E. Remold-O’Donnell

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SerpinB 1 Promotes Pancr eatic b Cell Proliferation Graphical

Richard D. Smith, A. Goldfine, M. Gritsenko, 2022 .

Evolution of Highly Polymorphic T Cell Populations in Siblings with the Wiskott-Aldrich Syndrome

S. Remold, E. Remold-O’Donnell, M. Lutskiy, 2008, PloS one.

WASP localizes to the membrane skeleton of platelets

A. Shcherbina, E. Remold-O’Donnell, M. Lutskiy, 2007, British journal of haematology.

WASP and N-WASP in human platelets differ in sensitivity to protease calpain.

T. Takenawa, H. Miki, E. Remold-O’Donnell, 2001, Blood.

Critical role of serpinB1 in regulating inflammatory responses in pulmonary influenza infection.

K. Hartshorn, M. White, C. Benarafa, 2011, The Journal of infectious diseases.

Phenotypic perturbation of B cells in the Wiskott–Aldrich syndrome

E. Remold-O’Donnell, F. Rosen, A. Shcherbina, 2005, Clinical and experimental immunology.

Early deficit of lymphocytes in Wiskott–Aldrich syndrome: possible role of WASP in human lymphocyte maturation

E. Remold-O’Donnell, F. Rosen, A. Shcherbina, 2004, Clinical and experimental immunology.

Wiskott–Aldrich syndrome protein is required for NK cell cytotoxicity and colocalizes with actin to NK cell-activating immunologic synapses

Michael J. Byrne, J. Orange, R. Geha, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Biosynthesis of human sialophorins and analysis of the polypeptide core.

E. Remold-O’Donnell, F. Rosen, D. Kenney, 1987, Biochemistry.

Lymphocytes with congenitally active WASP.

E. Remold-O’Donnell, 2010, Blood.

A Macrophage Invasion Mechanism for Mycobacteria Implicating the Extracellular Domain of Cd43

R. Arbeit, C. Carini, T. Gerken, 2000, The Journal of experimental medicine.

SURFACE PROTEIN ABNORMALITIES IN LYMPHOCYTES AND PLATELETS FROM PATIENTS WITH WISKOTT-ALDRICH SYNDROME

S. Perrine, R. Parkman, E. Remold-O’Donnell, 1981, The Lancet.

Characterization of a human lymphocyte surface sialoglycoprotein that is defective in Wiskott-Aldrich syndrome

R. Parkman, E. Remold-O’Donnell, F. Rosen, 1984, The Journal of experimental medicine.

Purification and chemical composition of gpL115, the human lymphocyte surface sialoglycoprotein that is defective in Wiskott-Aldrich syndrome.

A. Davis, K. Bhaskar, E. Remold-O’Donnell, 1986, The Journal of biological chemistry.

Sialophorin, a surface sialoglycoprotein defective in the Wiskott- Aldrich syndrome, is involved in human T lymphocyte proliferation

B. Bierer, S. Burakoff, S. Mentzer, 1987, The Journal of experimental medicine.

Expression on blood cells of sialophorin, the surface glycoprotein that is defective in Wiskott-Aldrich syndrome.

E. Remold-O’Donnell, F. Rosen, D. Kenney, 1987, Blood.

Enhancement of T-cell activation by the CD43 molecule whose expression is defective in Wiskott–Aldrich syndrome

B. Bierer, John K. Park, S. Burakoff, 1991, Nature.

Mosaicism of NK cells in a patient with Wiskott-Aldrich syndrome.

E. Remold-O’Donnell, M. Lutskiy, F. Rosen, 2005, Blood.

The serpin MNEI inhibits elastase-like and chymotrypsin-like serine proteases through efficient reactions at two active sites.

S. Shapiro, N. Schechter, T. Takayama, 2001, Biochemistry.

WASP plays a novel role in regulating platelet responses dependent on αIIbβ3 integrin outside‐in signalling

G. E. Gilbert, C. Benarafa, E. Remold-O’Donnell, 2010, British journal of haematology.

T cells of patients with the Wiskott-Aldrich syndrome have a restricted defect in proliferative responses.

C. Terhorst, J. Sancho, E. Remold-O’Donnell, 1993, Journal of immunology.

Defects in Wiskott-Aldrich syndrome blood cells.

E. Remold-O’Donnell, F. Rosen, D. Kenney, 1996, Blood.

Two proteolytic pathways for down-regulation of the barrier molecule CD43 of human neutrophils.

