J. Luly

发表

Conformation of an FK506 analog in aqueous solution is similar to the FKBP-bound conformation of FK506

A. Petros, S. Fesik, Heng Liang, 1993 .

Potent Inhibition of NFAT Activation and T Cell Cytokine Production by Novel Low Molecular Weight Pyrazole Compounds*

Julie A. Wilkins, U. Warrior, Yung-wu Chen, 2001, The Journal of Biological Chemistry.

Effects of the Renin Inhibitor A‐64662 in Monkeys and Rats with Varying Baseline Plasma Renin Activity

R. Luther, J. Plattner, H. Kleinert, 1988, Hypertension.

Nephrotoxicity studies of the immunosuppressants tacrolimus (FK506) and ascomycin in rat models.

G. Hsieh, J. Andrews, K. Mollison, 1998, Toxicology.

Discovery of less nephrotoxic FK506 analogs and determining immunophilin dependence of immunosuppressant nephrotoxicity with a novel single-dose rat cisplatin potentiation assay.

G. Hsieh, J. Andrews, K. Mollison, 1997, The Journal of pharmacology and experimental therapeutics.

Structure‐activity profiles of macrolactam immunosuppressant FK‐506 analogues

G. Carter, G. Hsieh, K. Mollison, 1993, FEBS letters.

Modified peptides which display potent and specific inhibition of human renin.

P. Marcotte, J. Plattner, H. Kleinert, 1987, Biochemical and biophysical research communications.

3,5-Bis(trifluoromethyl)pyrazoles: a novel class of NFAT transcription factor regulator.

Xiaoping Zhou, U. Warrior, C. Wegner, 2000, Journal of medicinal chemistry.

Synthesis and FKBP binding of small molecule mimics of the tricarbonyl region of FK506

A. Petros, S. Fesik, Gary T. Wang, 1994 .

Multidimensional NMR studies of immunosuppressants and their binding proteins

A. Petros, Y. Thériault, T. Logan, 1993 .

Patent Update: Anti-Inflammatory Patents Highlights from the First Half of 1992

S. Davidsen, J. Luly, J. Dellaria, 1992 .

A macrolactam inhibitor of T helper type 1 and T helper type 2 cytokine biosynthesis for topical treatment of inflammatory skin diseases.

J. Trevillyan, G. Carter, K. Marsh, 1999, The Journal of investigative dermatology.

Selective epimerization and skeletal resection in the ascomycin framework: A study of the biological consequences of lactam rotamer selection

R. Wagner, J. Luly, Y. Or, 1996 .

Structure-function studies in a series of carboxyl-terminal octapeptide analogues of anaphylatoxin C5a.

G. Carter, D. Quincy, K. Mollison, 1992, Journal of medicinal chemistry.

Chapter 22. Mechanism-Based Immunosuppressants

J. Luly, 1991 .

Synthesis and structure-activity relationship of 2-amino-3-heteroaryl-quinoxalines as non-peptide, small-molecule antagonists for interleukin-8 receptor.

D. T. Connor, B. Roth, S. Qin, 2003, Bioorganic & medicinal chemistry.

Synthesis and characterization of non-steroidal ligands for the glucocorticoid receptor: selective quinoline derivatives with prednisolone-equivalent functional activity.

M. Nakane, S. Elmore, P. Kym, 2001, Journal of medicinal chemistry.

Effects of angiotensinase inhibitors on plasma protein binding and IC50 determinations of renin inhibitors.

S. Rosenberg, B. Dayton, W. Baker, 1992, Clinical chemistry.

FKBP12-FK506 complex inhibits phosphatase activity of two mammalian isoforms of calcineurin irrespective of their substrates or activation mechanisms.

T. Kuno, C. Tanaka, C. Chang, 1993, Journal of biochemistry.

The Synthesis of (±)-Wilforonide

J. Schkeryantz, M. Coghlan, J. Luly, 1998 .

Routes to mitomycins. An improved synthesis of 7-methoxymitosene using palladium catalysis

H. Rapoport, J. Luly, 1984 .

Routes to mitomycins. Chirospecific synthesis of aziridinomitosenes

H. Rapoport, K. Shaw, J. Luly, 1985 .

New inhibitors of human renin that contain novel Leu-Val replacements.

J. Plattner, J. Cohen, J. Luly, 1987, Journal of medicinal chemistry.

Selective cell adhesion inhibitors: Barbituric acid based alpha4beta7--MAdCAM inhibitors.

B. Jaffee, M. Bazin, G. Larosa, 2008, Bioorganic & medicinal chemistry letters.

Amine addition to unsymmetrical benzoquinones

H. Rapoport, J. Luly, 1981 .

A synthesis of protected aminoalkyl epoxides from .alpha.-amino acids

J. Plattner, J. Luly, N. Yi, 1987 .

Routes to mitomycins. New syntheses of the 2,3,5,8-tetrahydro-5,8-dioxo-1H-pyrrolo[1,2-a]indole ring system. An efficient synthesis of 7-methoxymitosene

H. Rapoport, J. Luly, 1983 .

Optimization and in vivo evaluations of a series of small, potent, and specific renin inhibitors containing a novel Leu-Val replacement.

