P. Ingravallo

发表

In vitro antiviral activity of SCH446211 (SCH6), a novel inhibitor of the hepatitis C virus NS3 serine protease.

V. Pazienza, K. Abid, F. Negro, 2006, The Journal of antimicrobial chemotherapy.

In vitro antiviral activity of SCH 446211 ( SCH 6 ) , a novel inhibitor of the hepatitis C virus NS 3 serine protease

V. Pazienza, K. Abid, F. Negro, 2006 .

Characterization of monoclonal antibodies that specifically recognize the palm subdomain of hepatitis C virus nonstructural protein 5B polymerase.

Z. Hong, W. Zhong, B. Sodowich, 2001, Virus research.

Plasmodium vivax: malarial proteins associated with the membrane-bound caveola-vesicle complexes and cytoplasmic cleft structures of infected erythrocytes.

M. Galinski, J. Barnwell, M. Aikawa, 1990, Experimental parasitology.

Discovery of Ruzasvir (MK-8408): A Potent, Pan-Genotype HCV NS5A Inhibitor with Optimized Activity against Common Resistance-Associated Polymorphisms.

Rebecca T. Ruck, E. Asante-Appiah, Kung-I Feng, 2017, Journal of medicinal chemistry.

Interplay of Amino Acid Residues at Positions 28 and 31 in NS5A Defines Resistance Pathways in Hepatitis C Virus Genotype 2

E. Asante-Appiah, P. Qiu, F. Lahser, 2019, Antimicrobial Agents and Chemotherapy.

Discovery of 2-(4-sulfonamidophenyl)-indole 3-carboxamides as potent and selective inhibitors with broad hepatitis C virus genotype activity targeting HCV NS4B.

Z. Gu, A. Nomeir, F. Lahser, 2016, Bioorganic & medicinal chemistry letters.

Generation and Characterization of a Hepatitis C Virus NS3 Protease-Dependent Bovine Viral Diarrhea Virus

Z. Hong, W. Zhong, R. Donis, 2000, Journal of Virology.

MK-8325: A silyl proline-containing NS5A inhibitor with pan-genotype activity for treatment of HCV.

E. Asante-Appiah, M. Dwyer, A. Nomeir, 2018, Bioorganic & medicinal chemistry letters.

Kinetic analyses reveal potent and early blockade of hepatitis C virus assembly by NS5A inhibitors.

E. Asante-Appiah, S. Lemon, D. McGivern, 2014, Gastroenterology.

Characterization of hepatitis C virus resistance to grazoprevir reveals complex patterns of mutations following on-treatment breakthrough that are not observed at relapse

R. Bowden, E. Barnes, D. Bonsall, 2018, Infection and drug resistance.

Efficacy and safety of elbasvir/grazoprevir in treatment‐naive Chinese adults with hepatitis C virus infection: A randomized trial

E. Asante-Appiah, R. Talwani, Fu-Sheng Wang, 2020, JGH open : an open access journal of gastroenterology and hepatology.

Susceptibilities of Genotype 1a, 1b, and 3 Hepatitis C Virus Variants to the NS5A Inhibitor Elbasvir

A. Howe, P. Jumes, S. Black, 2015, Antimicrobial Agents and Chemotherapy.

Susceptibilities of Genotype 1 a , 1 b , and 3 Hepatitis C Virus Variants to the NS 5 A Inhibitor Elbasvir

A. Howe, P. Jumes, S. Black, 2015 .

Unraveling the structural basis of grazoprevir potency against clinically relevant substitutions in hepatitis C virus NS3/4A protease from genotype 1a

E. Asante-Appiah, Zhuyan Guo, Yuan Hu, 2017, The Journal of Biological Chemistry.

SCH 503034, a Mechanism-Based Inhibitor of Hepatitis C Virus NS3 Protease, Suppresses Polyprotein Maturation and Enhances the Antiviral Activity of Alpha Interferon in Replicon Cells

N. Butkiewicz, F. Gheyas, X. Tong, 2006, Antimicrobial Agents and Chemotherapy.

Discovery of potent macrocyclic HCV NS5A inhibitors.

