibits prostate cancer growth through reduction of insulin‐like growth factor‐I expression in prostate stromal cells

M. Kawada, Tohru Masuda, Shun‐ichi Ohba, 2009, International journal of cancer.

Inhibition of human immunodeficiency virus-associated reverse transcriptase by 14-O-acyladriamycins.

K. Umezawa, T. Takeuchi, K. Ajito, 1989, The Journal of antibiotics.

Structure-activity relationship of boronic acid derivatives of tyropeptin: proteasome inhibitors.

Takumi Watanabe, Yoshikazu Takahashi, Y. Akamatsu, 2010, Bioorganic & medicinal chemistry letters.

Structure-based design of derivatives of tyropeptin A as the potent and selective inhibitors of mammalian 20S proteasome.

Y. Umezawa, H. Iinuma, D. Ikeda, 2005, Bioorganic & medicinal chemistry letters.

Tyropeptins A and B, new proteasome inhibitors produced by Kitasatospora sp. MK993-dF2. II. Structure determination and synthesis.

H. Naganawa, T. Takeuchi, H. Iinuma, 2001, The Journal of antibiotics.

Synthesis of boronic acid derivatives of tyropeptin: proteasome inhibitors.

Y. Umezawa, Takumi Watanabe, Yoshikazu Takahashi, 2009, Bioorganic & medicinal chemistry letters.

A microplate assay for selective measurement of growth of epithelial tumor cells in direct coculture with stromal cells.

M. Kawada, M. Ishizuka, Y. Yoshimoto, 2004, Anticancer research.

Inhibitors of insulin-like growth factor-1 receptor tyrosine kinase are preferentially cytotoxic to nutrient-deprived pancreatic cancer cells.

D. Ikeda, S. Kunimoto, I. Momose, 2009, Biochemical and biophysical research communications.

NBRI17671, a new antitumor compound, produced by Acremonium sp. CR17671

M. Kawada, Takumi Watanabe, Hikaru Abe, 2010, The Journal of Antibiotics.

Transforming growth factor-beta1 modulates tumor-stromal cell interactions of prostate cancer through insulin-like growth factor-I.

M. Arakawa, M. Kawada, D. Ikeda, 2008, Anticancer research.

Insulin-like Growth Factor I Secreted from Prostate Stromal Cells Mediates Tumor-Stromal Cell Interactions of Prostate Cancer

M. Kawada, Tohru Masuda, H. Inoue, 2006 .

A New Proteasome Inhibitor, TP-110, Induces Apoptosis in Human Prostate Cancer PC-3 Cells

M. Kawada, D. Ikeda, I. Momose, 2007, Bioscience, biotechnology, and biochemistry.

Synthesis of (-)-15-deoxyspergualin and (-)-spergualin-15-phosphate.

T. Takeuchi, H. Umezawa, S. Kondo, 1982, The Journal of antibiotics.

Structure of an antitumor antibiotic, spergualin.

T. Takeuchi, H. Umezawa, H. Iinuma, 1981, The Journal of antibiotics.

Phthoxazolin A inhibits prostate cancer growth by modulating tumor–stromal cell interactions

M. Kawada, H. Inoue, D. Ikeda, 2009, Cancer science.

Highly tumorigenic human androgen receptor‐positive prostate cancer cells overexpress angiogenin

M. Arakawa, M. Kawada, Tohru Masuda, 2007, Cancer science.

Establishment of a highly tumorigenic LNCaP cell line having inflammatory cytokine resistance.

M. Kawada, Tohru Masuda, H. Inoue, 2006, Cancer letters.

Decatromicins A and B, new antibiotics produced by Actinomadura sp. MK73-NF4. II. Structure determination.

H. Naganawa, T. Takeuchi, H. Iinuma, 1999, The Journal of antibiotics.

Suppression of type II collagen-induced arthritis by ICM0301B, a new angiogenesis inhibitor

H. Kumagai, Tohru Masuda, Shun‐ichi Ohba, 2012, The Journal of Antibiotics.

Tripropeptins, Novel Antimicrobial Agents Produced by Lysobacter sp. Part 2. Structure Elucidation.

H. Naganawa, M. Igarashi, Y. Muraoka, 2004 .

Corrigendum: Tripropeptins, novel antimicrobial agents produced by Lysobacter sp. II. structure elucidation

H. Naganawa, M. Igarashi, Y. Muraoka, 2016, The Journal of Antibiotics.

Structure of ericamycin having a 2-azahexaphene ring system.

