Lynn Kimlicka

Structural Insights Into Disease Mutations of the Ryanodine Receptor

Z. Yuchi, F. V. Petegem, Lynn Kimlicka, 2013 .

Type 2 ryanodine receptor domain A contains a unique and dynamic α-helix that transitions to a β-strand in a mutant linked with a heritable cardiomyopathy.

M. Ikura, P. Stathopulos, F. van Petegem, 2013, Journal of molecular biology.

Disease mutations in the ryanodine receptor N-terminal region couple to a mobile intersubunit interface

F. van Petegem, Lynn Kimlicka, K. Lau, 2013, Nature Communications.

The amino-terminal disease hotspot of ryanodine receptors forms a cytoplasmic vestibule

Filip Van Petegem, F. V. Petegem, Ching-Chieh Tung, 2010, Nature.

The structural biology of ryanodine receptors

F. V. Petegem, Lynn Kimlicka, F. Petegem, 2011, Science China Life Sciences.

The clinical and genetic spectrum of catecholaminergic polymorphic ventricular tachycardia: findings from an international multicentre registry

Jeffrey M. Vinocur, P. Kannankeril, K. Collins, 2017, Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology.

The CPVT-associated RyR2 mutation G230C enhances store overload-induced Ca2+ release and destabilizes the N-terminal domains.

F. van Petegem, Lynn Kimlicka, Florian Hiess, 2013, The Biochemical journal.

The deletion of exon 3 in the cardiac ryanodine receptor is rescued by β strand switching.

F. van Petegem, Lynn Kimlicka, P. Lobo, 2011, Structure.

The cardiac ryanodine receptor N-terminal region contains an anion binding site that is targeted by disease mutations.

F. van Petegem, Z. Yuchi, Anna-Carin C. Carlsson, 2013, Structure.

The CPVT-associated RyR2 mutation G230C enhances store overload-induced Ca2+ release and destabilizes the N-terminal domains.

Lynn Kimlicka, Florian Hiess, Ruiwu Wang, 2013, The Biochemical journal.