D. Separovic

发表

Interaction of acid ceramidase inhibitor LCL521 with tumor response to photodynamic therapy and photodynamic therapy‐generated vaccine

A. Bielawska, Wei Zhang, M. Korbelik, 2016, International journal of cancer.

Enhanced Tumor Cures after Foscan Photodynamic Therapy Combined with the Ceramide Analog LCL29. Evidence from Mouse Squamous Cell Carcinomas for Sphingolipids as Biomarkers of Treatment Response

M. Korbelik, B. Ogretmen, A. Tarca, 2011, International journal of oncology.

Sphingomyelin synthase 1 suppresses ceramide production and apoptosis post-photodamage.

M. Tainsky, J. Kraniak, J. Bielawski, 2007, Biochemical and biophysical research communications.

Enhanced apoptotic cancer cell killing after Foscan photodynamic therapy combined with fenretinide via de novo sphingolipid biosynthesis pathway.

A. Bielawska, M. Korbelik, J. Bielawski, 2016, Journal of photochemistry and photobiology. B, Biology.

Enhanced killing of SCC17B human head and neck squamous cell carcinoma cells after photodynamic therapy plus fenretinide via the de novo sphingolipid biosynthesis pathway and apoptosis

A. Bielawska, M. Korbelik, J. Bielawski, 2015, International journal of oncology.

Ceramide and sphingosine-1-phosphate act as photodynamic therapy-elicited damage-associated molecular patterns: cell surface exposure.

Y. Hannun, M. Korbelik, Jinghai Sun, 2014, International immunopharmacology.

Ceramide synthase inhibitor fumonisin B1 inhibits apoptotic cell death in SCC17B human head and neck squamous carcinoma cells after Pc4 photosensitization

A. Bielawska, G. Divine, M. Korbelik, 2014, Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology.

Increased killing of SCCVII squamous cell carcinoma cells after the combination of Pc 4 photodynamic therapy and dasatinib is associated with enhanced caspase-3 activity and ceramide synthase 1 upregulation

A. Bielawska, M. Korbelik, P. Breen, 2013, International journal of oncology.

Dihydroceramide desaturase knockdown impacts sphingolipids and apoptosis after photodamage in human head and neck squamous carcinoma cells.

P. Breen, J. Bielawski, G. Bhatti, 2013, Anticancer research.

siRNA-mediated down-regulation of ceramide synthase 1 leads to apoptotic resistance in human head and neck squamous carcinoma cells after photodynamic therapy.

P. Breen, J. Bielawski, T. Gudz, 2012, Anticancer research.

A role for manganese superoxide dismutase in apoptosis after photosensitization.

M. Tainsky, J. Kraniak, L. Oberley, 2005, Biochemical and biophysical research communications.

De Novo Ceramide Accumulation Due to Inhibition of Its Conversion to Complex Sphingolipids in Apoptotic Photosensitized Cells*

M. Tainsky, K. Hanada, O. Kulaeva, 2004, Journal of Biological Chemistry.

A role for the de novo sphingolipids in apoptosis of photosensitized cells.

K. Hanada, E. Schmelz, B. Wispriyono, 2002, Experimental cell research.

Reactive oxygen species generation is independent of de novo sphingolipids in apoptotic photosensitized cells.

B. Taffe, K. Hanada, V. Dolgachev, 2003, Experimental cell research.

Phthalocyanine 4-photodynamic therapy induces ceramide generation and apoptosis in acid sphingomyelinase-deficient mouse embryonic fibroblasts.

H. Mukhtar, T. Davis, N. Ahmad, 2000, International journal of oncology.

FADD null mouse embryonic fibroblasts undergo apoptosis after photosensitization with the silicon phthalocyanine Pc 4.

T. Mak, W. Yeh, S. Chiu, 2001, Archives of biochemistry and biophysics.

Activation of phosphatidylcholine-selective phospholipase C by I1-imidazoline receptors in PC12 cells and rostral ventrolateral medulla

P. Ernsberger, M. Kester, M. Haxhiu, 1997, Brain Research.

Coupling of I1-imidazoline receptors to diacylglyceride accumulation in PC12 rat pheochromocytoma cells.

P. Ernsberger, M. Kester, D. Separovic, 1996, Molecular pharmacology.

Caspase-resistant vimentin suppresses apoptosis after photodynamic treatment with a silicon phthalocyanine in Jurkat cells.

N. Morishima, D. Separovic, I. Belichenko, 2001, Archives of biochemistry and biophysics.

C16-Ceramide Analog Combined with Pc 4 Photodynamic Therapy Evokes Enhanced Total Ceramide Accumulation, Promotion of DEVDase Activation in the Absence of Apoptosis, and Augmented Overall Cell Killing

A. Bielawska, J. Bielawski, J. Pierce, 2010, Journal of lipids.

Recombinant human tumor necrosis factor alpha does not potentiate cell killing after photodynamic therapy with a silicon phthalocyanine in A431 human epidermoid carcinoma cells.

H. Mukhtar, N. Ahmad, K. Azizuddin, 2001, International journal of oncology.

Fumonisin B1 does not prevent apoptosis in A431 human epidermoid carcinoma cells after photosensitization with a silicon phthalocyanine.