S. Gomi, Y. Ikeda, S. Kondo, 1998, The Journal of antibiotics.

A synthetic approach to benanomicin A. 2. Synthesis of the substituted 5,6-dihydrobenzo[a]naphthacenequinone.

T. Takeuchi, D. Ikeda, S. Kondo, 1997, The Journal of antibiotics.

Selective deoxygenation and O-methylation of benanomicin A: synthesis of 9-deoxy-, 9-O-methyl- and 14-O-methylbenanomicin A.

T. Takeuchi, M. Hamada, D. Ikeda, 1997, The Journal of antibiotics.

A synthetic approach to benanomicin A. 1. Synthesis of 5,6-dihydrobenzo[a]naphthacenequinone.

T. Takeuchi, D. Ikeda, S. Kondo, 1997, The Journal of antibiotics.

Synthesis of an Optically Active α-Tetralone: A Key Intermediate to Natural Benanomicinone

D. Ikeda, S. Kondo, S. Hirosawa, 1997 .

A Synthetic Approach to Benanomicin A: Synthesis of the Substituted 5,6-Dihydrobenzo[a]naphthacenequinone

D. Ikeda, S. Kondo, S. Hirosawa, 1997 .

Amino acid analogs of benanomicin A through desalaninebenanomicin A.

S. Huang, T. Takeuchi, S. Kondo, 1992, The Journal of antibiotics.

Antifungal and antiviral activities of benanomicins and their analogues.

T. Takeuchi, M. Hamada, S. Gomi, 1991, The Journal of antibiotics.

Antitumor Effect of Kigamicin D on Mouse Tumor Models

H. Esumi, M. Kawada, Shun‐ichi Ohba, 2006, The Journal of Antibiotics.

Structure determination of altemicidin by nmr spectroscopic analysis

H. Naganawa, A. Takahashi, Y. Okami, 1991 .

Involvement of doxorubicin-induced Fas expression in the antitumor effect of doxorubicin on Lewis lung carcinoma in vivo.

M. Kawada, M. Ishizuka, Y. Yoshimoto, 2005, International immunopharmacology.

Intervenolin, a new antitumor compound with anti-Helicobacter pylori activity, from Nocardia sp. ML96-86F2

A. Nomoto, M. Kawada, Takumi Watanabe, 2013, The Journal of Antibiotics.

NBRI16716A, a new antitumor compound against human prostate cancer cells, produced by Perisporiopsis melioloides Mer-f16716

M. Kawada, T. Kato, Tohru Masuda, 2010, The Journal of Antibiotics.

New atpenins, NBRI23477 A and B, inhibit the growth of human prostate cancer cells

M. Kawada, Go Tsujiuchi, D. Ikeda, 2009, The Journal of Antibiotics.

Transforming growth factor-β1 modulates tumor-stromal cell interactions of prostate cancer through insulin-like growth factor-I

M. Arakawa, M. Kawada, H. Inoue, 2007 .

ICM0301s, new angiogenesis inhibitors from Aspergillus sp. F-1491. I. Taxonomy, fermentation, isolation and biological activities.

K. Isshiki, M. Ishizuka, H. Kumagai, 2004, The Journal of antibiotics.

New Naphthoquinones, f13102A and B, from a Fungus Strain F-13102

M. Kawada, K. Isshiki, Y. Yoshimoto, 2005, The Journal of Antibiotics.

In vivo imaging of proteasome inhibition using a proteasome‐sensitive fluorescent reporter

A. Nomoto, Tohru Masuda, Shun‐ichi Ohba, 2012, Cancer science.

Synthesis and Activity of Tyropeptin A Derivatives as Potent and Selective Inhibitors of Mammalian 20S Proteasome

Y. Umezawa, H. Iinuma, D. Ikeda, 2005, Bioscience, biotechnology, and biochemistry.

ICM0301s, new angiogenesis inhibitors from Aspergillus sp. F-1491. II. Physico-chemical properties and structure elucidation.

H. Naganawa, M. Ishizuka, H. Kumagai, 2004, The Journal of antibiotics.

Increased ABCB1 Expression in TP-110-Resistant RPMI-8226 Cells

D. Ikeda, I. Momose, M. Iijima, 2010, Bioscience, biotechnology, and biochemistry.

Synthesis of 2''-amino-2''-deoxyarbekacin and its analogs having potent activity against methicillin-resistant Staphylococcus aureus.

