S. Gangwar

发表

N-Succinyl-(beta-alanyl-L-leucyl-L-alanyl-L-leucyl)doxorubicin: an extracellularly tumor-activated prodrug devoid of intravenous acute toxicity.

D. Shochat, V. Dubois, A. Trouet, 2001, Journal of medicinal chemistry.

Recent advances in the discovery and development of antibody – drug conjugates have led to FDA approvals and a rich clinical pipeline of promising new cancer therapies . Antibody – drug conjugates : current status and future directions

R. Borzilleri, P. Cardarelli, G. Vite, 2013 .

Pharmacokinetic characterization of BMS‐936561, an anti‐CD70 antibody‐drug conjugate, in preclinical animal species and prediction of its pharmacokinetics in humans

P. Marathe, M. Srinivasan, P. Cardarelli, 2016, Biopharmaceutics & drug disposition.

Adnectin–drug conjugates for Glypican-3-specific delivery of a cytotoxic payload to tumors

Martin C. Wright, J. Bryson, V. Lafont, 2018, Protein engineering, design & selection : PEDS.

Streamlined Total Synthesis of Uncialamycin and Its Application to the Synthesis of Designed Analogues for Biological Investigations.

K. Nicolaou, D. Mandal, G. Vite, 2016, Journal of the American Chemical Society.

High-Throughput Platform to Identify Antibody Conjugation Sites from Antibody-Drug Conjugate Libraries.

Xiaodi A Deng, A. Rajpal, S. West, 2020, Bioconjugate chemistry.

A Universal Affinity Capture LC-MS Assay for Evaluation of Biotransformation of Site-Specific Antibody Drug Conjugates in Preclinical Studies.

A. Rajpal, G. Dollinger, P. Strop, 2019, Analytical chemistry.

Design, Synthesis, and Structure-Activity Relationships of Novel Tetrahydroisoquinolino Benzodiazepine Dimer Antitumor Agents and Their Application in Antibody-Drug Conjugates.

A. Mathur, B. Warrack, A. Rajpal, 2020, Journal of medicinal chemistry.

CD10 is a key enzyme involved in the activation of tumor-activated peptide prodrug CPI-0004Na and novel analogues: implications for the design of novel peptide prodrugs for the therapy of CD10+ tumors.

Yi-hong Wang, D. King, G. Yarranton, 2003, Cancer research.

Macrocyclic pyrrolobenzodiazepine dimers as antibody-drug conjugate payloads.

R. Borzilleri, A. Tebben, Yong Zhang, 2017, Bioorganic & medicinal chemistry letters.

Discovery of Non-Nucleotide Small-Molecule STING Agonists via Chemotype Hybridization.

Alan S. Futran, Vijay T. Ahuja, Shana L. Posy, 2022, Journal of medicinal chemistry.

Asymmetric syntheses of 3-amino-2-methylpentanoic acids. Configurations of the β-amino acid in majusculamide C, 57-normajusculamide C and dolastatins 11 and 12

R. Bates, S. Gangwar, 1993 .

Dolastatin 11, a marine depsipeptide, arrests cells at cytokinesis and induces hyperpolymerization of purified actin.

E. Sausville, E. Hamel, P. Verdier-Pinard, 2001, Molecular pharmacology.

Dolastatins. 26. Synthesis and stereochemistry of dolastatin 11

G. Pettit, R. Bates, K. Mcclure, 1997 .

Synthesis and evaluation of the physicochemical properties of esterase-sensitive cyclic prodrugs of opioid peptides using coumarinic acid and phenylpropionic acid linkers.

R. Borchardt, W. Wang, T. Siahaan, 1999, The journal of peptide research : official journal of the American Peptide Society.

Methoxymetacyclophanes from 2,6-dimethylanisole

R. Bates, S. Gangwar, V. V. Kane, 1991 .

Asymmetric Syntheses of 3-Amino-2-methylpentanoic Acids. Configurations of the β-Amino Acid in Majusculamide C, 57- Normajusculamide C and Dolastatins 11 and 12.

R. Bates, S. Gangwar, 1993 .

SYNTHESIS OF A NOVEL ESTERASE-SENSITIVE CYCLIC PRODRUG OF A HEXAPEPTIDE USING AN (ACYLOXY)ALKOXY PROMOIETY

R. Borchardt, V. Stella, G. Pauletti, 1997 .

Novel detection of DNA-alkylated adducts of antibody-drug conjugates with potentially unique preclinical and biomarker applications.

Zemin Wang, A. Bell, M. Srinivasan, 2013, Bioanalysis.

Structural requirements for intestinal absorption of peptide drugs

R. Borchardt, G. Knipp, G. Pauletti, 1996 .

Total Synthesis of Meayamycin and O-Acyl Analogues.

D. Boger, Anindya Sarkar, G. Vite, 2020, Organic letters.

Prodrug strategies to enhance the intestinal absorption of peptides

R. Borchardt, V. Stella, G. Pauletti, 1997 .

Synthesis, structure-activity relationship studies and evaluation of a TLR 3/8/9 agonist and its analogues

D. Boger, J. Naglich, Anindya Sarkar, 2021, Medicinal Chemistry Research.

Uncialamycin as a novel payload for antibody drug conjugate (ADC) based targeted cancer therapy.

D. Langley, Yichong Wang, P. Sivaprakasam, 2019, Bioorganic & medicinal chemistry letters.

Antibody-drug conjugates: current status and future directions.

