Melissa A. Mefford

Mechanistic Insights into Mammalian Pre‐mRNA Splicing

J. P. Staley, S. Fica, E. C. Small, 2013 .

A 4-base pair core-enclosing helix in telomerase RNA is essential and binds to the TERT catalytic protein subunit

D. Zappulla, Melissa A. Mefford, Evan P. Hass, 2020, bioRxiv.

A 4-Base-Pair Core-Enclosing Helix in Telomerase RNA Is Essential for Activity and for Binding to the Telomerase Reverse Transcriptase Catalytic Protein Subunit

D. Zappulla, Melissa A. Mefford, Evan P. Hass, 2020, Molecular and Cellular Biology.

RNA connectivity requirements between conserved elements in the core of the yeast telomerase RNP

D. Zappulla, David C. Zappulla, Melissa A. Mefford, 2013, The EMBO journal.

Evidence for a group II intron-like catalytic triplex in the spliceosome

J. Piccirilli, S. Fica, Jonathan P Staley, 2014, Nature Structural &Molecular Biology.

U2 toggles iteratively between the stem IIa and stem IIc conformations to promote pre-mRNA splicing.

Melissa A. Mefford, J. Staley, Angela K Hilliker, 2007, Genes & development.

Physical Connectivity Mapping by Circular Permutation of Human Telomerase RNA Reveals New Regions Critical for Activity and Processivity

D. Zappulla, David C. Zappulla, Melissa A. Mefford, 2015, Molecular and Cellular Biology.

Evidence that U2/U6 helix I promotes both catalytic steps of pre-mRNA splicing and rearranges in between these steps.

Jonathan P Staley, Melissa A. Mefford, J. Staley, 2009, RNA.