T. Kudo, T. Takeuchi, T. Usui, 1994, The Journal of antibiotics.

Altemicidin, a new acaricidal and antitumor substance. II. Structure determination.

H. Naganawa, T. Takeuchi, A. Takahashi, 1989, The Journal of antibiotics.

Absolute Configuration of Kigamicins A, C and D

H. Naganawa, Hikaru Nakamura, D. Ikeda, 2005, The Journal of Antibiotics.

Heliquinomycin, a new inhibitor of DNA helicase, produced by Streptomyces sp. MJ929-SF2 II. Structure determination of heliquinomycin.

K. Nishikawa, H. Naganawa, T. Takeuchi, 1997, The Journal of antibiotics.

Effect of Cytogenin, a Novel Immunomodulator, on Streptozotocin-induced Diabetes in Mice

K. Wakazono, K. Isshiki, M. Ishizuka, 2005, The Journal of Antibiotics.

Altemicidin, a new acaricidal and antitumor substance. I. Taxonomy, fermentation, isolation and physico-chemical and biological properties.

T. Takeuchi, A. Takahashi, S. Kurasawa, 1989, The Journal of antibiotics.

Bagougeramines A and B, new nucleoside antibiotics produced by a strain of Bacillus circulans. II. Physico-chemical properties and structure determination.

H. Naganawa, H. Umezawa, A. Takahashi, 1986, The Journal of antibiotics.

FERMENTATION , ISOLATION AND PHYSICO-CHEMICAL AND BIOLOGICAL PROPERTIES

T. Takeuchi, A. Takahashi, S. Kurasawa, 2006 .

D-beta-lysylmethanediamine, a new biogenetic amine produced by a Streptomyces.

T. Takeuchi, M. Hamada, H. Umezawa, 1986, The Journal of antibiotics.

Studies on Aminosugars. XXVIII. Synthesis of β-L-Idopyranosides through the Corresponding 5-Enopyranosides

D. Ikeda, S. Umezawa, T. Tsuchiya, 1971 .

Orally absorbable D-forphenicinol-cephalosporins.

S. Huang, T. Takeuchi, M. Hamada, 1989, The Journal of antibiotics.

Mitochondrial inhibitors show preferential cytotoxicity to human pancreatic cancer PANC-1 cells under glucose-deprived conditions.

H. Esumi, M. Kawada, T. Yamori, 2010, Biochemical and biophysical research communications.

N-salicylidene derivatives of pirarubicin.

T. Takeuchi, K. Ajito, S. Kondo, 1989, The Journal of antibiotics.

Rakicidin A: a hypoxia-selective cytotoxin.

D. Ikeda, S. Kunimoto, Y. Yamazaki, 2007, Biological & pharmaceutical bulletin.

Synthesis of demethyl derivatives of istamycin A.

H. Umezawa, S. Kondo, D. Ikeda, 1980, The Journal of antibiotics.

Isolation and structures of istamycin components

Makoto Yoshida, H. Umezawa, D. Ikeda, 1982 .

New aminoglycoside antibiotics, istamycins A and B.

H. Umezawa, Y. Okami, K. Hotta, 1979, The Journal of antibiotics.

A New Terrein Glucoside, a Novel Inhibitor of Angiogenin Secretion in Tumor Angiogenesis

M. Arakawa, M. Kawada, D. Ikeda, 2008, The Journal of Antibiotics.

The total synthesis of spergualin, an antitumor antibiotic.

H. Umezawa, H. Iinuma, Y. Ikeda, 1981, The Journal of antibiotics.

Synthesis of 1-N-[(S)-4-amino-2-hydroxybutyryl]-3'-deoxyribostamycin (3'-deoxybutirosin B).

H. Umezawa, D. Ikeda, S. Umezawa, 1976 .

Synthesis of 3'-deoxybutirosin B.

H. Umezawa, D. Ikeda, S. Umezawa, 1975, The Journal of antibiotics.

Synthesis of Butirosin B and Its 3′,4′-Dideoxy Derivative

H. Umezawa, D. Ikeda, S. Umezawa, 1974 .

Synthesis of butirosin B.

H. Umezawa, D. Ikeda, S. Umezawa, 1972, The Journal of antibiotics.

Syntheses and properties of the 6"-deoxy or 4",6"-dideoxy derivatives of the kanamycin antibiotics.