James I. Fells, E. Asante-Appiah, C. Coburn, 2016, Bioorganic & medicinal chemistry letters.

Discovery of silyl proline containing HCV NS5A inhibitors with pan-genotype activity: SAR development.

M. Dwyer, A. Nomeir, R. Mazzola, 2016, Bioorganic & medicinal chemistry letters.

Discovery of (1R,5S)-N-[3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]- 3-[2(S)-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]- 6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2(S)-carboxamide (SCH 503034), a selective, potent, orally bioavailable hepatitis C virus NS3 protease inhibitor:

Weiying Yang, Zhuyan Guo, Andrea Hart, 2006, Journal of medicinal chemistry.

A reticulocyte-binding protein complex of plasmodium vivax merozoites

Mary R. Galinski, M. Galinski, J. Barnwell, 1992, Cell.

Virus-Specific Cofactor Requirement and Chimeric Hepatitis C Virus/GB Virus B Nonstructural Protein 3

S. Lemon, Z. Hong, W. Zhong, 2000, Journal of Virology.

Nucleoside triphosphatase and RNA helicase activities associated with GB virus B nonstructural protein 3.

Z. Hong, W. Zhong, N. Yao, 1999, Virology.

A human 88-kD membrane glycoprotein (CD36) functions in vitro as a receptor for a cytoadherence ligand on Plasmodium falciparum-infected erythrocytes.

J. Barnwell, M. Yamaya, R. Nachman, 1989, The Journal of clinical investigation.

Discovery of Chromane Containing Hepatitis C Virus (HCV) NS5A Inhibitors with Improved Potency against Resistance-Associated Variants.

E. Asante-Appiah, C. Coburn, S. Agrawal, 2016, Journal of medicinal chemistry.

P0891 : Resistance analysis of virologic failures in Hepatitis C genotype 1 infected patients treated with grazoprevir/elbasvir +/− ribavirin: The C-worthy study

P. Harrigan, A. Howe, C. Brumme, 2015 .

Evolutionary pathways to NS5A inhibitor resistance in genotype 1 hepatitis C virus

C. Burch, Shuntai Zhou, F. Hu, 2018, Antiviral Research.

Extensive polymorphism in the Plasmodium vivax merozoite surface coat protein MSP-3α is limited to specific domains

J. Rayner, M. Galinski, J. Barnwell, 2002, Parasitology.

Two Plasmodium falciparum genes express merozoite proteins that are related to Plasmodium vivax and Plasmodium yoelii adhesive proteins involved in host cell selection and invasion.

J. Rayner, M. Galinski, J. Barnwell, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Plasmodium vivax, P. cynomolgi, and P. knowlesi: identification of homologue proteins associated with the surface of merozoites.

M. Galinski, J. Barnwell, F. Perler, 1999, Experimental parasitology.

Plasmodium vivax merozoite surface proteins-3β and-3γ share structural similarities with P. vivax merozoite surface protein-3α and define a new gene family ☆

M. Galinski, J. Barnwell, P. Ingravallo, 2001 .

Plasmodium vivax merozoite surface protein-3 contains coiled-coil motifs in an alanine-rich central domain.

M. Galinski, J. Barnwell, J. Crosby, 1999, Molecular and biochemical parasitology.

Antiviral Activity and Resistance Analysis of NS3/4A Protease Inhibitor Grazoprevir and NS5A Inhibitor Elbasvir in Hepatitis C Virus GT4 Replicons

D. Nickle, E. Asante-Appiah, P. Qiu, 2017, Antimicrobial Agents and Chemotherapy.

Structure-activity relationships of proline modifications around the tetracyclic-indole class of NS5A inhibitors.

Rebecca T. Ruck, E. Asante-Appiah, C. Coburn, 2016, Bioorganic & medicinal chemistry letters.

Alternative core development around the tetracyclic indole class of HCV NS5A inhibitors.

James I. Fells, E. Asante-Appiah, C. Coburn, 2016, Bioorganic & medicinal chemistry letters.

Substituted tetracyclic indole core derivatives of HCV NS5A inhibitor MK-8742.