E. Remold-O’Donnell, D. Parent, 1994, Journal of immunology.

Neutrophil elastase‐deficient mice form neutrophil extracellular traps in an experimental model of deep vein thrombosis

D. Wagner, K. Martinod, E. Remold-O’Donnell, 2016, Journal of thrombosis and haemostasis : JTH.

Proteinase 3-dependent caspase-3 cleavage modulates neutrophil death and inflammation.

K. Ye, Peng Liu, Jiaxi Zhou, 2014, The Journal of clinical investigation.

Inflammation induces hemorrhage in thrombocytopenia.

D. Wagner, B. Ho-Tin-Noé, T. Goerge, 2008, Blood.

A fast-acting elastase inhibitor in human monocytes

E. Remold-O’Donnell, 1985, The Journal of experimental medicine.

Stimulation and desensitization of macrophage adenylate cyclase by prostaglandins and catecholamines.

E. Remold-O’Donnell, 1974, The Journal of biological chemistry.

An Alu-mediated deletion at Xp11.23 leading to Wiskott-Aldrich syndrome

E. Remold-O’Donnell, M. Lutskiy, F. Rosen, 2002, Human Genetics.

Specific sensitivity of CD43 to neutrophil elastase.

E. Remold-O’Donnell, D. Parent, 1995, Blood.

Downregulation of Neutrophil CD43 by Opsonized Zymosan

E. Remold-O’Donnell, D. Parent, 1995 .

Specific Sensitivity of CD 43 to Neutrophil Elastase

E. Remold-O’Donnell, D. Parent, 2022 .

Neutrophil Serine Proteinases Inactivate Surfactant Protein D by Cleaving within a Conserved Subregion of the Carbohydrate Recognition Domain*

R. Mecham, E. Crouch, T. Hirche, 2004, Journal of Biological Chemistry.

Human monocyte/neutrophil elastase inhibitor (MNEI) is regulated by PU.1/SPI‐1, SP1, and NF‐κB

W. Zeng, E. Remold-O’Donnell, Weilan Zeng, 2000, Journal of cellular biochemistry.

Characterization of Four Murine Homologs of the Human ov-serpin Monocyte Neutrophil Elastase Inhibitor MNEI (SERPINB1)*

P. Bird, C. Benarafa, W. Zeng, 2002, The Journal of Biological Chemistry.

Recombinant human Monocyte/Neutrophil elastase inhibitor protects rat lungs against injury from cystic fibrosis airway secretions.

R. Rogers, E. Remold-O’Donnell, J. Cooley, 1999, American journal of respiratory cell and molecular biology.

Linkage of neutrophil serine proteases and decreased surfactant protein-A (SP-A) levels in inflammatory lung disease

F. Accurso, F. Rubio, E. Remold-O’Donnell, 2004, Thorax.

Wiskott-Aldrich syndrome in a female.

Y. Sasahara, E. Remold-O’Donnell, M. Lutskiy, 2002, Blood.

The neutrophil serine protease inhibitor serpinb1 preserves lung defense functions in Pseudomonas aeruginosa infection

G. Priebe, C. Benarafa, E. Remold-O’Donnell, 2007, The Journal of experimental medicine.

Increased surfactant protein D fails to improve bacterial clearance and inflammation in serpinB1-/- mice.

E. Crouch, P. Zhao, C. Benarafa, 2012, American journal of respiratory cell and molecular biology.

Alteration of hormone-stimulated cyclic AMP synthesis in guinea pig peritoneal macrophages.

H. Alpert, E. Remold-O’Donnell, 1979, Cellular immunology.

Enhanced PGE production by MAF-treated peritoneal exudate macrophages.

W. Piessens, E. Remold-O’Donnell, S. Friedman, 1979, Cellular immunology.

SERPINB1 upregulation is associated with in vivo complex formation with neutrophil elastase and cathepsin G in a baboon model of bronchopulmonary dysplasia.

R. Yasumatsu, C. Benarafa, E. Remold-O’Donnell, 2006, American journal of physiology. Lung cellular and molecular physiology.

Moesin, the major ERM protein of lymphocytes and platelets, differs from ezrin in its insensitivity to calpain

A. Bretscher, E. Remold-O’Donnell, A. Shcherbina, 1999, FEBS letters.

Effect of platelet calpain on normal T-lymphocyte CD43: hypothesis of events in the Wiskott-Aldrich syndrome.

