P. Virta

发表

Expanding the Scope of the Cleavable N-(Methoxy)oxazolidine Linker for the Synthesis of Oligonucleotide Conjugates

Heidi J. Korhonen, A. Aho, Antti Äärelä, 2021, Molecules.

Conjugation of Oligonucleotides to Peptide Aldehydes via a pH-Responsive N-Methoxyoxazolidine Linker.

Heidi J. Korhonen, A. Aho, P. Virta, 2020, Organic letters.

3-Fluoro-2-mercuri-6-methylaniline nucleotide as a high-affinity nucleobase-specific hybridization probe.

T. Lönnberg, P. Virta, Asmo Aro-Heinilä, 2019, Bioconjugate chemistry.

19 F NMR Spectroscopic Analysis of the Binding Modes in Triple-Helical Peptide Nucleic Acid (PNA)/MicroRNA Complexes.

R. Strömberg, M. Murtola, P. Virta, 2017, Chemistry.

Synthesis of C-5, C-2' and C-4'-neomycin-conjugated triplex forming oligonucleotides and their affinity to DNA-duplexes.

P. Virta, Ville Tähtinen, Lotta Granqvist, 2015, Bioorganic & medicinal chemistry.

Site-Specific Linking of an Oligonucleotide to Mono- and Bivalent Recombinant Antibodies with SpyCatcher-SpyTag System for Immuno-PCR

T. Huovinen, U. Lamminmäki, Antti Äärelä, 2020, ACS omega.

Single-label time-resolved luminescence assay for estrogen receptor--ligand binding.

P. Hänninen, H. Härmä, Merja Lahdenranta, 2011, Analytical biochemistry.

Synthesis of Bicyclic Peptides

H. Lönnberg, P. Virta, T. Karskela, 2006 .

Treatment of hypertension in the elderly with labetalol.

P. Virta, A. Eisalo, 2009, Acta medica Scandinavica. Supplementum.

The DNA polymerase of bacteriophage YerA41 replicates its T-modified DNA in a primer-independent manner

J. Vogel, M. Skurnik, A. Bhattacharjee, 2022, Nucleic acids research.

Assembly of Bleomycin Saccharide-Decorated Spherical Nucleic Acids

M. Yliperttula, T. Viitala, E. Vuorimaa-Laukkanen, 2022, Bioconjugate chemistry.

Controlled Monofunctionalization of Molecular Spherical Nucleic Acids on a Buckminster Fullerene Core

Heidi J. Korhonen, M. Yliperttula, T. Viitala, 2021, Bioconjugate chemistry.

Solid-Supported Porphyrins Useful for the Synthesis of Conjugates with Oligomeric Biomolecules.

T. Grönroos, O. Solin, S. Jadhav, 2016, Bioconjugate chemistry.

Covalently Mercurated Molecular Beacon for Discriminating the Canonical Nucleobases

T. Lönnberg, P. Virta, Asmo Aro-Heinilä, 2020, Chembiochem : a European journal of chemical biology.

Synthesis of Azide-Modified Chondroitin Sulfate Precursors: Substrates for “Click”- Conjugation with Fluorescent Labels and Oligonucleotides

H. Lönnberg, S. Jadhav, Prasannakumar Deshpande, 2018, Bioconjugate chemistry.

Synthesis and cellular uptake of fluorescently labeled multivalent hyaluronan disaccharide conjugates of oligonucleotide phosphorothioates.

A. Urtti, H. Lönnberg, Melina M. Malinen, 2008, Bioconjugate chemistry.

Solution‐Phase Synthesis of Short Oligo‐2′‐deoxyribonucleotides by Using Clustered Nucleosides as a Soluble Support

P. Virta, V. Kungurtsev, J. Laakkonen, 2013 .

Synthesis of fluorine-labeled peptide nucleic acid building blocks as sensors for the 19F NMR spectroscopic detection of different hybridization modes.

P. Ingman, M. Murtola, P. Virta, 2013, The Journal of organic chemistry.

Solution phase synthesis of short oligoribonucleotides on a precipitative tetrapodal support

H. Lönnberg, Alejandro Gimenez Molina, P. Virta, 2014, Beilstein journal of organic chemistry.

Solid-supported synthesis of oligomeric bioconjugates

H. Lönnberg, P. Virta, Johanna Katajisto, 2003 .

Discovery of the Showdomycin Gene Cluster from Streptomyces showdoensis ATCC 15227 Yields Insight into the Biosynthetic Logic of C-Nucleoside Antibiotics.