S. Chiu, D. Separovic, B. Nagy, 2000, Journal of photochemistry and photobiology. B, Biology.

Stress-activated signaling responses leading to apoptosis following photodynamic therapy

Jin He, Nancy L. Oleinick, Duska Separovic, 1998, Photonics West - Biomedical Optics.

Ceramide generation in response to photodynamic treatment of L5178Y mouse lymphoma cells.

D. Separovic, N. L. Oleinick, J. He, 1997, Cancer research.

Association of Ceramide Accumulation with Photodynamic Treatment‐Induced Cell Death

N. Oleinick, K. Mann, D Separovic, 1998, Photochemistry and photobiology.

Niemann-Pick human lymphoblasts are resistant to phthalocyanine 4-photodynamic therapy-induced apoptosis.

D. Boothman, A. Haimovitz-Friedman, M. McLoughlin, 1999, Biochemical and biophysical research communications.

Suppression of sphingomyelin synthase 1 by small interference RNA is associated with enhanced ceramide production and apoptosis after photodamage.

A. Tarca, J. Bielawski, K. Hanada, 2008, Experimental cell research.

Detecting changes in the mitochondrial membrane potential by quantitative fluorescence microscopy

Jason C. Young, U. Stochaj, M. Kodiha, 2015 .

Racial Disparities in the Molecular Landscape of Cancer.

E. Heath, E. Obeid, A. Vanderwalde, 2018, Anticancer research.

Altered Levels of Serum Ceramide, Sphingosine and Sphingomyelin Are Associated with Colorectal Cancer: A Retrospective Pilot Study.

A. Bielawska, P. Philip, A. Shields, 2017, Anticancer research.

Increased ceramide accumulation correlates with downregulation of the autophagy protein ATG‐7 in MCF‐7 cells sensitized to photodamage

A. Tarca, J. Bielawski, A. Kelekar, 2010, Archives of biochemistry and biophysics.

Downregulation of the autophagy protein ATG-7 correlates with distinct sphingolipid profile in MCF-7 cells sensitized to photodamage

David Kessel, Duska Separovic, Ameeta Kelekar, 2009, World Congress of the International Photodynamic Association.

C6-pyridinium ceramide sensitizes SCC17B human head and neck squamous cell carcinoma cells to photodynamic therapy.

A. Bielawska, M. Korbelik, J. Bielawski, 2015, Journal of Photochemistry and Photobiology. B: Biology.

Fumonisin B1 Inhibits Endoplasmic Reticulum Stress Associated-apoptosis After FoscanPDT Combined with C6-Pyridinium Ceramide or Fenretinide.

A. Bielawska, M. Korbelik, J. Bielawski, 2017, Anticancer research.

Amplification of cancer cell apoptosis in photodynamic therapy‐treated tumors by adjuvant ceramide analog LCL29

Wei Zhang, M. Korbelik, D. Separovic, 2011, Lasers in surgery and medicine.

Increased tumour dihydroceramide production after Photofrin-PDT alone and improved tumour response after the combination with the ceramide analogue LCL29. Evidence from mouse squamous cell carcinomas

M. Korbelik, B. Ogretmen, A. Tarca, 2009, British Journal of Cancer.

Ceramide and Sphingosine-1-Phosphate/Sphingosine act as Photodynamic Therapy-Elicited Damage-Associated Molecular Patterns: Release from Cells and Impact on Tumor-Associated Macrophages

Wei Zhang, M. Korbelik, J. Bielawski, 2014 .

Monitoring ceramide and sphingosine-1-phosphate levels in cancer cells and macrophages from tumours treated by photodynamic therapy

Wei Zhang, M. Korbelik, D. Separovic, 2012, Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology.

Cationic ceramides and analogues, LCL30 and LCL85, as adjuvants to photodynamic therapy of tumors.

A. Bielawska, Wei Zhang, M. Korbelik, 2013, Journal of photochemistry and photobiology. B, Biology.

Combining anticancer agents photodynamic therapy and LCL85 leads to distinct changes in the sphingolipid profile, autophagy, caspase-3 activation in the absence of cell death, and long-term sensitization.

A. Bielawska, P. Breen, J. Bielawski, 2011, Biochemical and biophysical research communications.

Tumor PDT-associated immune response: relevance of sphingolipids

Mladen Korbelik, Duska Separovic, Soroush Merchant, 2010, BiOS.

Ceramide response post-photodamage is absent after treatment with HA14-1.

D. Kessel, K. Hanada, D. Separovic, 2006, Biochemical and biophysical research communications.

Guidelines for the use and interpretation of assays for monitoring autophagy

Robert Clarke, Hong Jiang, Hiroyuki Ishida, 2012 .

Guidelines for the use and interpretation of assays for monitoring autophage

T. P. Neufeld, Thomas J. Begley, H. Coller, 2012 .

C6-pyridinium ceramide sensitizes SCC17B human head and neck squamous cell carcinoma cells to photodynamic therapy.

A. Bielawska, M. Korbelik, J. Bielawski, 2015, Journal of photochemistry and photobiology. B, Biology.