G. Tans

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Peptide Bond Cleavages and Loss of Functional Activity during Inactivation of Factor Va and Factor VaR506Q by Activated Protein C (*)

H. Hemker, G. Nicolaes, J. Rosing, 1995, The Journal of Biological Chemistry.

A Prothrombinase-based Assay for Detection of Resistance to Activated Protein C

H. Hemker, G. Nicolaes, R. van Oerle, 1996, Thrombosis and Haemostasis.

associated with a mild bleeding phenotype in patients homozygous for Co-inheritance of FV Leiden enhances thrombin formation and is

M. Pinotti, E. Castoldi, G. Tans, 2013 .

is associated with a mild bleeding phenotype in patients homozygous Coinheritance of Factor V (FV) Leiden enhances thrombin formation and

F. Bernardi, M. Pinotti, J. Rosing, 2013 .

Impaired APC cofactor activity of factor V plays a major role in the APC resistance associated with the factor V Leiden (R506Q) and R2 (H1299R) mutations.

D. Girelli, G. Nicolaes, J. Rosing, 2004, Blood.

Coinheritance of Factor V (FV) Leiden enhances thrombin formation and is associated with a mild bleeding phenotype in patients homozygous for the FVII 9726+5G>A (FVII Lazio) mutation.

F. Bernardi, M. Pinotti, J. Rosing, 2003, Blood.

Effect of in vitro fertilization treatment and subsequent pregnancy on the protein C pathway

K. Hamulýak, J. Rosing, A. Nap, 2001, British journal of haematology.

Effects of Hereditary and Acquired Risk Factors of Venous Thrombosis on a Thrombin Generation-Based APC Resistance Test

J. van der Meer, K. Hamulýak, J. Rosing, 2002, Thrombosis and Haemostasis.

Active Site-labeled Prothrombin Inhibits Prothrombinase in Vitro and Thrombosis in Vivo*

B. Furie, J. Rosing, P. Panizzi, 2011, The Journal of Biological Chemistry.

Development of a calibrated automated thrombography based thrombin generation test in mouse plasma

J. Rosing, B. V. van Vlijmen, B. Vlijmen, 2007, Journal of thrombosis and haemostasis : JTH.

Oral contraceptives and venous thrombosis: different sensitivities to activated protein C in women using second‐ and third‐generation oral contraceptives

H. Hemker, G. Nicolaes, R. van Oerle, 1997, British journal of haematology.

Simple and rapid method to determine the binding of blood clotting factor X to phospholipid vesicles.

J. Rosing, G. Tans, R. Zwaal, 1981, Biochemistry.

Inhibition of factor XIa by antithrombin III.

H. Hemker, G. Tans, H. Soons, 1987, Biochemistry.

Studies on the effect of serine protease inhibitors on activated contact factors. Application in amidolytic assays for factor XIIa, plasma kallikrein and factor XIa.

J. Griffin, J. Rosing, G. Tans, 1987, European journal of biochemistry.

The effect of platelets in the activation of human blood coagulation factor IX by factor XIa.

H. Hemker, G. Tans, H. Soons, 1986, Blood.

The effect of platelets in the activation of human blood coagulation factor IX by factor XIa

H. Hemker, G. Tans, H. Soons, 1986 .

Activation of Bovine Factor IX By Bovine Factor XIa . Active Site Titration Of Factor IXa and Development of A spectro-Photometric assay for Factor IX

H. Hemker, J. Rosing, G. Tans, 1981 .

Activated protein C resistance determined with a thrombin generation‐based test predicts for venous thrombosis in men and women

F. Rosendaal, R. Bertina, J. Rosing, 2003, British journal of haematology.

Effect of activated protein C on thrombin generation and on the thrombin potential in plasma of normal and APC‐resistant individuals

H. Hemker, G. Nicolaes, J. Rosing, 1997, Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis.

Protein C activation on endothelial cells by prothrombin activation products generated in situ: meizothrombin is a better protein C activator than alpha-thrombin.