B. Baral, M. Metsä-Ketelä, G. Belogurov, 2017, ACS chemical biology.

Synthesis of an Azide- and Tetrazine-Functionalized [60]Fullerene and Its Controlled Decoration with Biomolecules

J. J. Valle-Delgado, M. Yliperttula, M. Österberg, 2021, ACS omega.

Utilization of intrachain 4'-C-azidomethylthymidine for preparation of oligodeoxyribonucleotide conjugates by click chemistry in solution and on a solid support.

H. Lönnberg, P. Virta, A. Kiviniemi, 2008, Bioconjugate chemistry.

Synthesis of aminoglycoside-3'-conjugates of 2'-O-methyl oligoribonucleotides and their invasion to a 19F labeled HIV-1 TAR model.

P. Virta, A. Kiviniemi, 2011, Bioconjugate chemistry.

4'-C-[(4-trifluoromethyl-1H-1,2,3-triazol-1-yl)methyl]thymidine as a sensitive (19)F NMR sensor for the detection of oligonucleotide secondary structures.

P. Virta, Lotta Granqvist, 2014, The Journal of organic chemistry.

Synthesis of multi-galactose-conjugated 2'-O-methyl oligoribonucleotides and their in vivo imaging with positron emission tomography.

H. Liljenbäck, H. Lönnberg, A. Roivainen, 2014, Bioorganic & medicinal chemistry.

Solid-supported NOTA and DOTA chelators useful for the synthesis of 3'-radiometalated oligonucleotides.

H. Liljenbäck, H. Lönnberg, A. Roivainen, 2012, Bioconjugate chemistry.

Synthesis of Short Oligodeoxyribonucleotides by Phosphotriester Chemistry on a Precipitative Tetrapodal Support

H. Lönnberg, P. Virta, V. Kungurtsev, 2013 .

Characterization of C-nucleoside Antimicrobials from Streptomyces albus DSM 40763: Strepturidin is Pseudouridimycin

M. Metsä-Ketelä, G. Belogurov, J. Niemi, 2019, Scientific Reports.

The role of the maleimide ring system on the structure-activity relationship of showdomycin.

Heidi J. Korhonen, M. Metsä-Ketelä, G. Belogurov, 2022, European journal of medicinal chemistry.

Zn2+ Complexes of 3,5-Bis[(1,5,9-triazacyclododecan-3-yloxy)methyl]phenyl Conjugates of Oligonucleotides as Artificial RNases: The Effect of Oligonucleotide Conjugation on Uridine Selectivity of the Cleaving Agent

H. Lönnberg, P. Virta, E. Burakova, 2013 .

The Zn2+ Complex of 1,4,7,10-Tetraazacyclododecane as an Artificial Nucleobase

H. Lönnberg, M. Aromaa, T. Lönnberg, 2011, Nucleosides, nucleotides & nucleic acids.

Di(azacrown) conjugates of 2'-O-methyl oligoribonucleotides as sequence-selective artificial ribonucleases.

H. Lönnberg, P. Virta, K. Ketomäki, 2007, Bioconjugate chemistry.

Synthesis of an Alkyne-Modified Bleomycin Disaccharide Precursor, Conversion to a 18 F-Labeled Radiotracer, and Preliminary in vivo-PET Imaging Studies

T. Grönroos, O. Solin, S. Maity, 2018, European Journal of Organic Chemistry.

Acetylated and Methylated β-Cyclodextrins as Viable Soluble Supports for the Synthesis of Short 2′-Oligodeoxyribo-nucleotides in Solution

H. Lönnberg, P. Virta, V. Kungurtsev, 2012, Molecules.

2'-O-[(4-CF3-triazol-1-yl)methyl] Uridine - A Sensitive (19)F NMR Sensor for the Detection of RNA Secondary Structures.

P. Virta, Lotta Granqvist, 2015, The Journal of organic chemistry.

Orthogonally protected cyclo-beta-tetrapeptides as solid-supported scaffolds for the synthesis of glycoclusters.

H. Lönnberg, P. Virta, Marika Karskela, 2006, The Journal of organic chemistry.

The mechanism of the nucleo-sugar selection by multi-subunit RNA polymerases

K. Murakami, M. Metsä-Ketelä, G. Belogurov, 2020, Nature Communications.

Oxazinomycin arrests RNA polymerase at the polythymidine sequences

M. Metsä-Ketelä, A. Malinen, G. Belogurov, 2019, Nucleic acids research.

Synthesis of Orthogonally Protected Bis(aminomethyl)malonic Acid, and Its Use as a Key Building Block in the Preparation of Cyclic Peptide Conjugates of 2‐N‐Alkyl‐1,2,3,4‐tetrahydroisoquinoline on a Solid Support

H. Lönnberg, P. Virta, T. Karskela, 2001 .

Synthesis and In Vivo PET Imaging of Hyaluronan Conjugates of Oligonucleotides.