E. Asante-Appiah, C. Coburn, M. Dwyer, 2016, Bioorganic & medicinal chemistry letters.

Alkyl substituted aminal derivatives of HCV NS5A inhibitor MK-8742.

E. Asante-Appiah, C. Coburn, M. Dwyer, 2016, Bioorganic & medicinal chemistry letters.

Aryl or heteroaryl substituted aminal derivatives of HCV NS5A inhibitor MK-8742.

E. Asante-Appiah, C. Coburn, M. Dwyer, 2016, Bioorganic & medicinal chemistry letters.

Discovery of SCH446211 (SCH6): a new ketoamide inhibitor of the HCV NS3 serine protease and HCV subgenomic RNA replication.

S. Tamura, S. Kemp, M. Lim-Wilby, 2006, Journal of medicinal chemistry.

Discovery of fused tricyclic core containing HCV NS5A inhibitors with pan-genotype activity.

James I. Fells, E. Asante-Appiah, C. Coburn, 2016, Bioorganic & medicinal chemistry letters.

A peptide derived from hepatitis C virus E2 envelope protein inhibits a post-binding step in HCV entry.

R. Ralston, M. Tewari, P. Ingravallo, 2010, Antiviral research.

Merozoite surface protein-9 of Plasmodium vivax and related simian malaria parasites is orthologous to p101/ABRA of P. falciparum.

E. Vargas-Serrato, M. Galinski, J. Barnwell, 2002, Molecular and biochemical parasitology.

Screening for Antiviral Inhibitors of the HIV Integrase—LEDGF/p75 Interaction Using the AlphaScreen™ Luminescent Proximity Assay

J. Howe, B. Feld, C. Lunn, 2008, Journal of biomolecular screening.

Elbasvir/grazoprevir in Asia‐Pacific/Russian participants with chronic hepatitis C virus genotype 1, 4, or 6 infection

R. Talwani, I. Sheen, J. George, 2018, Hepatology communications.

Efficacy and safety of elbasvir/grazoprevir in participants with hepatitis C virus genotype 1, 4, or 6 infection from the Asia–Pacific region and Russia: Final results from the randomized C‐CORAL study

E. Asante-Appiah, R. Talwani, Fu-Sheng Wang, 2018, Journal of gastroenterology and hepatology.

The Combination of Grazoprevir, a Hepatitis C Virus (HCV) NS3/4A Protease Inhibitor, and Elbasvir, an HCV NS5A Inhibitor, Demonstrates a High Genetic Barrier to Resistance in HCV Genotype 1a Replicons

D. Hazuda, E. Asante-Appiah, A. Howe, 2016, Antimicrobial Agents and Chemotherapy.

In Vitro Antiviral Profile of Ruzasvir, a Potent and Pangenotype Inhibitor of Hepatitis C Virus NS5A

E. Asante-Appiah, F. Lahser, S. Agrawal, 2018, Antimicrobial Agents and Chemotherapy.

Plasmodium vivax merozoite surface proteins-3beta and-3gamma share structural similarities with P. vivax merozoite surface protein-3alpha and define a new gene family.

M. Galinski, J. Barnwell, P. Ingravallo, 2001, Molecular and biochemical parasitology.

Interferon in Replicon Cells Enhances the Antiviral Activity of Alpha Suppresses Polyprotein Maturation and of Hepatitis C Virus NS 3 Protease , SCH 503034 , a Mechanism-Based Inhibitor

F. Gheyas, X. Tong, C. Jiang, 2005 .

Efficacy and safety of elbasvir/grazoprevir in treatment-naïve patients with chronic HCV GT 1, GT 4 and GT 6 infection (C-CORAL): a phase III randomized multinational clinical trial

R. Talwani, I. Sheen, J. George, 2017 .

Matched and mixed cap derivatives in the tetracyclic indole class of HCV NS5A inhibitors.

E. Asante-Appiah, C. Coburn, M. Dwyer, 2016, Bioorganic & medicinal chemistry letters.

Plasmodium vivax merozoite surface protein PvMSP-3 beta is radically polymorphic through mutation and large insertions and deletions.

J. Rayner, M. Galinski, J. Barnwell, 2004, Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases.