S. George

发表

Cadmium effects on plaice liver xenobiotic and metal detoxication systems: dose-response

S. George, S. George, 1989 .

Molecular biomarkers and toxic consequences of impact by organic pollution in aquatic organisms

L. Förlin, S. George, D. R. Livingston, 1994 .

Molecular modelling of CYP1 family enzymes CYP1A1, CYP1A2, CYP1A6 and CYP1B1 based on sequence homology with CYP102.

D. Lewis, B. Lake, A. Beresford, 1999, Toxicology.

Copper transporter 1, metallothionein and glutathione reductase genes are differentially expressed in tissues of sea bream (Sparus aurata) after exposure to dietary or waterborne copper.

M. Minghetti, M. Leaver, E. Carpené, 2008, Comparative biochemistry and physiology. Toxicology & pharmacology : CBP.

The effect of chelating agents on the uptake and accumulation of cadmium by Mytilus edulis

T. L. Coombs, S. George, 1977 .

Toxicity of malathion to nile tilapia, Oreochromis niloticus and modulation by other environmental contaminants

S. George, A. Pathiratne, S. George, 1998 .

Copper induces Cu-ATPase ATP7A mRNA in a fish cell line, SAF1.

J. Taggart, M. Minghetti, M. Auslander, 2011, Comparative biochemistry and physiology. Toxicology & pharmacology : CBP.

Clonal adaptation of cancer cells in flatfish liver to environmental contamination by changes in expression of P-gp related MXR, CYP450, GST-A and G6PDH activity

A. Köhler, B. Lauritzen, L. Förlin, 1998 .

Regulation of hepatic glutathione S-transferase expression in flounder

M. Leaver, S. George, K. Scott, 1992 .

Molecular responses of European flounder (Platichthys flesus) chronically exposed to contaminated estuarine sediments.

Amer M. Diab, I. Davies, M. Viant, 2014, Chemosphere.

STUDIES OF A FATAL POLLUTANT-INDUCED HYPERBILIRUBINAEMIA IN SPAWNING ATLANTIC SALMON

S. Brown, D. Groman, S. George, 1992 .

Dietary crude oil exposure during sexual maturation induces hepatic mixed function oxygenase (CYP1A) activity at very low environmental temperatures in Polar cod Boreogadus saida

S. George, Christiansen Js, B. Killie, 1995 .

Induction of cytochrome P450 1A1 and conjugating enzymes in rainbow trout (Oncorhynchus mykiss) liver : a time course study

L. Förlin, M. Celander, M. Leaver, 1993 .

Metallothionein induction in cultured fibroblasts and liver of a marine flatfish, the turbot,Scophthalmus maximus

M. Leaver, S. George, D. Burgess, 1992, Fish Physiology and Biochemistry.

Purification and properties of plaice liver cytosolic glutathione-S-transferases

S. George, P. Young, 1988 .

Differential expression and induction of UDP-glucuronosyltransferase isoforms in hepatic and extrahepatic tissues of a fish, Pleuronectes platessa: immunochemical and functional characterization.

B. Burchell, S. George, D. Clarke, 1992, Toxicology and applied pharmacology.

Allelic variations in the plaice UGT1B1 gene.

M. Leaver, S. George, 2002, Marine environmental research.

Structural Studies of a UDP-glucuronosyltransferase gene from the plaice (Pleuronectes platessa)

M. Leaver, S. George, Joy Wright, 1998 .

Characterization and molecular analysis of hepatic microsomal UDP-glucuronosyltransferases in the marine fish, Pleuronectes platessa

B. Burchell, S. George, D. Clarke, 1988 .

Multiplicity of UDP-glucuronosyltransferases in fish. Purification and characterization of a phenol UDP-glucuronosyltransferase from the liver of a marine teleost, Pleuronectes platessa.

B. Burchell, S. George, D. Clarke, 1992, The Biochemical journal.

Induction of cytochrome p-450 monooxygenase activities in plaice by ‘model’ inducers and drilling muds

D. Raffaelli, M. Leaver, S. George, 1988 .

Functional and immunochemical comparison of hepatic UDP-glucuronosyltransferases in a piscine and a mammalian species.

B. Burchell, S. George, D. Clarke, 1992, Comparative biochemistry and physiology. B, Comparative biochemistry.

Activities of pollutant metabolising and detoxication systems in the liver of the plaice, Pleuronectes platessa: Sex and seasonal variations in non-induced fish

M. Leaver, S. George, D. Clarke, 1990 .

Glucuronidation in fish

B. Burchell, S. George, D. Clarke, 1991 .

Cytochrome P450 1A1 cDNA from plaice (Pleuronectes platessa) and induction of P450 1A1 mRNA in various tissues by 3-methylcholanthrene and isosafrole.

M. Leaver, S. George, L. Pirrit, 1993, Molecular marine biology and biotechnology.

Development of a fish in vitro cell culture model to investigate oxidative stress and its modulation by dietary vitamin E.

S. George, J. Wright, C. Riley, 2000, Marine environmental research.

Abnormal Hepatic Copper Storage in a Teleost Fish (Morone americana)

J. Frazier, S. M. Baksi, T. Bunton, 1987, Veterinary pathology.

Cloning of the major 3-MC inducible phase I and phase II detoxification enzymes of plaice liver

M. Leaver, S. George, L. Pirrit, 1995 .

SUBCELLULAR ACCUMULATION AND DETOXICATION OF METALS IN AQUATIC ANIMALS

S. George, 1982 .

Influence of dietary PUFA content on cytochrome P450 and transferase activities in atlantic salmon (salmo salar)

J. Henderson, S. George, 1992 .

The kinetics of accumulation and excretion of ferric hydroxide in Mytilus edulis (I.) and its distribution in the tissues

T. L. Coombs, S. George, B. Pirie, 1976 .

Temporal studies of the impact of the braer oilspill on inshore feral fish from Shetland, Scotland

J. Conroy, S. George, J. Wright, 1995 .

In vitro alternatives to whole animal testing. Comparative cytotoxicity studies of divalent metals in established cell lines derived from tropical and temperate water fish species in a neutral red assay

S. George, S. Magwood, 1996 .

Fish and mammalian liver cytosolic glutathione S-transferases: Substrate specificities and immunological comparison

J. Hayes, I. Nimmo, S. George, 1989 .

The time course of effects of cadmium and 3-methylcholanthrene on activities of enzymes of xenobiotic metabolism and metallothionein levels in the plaice, Pleuronectes platessa.

S G George, P Young, S. George, 1986, Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology.

Molecular evidence for multiple UDP-glucuronosyltransferase gene familes in fish.

S. George, Bryony Taylor, 2002, Marine environmental research.

A cytochrome P4501B gene from a fish, Pleuronectes platessa.

M. Leaver, S. George, Steven G George, 2000, Gene.

Evidence from heterologous expression of glutathione S-transferases A and A1 of the plaice (Pleuronectes platessa) that their endogenous role is in detoxification of lipid peroxidation products.

M. Leaver, E. Martı́nez-Lara, S. George, 2002, Marine environmental research.

A piscine glutathione S-transferase which efficiently conjugates the end-products of lipid peroxidation

M. Leaver, S. George, S. George, 1998 .

Alternatives to whole animal testing: Use of cDNA probes for studies of phase I and II enzyme induction in isolated plaice hepatocytes

M. Leaver, S. George, N. Hitchman, 1995 .

Fish metallothioneins: Molecular cloning studies and induction in cultured cells

M. Leaver, S. George, D. Burgess, 1989 .

An in vitro procedure for evaluation of early stage oxidative stress in an established fish cell line applied to investigation of PHAH and pesticide toxicity.

S. George, M.-J. Ruiz-Leal, 2004, Marine environmental research.

Structure of the plaice glutathione S-transferase A gene

M. Leaver, S. George, 1995 .

Detoxication of metals by marine bivalves: An ultrastructural study of the compartmentation of copper and zinc in the oyster Ostrea edulis

T. L. Coombs, S. George, P. T. Grant, 1978 .

Heavy metal detoxication in Mytilus kidney--an in vitro study of Cd- and Zn-binding to isolated tertiary lysosomes.

S. George, 1983, Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology.

Studies on the enzymology of purified preparations of brush border from rabbit kidney.

