Carl P. Haslam

发表

The Evolution of MALDI-TOF Mass Spectrometry toward Ultra-High-Throughput Screening: 1536-Well Format and Beyond

Melanie V. Leveridge, Rainer Paape, Peter S Marshall, 2016, Journal of biomolecular screening.

Discovery of 2-[(2,4-dichlorophenyl)amino]-N-[(tetrahydro- 2H-pyran-4-yl)methyl]-4-(trifluoromethyl)- 5-pyrimidinecarboxamide, a selective CB2 receptor agonist for the treatment of inflammatory pain.

I. Chessell, A. Naylor, C. O'shaughnessy, 2007 .

Selectivity of d[Cha4]AVP and SSR149415 at human vasopressin and oxytocin receptors: evidence that SSR149415 is a mixed vasopressin V1b/oxytocin receptor antagonist

A. Green, Bryony A Dickinson, O. Curcuruto, 2005, British journal of pharmacology.

Pharmacology of GPR 55 in Yeast and Identification of GSK 494581 A as a Mixed-Activity Glycine Transporter Subtype 1 Inhibitor and GPR 55 Agonist

S. Dowell, D. Daniels, Andrew J. Brown, 2011 .

Structural and mechanistic basis of differentiated inhibitors of the acute pancreatitis target kynurenine-3-monooxygenase

C. Chung, D. Mole, J. Liddle, 2017, Nature Communications.

Assaying kinase activity of the TPL-2/NF-κB1 p105/ABIN-2 complex using an optimal peptide substrate

P. Chakravarty, S. Ley, S. Kjær, 2017, The Biochemical journal.

Structure-Activity Relationship of the GPR55 Antagonist, CID16020046

S. Dowell, Andrew J. Brown, Carl P. Haslam, 2018, Pharmacology.

Synthesis and evaluation of 3-amino-6-aryl-pyridazines as selective CB(2) agonists for the treatment of inflammatory pain.

Andrew J. Brown, P. Beswick, Robert J Gleave, 2010, Bioorganic & medicinal chemistry letters.

2-Amino-5-aryl-pyridines as selective CB2 agonists: synthesis and investigation of structure-activity relationships.

Andrew J. Brown, P. Beswick, Robert J Gleave, 2009, Bioorganic & medicinal chemistry letters.

Pyridine-3-carboxamides as novel CB(2) agonists for analgesia.

I. Wall, I. Chessell, A. Naylor, 2009, Bioorganic & medicinal chemistry letters.

Pharmacology of GPR55 in yeast and identification of GSK494581A as a mixed-activity GlyT1 inhibitor and GPR55 agonist.

D. Daniels, Andrew J. Brown, A. Wise, 2010 .

The discovery of potent and selective kynurenine 3-monooxygenase inhibitors for the treatment of acute pancreatitis.

M. Hann, D. Mole, J. Liddle, 2017, Bioorganic & medicinal chemistry letters.

Discovery of 1-[4-(3-chlorophenylamino)-1-methyl-1H-pyrrolo[3,2-c]pyridin-7-yl]-1-morpholin-4-ylmethanone (GSK554418A), a brain penetrant 5-azaindole CB2 agonist for the treatment of chronic pain.

Michael A. Briggs, I. Chessell, A. Naylor, 2009, Journal of medicinal chemistry.

Discovery of 2-[(2,4-dichlorophenyl)amino]-N-[(tetrahydro- 2H-pyran-4-yl)methyl]-4-(trifluoromethyl)- 5-pyrimidinecarboxamide, a selective CB2 receptor agonist for the treatment of inflammatory pain.

I. Chessell, A. Naylor, C. O'shaughnessy, 2007, Journal of medicinal chemistry.

Kynurenine–3–monooxygenase inhibition prevents multiple organ failure in rodent models of acute pancreatitis

J. Iredale, S. Howie, J. Hughes, 2015, Nature Medicine.

Cell Penetrant Inhibitors of the KDM4 and KDM5 Families of Histone Lysine Demethylases. 2. Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives.

David M. Wilson, Melanie V. Leveridge, G. Drewes, 2016, Journal of medicinal chemistry.

Reducing False Positives through the Application of Fluorescence Lifetime Technology: A Comparative Study Using TYK2 Kinase as a Model System

P. Rowland, P. Craggs, Bhumika Karamshi, 2021, SLAS discovery : advancing life sciences R & D.

Configuration of a High-Content Imaging Platform for Hit Identification and Pharmacological Assessment of JMJD3 Demethylase Enzyme Inhibitors

Melanie Leveridge, Emma Jones, John Liddle, 2012, Journal of biomolecular screening.

Lead Discovery for Human Kynurenine 3-Monooxygenase by High-Throughput RapidFire Mass Spectrometry

D. Mole, J. Liddle, I. Uings, 2014, Journal of biomolecular screening.

Pharmacology of GPR55 in Yeast and Identification of GSK494581A as a Mixed-Activity Glycine Transporter Subtype 1 Inhibitor and GPR55 Agonist

S. Dowell, D. Daniels, Andrew J. Brown, 2011, Journal of Pharmacology and Experimental Therapeutics.

Development of a Series of Kynurenine 3-Monooxygenase Inhibitors Leading to a Clinical Candidate for the Treatment of Acute Pancreatitis.

Xiaozhong Zheng, D. Mole, D. Clapham, 2017, Journal of medicinal chemistry.

Structure-activity studies of Streptococcus pyogenes enzyme SpyCEP reveal high affinity for CXCL8 in the SpyCEP C-terminal

R. Edwards, A. Fosberry, Jonathan C. Brown, 2021, bioRxiv.

Cell Penetrant Inhibitors of the KDM4 and KDM5 Families of Histone Lysine Demethylases. 1. 3-Amino-4-pyridine Carboxylate Derivatives.

Douglas W. Thomson, David M. Wilson, Melanie V. Leveridge, 2016, Journal of medicinal chemistry.

Non-conventional serine protease activity of the CXC chemokine-cleaving streptococcal 1 enzyme ,

A. Fosberry, D. Mossakowska, J. Pease, 2021 .

2-Amino-5-aryl-pyridines as selective CB2 agonists: synthesis and investigation of structure-activity relationships.

Andrew J. Brown, P. Beswick, Robert J Gleave, 2009, Bioorganic & medicinal chemistry letters.