Si Wu

发表

Distinct microscopic mechanisms for the accelerated aggregation of pathogenic Tau mutants revealed by kinetic analysis.

S. Perrett, Liu Hong, Qiong-Qiong Yao, 2020, Physical chemistry chemical physics : PCCP.

Interaction between bacterial outer membrane proteins and periplasmic quality control factors: a kinetic partitioning mechanism.

Xin Sheng Zhao, Z. Chang, Si Wu, 2011, The Biochemical journal.

Protein Microgels from Amyloid Fibril Networks.

Ulyana Shimanovich, T. Knowles, S. Perrett, 2019, Advances in experimental medicine and biology.

Influence of specific HSP70 domains on fibril formation of the yeast prion protein Ure2

Alexander K. Buell, C. Dobson, Gary W. Jones, 2013, Philosophical Transactions of the Royal Society B: Biological Sciences.

Influence of specific HSP 70 domains on fibril formation of the yeast prion protein Ure 2

C. Dobson, Gary W. Jones, L. Itzhaki, 2013 .

Kinetic diversity of amyloid oligomers

C. Dobson, D. Klenerman, S. Linse, 2020, Proceedings of the National Academy of Sciences.

A co-expression strategy to achieve labeling of individual subunits within a dimeric protein for single molecule analysis.

Jie Yang, S. Perrett, Fei Lou, 2017, Chemical communications.

Hsp70 in Redox Homeostasis

S. Perrett, Hong Zhang, Weibin Gong, 2022, Cells.

The use of sortase-mediated ligation for the immobilisation of bacterial adhesins onto fluorescence-labelled microspheres: a novel approach to analyse bacterial adhesion to host cells

T. Proft, Si Wu, 2010, Biotechnology Letters.

Conformational Expansion of Tau in Condensates Promotes Irreversible Aggregation.

T. Knowles, S. Perrett, G. Krainer, 2021, Journal of the American Chemical Society.

A fast and efficient procedure to produce scFvs specific for large macromolecular complexes.

J. Doudna, A. Ke, Si Wu, 2007, Journal of immunological methods.

Kinetics of the conformational cycle of Hsp70 reveals the importance of the dynamic and heterogeneous nature of Hsp70 for its function

Jie Yang, Hong Zhang, S. Perrett, 2020, Proceedings of the National Academy of Sciences.

S-Glutathionylation of human inducible Hsp70 reveals a regulatory mechanism involving the C-terminal α-helical lid.

Jie Yang, Xinxin Chen, Hong Zhang, 2020, The Journal of biological chemistry.

Unravelling the microscopic characteristics of intrinsically disordered proteins upon liquid-liquid phase separation.

S. Perrett, Si Wu, Jitao Wen, 2022, Essays in biochemistry.

Distinct lipid membrane-mediated pathways of Tau assembly revealed by single-molecule analysis.

S. Perrett, Qiong-Qiong Yao, Si Wu, 2022, Nanoscale.

Single Molecule Characterization of Amyloid Oligomers

Jie Yang, S. Perrett, Si Wu, 2021, Molecules.

Amelioration of aggregate cytotoxicity by catalytic conversion of protein oligomers into amyloid fibrils.

C. Dobson, Jie Yang, T. Knowles, 2020, Nanoscale.

Studying protein folding in health and disease using biophysical approaches

Hong Zhang, S. Perrett, Weibin Gong, 2021, Emerging topics in life sciences.

Reversible Redox-Dependent Conformational Switch of the C-Terminal α-Helical Lid of Human Hsp70 Observed by In-Cell NMR

Hong Zhang, S. Perrett, Weibin Gong, 2022, ACS Chemical Biology.

Direct Observation of Oligomerization by Single Molecule Fluorescence Reveals a Multistep Aggregation Mechanism for the Yeast Prion Protein Ure2

C. Dobson, Jie Yang, T. Knowles, 2018, Journal of the American Chemical Society.

PES inhibits human-inducible Hsp70 by covalent targeting of cysteine residues in the substrate-binding domain

Jie Yang, S. Perrett, Hong Zhang, 2020, The Journal of biological chemistry.

Effect of evolution of the C‐terminal region on chaperone activity of Hsp70

Hong Zhang, S. Perrett, Si Wu, 2022, Protein science : a publication of the Protein Society.

Methylene blue accelerates liquid-to-gel transition of tau condensates impacting tau function and pathology

Yongqi Huang, Zhengding Su, H. Mao, 2023, Nature communications.