E. Umemura

发表

Synthesis and structure–activity relationships of novel lincomycin derivatives. Part 2. Synthesis of 7(S)-7-deoxy-7-(4-morpholinocarbonylphenylthio)lincomycin and its 3-dimensional analysis with rRNA

K. Ajito, Yoshinari Wakiyama, K. Kumura, 2015, The Journal of Antibiotics.

Synthesis and structure–activity relationships of novel lincomycin derivatives. Part 1. Newly generated antibacterial activities against Gram-positive bacteria with erm gene by C-7 modification

K. Ajito, Yoshinari Wakiyama, K. Kumura, 2015, The Journal of Antibiotics.

Synthesis and antibacterial activity of novel lincomycin derivatives. III. Optimization of a phenyl thiadiazole moiety

K. Ajito, Yoshinari Wakiyama, K. Kumura, 2017, The Journal of Antibiotics.

Synthesis and antibacterial activity of novel lincomycin derivatives. IV. Optimization of an N-6 substituent

Keiko Yamada, K. Ajito, Yoshinari Wakiyama, 2017, The Journal of Antibiotics.

Synthesis and antibacterial activity of novel lincomycin derivatives. II. Exploring (7S)-7-(5-aryl-1,3,4-thiadiazol-2-yl-thio)-7-deoxylincomycin derivatives

K. Ajito, Yoshinari Wakiyama, K. Kumura, 2016, The Journal of Antibiotics.

Synthesis and antibacterial activity of novel lincomycin derivatives. I. Enhancement of antibacterial activities by introduction of substituted azetidines

K. Ajito, Yoshinari Wakiyama, K. Kumura, 2016, The Journal of Antibiotics.

A synthetic study of methyl 3-deoxy-3-fluoro-α-d-glucopyranosides from methyl 2,3-anhydro-α-d-allopyranosides, and synthesis of 3′-deoxy-3′-fluorokanamycin A and 3′-chloro-3′-deoxykanamycin A

Koichi Tanaka, Yoshihiko Kobayashi, E. Umemura, 1992 .

Synthesis of 6"-chloro-6"-deoxyamikacin and some its analogs.

K. Tanaka, E. Umemura, S. Umezawa, 1990, The Journal of antibiotics.

An improved synthesis of 3′,4′-dideoxykanamycin B

E. Umemura, S. Fukatsu, T. Yoneta, 1979 .

CP6679, a new injectable cephalosporin. Part 1: synthesis and structure-activity relationships.

T. Kudo, T. Ida, E. Umemura, 2000, Bioorganic & medicinal chemistry.

Novel cephalosporin derivatives possessing a bicyclic heterocycle at the 3-position. Part II: Synthesis and antibacterial activity of 3-(5-methylthiazolo[4,5-c]pyridinium-2-yl)-thiomethylcephalosporin derivatives and related compounds.

E. Umemura, A. Tamura, K. Iwamatsu, 1998, Bioorganic & medicinal chemistry.

Synthesis of low-toxicity, 5-deoxy-5-fluoro and 5-deoxy-5,5-difluoro derivatives of arbekacin and its analogs, and study of structure-toxicity relationships.

T. Takeuchi, M. Hamada, T. Shitara, 1993, Carbohydrate research.

Synthesis of 3′,4′,6′-Trideoxy-6′-Fluorokanamycin C, 3′,4′-Dideoxy-6′-C-(fluoromethyl)kanamycin B, and Their 1-N-[(S)-4-Amino-2-hydroxybutanoyl] Derivatives

E. Umemura, S. Umezawa, T. Tsuchiya, 1990 .

Discovery of 2-hydroxyarbekacin, a new aminoglycoside antibiotic with reduced nephrotoxicity

Yoshihiko Kobayashi, M. Shibasaki, Yoshiaki Takahashi, 2017, Journal of antibiotics (Tokyo. 1968).

Synthesis of 5-deoxy-5-epifluoro derivatives of arbekacin, amikacin, and 1-N-[(S)-4-amino-2-hydroxybutanoyl]tobramycin (study on structure--toxicity relationships).

T. Shitara, E. Umemura, T. Tsuchiya, 1995, Carbohydrate research.

Synthesis of Low-Toxicity, 5-Deoxy-5-fluoro, and 5-Deoxy-5,5-difluoro Derivatives of Arbekacin and Its Analogs, and Study of Structure- Toxicity Relationships.

T. Takeuchi, M. Hamada, T. Shitara, 1993 .

Synthesis of 3′,4′,6′‐Trideoxy‐6′‐fluorokanamycin C, 3′,4′‐Dideoxy‐6′‐ C‐(fluoromethyl)kanamycin B, and Their 1‐N‐((S)‐4‐Amino‐2‐ hydroxybutanoyl) Derivatives.

E. Umemura, S. Umezawa, T. Tsuchiya, 1991 .

Synthesis of 1-N-(D-threo- and racemic erythro-3-amino-2-hydroxybutanoyl)-2',3'-dideoxykanamycin A.

E. Umemura, S. Umezawa, T. Tsuchiya, 1988, The Journal of antibiotics.

Modification of Aminocyclitol Antibiotics. 6. Preparation of 5-Deoxykanamycin B

S. Nishiyama, E. Umemura, T. Suami, 1978 .

Synthesis of 5‐Deoxy‐5‐epifluoro Derivatives of Arbekacin, Amikacin, and 1‐N‐((S)‐4‐Amino‐2‐hydroxybutanoyl)tobramycin (Study on Structure‐ Toxicity Relationships).

T. Shitara, E. Umemura, T. Tsuchiya, 1996 .

Synthesis of 5-deoxy-5-fluoro- and 5-deoxy-5,5-difluoro-netilmicin.

E. Umemura, S. Umezawa, T. Tsuchiya, 1993, Carbohydrate Research.

Synthesis and antibacterial activity of 1-N-[(S)-ω-amino-2-hydroxyalkyl] derivatives of dibekacin, 5-deoxydibekacin, 3′-deoxykanamycin A and gentamicin B

Yoshiaki Takahashi, T. Miyake, E. Umemura, 2015, The Journal of Antibiotics.

MODIFICATION OF AMINOCYCLITOL ANTIBIOTICS. 6. PREPARATION OF 5-DEOXYKANAMYCIN N B

S. Nishiyama, E. Umemura, T. Suami, 1978 .

Characterization of compound A, a novel lincomycin derivative active against methicillin-resistant Staphylococcus aureus

K. Maebashi, K. Ajito, Keiko Yamada, 2020, The Journal of Antibiotics.

Synthesis and SARs of novel lincomycin derivatives Part 5: optimization of lincomycin analogs exhibiting potent antibacterial activities by chemical modification at the 6- and 7-positions

Y. Hayashi, K. Ajito, Yoshinari Wakiyama, 2017, The Journal of Antibiotics.

Synthesis and structure–activity relationships of novel lincomycin derivatives. Part 4: synthesis of novel lincomycin analogs modified at the 6- and 7-positions and their potent antibacterial activities

Keiko Yamada, K. Ajito, T. Okutomi, 2017, The Journal of Antibiotics.

Synthesis and structure–activity relationships of novel lincomycin derivatives part 3: discovery of the 4-(pyrimidin-5-yl)phenyl group in synthesis of 7(S)-thiolincomycin analogs

K. Ajito, Yoshinari Wakiyama, K. Kumura, 2016, The Journal of Antibiotics.

Aprosamine Derivatives Active against Multidrug-Resistant Gram-Negative Bacteria.

M. Shibasaki, C. Hayashi, M. Igarashi, 2023, ACS infectious diseases.