R. Maki, J. Plattner, H. Kleinert, 1987, Journal of medicinal chemistry.

Renin inhibitors. Dipeptide analogues of angiotensinogen utilizing a dihydroxyethylene transition-state mimic at the scissile bond to impart greater inhibitory potency.

D. Egan, P. Marcotte, H. Kleinert, 1988, Journal of medicinal chemistry.

New inhibitors of human renin that contain novel Leu-Val replacements. Examination of the P1 site.

J. Greer, G. Bolis, J. Plattner, 1988, Journal of medicinal chemistry.

Cysteine alkylation in unprotected peptides: synthesis of a carbavasopressin analog by intramolecular cysteine alkylation

R. Clark, J. Luly, Y. Or, 1991 .

Isotope-edited NMR of cyclosporin A bound to cyclophilin: evidence for a trans 9,10 amide bond.

D. Egan, T. Holzman, R. Simmer, 1990, Science.

Routes to mitomycins. Application of iminium salts to the synthesis of 7-methoxymitosene

H. Rapoport, J. Luly, 1982 .

Synthesis of 4-substituted 4-arylpiperidines

G. Harriman, J. Luly, Jianxing Shao, 2000 .

Synthesis of 4-Substituted 4-Arylpiperidines.

J. Luly, C. HarrimanGeraldine, Jianxing Shao, 2001 .

Discovery of ascomycin analogs with potent topical but weak systemic activity for treatment of inflammatory skin diseases.

P. Wiedeman, J. Trevillyan, K. Marsh, 1998, Current pharmaceutical design.

The chemistry of ascomycin: Structure determination and synthesis of pyrazole analogues

R. Henry, R. Clark, J. McAlpine, 1993 .

A convenient stereoselective synthesis of 1,2,3-aminodiols from .alpha.-amino acids

J. Plattner, J. Luly, N. Bamaung, 1988 .

A novel antiinflammatory maintains glucocorticoid efficacy with reduced side effects.

M. Nakane, S. Elmore, R. Turner, 2003, Molecular endocrinology.

Inhibitor binding induces structural changes in porcine pepsin.

C. Abad-Zapatero, J. Erickson, D. Neidhart, 1991, Advances in experimental medicine and biology.

Improved methods for transplanting split-heart neonatal cardiac grafts into the ear pinna of mice and rats.

G. Hsieh, J. Andrews, K. Mollison, 1998, Journal of pharmacological and toxicological methods.

Neointimal formation after balloon-induced vascular injury in Yucatan minipigs is reduced by oral rapamycin.

C. Wegner, G. Hsieh, S. Burke, 1999, Journal of cardiovascular pharmacology.

Structure of a pepsin/renin inhibitor complex reveals a novel crystal packing induced by minor chemical alterations in the inhibitor.

C. Abad-Zapatero, J. Erickson, L. Chen, 1992, Acta crystallographica. Section B, Structural science.

Isotope-edited proton NMR study on the structure of a pepsin/inhibitor complex.

S. Fesik, C. Abad-Zapatero, J. Erickson, 1988, Biochemistry.

Profile of the Renin Inhibitor, Enalkiren (ABBOTT‐64662)

R. Luther, M. Karol, J. Plattner, 1990 .

Rapamycin analogs with reduced systemic exposure.

P. Wiedeman, J. Trevillyan, G. Carter, 2005, Bioorganic & medicinal chemistry letters.

Renin inhibitors. Dipeptide analogues of angiotensinogen utilizing a structurally modified phenylalanine residue to impart proteolytic stability.

J. Greer, H. Sham, P. Marcotte, 1988, Journal of Medicinal Chemistry.

Renin inhibitors Improvements in the stability and biological activity of small peptides containing novel Leu‐Val replacements

P. Marcotte, J. Plattner, H. Kleinert, 1988, FEBS Letters.

Identification and synthesis of a receptor binding site of human anaphylatoxin C5a.

G. Carter, D. Quincy, K. Mollison, 1991, Journal of medicinal chemistry.

Conformation of two non‐immunosuppressive FK506 analogs when bound to FKBP by isotope‐filtered NMR

A. Petros, S. Fesik, J. Luly, 1992, FEBS letters.

Amide proton exchange rates of a bound pepsin inhibitor determined by isotope-edited proton NMR experiments.

S. Fesik, J. Luly, H. Stein, 1987, Biochemical and biophysical research communications.

Isotope-filtered proton NMR experiments for the conformational determination of peptides in solution and bound to biomacromolecules

E. Olejniczak, S. Fesik, R. Gampe, 1988 .

Studies on an immunosuppressive macrolactam, ascomycin: synthesis of a C-33 hydroxyl derivative.

G. Hsieh, K. Mollison, J. Luly, 1998, Bioorganic & medicinal chemistry letters.