J. Kenny, S. George, S. George, 1973, The Biochemical journal.

Metal-Containing Blood Cells of Oysters: Ultrastructure, Histochemistry and X-Ray Microanalysis

J. D. Thomson, S. George, D. Lytton, 1984, Journal of the Marine Biological Association of the United Kingdom.

Cellular metal distribution in the Pacific oyster, Crassostrea gigas (Thun.) determined by quantitative X-ray microprobe analysis

J. D. Thomson, S. George, B. Pirie, 1985 .

Comparison of xenobiotic metabolizing enzymes of Tilapia with those of other fish species and interspecies relationships between gene families

S. George, A. Pathiratne, 1996 .

MECHANISMS OF IMMOBILIZATION AND DETOXICATION OF METALS IN MARINE ORGANISMS

T. L. Coombs, S. George, S. George, 1978 .

Metabolism of zinc in the mussel, Mytilus edulis (L.): a combined ultrastructural and biochemical study

S. George, B. Pirie, S. George, 1980, Journal of the Marine Biological Association of the United Kingdom.

Cross species application of DNA microarrays in fish

A. Cossins, J. Chipman, M. Tom, 2008 .

Estimating the Efficiency of Fish Cross-Species cDNA Microarray Hybridization

Raphael Cohen, V. Chalifa-Caspi, J. Chipman, 2007, Marine Biotechnology.

Application of real time PCR determination to assess interanimal variabilities in CYP1A induction in the European flounder (Platichthys flesus).

J. Taggart, S. George, T. Dixon, 2002, Marine environmental research.

Identification of cytochrome P450 1B-like sequences in two teleost fish species (scup, Stenotomus chrysops and plaice, Pleuronectes platessa) and in a cetacean (striped dolphin, Stenella coeruleoalba).

J. Stegeman, M. Leaver, R. Dickerson, 2000, Marine environmental research.

Importance of Chemical Species in Uptake, Loss, and Toxicity of Elements for Marine Organisms

S. George, M. Bernhard, S. George, 1986 .

Heavy metal detoxication in the mussel Mytilus edulis-composition of Cd-containing kidney granules (tertiary lysosomes).

S. George, 1983, Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology.

Characterization of metal-containing granules from the kidney of the common mussel, Mytilus edulis

T. L. Coombs, S. George, B. Pirie, 1982 .

Use of Electron Microscope X-ray Analysis in the Determination of Detoxication Mechanisms for Heavy Metals in Shellfish

T. L. Coombs, S. George, B. Pirie, 1980 .

The occurrence of cadmium in sub-cellular particles in the kidney of the marine mussel, Mytilus edulis, exposed to cadmium. The use of electron microprobe analysis.

S. George, B. Pirie, 1979, Biochimica et biophysica acta.

THE EFFECT OF SALINITY ON THE UPTAKE OF CADMIUM BY THE COMMON MUSSEL, MYTILUS EDULIS (L.)

T. L. Coombs, E. Carpené, S. George, 1978 .

Effects of high stability iron-complexes on the kinetics of iron accumulation and excretion in Mytilus edvlis (L.)

T. L. Coombs, S. George, 1977 .

Control of metallothionein expression by hormones and stressors in cultured fish cell lines

S. George, D. Burgess, N. Frerichs, 1993 .

Toxicology of Aquatic Pollution: In vitro toxicology of aquatic pollutants: use of cultured fish cells

S. George, 1996 .

Levels of cellular glutathione and metallothionein affect the toxicity of oxidative stressors in an established carp cell line.

E. Carpené, E. Martı́nez-Lara, M. Kindt, 2000, Marine environmental research.

Dipeptidyl peptidase IV, a kidney brush-border serine peptidase.

A. G. Booth, E. Wood, S. George, 1976, The Biochemical journal.

Purification and characterization of multiple glutathione transferase isoenzymes from grey mullet liver

J. Bárcena, E. Martı́nez-Lara, S. George, 1997, Cellular and Molecular Life Sciences CMLS.

241Am binding-components in the digestive gland cells of the marine prosobranch Littorina littorea

P. Germain, J. Pieri, F. Goudard, 1986 .

Biochemical and ultrastructural observations of long-term silver accumulation in the mussel, Mytilus edulis

D. A. Nelson, A. Calabrese, S. George, 1986 .

Intracellular control of Cd concentrations in marine mussels

S. George, 1984 .

Effects of cadmium exposure on metal-containing amoebocytes of the oyster Ostrea edulis

J. Frazier, S. George, B. Pirie, 1983 .

University of Birmingham Integrating omic technologies into aquatic ecological risk assessment and environmental monitoring

M. Viant, F. Falciani, P. Lord, 2009 .

Isolation and elemental analysis of metal-rich granules from the kidney of the scallop, Pecten maximus (L.)