E. Remold-O’Donnell, J. V. Van Brocklyn, D. Kenney, 1992, Blood.

A SerpinB1 Regulatory Mechanism Is Essential for Restricting Neutrophil Extracellular Trap Generation

P. Zhao, E. Remold-O’Donnell, J. Cooley, 2012, The Journal of Immunology.

SerpinB1 in cystic fibrosis airway fluids: quantity, molecular form and mechanism of elastase inhibition

F. Accurso, M. Sontag, E. Remold-O’Donnell, 2010, European Respiratory Journal.

Molecular characterization of sialophorin (CD43), the lymphocyte surface sialoglycoprotein defective in Wiskott-Aldrich syndrome.

G. Bruns, C. Shelley, A. Whitehead, 1989, Proceedings of the National Academy of Sciences of the United States of America.

Inhibitory properties of recombinant human monocyte/neutrophil elastase inhibitor.

J. Hoidal, T. Sugimori, E. Remold-O’Donnell, 1995, American journal of respiratory cell and molecular biology.

Myeloid conditional deletion and transgenic models reveal a threshold for the neutrophil survival factor Serpinb1

I. Touw, P. Basilico, C. Benarafa, 2016, Biological chemistry.

Two proteinase inhibitors associated with peritoneal macrophages.

K. Lewandrowski, E. Remold-O’Donnell, 1983, The Journal of biological chemistry.

A substrate‐based approach to convert SerpinB1 into a specific inhibitor of proteinase 3, the Wegener's granulomatosis autoantigen

G. Jégot, B. Korkmaz, F. Gauthier, 2011, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Genotype-Proteotype Linkage in the Wiskott-Aldrich Syndrome1

F. Rosen, E. Remold-O’Donnell, M. Lutskiy, 2005, The Journal of Immunology.

Platelets Amplify Inflammation in Arthritis via Collagen-Dependent Microparticle Production

Richard W. Farndale, Eric Boilard, Michael E. Weinblatt, 2010, Science.

Pathological events in platelets of Wiskott‐Aldrich syndrome patients

E. Remold-O’Donnell, F. Rosen, A. Shcherbina, 1999, British journal of haematology.

Patterns of neutrophil serine protease‐dependent cleavage of surfactant protein D in inflammatory lung disease

F. Accurso, E. Crouch, Barbara McDonald, 2008, Journal of leukocyte biology.

Purification of plasma membrane of guinea pig peritoneal macrophages.

E. Remold-O’Donnell, 1977, Preparative biochemistry.

N-terminal sequence of human leukocyte glycoprotein Mo1: conservation across species and homology to platelet IIb/IIIa.

M. Arnaout, R. Todd, M. Pierce, 1986, Biochimica et biophysica acta.

Evidence implicating calpain (Ca2+ ‐dependent neutral protease) in the destructive thrombocytopenia of the Wiskott‐Aldrich syndrome

E. Remold-O’Donnell, F. Rosen, D. Kenney, 1994, British journal of haematology.

T cell lines characterize events in the pathogenesis of the Wiskott- Aldrich syndrome

E. Remold-O’Donnell, F. Rosen, D. Kenney, 1992, The Journal of experimental medicine.

The Serpins Are an Expanding Superfamily of Structurally Similar but Functionally Diverse Proteins

J. Whisstock, J. Irving, D. Lomas, 2001, The Journal of Biological Chemistry.

WASP levels in platelets and lymphocytes of wiskott-aldrich syndrome patients correlate with cell dysfunction.

A Shcherbina, F S Rosen, E Remold-O'Donnell, 1999, Journal of immunology.

Sequence and molecular characterization of human monocyte/neutrophil elastase inhibitor.

E. Remold-O’Donnell, J. Chin, M. Alberts, 1992, Proceedings of the National Academy of Sciences of the United States of America.

SerpinB1 controls encephalitogenic T helper cells in neuroinflammation

B. Becher, L. Henderson, P. Bird, 2019, Proceedings of the National Academy of Sciences.

Structure of the human sialophorin (CD43) gene. Identification of features atypical of genes encoding integral membrane proteins.

C. Shelley, A. Whitehead, E. Remold-O’Donnell, 1990, The Biochemical journal.

Radiolabeling Carbohydrate Moieties of macrophage Surface Glycoprotdns

E. Remold-O’Donnell, 2003 .

Macrophage component gp160, a major trypsin-sensitive surface glycoprotein

E. Remold-O’Donnell, 1980, The Journal of experimental medicine.

Relationship of proteinases and proteinase inhibitors with microbial presence in chronic lung disease of prematurity

S. Kotecha, O. B. Spiller, M. Beeton, 2010, Thorax.

Morphological abnormalities in the lymphocytes of patients with the Wiskott-Aldrich syndrome.

