S. Bogen

发表

In vitro antiviral activity of SCH446211 (SCH6), a novel inhibitor of the hepatitis C virus NS3 serine protease.

V. Pazienza, K. Abid, F. Negro, 2006, The Journal of antimicrobial chemotherapy.

In vitro antiviral activity of SCH 446211 ( SCH 6 ) , a novel inhibitor of the hepatitis C virus NS 3 serine protease

V. Pazienza, K. Abid, F. Negro, 2006 .

P4 capped amides and lactams as HCV NS3 protease inhibitors with improved potency and DMPK profile.

X. Tong, A. Prongay, V. Girijavallabhan, 2010, Bioorganic & medicinal chemistry letters.

Design and synthesis of novel fluoro amino acids: synthons for potent macrocyclic HCV NS3 protease inhibitors

F. G. Njoroge, Weing Yang, N. Shih, 2010 .

Hepatitis C virus NS3-4A serine protease inhibitors: SAR of new P1 derivatives of SCH 503034.

A. Arasappan, F. G. Njoroge, W. Pan, 2008, Bioorganic & medicinal chemistry letters.

Cyclic sulfones as novel P3-caps for hepatitis C virus NS3/4A (HCV NS3/4A) protease inhibitors: synthesis and evaluation of inhibitors with improved potency and pharmacokinetic profiles.

X. Tong, A. McPhail, A. Arasappan, 2010, Journal of medicinal chemistry.

Syntheses of nucleosides with a 1′,2′-β-lactam moiety as potential inhibitors of hepatitis C virus NS5B polymerase

Q. Dang, Jie Yin, P. Meinke, 2014 .

Syntheses of 1′,2′-cyclopentyl nucleosides as potential antiviral agents

Q. Dang, P. Meinke, D. Olsen, 2014 .

Mutations Conferring Resistance to SCH6, a Novel Hepatitis C Virus NS3/4A Protease Inhibitor

S. Lemon, X. Tong, N. Bourne, 2006, Journal of Biological Chemistry.

Design of a radical translocation step through 1, n (n = 5, 6, 7) hydrogen transfers for incorporation into new radical cascades

R. Thouvenot, L. Fensterbank, M. Malacria, 1997 .

5-Endo-Trig Radical Cyclizations of Bromomethyldimethylsilyl Diisopropylpropargylic Ethers. A Highly Diastereoselective Access to Functionalized Cyclopentanes.

L. Fensterbank, M. Malacria, M. Gulea, 1999, The Journal of organic chemistry.

Totalsynthese von Lankacyclinol

David R. Williams, G. Cortez, S. Bogen, 2000 .

Total Synthesis of Lankacyclinol

David R. Williams, G. Cortez, S. Bogen, 2000 .

The introduction of P4 substituted 1-methylcyclohexyl groups into Boceprevir: a change in direction in the search for a second generation HCV NS3 protease inhibitor.

Zhuyan Guo, Frank Bennett, X. Tong, 2010, Bioorganic & medicinal chemistry letters.

Synthesis of sterically hindered 3,5,5-trimethyl 2,6-dioxo tetrahydro pyrimidine as HCV protease inhibitors

R. Doll, F. G. Njoroge, N. Shih, 2010 .

Discovery of potent sulfonamide P4-capped ketoamide second generation inhibitors of hepatitis C virus NS3 serine protease with favorable pharmacokinetic profiles in preclinical species.

R. Doll, Zhuyan Guo, A. Arasappan, 2010, Bioorganic & medicinal chemistry.

Discovery of (1R,5S)-N-[3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]- 3-[2(S)-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]- 6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2(S)-carboxamide (SCH 503034), a selective, potent, orally bioavailable hepatitis C virus NS3 protease inhibitor:

Weiying Yang, Zhuyan Guo, Andrea Hart, 2006, Journal of medicinal chemistry.

Unprecedented Radical Cyclizations Cascade Leading to Bicyclo[3.1.1]Heptanes. Toward a New Generation of Radical Cascades

L. Fensterbank, M. Malacria, S. Bogen, 1997 .

Study of a Radical Cyclizations Cascade Leading to Bicyclo[3.1.1]heptanes.

L. Fensterbank, M. Malacria, S. Bogen, 1999, The Journal of organic chemistry.

Variations on radical cascades of vinyl radicals generated from bromomethyldimethylsilyl propargyl ethers

L. Fensterbank, M. Malacria, S. Bogen, 1996 .

5-endo-trig Radical Cyclizations: A New Means to the Stereoselective Synthesis of Cyclopentanes and Diquinanes

M. Malacria, S. Bogen, 1996 .

Syntheses of 4′-spirocyclic phosphono-nucleosides as potential inhibitors of hepatitis C virus NS5B polymerase

Q. Dang, P. Meinke, D. Olsen, 2014 .

[3+2] Cycloaddition of trimethylenemethane (TMM) to α,β-unsaturated γ-lactam. Preparation of 5,5-fused proline surrogates

V. Girijavallabhan, S. Bogen, A. Saksena, 2003 .

Radical cyclization of homopropargylic bromomethyldimethylsilyl ethers. Evidence for a hetero-trans-cycloheptene intermediate

L. Fensterbank, M. Malacria, S. Bogen, 2001 .

134 In vitro antiviral activity of SCH6, a novel inhibitor of the hepatitis C virus NS3 serine protease

K. Abid, C. Rossi, F. Negro, 2003 .

moieties as potential inhibitors of hepatitis C virus NS5B polymerase

Q. Dang, P. Meinke, D. Olsen, 2014 .

Syntheses of Nucleosides with 2′‐Spirolactam and 2′‐Spiropyrrolidine Moieties as Potential Inhibitors of Hepatitis C Virus NS5B Polymerase.