S. Jalkanen, V. Kytö, A. Saraste, 2016, Bioconjugate chemistry.

An Aminooxy‐Functionalized Non‐Nucleosidic Phosphoramidite for the Construction of Multiantennary Oligonucleotide Glycoconjugates on a Solid Support

H. Lönnberg, P. Virta, Johanna Katajisto, 2005, Current protocols in nucleic acid chemistry.

Characterization of RNA invasion by (19)F NMR spectroscopy.

P. Virta, A. Kiviniemi, 2010, Journal of the American Chemical Society.

Characterization of G-Quadruplex/Hairpin Transitions of RNAs by 19 F NMR Spectroscopy.

P. Virta, Lotta Granqvist, 2016, Chemistry.

4-Oxoheptanedioic acid: an orthogonal linker for solid-phase synthesis of base-sensitive oligonucleotides

H. Lönnberg, P. Virta, Päivi Poijärvi-Virta, 2008 .

Immobilized Carbohydrates for Preparation of 3′‐Glycoconjugated Oligonucleotides

Heidi J. Korhonen, A. Aho, Antti Äärelä, 2020, Current protocols in nucleic acid chemistry.

Solid-supported 2'-O-glycoconjugation of oligonucleotides by azidation and click reactions.

S. Mikhailov, H. Lönnberg, M. Drenichev, 2011, Bioconjugate chemistry.

Synthesis of aminoglycoside conjugates of 2'-O-methyl oligoribonucleotides.

P. Virta, K. Ketomäki, 2008, Bioconjugate chemistry.

Solid-phase synthesis of base-sensitive oligonucleotides

P. Virta, 2008 .

Synthesis of Aminoglycoside-2′-O-Methyl Oligoribonucleotide Fusions

A. Kraszewski, P. Virta, Ville Tähtinen, 2017, Molecules.

Assembly of Short Oligoribonucleotides from Commercially Available Building Blocks on a Tetrapodal Soluble Support

H. Lönnberg, P. Virta, Amit M Jabgunde, 2015 .

2,2-Bis(ethoxycarbonyl)- and 2-(alkylaminocarbonyl)-2-cyano-substituted 3-(pivaloyloxy)propyl groups as biodegradable phosphate protections of oligonucleotides.

H. Lönnberg, P. Virta, P. Heinonen, 2005, Bioconjugate chemistry.

Synthesis of oligonucleotide glycoconjugates using sequential click and oximation ligations.

H. Lönnberg, P. Virta, Marika Karskela, 2010, Bioconjugate chemistry.

Solid-phase synthesis of multiantennary oligonucleotide glycoconjugates utilizing on-support oximation.

H. Lönnberg, P. Virta, Johanna Katajisto, 2004, Bioconjugate chemistry.

Stability of the Phosphotriester PDE6D Inhibitors

D. Abankwa, Ahmed Sabt, M. Ora, 2021, ChemistrySelect.

Synthesis of achiral α,α-disubstituted β-alanines, and their use in construction of libraries of β-peptide conjugates of N-2-alkyl-1,2,3,4-tetrahydroisoquinolines on a solid support

H. Lönnberg, P. Virta, P. Heinonen, 1999 .

Zinc Ion-Dependent Peptide Nucleic Acid-Based Artificial Enzyme that Cleaves RNA—Bulge Size and Sequence Dependence

R. Strömberg, M. Murtola, A. Ghidini, 2017, Molecules.

PDE6D Inhibitors with a New Design Principle Selectively Block K-Ras Activity

C. Alam, A. Stephen, A. Papageorgiou, 2019, ACS omega.

In Vivo Bone-Targeting of Bis(phosphonate)-Conjugated Double Helical RNA Monitored by Positron Emission Tomography.