R. Parkman, E. Remold-O’Donnell, F. Rosen, 1986, Blood.

A serpin from human tumor cells with direct lymphoid immunomodulatory activity: mitogenic stimulation of human tumor-infiltrating lymphocytes.

B. Packard, A. Komoriya, E. Remold-O’Donnell, 1995, Biochimica et biophysica acta.

Protein kinase activity associated with the surface of guinea pig macrophages

E. Remold-O’Donnell, 1978, The Journal of experimental medicine.

HEMOSTASIS , THROMBOSIS , AND VASCULAR BIOLOGY Role of Caspase in a Subset of Human Platelet Activation Responses

E. Remold-O’Donnell, A. Shcherbina, 1999 .

GPL-115 deficiency: a new class of immunodeficiencies.

F. Rosen, R. Parkman, E. Remold-O’Donnell, 1983, Birth defects original article series.

The Wiskott-Aldrich Syndrome and CD43

E. Remold-O’Donnell, F. Rosen, D. Kenney, 1989 .

Immune abnormalities in patients lacking a lymphocyte surface glycoprotein.

F. Rosen, J. Rappeport, R. Parkman, 1984, Clinical immunology and immunopathology.

Characterization and chromosomal localization of ELANH2, the gene encoding human monocyte/neutrophil elastase inhibitor.

E. Evans, E. Remold-O’Donnell, J. Cooley, 1995, Genomics.

[26] Isolation and purification of initiation factors f1 and f2

J. Hershey, D. Kolakofsky, R. Thach, 1971 .

A new method for the purification of initiation factor F2 in high yield, and an estimation of stoichiometry in the binding reaction.

R. Thach, E. Remold-O’Donnell, 1970, The Journal of biological chemistry.

Variable expression of WASP in B cell lines of Wiskott-Aldrich syndrome patients.

F. Finkelman, C. June, D. Perkins, 1997, Journal of immunology.

A novel protocol to identify mutations in patients with wiskott-Aldrich syndrome.

E. Remold-O’Donnell, M. Lutskiy, J. Cooley, 2002, Blood cells, molecules & diseases.

Sialophorin (CD43) and the Wiskott-Aldrich syndrome.

E. Remold-O’Donnell, F. Rosen, 1990, Immunodeficiency reviews.

Correlate with Cell Dysfunction of Wiskott-Aldrich Syndrome Patients WASP Levels in Platelets and Lymphocytes

E. Remold-O’Donnell, F. Rosen, A. Shcherbina, 1999 .

SerpinB1 protects the mature neutrophil reserve in the bone marrow

T. Cremona, C. Benarafa, E. Remold-O’Donnell, 2011, Journal of leukocyte biology.

A monoclonal antibody to sialophorin (CD43) induces homotypic adhesion and activation of human monocytes

T. Lebien, H. Remold, Y. Nong, 1989, The Journal of experimental medicine.

Mechanism of mononuclear cell activation by an anti-CD43 (sialophorin) agonistic antibody.

R. Geha, T. Chatila, F. Rosen, 1989, Journal of immunology.

The ovalbumin serpins revisited: perspective from the chicken genome of clade B serpin evolution in vertebrates.

Charaf Benarafa, C. Benarafa, Eileen Remold-O'Donnell, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Comparison of human chromosome 6p25 with mouse chromosome 13 reveals a greatly expanded ov-serpin gene repertoire in the mouse.

G. Mirza, J. Ragoussis, P. Denny, 2002, Genomics.

Production of recombinant human monocyte/neutrophil elastase inhibitor (rM/NEI).

E. Remold-O’Donnell, J. Cooley, R. Mandle, 1998, Protein expression and purification.

Structure and sequence of human M/NEI (monocyte/neutrophil elastase inhibitor), an Ov-serpin family gene.

G. Silverman, W. Zeng, E. Remold-O’Donnell, 1998, Gene.

SerpinB1: A Global Regulator of Neutrophil Homeostasis

Lifei Hou, E. Remold-O’Donnell, K. Farley, 2015 .

SerpinB1 Promotes Pancreatic β Cell Proliferation.

Richard D. Smith, A. Goldfine, M. Gritsenko, 2016, Cell metabolism.