H. Umezawa, S. Kondo, D. Ikeda, 1980, The Journal of antibiotics.

Synthesis and properties of the 6'-C-alkyl derivatives of 3',4'-dideoxykanamycin B.

H. Umezawa, S. Kondo, D. Ikeda, 1979, The Journal of antibiotics.

Studies on Aminosugars. XXXVI. Syntheses of 3′,4′-Dideoxy-and 3′,4′,5″-Trideoxyribostamycin

H. Umezawa, Toshihisa Suzuki, D. Ikeda, 1973 .

Synthesis of 3',4'-dideoxy and 3',4',5''-trideoxyribostamycin active against kanamycin-resistant E. coli and P. aeruginosa.

H. Umezawa, D. Ikeda, S. Umezawa, 1972, The Journal of antibiotics.

New 2''-amino derivatives of arbekacin, potent aminoglycoside antibiotics against methicillin-resistant Staphylococcus aureus.

T. Kudo, T. Takeuchi, T. Usui, 1993, The Journal of antibiotics.

A predominant role of amino groups in the antibacterial action of aminoglycosides: synthesis of hexa- and heptadeoxykanamycin derivatives.

H. Umezawa, S. Kondo, D. Ikeda, 1983, The Journal of antibiotics.

Chemical modification of 3'-deoxyamikacin.

H. Umezawa, S. Kondo, D. Ikeda, 1982, The Journal of antibiotics.

Chemical modification of 5,3',4'-trideoxykanamycin B.

H. Umezawa, S. Kondo, D. Ikeda, 1981, The Journal of antibiotics.

Drug‐induced readthrough of premature stop codons leads to the stabilization of laminin α2 chain mRNA in CMD myotubes

J. Rousset, L. Bidou, G. Butler-Browne, 2008, The journal of gene medicine.

Negamycin restores dystrophin expression in skeletal and cardiac muscles of mdx mice.

K. Kaga, Y. Nonomura, T. Hara, 2003, Journal of biochemistry.

In vitro and in vivo antimicrobial activity of TS2037, a novel aminoglycoside antibiotic

K. Maebashi, T. Usui, D. Ikeda, 2018, The Journal of Antibiotics.

Synthesis and antibacterial activity of 5-deoxy-5-episubstituted arbekacin derivatives.

K. Maebashi, T. Usui, D. Ikeda, 2007, Bioorganic & medicinal chemistry letters.

Effect of varying the 4''-position of arbekacin derivatives on antibacterial activity against MRSA and Pseudomonas aeruginosa.

K. Maebashi, T. Usui, D. Ikeda, 2007, Bioorganic & medicinal chemistry letters.

Synthesis and antibacterial activity of novel neamine derivatives.

K. Maebashi, T. Usui, D. Ikeda, 2006, Bioorganic & medicinal chemistry letters.

The 6'-amidine derivatives of amikacin and dibekacin.

H. Umezawa, S. Kondo, D. Ikeda, 1984, The Journal of antibiotics.

The chemical conversion of gentamine C1a into gentamine C2 and its 6'-epimer.

H. Umezawa, S. Kondo, D. Ikeda, 1979, The Journal of antibiotics.

SYNTHESIS OF 3'-DEOXYRIBOSTAMYCIN

Hamao Umezawa, Tsutomu Tsuchiya, Sumio Umezawa, 1973 .

SYNTHESIS OF 3'', 4''-DIDEOXYBUTIROSIN B

M. Hamada, H. Umezawa, D. Ikeda, 1973 .

Synthesis of istamycin A.

H. Umezawa, S. Kondo, D. Ikeda, 1979, The Journal of antibiotics.

STUDIES ON AMINOSUGARS PART 36, SYNTHESES OF 3′,4′-DIDEOXY- AND 3′,4′,5′-TRIDEOXY-RIBOSTAMYCIN

H. Umezawa, Toshihisa Suzuki, D. Ikeda, 1973 .

Negamycin-therapy in Skeletal and Cardiac Muscles of mdx Mice

Y. Nonomura, T. Hara, M. Arakawa, 2003 .

Letter: Synthesis of 1-N-((s)-4-amino-2-hydroxybutyryl)-3',4'-dideoxyneamine.

H. Umezawa, D. Ikeda, S. Umezawa, 1973, The Journal of antibiotics.

Some chemical modifications of istamycin B.