H. Liljenbäck, H. Lönnberg, A. Roivainen, 2016, Molecular pharmaceutics.

Synthesis and Applicability of Base‐Discriminating DNA‐Triplex‐Forming 19F NMR Probes

P. Virta, Ville Tähtinen, Naresh Bhuma, 2018 .

Synthesis of Biotinylated Multipodal Glycoclusters on a Solid Support

H. Lönnberg, P. Virta, Marika Karskela, 2012 .

Pseudouridine-Modifying Enzymes SapB and SapH Control Entry into the Pseudouridimycin Biosynthetic Pathway

G. Schneider, R. Schnell, J. Niemi, 2023, ACS chemical biology.

Synthesis of fully protected trinucleotide building blocks on a disulphide-linked soluble support

Ruth Suchsland, Bettina Appel, S. Müller, 2021, RSC advances.

Influence of Chinoin‐170, a Novel Antitussive, on the Mucociliary Activity in Respiratory Airways of Rats, Rabbits, Guinea‐pigs and Man

J. Nuutinen, V. Saano, P. Virta, 1993, The Journal of pharmacy and pharmacology.

Synthesis of Bicyclic Peptides

P. Virta, T. Karskela, H. Lonnberg, 2006 .

Drug-to-Antibody Ratio Estimation via Proteoform Peak Integration in the Analysis of Antibody-Oligonucleotide Conjugates with Orbitrap Fourier Transform Mass Spectrometry.

Anton N. Kozhinov, L. Menin, V. Nesatyy, 2021, Analytical chemistry.

Synthesis of Glycosidic (β-1′′→6, 3′ and 4′) Site Isomers of Neomycin B and Their Effect on RNA and DNA Triplex Stability

P. Virta, Ville Tähtinen, Lotta Granqvist, 2019, Molecules.

γ‐(S)‐Guanidinylmethyl‐Modified Triplex‐Forming Peptide Nucleic Acids Increase Hoogsteen‐Face Affinity for a MicroRNA and Enhance Cellular Uptake

J. Tuomela, P. Virta, Ville Tähtinen, 2019, Chembiochem : a European journal of chemical biology.

Stereo-Controlled Liquid Phase Synthesis of Phosphorothioate Oligonucleotides on a Soluble Support

Alejandro Gimenez Molina, M. Ora, P. Virta, 2023, The Journal of organic chemistry.

More versatile synthesis of oligonucleotides

P. Virta, 2021, Science.

Characterization of C-nucleoside Antimicrobials from Streptomyces albus DSM 40763: Strepturidin is Pseudouridimycin

G. Belogurov, J. Niemi, K. Palmu, 2019, Scientific Reports.

Noninvasive and Quantitative Monitoring of the Distributions and Kinetics of MicroRNA-Targeting Molecules in Vivo by Positron Emission Tomography

H. Liljenbäck, H. Lönnberg, A. Roivainen, 2019, Molecular pharmaceutics.

In Vivo Imaging of [60]Fullerene-Based Molecular Spherical Nucleic Acids by Positron Emission Tomography

A. Airaksinen, H. Liljenbäck, A. Roivainen, 2023, Molecular pharmaceutics.

Synthesis of C-5, C-2' and C-4'-neomycin-conjugated triplex forming oligonucleotides and their affinity to DNA-duplexes.

P. Virta, Ville Tähtinen, Lotta Granqvist, 2015, Bioorganic & medicinal chemistry.

Solid-supported synthesis and click conjugation of 4'-C-alkyne functionalized oligodeoxyribonucleotides.

H. Lönnberg, P. Virta, A. Kiviniemi, 2010, Bioconjugate chemistry.

Tetrazine Glycoconjugate for Pretargeted Positron Emission Tomography Imaging of trans-Cyclooctene-Functionalized Molecular Spherical Nucleic Acids

A. Airaksinen, H. Liljenbäck, J. Rautio, 2023, ACS Omega.

Preparation of a disulfide-linked precipitative soluble support for solution-phase synthesis of trimeric oligodeoxyribonucleotide 3´-(2-chlorophenylphosphate) building blocks

H. Lönnberg, P. Virta, Amit M Jabgunde, 2015, Beilstein journal of organic chemistry.

Synthesis of Site-Specific Antibody–[60]Fullerene–Oligonucleotide Conjugates for Cellular Targeting

Patrik Holm, Antti Äärelä, P. Virta, 2023, ACS applied bio materials.

Synthesis of protected 2′-O-deoxyribonucleotides on a precipitative soluble support: a useful procedure for the preparation of trimer phosphoramidites

H. Lönnberg, P. Virta, V. Kungurtsev, 2016 .

Characterization of RNA invasion by (19)F NMR spectroscopy.

P. Virta, A. Kiviniemi, 2010, Journal of the American Chemical Society.