V. Dobrovolsky

发表

Analysis of In Vivo Mutation in the Hprt and Tk Genes of Mouse Lymphocytes.

J. Shaddock, R. Heflich, V. Dobrovolsky, 2020, Methods in molecular biology.

Analysis of in vivo mutation in the Hprt and Tk genes of mouse lymphocytes.

J. Shaddock, R. Heflich, V. Dobrovolsky, 2014, Methods in molecular biology.

Genome-wide mutation detection by interclonal genetic variation.

Mason G. Pearce, L. P. McDaniel, Javier R Revollo, 2018, Mutation research. Genetic toxicology and environmental mutagenesis.

Efficient human IFN-gamma expression in the mammary gland of transgenic mice.

O. Lagutin, Y. Khodarovich, N. Jenkins, 1999, Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.

Frequency and types of spontaneous Hprt lymphocyte mutations in Pms2-deficient mice.

R. Mittelstaedt, J. Shaddock, B. Parsons, 2006, Mutation research.

Pms2 deficiency results in increased mutation in the Hprt gene but not the Tk gene of Tk(+/-) transgenic mice.

R. Mittelstaedt, J. Shaddock, B. Parsons, 2003, Mutagenesis.

Effect of arylformamidase (kynurenine formamidase) gene inactivation in mice on enzymatic activity, kynurenine pathway metabolites and phenotype.

J. Casida, J. Bergquist, D. Doerge, 2005, Biochimica et biophysica acta.

Micronucleated erythrocyte frequency in control and azidothymidine-treated Tk+/+, Tk+/- and Tk-/- mice.

R. Mittelstaedt, S. Morris, L. J. McGarrity, 2005, Mutation research.

Mice deficient for cytosolic thymidine kinase gene develop fatal kidney disease.

R. Heflich, T. Bucci, V. Dobrovolsky, 2003, Molecular genetics and metabolism.

Frequency of Hprt mutant lymphocytes and micronucleated erythrocytes in p53‐haplodeficient mice treated perinatally with AZT and AZT in combination with 3TC

R. Mittelstaedt, J. Shaddock, M. Bishop, 2007, Environmental and molecular mutagenesis.

Other transgenic mutation assays: Development of a novel mouse tk+/− embryonic stem cell line for use in mutagenicity studies

D. Casciano, R. Heflich, V. Dobrovolsky, 1996, Environmental and molecular mutagenesis.

Spectrum of benzo[a]pyrene-induced mutations in the Pig-a gene of L5178YTk+/- cells identified with next generation sequencing.

Mason G. Pearce, R. Heflich, Javier R Revollo, 2017, Mutation research.

Evaluating the weak in vivo micronucleus response of a genotoxic carcinogen, aristolochic acids.

W. Ding, J. Shaddock, J. Bhalli, 2013, Mutation research.

Detection of in vivo mutation in the Hprt and Pig-a genes of rat lymphocytes.

R. Mittelstaedt, J. Shaddock, R. Heflich, 2013, Methods in molecular biology.

Establishing a novel Pig‐a gene mutation assay in L5178YTk+/− mouse lymphoma cells

H. Rosenfeldt, Mason G. Pearce, R. Heflich, 2018, Environmental and molecular mutagenesis.

Report on stage III Pig‐a mutation assays using benzo[a]pyrene

J. Shaddock, J. Bhalli, Mason G. Pearce, 2011, Environmental and molecular mutagenesis.

Evaluation of the mutagenic effects of Molnupiravir and N4‐hydroxycytidine in bacterial and mammalian cells by HiFi sequencing

Javier R Revollo, V. Dobrovolsky, P. McKinzie, 2022, Environmental and molecular mutagenesis.

Genotoxicity of malachite green and leucomalachite green in female Big Blue B6C3F1 mice.

R. Mittelstaedt, N. Mei, Tao Chen, 2004, Mutation research.

Whole genome and normalized mRNA sequencing reveal genetic status of TK6, WTK1, and NH32 human B-lymphoblastoid cell lines.

B. Ning, S. Morris, D. Petibone, 2016, Mutation research. Genetic toxicology and environmental mutagenesis.

N-Glycosylation of Recombinant Human Interferon-γ Produced in Different Animal Expression Systems

D. James, R. Freedman, M. Hoare, 1995, Bio/Technology.

7,12‐dimethylbenz[a]anthracene‐induced mutation in the Tk gene of Tk+/− mice: Automated scoring of lymphocyte clones using a fluorescent viability indicator

J. Shaddock, R. Heflich, V. Dobrovolsky, 2000, Environmental and molecular mutagenesis.

Frequency of Tk and Hprt lymphocyte mutants and bone marrow micronuclei in B6C3F(1)/Tk+/- mice treated neonatally with zidovudine and lamivudine.

J. Shaddock, M. Bishop, F. Beland, 2002, Carcinogenesis.

In vivo mutation analysis using the ΦX174 transgenic mouse and comparisons with other transgenes and endogenous genes.

R. Delongchamp, C. R. Valentine, Mason G. Pearce, 2010, Mutation research.

Reactive oxygen species and c-Jun N-terminal kinases contribute to TEMPO-induced apoptosis in L5178Y cells.