Aerosol treatment with MNEI suppresses bacterial proliferation in a model of chronic Pseudomonas aeruginosa lung infection

A. Cantin, D. Woods, E. Remold-O’Donnell, 2005, Pediatric pulmonology.

Elastase inhibitor. Characterization of the human elastase inhibitor molecule associated with monocytes, macrophages, and neutrophils

R. Rose, E. Remold-O’Donnell, J. C. Nixon, 1989, The Journal of experimental medicine.

The ovalbumin family of serpin proteins

Eileen Remold-O'Donnell, E. Remold-O’Donnell, 1993, FEBS letters.

Purification and properties of DNA-dependent RNA-polymerase from Bacillus stearothermophilus.

W. Zillig, E. Remold-O’Donnell, 1969, European journal of biochemistry.

8B4/20, a private CD43 epitope on developing human thymocytes, is involved in thymocyte maturation.

J. Geginat, M. Fabbi, D. Ramarli, 1999, Journal of immunology.

Thymocyte Maturation Developing Human Thymocytes , Is Involved 8 B 4 / 20 , A Private CD 43 Epitope on Remold

J. Geginat, M. Fabbi, D. Ramarli, 1999 .

DFP-sensitive polypeptides of the guinea pig peritoneal macrophage.

H. Remold, L. Heck, E. Remold-O’Donnell, 1978, Biochemical and biophysical research communications.

High incidence of lymphomas in a subgroup of wiskott–aldrich syndrome patients

F. Candotti, E. Remold-O’Donnell, F. Rosen, 2003, British journal of haematology.

The cytoskeletal linker protein moesin: decreased levels in Wiskott‐Aldrich syndrome platelets and identification of a cleavage pathway in normal platelets

A. Bretscher, E. Remold-O’Donnell, F. Rosen, 1999, British journal of haematology.

Dynamic association of moesin with the membrane skeleton of thrombin- activated platelets.

A. Bretscher, E. Remold-O’Donnell, D. Kenney, 1999, Blood.

Signal transduction via leukocyte antigen CD43 (sialophorin). Feedback regulation by protein kinase C.

R. Geha, T. Chatila, F. Rosen, 1990, Journal of immunology.

Alterations in the renal elastin-elastase system in type 1 diabetic nephropathy identified by proteomic analysis.

B. Rovin, W. Pierce, J. Klein, 2004, Journal of the American Society of Nephrology : JASN.

Regulation of synthesis of macrophage adhesion molecule, a heterodimeric membrane glycoprotein.

E. Remold-O’Donnell, 1988, Journal of immunology.

The protease cathepsin L regulates Th17 cell differentiation.

M. Bogyo, S. Olson, R. Pike, 2015, Journal of autoimmunity.

T cell intrinsic SerpinB1 and a cathepsin protease serve as yin and yang to control Th17 differentiation (LYM3P.732)

Lifei Hou, E. Remold-O’Donnell, J. Cooley, 2014 .

Characterization of macrophage adhesion molecule.

B. Savage, E. Remold-O’Donnell, 1988, Biochemistry.

Molecular cloning of the alpha subunit of human and guinea pig leukocyte adhesion glycoprotein Mo1: chromosomal localization and homology to the alpha subunits of integrins.

D. Tenen, M. Arnaout, M. Pierce, 1988, Proceedings of the National Academy of Sciences of the United States of America.

SerpinB 1 regulates homeostatic expansion of IL-17 and CD 4 Th 17 cells

Mark S. Sundrud, P. Zhao, Lifei Hou, 2014 .

Proteolytic fragmentation of sialophorin (CD43). Localization of the activation-inducing site and examination of the role of sialic acid.

E. Remold-O’Donnell, F. Rosen, 1990, Journal of immunology.

Macrophage surface component gp160: sensitivity to plasmin and other proteases.

K. Lewandrowski, E. Remold-O’Donnell, 1982, Journal of immunology.

Downregulation of neutrophil CD43 by opsonized zymosan.

E. Remold-O’Donnell, D. Parent, 1995, Blood.

Purification, composition, and structure of macrophage adhesion molecule.

B. Savage, E. Remold-O’Donnell, 1988, Biochemistry.

Inflammation induces hemorrhage in thrombocytopenia.

D. Wagner, B. Ho-Tin-Noé, T. Goerge, 2008, Blood.

Relationship of proteinases and proteinase inhibitors with microbial presence in chronic lung disease of prematurity

S. Kotecha, M. Beeton, N. Maxwell, 2010, Thorax.

The neutrophil serine protease inhibitor serpinb1 preserves lung defense functions in Pseudomonas aeruginosa infection

G. Priebe, C. Benarafa, E. Remold-O’Donnell, 2007, Journal of Experimental Medicine.