T. L. Coombs, S. George, B. Pirie, 1980 .

Inducibility of metallothionein mRNA expression and cadmium tolerance in larvae of a marine teleost, the turbot (Scophthalmus maximus).

S. George, P. Tytler, P. Hodgson, 1996, Fundamental and applied toxicology : official journal of the Society of Toxicology.

Detection of the bacterium Flavobacterium psychrophilum from a natural infection in rainbow trout, Oncorhynchus mykiss (Walbaum), using formalin-fixed, wax-embedded fish tissues.

H. Ferguson, M. Crumlish, S. George, 2007, Journal of fish diseases.

Gene expression responses of European flounder (Platichthys flesus) to 17-beta estradiol.

Amer M. Diab, Tim D Williams, T. Williams, 2007, Toxicology letters.

Identification of 137Cs‐ and 241Am‐binding sites in the oyster crassostrea gigas

P. Germain, J. Durand, J. Pieri, 1996, Biochemistry and molecular biology international.

Subcellular localisation and identification of95mTc- and241Am-binding ligands in the hepatopancreas of the lobsterHomarus gammarus

J. Durand, J. Pieri, F. Goudard, 1991 .

Biotransformation in Fishes

Daniel Schlenk, Stephen G. George, Malin Celander, 2008 .

Temporal variation of total mercury concentrations and burdens in the liver of eelpout Zoarces viviparus from the Forth Estuary, Scotland:implications for mercury biomonitoring

D. McLusky, S. Mathieson, S. George, 1996 .

Adaptive differences in gene expression in European flounder (Platichthys flesus)

J. Hemmer-Hansen, E. Nielsen, V. Loeschcke, 2007, Molecular ecology.

Characterisation of cadmium-binding proteins from mussels, Mytilus edulis (L), exposed to cadmium.

T. L. Coombs, E. Carpené, S. George, 1979, Biochimica et biophysica acta.

Cadmium kinetics in oysters — a comparative study of Crassostrea gigas and Ostrea edulis

J. Frazier, S. George, 1983 .

Ultrastructure of the heart and excretory system of Mytilus edulis (L.)

S. George, B. Pirie, 1979, Journal of the Marine Biological Association of the United Kingdom.

Conservation of the tandem arrangement of alpha 1-microglobulin/bikunin mRNA: cloning of a cDNA from plaice (Pleuronectes platessa).

M. Leaver, S. George, J. Wright, 1994, Comparative biochemistry and physiology. Biochemistry and molecular biology.

The localization of peptidases in microvilli from the brush border of the proximal renal tubule of the rabbit.

S. George, A. Kenny, S. Aparicio, 1969, The Biochemical journal.

A peroxisomal proliferator-activated receptor gene from the marine flatfish, the plaice (Pleuronectes platessa)

M. Leaver, S. George, J. Wright, 1998 .

On the development of the olfactory and the gustatory organs of the Dover sole, Solea solea, during metamorphosis

J. Adron, S. Appelbaum, A. Mackie, 1983, Journal of the Marine Biological Association of the United Kingdom.

Hepatic gene expression in flounder chronically exposed to multiply polluted estuarine sediment: Absence of classical exposure 'biomarker' signals and induction of inflammatory, innate immune and apoptotic pathways.

Amer M. Diab, Tim D Williams, T. Williams, 2010, Aquatic toxicology.

STRUCTURE AND FUNCTION OF CHLORIDE CELLS IN THE GILLS OF ANGUILLA ANGUILLA

J. Sargent, S. George, B. Pirie, 1978 .

Multiple Cu-ATPase genes are differentially expressed and transcriptionally regulated by Cu exposure in sea bream, Sparus aurata.

M. Minghetti, M. Leaver, S. George, 2010, Aquatic toxicology.

Transcriptomic responses of European flounder (Platichthys flesus) liver to a brominated flame retardant mixture.

C. Collins, R. Kuiper, T. Williams, 2013, Aquatic toxicology.

Piscine UDP-glucuronosyltransferase 1B.

M. Leaver, E. Boukouvala, S. George, 2007, Aquatic toxicology.

The GENIPOL European flounder Platichthys flesus L. toxicogenomics microarray: application for investigation of the response to furunculosis vaccination

Amer M. Diab, James K. Chipman, J. Chipman, 2008 .

Development of the GENIPOL European flounder (Platichthys flesus) microarray and determination of temporal transcriptional responses to cadmium at low dose.

Ana Conesa, Amer M. Diab, Tim D Williams, 2006, Environmental science & technology.

Isolation, properties and induction of plaice liver cytosolic glutathione-S-transferases

S. George, G. Buchanan, S. George, 1990, Fish Physiology and Biochemistry.

Towards a System Level Understanding of Non-Model Organisms Sampled from the Environment: A Network Biology Approach

Francesco Falciani, John M. Herbert, Mark R. Viant, 2011, PLoS Comput. Biol..

Integrating Omic Technologies into Aquatic Ecological Risk Assessment and Environmental Monitoring: Hurdles, Achievements, and Future Outlook

William H. Benson, Francesco Falciani, Nancy D. Denslow, 2009, Environmental health perspectives.

Molecular cloning of troponin I expressed in fast white muscle of a teleost fish, the Atlantic herring (Clupea harengus L.).

K. Hastings, M. Leaver, S. George, 1996, Biochimica et biophysica acta.

Structure and expression of a cluster of glutathione S-transferase genes from a marine fish, the plaice (Pleuronectes platessa).

M J Leaver, J Wright, S G George, 1997, The Biochemical journal.

Hepatic transcriptomic profiles of European flounder (Platichthys flesus) from field sites and computational approaches to predict site from stress gene responses following exposure to model toxicants.

Amer M. Diab, F. Falciani, T. Williams, 2008, Aquatic toxicology.

Transcriptomic responses of European flounder (Platichthys flesus) to model toxicants.

Amer M. Diab, F. Falciani, T. Williams, 2008, Aquatic toxicology.

Molecular studies of the phase II xenbiotic conjugative enzymes of marine pleuronectid flatfish

M. Leaver, S. George, D. Clarke, 1992 .

A retrospective analysis to explore the applicability of fish biomarkers and sediment bioassays along contaminated salinity transects

J. Postma, A. Murk, F. J. Schooten, 2009 .

Regulation of metallothionein in teleosts: induction of MTmRNA and protein by cadmium in hepatic and extrahepatic tissues of a marine flatfish, the turbot (Scophthalmus maximus).

S. George, J. Wright, K. Todd, 1996, Comparative biochemistry and physiology. Part C, Pharmacology, toxicology & endocrinology.

Metallothionein as an indicator of water quality: assessment of the bioavailability of cadmium, copper, mercury and zinc in aquatic animals at the cellular level

W. J. Langston, W. Langston, S. G. George, 1994 .

Cloning and characterization of the major hepatic glutathione S-transferase from a marine teleost flatfish, the plaice (Pleuronectes platessa), with structural similarities to plant, insect and mammalian Theta class isoenzymes.

M. Leaver, S. George, K. Scott, 1993, The Biochemical journal.

Chemical Species in Marine and Estuarine Systems

M. Andreae, M. Vestal, J. Duinker, 1986 .

Induction of piscine metallothionein as a primary response to heavy metal pollutants: applicability of new sensitive molecular probes

Michael J. Leaver, Stephen G. George, Peter Kille, 1992 .

The intracellular localization of some particulate peptidases in the kidney of the rat and the rabbit.

S. George, A. Kenny, Y. L. Wong-Leung, 1968, Biochemical Journal.

M. Leaver, S. George, K. Scott, 1993, The Biochemical journal.

University of Birmingham Towards a System Level Understanding of Non-Model Organisms Sampled from the Environment: A Network Biology Approach

Amer M. Diab, M. Viant, F. Falciani, 2011 .