C. Wolfman

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6-Bromoflavone, a high affinity ligand for the central benzodiazepine receptors is a member of a family of active flavonoids.

H. Viola, B. Cassels, P. Waterman, 1996, Biochemical and biophysical research communications.

Synthesis of halogenated/nitrated flavone derivatives and evaluation of their affinity for the central benzodiazepine receptor

J. Medina, H. Viola, M. Colombo, 1997 .

Apigenin, a component of Matricaria recutita flowers, is a central benzodiazepine receptors-ligand with anxiolytic effects.

J. Medina, H. Viola, R. Silveira, 1995, Planta medica.

Recovery of central noradrenergic neurons one year after the administration of the neurotoxin DSP4

J. Medina, R. Silveira, D. Calvo, 1994, Neurochemistry International.

Thyroid hormone regulation of adrenergic receptors and beta-adrenergic responsiveness in the rat submandibular gland.

J. Medina, M. Levi de Stein, C. Wolfman, 1984, Life sciences.

Time course of changes in [3H]prazosin binding after catecholaminergic denervation by 6-hydroxydopamine in rat cerebral cortex Inhibitory effects of ascorbic acid on the α 1-adrenoceptor

E. Robertis, C. Wolfman, M. L. Stein, 1983, Neuropharmacology.

6-Methyl-3'-bromoflavone, a high-affinity ligand for the benzodiazepine binding site of the GABA(A) receptor with some antagonistic properties.

L. Izquierdo, J. Medina, H. Viola, 1999, Biochemical and biophysical research communications.

6-Bromo-3′-nitroflavone, a new high affinity benzodiazepine receptor agonist recognizes two populations of cerebral cortical binding sites

J. Medina, H. Viola, A. Paladini, 1997 .

Post-training down-regulation of memory consolidation by a GABA-A mechanism in the amygdala modulated by endogenous benzodiazepines.

I. Izquierdo, J. Medina, R. Walz, 1990, Behavioral and neural biology.

Benzodiazepine-like molecules, as well as other ligands for the brain benzodiazepine receptors, are relatively common constituents of plants.

J. Medina, M. Levi de Stein, C. Peña, 1989, Biochemical and biophysical research communications.

The “Anxiety State” and Its Relation with Rat Models of Memory and Habituation

J. Medina, H. Viola, C. Cunha, 1999, Neurobiology of Learning and Memory.

Possible anxiolytic effects of chrysin, a central benzodiazepine receptor ligand isolated from Passiflora Coerulea

J. Medina, H. Viola, A. Paladini, 1994, Pharmacology Biochemistry and Behavior.

Detection of benzodiazepine receptor ligands in small libraries of flavone derivatives synthesized by solution phase combinatorial chemistry.

J H Medina, J. Medina, H. Viola, 1998, Biochemical and biophysical research communications.

6,3'-Dinitroflavone, a novel high affinity ligand for the benzodiazepine receptor with potent anxiolytic properties

J. Medina, H. Viola, P. Waterman, 1995 .

Flavonoids and the Central Nervous System: from Forgotten Factors to Potent Anxiolytic Compounds

J. Medina, H. Viola, A. Paladini, 1999, The Journal of pharmacy and pharmacology.

Neuroactive flavonoids: new ligands for the Benzodiazepine receptors.

J. Medina, H. Viola, D. Calvo, 1998, Phytomedicine : international journal of phytotherapy and phytopharmacology.

Chrysin (5,7-di-OH-flavone), a naturally-occurring ligand for benzodiazepine receptors, with anticonvulsant properties.

J H Medina, J. Medina, M. Levi de Stein, 1990, Biochemical pharmacology.

Cirsiliol and caffeic acid ethyl ester, isolated from Salvia guaranitica, are competitive ligands for the central benzodiazepine receptors.

J. Medina, H. Viola, P. Waterman, 1996, Phytomedicine : international journal of phytotherapy and phytopharmacology.

Proconvulsant and ‘anxiogenic’ effects of n-butyl β carboline-3-carboxylate, an endogenous benzodiazepine binding inhibitor from brain

J. Medina, M. L. Novas, E. Robertis, 1988, Pharmacology Biochemistry and Behavior.

Overview—Flavonoids: A New Family of Benzodiazepine Receptor Ligands

J. Medina, H. Viola, Jorge H. Medina, 1997, Neurochemical Research.

Memory modulation by brain benzodiazepines.