H. Umezawa, S. Gomi, S. Kondo, 1983, The Journal of antibiotics.

Isolation and synthesis of 2″-N-formimidoylistamycins A and B, new istamycin components

H. Umezawa, S. Gomi, D. Ikeda, 1982 .

Synthesis of the 3-O-demethyl and 2"-N-formimidoyl derivatives of istamycin B.

H. Umezawa, S. Kondo, D. Ikeda, 1980, The Journal of antibiotics.

2"-N-formimidoylistamycin A and B produced by Streptomyces tenjimariensis.

H. Umezawa, Y. Okami, K. Hotta, 1982, The Journal of antibiotics.

1-Epidactimicin, a new aminoglycoside antibiotic converted from fortimicin B by a blocked mutant of istamycin-producing Streptomyces tenjimariensis.

H. Naganawa, M. Hamada, Y. Okami, 1989, The Journal of antibiotics.

Isolation and structure determination of novel phosphatidylinositol kinase inhibitors, echiguanines A and B, from Streptomyces sp.

H. Naganawa, T. Takeuchi, H. Nishioka, 1991, Journal of natural products.

Insulin-like growth factor I secreted from prostate stromal cells mediates tumor-stromal cell interactions of prostate cancer.

M. Kawada, Tohru Masuda, H. Inoue, 2006, Cancer research.

Isolation and structure of a new antibiotic, indolizomycin, produced by a strain SK2-52 obtained by interspecies fusion treatment.

H. Naganawa, H. Umezawa, Y. Okami, 1984, The Journal of antibiotics.

Inhibitory Activity of the Hypoxia-inducible Factor-1 Pathway by Tartrolone C

M. Kawada, N. Kinoshita, D. Ikeda, 2006, The Journal of Antibiotics.

Synthesis and activity of 3-(isoxazolin-5-yl)- and 3-(isoxazol-4-yl)cephalosporins.

S. Huang, T. Takeuchi, Y. Koyama, 1992, The Journal of antibiotics.

Orally active pivaloyloxymethyl 3-(isoxazolidin-5-yl)cephalosporins.

S. Huang, T. Takeuchi, Y. Koyama, 1992, The Journal of antibiotics.

Improved antitumor effects of 3'-deamino-3'-morpholino derivatives of pirarubicin.

T. Takeuchi, K. Ajito, S. Kondo, 1990, The Journal of antibiotics.

Tripropeptins, novel antimicrobial agents produced by Lysobacter sp.

Daishiro Ikeda, Hiroshi Naganawa, Ryuichi Sawa, 2004, The Journal of antibiotics.

Rubratoxin A specifically and potently inhibits protein phosphatase 2A and suppresses cancer metastasis

Y. Umezawa, M. Kawada, S. Wada, 2010, Cancer science.

New antibiotics clazamycins A and B.

T. Takeuchi, M. Hamada, H. Umezawa, 1979, The Journal of antibiotics.

Ceramidastin, a novel bacterial ceramidase inhibitor, produced by Penicillium sp. Mer-f17067

M. Kawada, H. Kumagai, H. Inoue, 2009, The Journal of Antibiotics.

Aminoglycoside antibiotics reduce glucose reabsorption in kidney through down-regulation of SGLT1.

M. Kawada, M. Ishizuka, T. Usui, 2003, Biochemical and biophysical research communications.

Synthesis of 3″-Dehydro-4-O-methylbarminomycin II Having an Eight-membered Acetal-azomethine Ring

T. Takeuchi, K. Ajito, D. Ikeda, 1990 .

New hydroxybenanomicins produced by Actinomadura.

T. Takeuchi, S. Inouye, S. Gomi, 1992, Drugs under experimental and clinical research.

Anthracyclines, small-molecule inhibitors of hypoxia-inducible factor-1 alpha activation.

K. Nose, K. Egawa, D. Ikeda, 2006, Biological & pharmaceutical bulletin.

Citric acid inhibits a bacterial ceramidase and alleviates atopic dermatitis in an animal model

M. Kawada, H. Inoue, D. Ikeda, 2010, Journal of antibiotics (Tokyo. 1968).

Biosynthesis of 2-deoxystreptamine.

Y. Uehara, H. Umezawa, M. Hori, 1985, The Journal of antibiotics.

Dotriacolide, a new beta-lactamase inhibitor.

T. Takeuchi, T. Sawa, M. Hamada, 1981, The Journal of antibiotics.