R. Borzilleri, P. Cardarelli, G. Vite, 2014, Drug discovery today.

Chemical Modification of Linkers Provides Stable Linker-Payloads for the Generation of Antibody-Drug Conjugates.

A. Mathur, H. D. King, G. Vite, 2020, ACS medicinal chemistry letters.

Design, synthesis and biological evaluation of phenol-linked uncialamycin antibody-drug conjugates.

A. Mathur, G. Vite, Y. Poudel, 2019, Bioorganic & medicinal chemistry letters.

Synthesis and Biological Evaluation of a Carbamate-Containing Tubulysin Antibody Drug Conjugate.

P. Cardarelli, Gregory Vite, C. Rao-Naik, 2020, Bioconjugate chemistry.

Tylophora compounds as Na+/K(+)-ATPase inhibitors.

D. P. Dolata, J. Gnabre, J. Pinnas, 1993, General Pharmacology.

CPI-0004Na An extracellularly tumor-activated prodrug of doxorubicin

G. Yarranton, V. Dubois, A. Trouet, 2000 .

Esterase-Sensitive Cyclic Prodrugs of Peptides: Evaluation of an Acyloxyalkoxy Promoiety in a Model Hexapeptide

R. Borchardt, G. Pauletti, T. Siahaan, 1996, Pharmaceutical Research.

CD 10 Is a Key Enzyme Involved in the Activation of Tumor-activated Peptide Prodrug CPI-0004 Na and Novel Analogues : Implications for the Design of Novel Peptide Prodrugs for the Therapy of CD 10 Tumors

Yi-hong Wang, D. King, G. Yarranton, 2003 .

DNA-Model-Based Design and Execution of Some Fused Benzodiazepine Hybrid Payloads for Antibody-Drug Conjugate Modality.

Martin D. Eastgate, D. Langley, I. Mcdonald, 2021, ACS medicinal chemistry letters.

Single, low dose treatment of lymphoma and renal cancer xenografts with human anti-CD70 antibody-toxin conjugates, results in long term cures

J. Terrett, D. King, P. Cardarelli, 2007 .

Thimet oligopeptidase (EC 3.4.24.15) activates CPI-0004Na, an extracellularly tumour-activated prodrug of doxorubicin.

B. Reitz, R. Wattiez, T. Nguyen, 2006, European journal of cancer.

Human antibody conjugates of potential utility for prostate cancer therapy: A comparison of MGBA conjugates with antibodies targeting a cell surface target (prostate-specific membrane antigen) and an extracellular matrix target (Mindin/RG-1)

J. Terrett, D. King, P. Cardarelli, 2008 .

Ptk7 as a direct and tumor stroma target in multiple solid malignancies

J. Terrett, D. King, Haichun Huang, 2008 .

Phenylpropionic Acid-Based Cyclic Prodrugs of Opioid Peptides that Exhibit Metabolic Stability to Peptidases and Excellent Cellular Permeation

R. Borchardt, T. Siahaan, O. Gudmundsson, 2004, Pharmaceutical Research.

Therapeutic index improvement of antibody-drug conjugates

H. Gerber, S. Gangwar, A. Betts, 2023, mAbs.

Synthesis of an esterase-sensitive cyclic prodrug of a model hexapeptide having enhanced membrane permeability and enzymatic stability using an acyloxyalkoxy promoiety.

R. Borchardt, V. Stella, G. Pauletti, 1999, Methods in molecular medicine.

Discovery of Approaches by Various Machine learning Ensemble Model and Features Selection Method in Critical Heart Disease Diagnosis

Gyanendra Kumar Pal, S. Gangwar, 2022, International Research Journal on Advanced Science Hub.

Improvement of oral peptide bioavailability: Peptidomimetics and prodrug strategies.

Jeffrey, R. Borchardt, G. Pauletti, 1997, Advanced drug delivery reviews.

Synthesis and evaluation of the physicochemical properties of esterase-sensitive cyclic prodrugs of opioid peptides using an (acyloxy)alkoxy linker.

R. Borchardt, A. Bak, T. Siahaan, 1999, The journal of peptide research : official journal of the American Peptide Society.

Esterase-Sensitive Cyclic Prodrugs of Peptides: Evaluation of a Phenylpropionic Acid Promoiety in a Model Hexapeptide

R. Borchardt, G. Pauletti, B. Wang, 2004, Pharmaceutical Research.

Synthesis of a Novel Esterase-Sensitive Cyclic Prodrug System for Peptides That Utilizes a “Trimethyl Lock”-Facilitated Lactonization Reaction

R. Borchardt, G. Pauletti, B. Wang, 1997 .

Identification and Optimization of Small Molecule Pyrazolopyrimidine TLR7 Agonists for Applications in Immuno-oncology.

Murugaiah A. M. Subbaiah, G. Schieven, A. Mathur, 2024, ACS medicinal chemistry letters.

Discovery of Novel TLR7 Agonists as Systemic Agent for Combination With aPD1 for Use in Immuno-oncology.

G. Schieven, A. Mathur, D. Critton, 2024, ACS medicinal chemistry letters.

The Effect of Conformation on Membrane Permeability of an Acyloxyalkoxy-linked Cyclic Prodrug of a Model Hexapeptide

R. Borchardt, S. Jois, T. Siahaan, 1996, Pharmaceutical Research.