I. Izquierdo, J. Medina, D. Jerusalinsky, 1991, Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas.

Isolation of pharmacologically active benzodiazepine receptor ligands from Tilia tomentosa (Tiliaceae).

J. Medina, H. Viola, M. Levi de Stein, 1994, Journal of ethnopharmacology.

Benzodiazepines in the brain

I. Izquierdo, J. Medina, C. Peña, 2007, Molecular Neurobiology.

6-Chloro-3′-nitroflavone is a Potent Ligand for the Benzodiazepine Binding Site of the GABAA Receptor Devoid of Intrinsic Activity

J. Medina, H. Viola, J. Goutman, 2000, Pharmacology Biochemistry and Behavior.

Intrahippocampal or intraamygdala infusion of KN62, a specific inhibitor of calcium/calmodulin-dependent protein kinase II, causes retrograde amnesia in the rat.

I. Izquierdo, J. Medina, M. Bianchin, 1994, Behavioral and neural biology.

Habituation and inhibitory avoidance training alter brain regional levels of benzodiazepine-like molecules and are affected by intracerebral flumazenil microinjection

I. Izquierdo, J. Medina, H. Viola, 1991, Brain Research.

Anxioselective properties of 6,3'-dinitroflavone, a high-affinity benzodiazepine receptor ligand.

I. Izquierdo, J. Medina, H. Viola, 1996, European journal of pharmacology.

Effect of various training procedures on performance in an elevated plus-maze: Possible relation with brain regional levels of benzodiazepine-like molecules

I. Izquierdo, J. Medina, C. Cunha, 1992, Pharmacology Biochemistry and Behavior.

Effects of prenatal diazepam on two-way avoidance behavior, swimming navigation and brain levels of benzodiazepine-like molecules in male roman high- and low-avoidance rats

J. Medina, A. Tobeña, R. M. Escorihuela, 1995, Psychopharmacology.

Pharmacological Characterization of 6-Bromo-3′-nitroflavone, a Synthetic Flavonoid with High Affinity for the Benzodiazepine Receptors

J. Medina, H. Viola, P. Ardenghi, 1998, Pharmacology Biochemistry and Behavior.

Inhibitory Avoidance Training Induces Rapid and Selective Changes in3[H]AMPA Receptor Binding in the Rat Hippocampal Formation

I. Izquierdo, J. Medina, M. Cammarota, 1995, Neurobiology of Learning and Memory.

Ricinine-Elicited Seizures A Novel Chemical Model of Convulsive Seizures

J. Medina, C. Cunha, F. Scorza, 2000, Pharmacology Biochemistry and Behavior.

NMDA-receptor-dependent, muscimol-sensitive role of the entorhinal cortex in post-training memory processing.

I. Izquierdo, J. Medina, R. Walz, 1992, Behavioural pharmacology.

Sedative and hypnotic properties of Salvia guaranitica St. Hil. and of its active principle, Cirsiliol.

J. Medina, H. Viola, A. Paladini, 1997, Phytomedicine : international journal of phytotherapy and phytopharmacology.

Benzodiazepine receptors in rat cerebral cortex and hippocampus undergo rapid and reversible changes after acute stress

J. Medina, M. L. Novas, E. Robertis, 1983, Neuroscience.

Benzodiazepine receptor ligand influences on learning: an endogenous modulatory mechanism mediated by benzodiazepines possibly of alimentary origin.

I. Izquierdo, J. Medina, C. Wolfman, 1991, Memorias do Instituto Oswaldo Cruz.

Effect of post-training injections of flumazenil into the amygdala, hippocampus and septum on retention of habituation and of inhibitory avoidance in rats.

I. Izquierdo, J. Medina, M. Bianchin, 1991, Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas.

Intra-hippocampal KN-62 hinders the memory of habituation acquired alone, but not simultaneously with a water-finding task.

I. Izquierdo, L. Izquierdo, C. Wolfman, 1999, Behavioural pharmacology.