Q. Dang, P. Meinke, D. Olsen, 2014 .

Novel intramolecular aminohydroxylation toward the syntheses of 2′-amino-2′-ethynyl nucleosides

P. Tawa, I. Davies, A. Kerekes, 2021 .

Phe19 Modification of HDM2-p53 PPI Inhibitors to Alleviate CYP3A4 Metabolism/Mechanism-based Inhibition Liability.

Yaolin Wang, T. Guzi, R. Doll, 2022, Bioorganic & medicinal chemistry letters.

Structure-activity relationship study of 4-substituted piperidines at Leu26 moiety of novel p53-hDM2 inhibitors.

C. Strickland, B. Lahue, G. Shipps, 2016, Bioorganic & medicinal chemistry letters.

Discovery of novel P3 sulfonamide-capped inhibitors of HCV NS3 protease. Inhibitors with improved cellular potencies.

X. Tong, A. Arasappan, K. Cheng, 2009, Bioorganic & medicinal chemistry.

Discovery of the HCV NS3/4A protease inhibitor (1R,5S)-N-[3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3- [2(S)-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]- 6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2(S)-carboxamide (Sch 503034) II. Key steps in structure-based optimization.

Zhuyan Guo, Frank Bennett, Rong-Sheng Yang, 2007, Journal of medicinal chemistry.

Computational Study of the Effects of Mutations A156T, D168V, and D168Q on the Binding of HCV Protease Inhibitors.

X. Tong, T. Fischmann, Zhuyan Guo, 2006, Journal of chemical theory and computation.

Discovery of Narlaprevir (SCH 900518): A Potent, Second Generation HCV NS3 Serine Protease Inhibitor.

Weiying Yang, Frank Bennett, Jesse Wong, 2010, ACS medicinal chemistry letters.

Discovery of SCH446211 (SCH6): a new ketoamide inhibitor of the HCV NS3 serine protease and HCV subgenomic RNA replication.

S. Tamura, S. Kemp, M. Lim-Wilby, 2006, Journal of medicinal chemistry.

Radical Cyclization of Bromomethyldimethylsilyl Propargyl Ethers; a General Method for the Stereoselective Synthesis of Variously Substituted Trimethylenemethane (TMM) Precursors

M. Malacria, S. Bogen, M. Journet, 1994 .

Second-generation highly potent and selective inhibitors of the hepatitis C virus NS3 serine protease.

Weiying Yang, Frank Bennett, X. Tong, 2009, Journal of medicinal chemistry.

Core modification of substituted piperidines as novel inhibitors of HDM2-p53 protein-protein interaction.

Yaolin Wang, R. Doll, B. Lahue, 2014, Bioorganic & medicinal chemistry letters.

Concise syntheses and HCV NS5B polymerase inhibition of (2'R)-3 and (2'S)-2'-ethynyluridine-10 and related nucleosides.

M. Senior, A. Malikzay, P. Tawa, 2017, Bioorganic & Medicinal Chemistry Letters.

Hepatitis C virus NS3-4A serine protease inhibitors: SAR of P'2 moiety with improved potency.

S. Tamura, N. Yao, B. Malcolm, 2005, Bioorganic & medicinal chemistry letters.

Toward the back-up of boceprevir (SCH 503034): discovery of new extended P4-capped ketoamide inhibitors of hepatitis C virus NS3 serine protease with improved potency and pharmacokinetic profiles.

Zhuyan Guo, Frank Bennett, Sumei Ruan, 2009, Journal of medicinal chemistry.

Toward second generation hepatitis C virus NS3 serine protease inhibitors: discovery of novel P4 modified analogues with improved potency and pharmacokinetic profile.

Frank Bennett, X. Tong, A. Arasappan, 2009, Journal of medicinal chemistry.

Depeptidization efforts on P3-P2' alpha-ketoamide inhibitors of HCV NS3-4A serine protease: effect on HCV replicon activity.

F. G. Njoroge, S. Agrawal, S. Ruan, 2006, Bioorganic & medicinal chemistry letters.

Discovery of Novel 3,3-Disubstituted Piperidines as Orally Bioavailable, Potent, and Efficacious HDM2-p53 Inhibitors.

W. R. Bishop, D. Hicklin, G. Scapin, 2016, ACS medicinal chemistry letters.

Hepatitis C virus NS3-4A serine protease inhibitors: use of a P2-P1 cyclopropyl alanine combination for improved potency.

V. Madison, A. Arasappan, F. G. Njoroge, 2005, Bioorganic & medicinal chemistry letters.

Discovery and structure-activity relationship of P1-P3 ketoamide derived macrocyclic inhibitors of hepatitis C virus NS3 protease.

Andrea Hart, Robert Chase, Sony Agrawal, 2009, Journal of medicinal chemistry.

Design, synthesis, and evaluation of oxygen-containing macrocyclic peptidomimetics as inhibitors of HCV NS3 protease.

X. Tong, Melissa L. Blackman, J. Pichardo, 2009, Journal of medicinal chemistry.

Studies of Acyl Nitrene Insertions. A Stereocontrolled Route toward Lankacidin Antibiotics.

David R. Williams, S. Bogen, C. Rojas, 1999, The Journal of organic chemistry.