P. D. de Groot, J. Rosing, T. Hackeng, 1996, The Biochemical journal.

Effect of oral contraceptives on thrombin generation measured via calibrated automated thrombography

F. Rosendaal, R. Bertina, P. Sandset, 2007, Thrombosis and Haemostasis.

Low-dose oral contraceptives and acquired resistance to activated protein C: a randomised cross-over study

M. Prins, H. Büller, G. Nicolaes, 1999, The Lancet.

Lipid phase transitions and procoagulant activity.

H. Hemker, P. Comfurius, G. Tans, 1979, European journal of biochemistry.

5B.2 Mechanism of hormonal therapy related thrombosis

J. Rosing, G. Tans, S. Tchaikovski, 2007 .

Venous thrombosis and oral contraceptives: current status.

J. Rosing, G. Tans, S. Tchaikovski, 2006, Women's health.

Venous Thrombosis and Oral Contraceptives: Current Status

J. Rosing, G. Tans, S. Tchaikovski, 2006 .

Determinants of the APTT‐ and ETP‐based APC sensitivity tests

F. Rosendaal, R. Bertina, P. Sandset, 2005, Journal of thrombosis and haemostasis : JTH.

Acquired resistance to activated protein C in breast cancer patients

M. Nijziel, R. van Oerle, E. V. van Pampus, 2003, British journal of haematology.

Venous thrombosis and changes of hemostatic variables during cross-sex hormone treatment in transsexual people.

J. Rosing, S. Zweegman, L. Gooren, 2003, The Journal of clinical endocrinology and metabolism.

Oral contraceptives, thrombosis and haemostasis.

J. Rosing, J. Curvers, G. Tans, 2001, European journal of obstetrics, gynecology, and reproductive biology.

A Randomized Cross-over Study on the Effects of Levonorgestrel- and Desogestrel-containing Oral Contraceptives on the Anticoagulant Pathways

M. Prins, H. Büller, S. Middeldorp, 2000, Thrombosis and Haemostasis.

Effects of oral contraceptives on hemostasis and thrombosis.

J. Rosing, G. Tans, 1999, American journal of obstetrics and gynecology.

Acquired APC resistance and oral contraceptives: differences between two functional tests

G. Nicolaes, R. van Oerle, K. Hamulýak, 1999, British journal of haematology.

Molecular Biology and Pathophysiology of APC Resistance : Current Insights and Clinical lmplications

H. Hemker, J. Rosing, G. Tans, 2022 .

Protein S is a cofactor for tissue factor pathway inhibitor.

J. Rosing, T. Hackeng, G. Tans, 2008, Thrombosis research.

Expression of the normal factor V allele modulates the APC resistance phenotype in heterozygous carriers of the factor V Leiden mutation

F. Bernardi, J. Rosing, P. Simioni, 2005, Journal of thrombosis and haemostasis : JTH.

Expression of Allosteric Linkage between the Sodium Ion Binding Site and Exosite I of Thrombin during Prothrombin Activation*

G. Nicolaes, J. Rosing, P. E. Bock, 2007, Journal of Biological Chemistry.

Activation of Factor IX by Factor XIa - A Spectrophotometric Assay for Factor IX in Human Plasma

H. Hemker, J. Rosing, G. Tans, 1982, Thrombosis and Haemostasis.

Effects on Coagulation of Levonorgestrel- and Desogestrel-containing Low Dose Oral Contraceptives: a Cross-over Study

M. Prins, H. Büller, S. Middeldorp, 2000, Thrombosis and Haemostasis.

Increased Fibrinolytic Activity during Use of Oral Contraceptives Is Counteracted by an Enhanced Factor XI-independent down Regulation of Fibrinolysis

M. Prins, H. Büller, S. Middeldorp, 2000, Thrombosis and Haemostasis.

An overview of antiplatelet and antithrombotic drugs.

V. Fuster, S. Moncada, E. Lapetina, 1985, Haemostasis.

Comparison of anticoagulant and procoagulant activities of stimulated platelets and platelet-derived microparticles.

J. Griffin, J. Rosing, G. Tans, 1991, Blood.

C4b-binding protein protects coagulation factor Va from inactivation by activated protein C.

J. Rosing, J. Meijers, B. Bouma, 2000, Biochemistry.

Meizothrombin, a Major Product of Factor Xa-Catalyzed Prothrombin Activation

J. Rosing, G. Tans, 1988, Thrombosis and Haemostasis.

Coagulation Factor V: An Old Star Shines Again

J. Rosing, G. Tans, 1997, Thrombosis and Haemostasis.

Factor V Enhances the Cofactor Function of Protein S in the APC-Mediated Inactivation of Factor VIII: Influence of the Factor VR506Q Mutation

J. Rosing, H. Schwarz, I. Pabinger, 1996, Thrombosis and Haemostasis.

Factor Va Is Inactivated by Activated Protein C in the Absence of Cleavage Sites at Arg-306, Arg-506, and Arg-679*

R. Bertina, J. Rosing, H. L. Vos, 2004, Journal of Biological Chemistry.

Activation of human factor V by meizothrombin.

H. Hemker, G. Nicolaes, A. V. van Zonneveld, 1994, The Journal of biological chemistry.

Human factor Va1 and factor Va2: properties in the procoagulant and anticoagulant pathways.

H. Hemker, G. Nicolaes, J. Rosing, 1997, Biochemistry.

Mutations in the R2 FV Gene Affect the Ratio between the Two FV Isoforms in Plasma

D. Girelli, F. Bernardi, J. Rosing, 2000, Thrombosis and Haemostasis.

Influence of Factor V and Factor Va on APC-Induced Cleavage of Human Factor VIII

J. Rosing, H. Schwarz, K. Váradi, 1995, Thrombosis and Haemostasis.

Characterization of two forms of human factor Va with different cofactor activities.

H. Hemker, J. Rosing, G. Tans, 1993, The Journal of biological chemistry.

Sulfatide-dependent autoactivation of human blood coagulation Factor XII (Hageman Factor).

J. Griffin, J. Rosing, G. Tans, 1983, The Journal of biological chemistry.

Isolation and functional properties of the heavy and light chains of human plasma kallikrein.

J. Griffin, B. Bouma, F. van der Graaf, 1982, The Journal of biological chemistry.

The Role of Surfaces in the Mechanism of Blood Coagulation

H. Hemker, G. Tans, 1979 .

Combined formative and summative professional behaviour assessment approach in the bachelor phase of medical school: A Dutch perspective

J. Rethans, C. V. D. van der Vleuten, L. Schuwirth, 2010, Medical teacher.

The effect of phospholipids, calcium ions and protein S on rate constants of human factor Va inactivation by activated human protein C.

J. Griffin, H. Hemker, J. Rosing, 1992, European journal of biochemistry.

Endogenous factor V synthesis in megakaryocytes contributes negligibly to the platelet factor V pool.

J. Rosing, L. Debusscher, E. Castoldi, 2003, Haematologica.

The activated protein C (APC)-resistant phenotype of APC cleavage site mutants of recombinant factor V in a reconstituted plasma model

R. Bertina, J. Rosing, H. L. Vos, 2002, Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis.

Molecular biology and pathophysiology of APC resistance: current insights and clinical implications.

H. Hemker, J. Rosing, G. Tans, 1998, Seminars in thrombosis and hemostasis.

Meizothrombin formation during factor Xa-catalyzed prothrombin activation. Formation in a purified system and in plasma.

H. Hemker, J. Rosing, G. Tans, 1991, The Journal of biological chemistry.

Regulation of Platelet Factor Va-dependent Thrombin Generation by Activated Protein C at the Surface of Collagen-adherent Platelets*

H. Hemker, G. Willems, J. Briedé, 2001, The Journal of Biological Chemistry.

Activation of bovine factor V by an activator purified from the venom of Naja naja oxiana.

J. Rosing, G. Tans, R. Zwaal, 1992, Toxicon : official journal of the International Society on Toxinology.

Calcium-independent activation of prothrombin on membranes with positively charged lipids.

J. Rosing, G. Tans, H. Speijer, 1988, Biochemistry.

Activation of factor IX by factor XIa

H. Hemker, J. Rosing, G. Tans, 1982 .

Thrombosis and Haemostasis formerly Thrombosis et Diathesis Haemorrhagica founded

H. Hemker, J. Rosing, G. Tans, 2022 .

Novel Fluorescent Prothrombin Analogs as Probes of Staphylocoagulase-Prothrombin Interactions*

W. Bode, P. Panizzi, P. Fuentes-Prior, 2006, Journal of Biological Chemistry.

The Role of Phospholipids and Factor Va in the Mechanism of Prothrombin Activation

H. Hemker, J. Rosing, J. Govers-Riemslag, 1979 .

Amidolytic Detection of Prothrombin Activation Products after SDS-Gel Electrophoresis

J. Rosing, G. Tans, T. Janssen-Claessen, 1989, Thrombosis and Haemostasis.

The clinical application of a new specific functional assay to detect the factor V(Leiden) mutation associated with activated protein C resistance.

R. van Oerle, K. Hamulýak, J. Rosing, 1997, American journal of clinical pathology.

Effect of second- and third-generation oral contraceptives on the protein C system in the absence or presence of the factor VLeiden mutation: a randomized trial.

A. Algra, D. Grobbee, J. Rosing, 2004, Blood.

Changes of hemostatic variables during oral contraceptive use.

H. Büller, J. Rosing, B. Bouma, 2003, Seminars in vascular medicine.

Snake Venom Activators of Factor X: An Overview

J. Rosing, G. Tans, 2001, Pathophysiology of Haemostasis and Thrombosis.

Altered inactivation pathway of factor Va by activated protein C in the presence of heparin.

B. Dahlbäck, B. Villoutreix, G. Nicolaes, 2004, European journal of biochemistry.

An investigation of the coagulological potential of the venoms of some Central Asian snakes

H. Hemker, J. Rosing, G. Tans, 1993, Chemistry of Natural Compounds.

Procoagulant activities in venoms from central Asian snakes.

H. Hemker, J. Rosing, G. Tans, 1991, Toxicon : official journal of the International Society on Toxinology.

Structural and functional characterization of a prothrombin activator from the venom of Bothrops neuwiedi.

J. Rosing, M. Knapen, J. Govers-Riemslag, 1987, Biochimica et biophysica acta.

Protein S levels modulate the activated protein C resistance phenotype induced by elevated prothrombin levels

J. Rosing, E. Castoldi, G. Tans, 2006, Thrombosis and Haemostasis.

Effect of oral contraceptives on the anticoagulant activity of protein S in plasma

R. Koenen, J. Rosing, T. Hackeng, 2005, Thrombosis and Haemostasis.

Re-evaluation of the role of the protein S-C4b binding protein complex in activated protein C-catalyzed factor Va-inactivation.

B. Dahlbäck, G. Nicolaes, J. Rosing, 2008, Blood.

Protein S stimulates inhibition of the tissue factor pathway by tissue factor pathway inhibitor.

J. Rosing, T. Hackeng, G. Tans, 2006, Proceedings of the National Academy of Sciences of the United States of America.

Purified protein S contains multimeric forms with increased APC-independent anticoagulant activity.

G. Willems, J. Rosing, T. Hackeng, 2001, Biochemistry.

Effects of Protein S and Factor Xa on Peptide Bond Cleavages during Inactivation of Factor Va and Factor VaR506Q by Activated Protein C (*)

H. Hemker, G. Nicolaes, J. Rosing, 1995, The Journal of Biological Chemistry.

Protein S binds to and inhibits factor Xa.

José A Fernández, J. Griffin, J. A. Fernandez, 1994, Proceedings of the National Academy of Sciences of the United States of America.

Binding of protein S to factor Va associated with inhibition of prothrombinase that is independent of activated protein C.

J. Griffin, J. Rosing, R. Mesters, 1993, The Journal of biological chemistry.

Protein-protein interactions in contact activation of blood coagulation. Binding of high molecular weight kininogen and the 5-(iodoacetamido) fluorescein-labeled kininogen light chain to prekallikrein, kallikrein, and the separated kallikrein heavy and light chains.

J. Griffin, P. E. Bock, J. Shore, 1985, The Journal of biological chemistry.

Structural and Functional Characterization of Factor XII

J. Rosing, G. Tans, 1987, Seminars in thrombosis and hemostasis.

The suicide substrate reaction between plasminogen activator inhibitor 1 and thrombin is regulated by the cofactors vitronectin and heparin.

A. Horrevoets, H. Pannekoek, M. van Meijer, 1997, Blood.

AUTOACTIVATION OF HUMAN PLASMA PREKALLIKREIN

J Rosing, B. Lämmle, J. Griffin, 1987, Thrombosis and Haemostasis.

The role of phospholipid and factor VIIIa in the activation of bovine factor X.

H. Hemker, J. Rosing, G. Tans, 1981, The Journal of biological chemistry.

The role of phospholipids and factor Va in the prothrombinase complex.

H C Hemker, J Rosing, H. Hemker, 1980, The Journal of biological chemistry.

Functional properties of human factor Va lacking the Asp683-Arg709 domain of the heavy chain.

H. Hemker, J. Rosing, R. Ebberink, 1994, The Journal of biological chemistry.

Chemoselective Oxime Reactions in Proteins and Peptides by Using an Optimized Oxime Strategy: The Demise of Levulinic Acid

R. Koenen, H. Ippel, M. Kokozidou, 2013, Chembiochem : a European journal of chemical biology.

Procoagulant Proteins and Diagnostic Agents

J. Rosing, G. Tans, 2002 .

Factor V Activation and Inactivation by Venom Proteases

J. Rosing, G. Tans, José W. P. Govers-Riemslag, 2001, Pathophysiology of Haemostasis and Thrombosis.

Purification and properties of a prothrombin activator from the venom of Notechis scutatus scutatus.

J. Rosing, J. Govers-Riemslag, G. Tans, 1985, The Journal of biological chemistry.

A kinetic assay to determine prothrombin binding to membranes.

J. Rosing, J. Govers-Riemslag, G. Tans, 1998, Thrombosis research.

Purification and characterization of multisquamase, the prothrombin activator present in Echis multisquamatus venom.

H. Hemker, J. Rosing, J. Govers-Riemslag, 1997, Thrombosis research.

Chapter 239 – Multactivase

G. Tans, 2013 .

activated protein C-catalyzed factor Va-inactivation Re-evaluation of the role of the protein S-C4b binding protein complex in

B. Dahlbäck, G. Nicolaes, J. Rosing, 2013 .

Chapter 3 Multicomponent enzyme complexes of blood coagulation

J. Rosing, G. Tans, 1986 .

Properties of sulfatides in factor-XII-dependent contact activation.

J. Griffin, G. Tans, 1982, Blood.

Snake Venom Prothrombin Activators – The History

J. Rosing, G. Tans, 2010 .

Pregnancy‐associated changes in the hemostatic system in wild‐type and factor V Leiden mice

J. Rosing, B. V. van Vlijmen, G. Tans, 2009, Journal of thrombosis and haemostasis : JTH.

Reduced Factor V Concentration and Altered FV1/FV2 Ratio do not fully Explain R2-associated APC-resistance

G. Nicolaes, J. Rosing, E. Castoldi, 2002, Thrombosis and Haemostasis.

Functional Properties of Factor V and Factor Va Encoded by the R2-gene

D. Girelli, J. Rosing, D. Gemmati, 2001, Thrombosis and Haemostasis.

An Assay to Quantify the Two Plasma Isoforms of Factor V

J. Rosing, G. Tans, L. Hoekema, 2000, Thrombosis and Haemostasis.

The Ser460Pro mutation in recombinant protein S Heerlen does not affect its APC-cofactor and APC-independent anticoagulant activities

R. Koenen, J. Rosing, T. Hackeng, 2004, Thrombosis and Haemostasis.

C-terminal Residues 621–635 of Protein S Are Essential for Binding to Factor Va*

J. Griffin, J. Rosing, G. Tans, 1999, The Journal of Biological Chemistry.

The function of the heavy and light chain of human plasma kallikrein in the activation of factor XII.

J. Griffin, J. Rosing, G. Tans, 1986, Advances in experimental medicine and biology.

Prothrombin Activation by Snake Venom Proteases

J. Rosing, G. Tans, 1993 .

Structural and functional properties of snake venom prothrombin activators.

J. Rosing, G. Tans, 1992, Toxicon : official journal of the International Society on Toxinology.

Surface-dependent activation of human factor XII (Hageman factor) by kallikrein and its light chain.

J. Griffin, J. Rosing, G. Tans, 1985, European journal of biochemistry.

Autoactivation of human blood coagulation factor XII on dextran derivatives of different molecular weight.

H. Hemker, J. Nigretto, G. Tans, 1992, Thrombosis research.

Factor XIIa regulates the structure of the fibrin clot independently of thrombin generation through direct interaction with fibrin.

H. ten Cate, H. Philippou, N. Mutch, 2011, Blood.

thrombin generation through direct interaction with fibrin Factor XIIa regulates the structure of the fibrin clot independently of

H. Philippou, N. Mutch, R. Ariëns, 2012 .

Sulfatide bilayers as a surface for contact activation in human plasma.

J. Griffin, A. Verkleij, J. Yu, 1987, Biochemical and biophysical research communications.

Topological and kinetic aspects of phospholipids in blood coagulation

Robert F. A. Zwaal, J. Rosing, Guido Tans, 1980 .

Increased tissue factor pathway inhibitor activity is associated with myocardial infarction in young women: results from the RATIO study

A. Algra, F. Rosendaal, H. ten Cate, 2011, Journal of thrombosis and haemostasis : JTH.

randomized trial C system in the absence or presence of the factor VLeiden mutation: a Effect of second- and third-generation oral contraceptives on the protein

A. Algra, D. Grobbee, J. Rosing, 2013 .

Inventory of Exogenous Prothrombin Activators

J. Rosing, G. Tans, 1991, Thrombosis and Haemostasis.

Autocatalytic peptide bond cleavages in prothrombin and meizothrombin.

H. Hemker, J. Rosing, J. Govers-Riemslag, 1998, Biochemistry.

Notecarin D Binds Human Factor V and Factor Va with High Affinity in the Absence of Membranes*

J. I. Creamer, Hong Xu, G. Tans, 2011, The Journal of Biological Chemistry.

The APC-independent anticoagulant activity of protein S in plasma is decreased by elevated prothrombin levels due to the prothrombin G20210A mutation.

R. Koenen, R. van Oerle, K. Hamulýak, 2003, Blood.

Formation of meizothrombin as intermediate in factor Xa-catalyzed prothrombin activation.

J. Rosing, G. Tans, R. Zwaal, 1986, The Journal of biological chemistry.

Factor XI Activation by Meizothrombin: Stimulation by Phospholipid Vesicles Containing both Phosphatidylserine and Phosphatidylethanolamine

J. Meijers, B. Bouma, G. Tans, 1997, Thrombosis and Haemostasis.

Protein C activation by an activator purified from the venom of Agkistrodon halys halys

H. Hemker, R. Bertina, J. Rosing, 1993, Blood Coagulation and Fibrinolysis.

Effects of (Pre-)analytical Variables on Activated Protein C Resistance Determined Via a Thrombin Generation-based Assay

F. Rosendaal, R. Bertina, J. Rosing, 2002, Thrombosis and Haemostasis.

Prothrombin activation on membranes with anionic lipids containing phosphate, sulfate, and/or carboxyl groups.

J. Rosing, J. Govers-Riemslag, G. Tans, 1990, Biochemistry.

The Role of Thrombin Exosites I and II in the Activation of Human Coagulation Factor V*

B. Dahlbäck, G. Nicolaes, J. Rosing, 2007, Journal of Biological Chemistry.

Factor Va is inactivated by APC in the absence of cleavage sites at Arg 306 , Arg 506 and Arg 679

R. Bertina, J. Rosing, R. Dirven, 2003 .

Factor V gene mutations (R2gene) are associated with coronary artery disease in ederly people

D. Girelli, F. Bernardi, J. Rosing, 1999 .

Autocatalytic peptide bond cleavages in prothrombin and meizothrombin.

J. Rosing, G. Tans, José W. P. Govers-Riemslag, 1998, Biochemistry.

Functional properties of recombinant factor V mutated in a potential calcium-binding site.

B. Dahlbäck, B. Villoutreix, G. Nicolaes, 2004, Biochemistry.

Determinants of the APTT‐ and ETP‐based APC sensitivity tests

F. Rosendaal, R. Bertina, P. Sandset, 2005, Journal of thrombosis and haemostasis : JTH.

Protein C activation by an activator purified from the venom of Agkistrodon halys halys

H. Hemker, R. Bertina, J. Rosing, 1993, Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis.