Bin He

发表

Attenuation of NLRP3 Inflammasome Activation by Indirubin-Derived PROTAC Targeting HDAC6.

Hening Lin, Ting Liu, Yongjun Li, 2021, ACS chemical biology.

Reply to: Binding site for MDL-801 on SIRT6

Shaoyong Lu, Jian Zhang, Yingyi Chen, 2021, Nature Chemical Biology.

Identification of a cellularly active SIRT6 allosteric activator

Shaoyong Lu, Jian Zhang, Yingyi Chen, 2018, Nature Chemical Biology.

SIRT4 is the last puzzle of mitochondrial sirtuins.

F. Wang, Yefang Zhou, Ting Liu, 2018, Bioorganic & medicinal chemistry.

The mimics of Nε-acyl-lysine derived from cysteine as sirtuin inhibitors.

Hong Zhu, Qingjie Zhao, Jingshan Shen, 2018, Bioorganic & medicinal chemistry letters.

A mini-review on Sirtuin activity assays.

Ai-min Wang, Yanyu Lan, Yonglin Wang, 2015, Biochemical and biophysical research communications.

A FRET-based assay for screening SIRT6 modulators.

Hong Zhu, Jie Liu, Yan Li, 2015, European journal of medicinal chemistry.

A FRET-based assay for screening SIRT5 specific modulators.

Yan Li, Bin He, Ling You, 2015, Bioorganic & medicinal chemistry letters.

Histone Deacetylases as Epigenetic Targets for Treating Parkinson’s Disease

Lei Chen, Zhicheng Gu, Shu-xian Lin, 2022, Brain sciences.

Unexpected small molecules as novel SIRT2 suicide inhibitors.

Zhuoxian Cao, Jie Wang, Yonglong Zhao, 2020, Bioorganic & medicinal chemistry.

Novel adefovir mono L-amino acid ester, mono bile acid ester derivatives: Design, synthesis, biological evaluation, and molecular docking study

M. Luo, Tao Xiao, Jing Li, 2017, Medicinal Chemistry Research.

Nɛ-acetyl lysine derivatives with zinc binding groups as novel HDAC inhibitors

Ting Liu, Yongjun Li, F. Wang, 2019, Royal Society Open Science.

Development of a mitochondrial sirtuin 4 FRET assay based on its activity for removing 3-hydroxy-3-methylglutaryl (HMG) modification

Yonglong Zhao, Yongjun Li, Zhuoxian Cao, 2021, RSC advances.

Zinc-dependent deacetylases (HDACs) as potential targets for treating Alzheimer's disease.

Lei Chen, Zhicheng Gu, Shu-xian Lin, 2022, Bioorganic & medicinal chemistry letters.

Synthesis and antibacterial activity studies in vitro of indirubin-3′-monoximes

Da-peng Wang, Xiao-zhong Fu, Yonglong Zhao, 2022, RSC advances.

Expression of Amyloid Precursor Protein, Caveolin-1, Alpha-, Beta-, and Gamma-Secretases in Penumbra Cells after Photothrombotic Stroke and Evaluation of Neuroprotective Effect of Secretase and Caveolin-1 Inhibitors

Lei Chen, Bin He, A. Logvinov, 2022, Biomedicines.

Synthesis and Antitumor Activities of Chiral Dipeptide Thioureas Containing an Alpha-Aminophosphonate Moiety

Hong Zhu, Yonglin Wang, Yongjun Li, 2017, Molecules.

A Series of Novel HDAC Inhibitors with Anthraquinone as a Cap Group.

Zhuoxian Cao, Jie Wang, Yonglong Zhao, 2020, Chemical & pharmaceutical bulletin.

Zinc-dependent Deacetylase (HDAC) Inhibitors with Different ZBG Groups

Yan Li, Bin He, Fang Wang, 1969 .

A comprehensive overview of Artemisinin and its derivatives as anticancer agents.

Lei Chen, Zihang Zeng, Di Chen, 2022, European journal of medicinal chemistry.

Zinc-dependent Deacetylase (HDAC) Inhibitors with Different Zinc Binding Groups.

F. Wang, Yongjun Li, Jie Wang, 2019, Current topics in medicinal chemistry.

Enhanced Water Solubility and Anti-Tumor Activity of Oleanolic Acid through Chemical Structure Modification

Lei Chen, Wanli Yan, Zhicheng Gu, 2022, International journal of molecular sciences.

Anti-Neuroinflammatory Potential of Natural Products in the Treatment of Alzheimer’s Disease

Lei Chen, Zhicheng Gu, Bin He, 2023, Molecules.

Scutellarin inhibits Hela cell growth and glycolysis by inhibiting the activity of pyruvate kinase M2.

Hong Zhu, Yonglin Wang, Yongjun Li, 2017, Bioorganic & medicinal chemistry letters.

Indirubin Derivatives as Dual Inhibitors Targeting Cyclin-Dependent Kinase and Histone Deacetylase for Treating Cancer.

Hening Lin, Ting Liu, Yongjun Li, 2021, Journal of medicinal chemistry.

Shenxiong glucose injection inhibits H2O2-induced H9c2 cell apoptosis by activating the ERK signaling pathway.

Jiang Zheng, Yong-Jun Li, Yonglin Wang, 2021, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

Study on Anti-Proliferative Activity in Cancer Cells and Preliminary Structure-Activity Relationship of Pseudo-Peptide Chiral Thioureas: Structure-Activity Relationship of Pseudo-Peptide Chiral Thioureas

Hong Zhang, S. Liao, Yongjun Li, 2018 .

Development of a single-step fluorogenic sirtuin assay and its applications for high-throughput screening

Lei Chen, Shu-xian Lin, Di Chen, 2022, Organic & Biomolecular Chemistry.

Facilitated Drug Repurposing with Artemisinin-Derived PROTACs: Unveiling PCLAF as a Therapeutic Target.

Lei Chen, Zihang Zeng, Zhicheng Gu, 2023, Journal of medicinal chemistry.

Development of Fluorescence-Based Assays for Key Viral Proteins in the SARS-CoV-2 Infection Process and Lifecycle

Bin He, Yan Li, Mingzhenlong Deng, 2024, International journal of molecular sciences.

Serendipitous discovery of Class I HDAC inhibitors from rational design of molecular glue degraders targeting HDAC.

Zhicheng Gu, Di Chen, Bin He, 2023, European journal of medicinal chemistry.

Cysteine derivatives as acetyl lysine mimics to inhibit zinc-dependent histone deacetylases for treating cancer.

Hening Lin, Ting Liu, Yongjun Li, 2021, European journal of medicinal chemistry.

Development of a Fluorescent Assay and Imidazole-Containing Inhibitors by Targeting SARS-CoV-2 Nsp13 Helicase

Bin He, Mingzhenlong Deng, Chuang Zhang, 2024, Molecules.