Lei Guo, N. Mei, S. Dial, 2015, Chemico-biological interactions.

Frequency of Tk and Hprt lymphocyte mutants and bone marrow micronuclei in mice treated neonatally with zidovudine and didanosine.

J. Shaddock, M. Bishop, F. Beland, 2004, Mutagenesis.

Detection of In Vivo Mutation in the Hprt and Pig-a Genes of Rat Lymphocytes.

R. Mittelstaedt, J. Shaddock, R. Heflich, 2019, Methods in molecular biology.

The in vivo Pig-a assay: A report of the International Workshop On Genotoxicity Testing (IWGT) Workgroup.

K. Witt, P. White, S. Dertinger, 2015, Mutation research. Genetic toxicology and environmental mutagenesis.

Genotoxicity of furan in Big Blue rats.

R. Mittelstaedt, W. Ding, J. Shaddock, 2012, Mutation research.

The genotoxicity of acrylamide and glycidamide in big blue rats.

R. Mittelstaedt, N. Mei, J. Shaddock, 2010, Toxicological sciences : an official journal of the Society of Toxicology.

Evaluation of Macaca mulatta as a model for genotoxicity studies.

R. Mittelstaedt, S. Morris, J. Shaddock, 2009, Mutation research.

Lymphocyte Hprt mutant frequency and sperm toxicity in C57BL/6 mice treated chronically with Azathioprine.

R. Albertini, J. Shaddock, R. Heflich, 2005, Mutation research.

Analysis of mutations and bone marrow micronuclei in Big Blue rats fed leucomalachite green.

S. J. Culp, J. Shaddock, M. Bishop, 2004, Mutation research.

Mutagenicity of γ‐radiation, mitomycin C, and etoposide in the Hprt and Tk genes of Tk+/− mice †

J. Shaddock, R. Heflich, V. Dobrovolsky, 2002 .

Tk+/- mouse model for detecting in vivo mutation in an endogenous, autosomal gene.

D. Casciano, R. Heflich, V. Dobrovolsky, 1999, Mutation research.

Molecular analysis of in vivo mutations induced by N‐ethyl‐N‐nitrosourea in the autosomal Tk and the X‐linked Hprt genes of mouse lymphocytes

Tao Chen, R. Heflich, V. Dobrovolsky, 1999, Environmental and molecular mutagenesis.

Frequency and spectrum of ENU-induced mutation in the Phi X174 transgene in mouse splenic lymphocytes and their significance to spontaneous transgenic rodent mutation frequencies.

J. Shaddock, R. Delongchamp, C. R. Valentine, 2008, Mutagenesis.

Human γ‐interferon expression in the mammary gland of transgenic mice

V. P. Kuznetsov, O. Lagutin, T. Vinogradova, 1993 .

Sensitivity of the Pig-a assay for detecting gene mutation in rats exposed acutely to strong clastogens.

J. Shaddock, J. Bhalli, Mason G. Pearce, 2013, Mutagenesis.

The in vivo pig‐a gene mutation assay, a potential tool for regulatory safety assessment

S. Dertinger, R. Heflich, V. Dobrovolsky, 2010, Environmental and molecular mutagenesis.

Development of a mouse cell line containing the PhiX174 am3 allele as a target for detecting mutation.

R. Heflich, V. Dobrovolsky, J. B. Chen, 1999, Mutation research.

Detecting Mutations In Vivo

R. Heflich, V. Dobrovolsky, 2018 .

Ginkgo biloba leaf extract induces DNA damage by inhibiting topoisomerase II activity in human hepatic cells

Lei Guo, N. Mei, J. Xuan, 2015, Scientific Reports.

Accumulation and persistence of Pig-A mutant peripheral red blood cells following treatment of rats with single and split doses of N-ethyl-N-nitrosourea.

R. Heflich, V. Dobrovolsky, T. Kimoto, 2009, Mutation research.

Development of an in vivo gene mutation assay using the endogenous Pig‐A gene: II. Selection of Pig‐A mutant rat spleen T‐cells with proaerolysin and sequencing Pig‐A cDNA from the mutants

R. Mittelstaedt, Y. Katsuura, R. Heflich, 2008, Environmental and molecular mutagenesis.

The genetic toxicology of methylphenidate hydrochloride in non-human primates.

Chien-Ju Lin, Merle G Paule, Donald R Mattison, 2009, Mutation research.

Mechanism study of goldenseal-associated DNA damage

Lei Guo, N. Mei, Liqing Wan, 2013, Toxicology letters.

CD48‐deficient T‐lymphocytes from DMBA‐treated rats have de novo mutations in the endogenous Pig‐a gene

Mason G. Pearce, Javier R Revollo, V. Dobrovolsky, 2015, Environmental and molecular mutagenesis.

Mutational signatures in T‐lymphocytes of rats treated with N‐propyl‐N‐nitrosourea and procarbazine

Javier R Revollo, V. Dobrovolsky, T. Robison, 2021, Environmental and molecular mutagenesis.

CD59‐deficient bone marrow erythroid cells from rats treated with procarbazine and propyl‐nitrosourea have mutations in the Pig‐a gene

R. Mittelstaedt, Mason G. Pearce, R. Lapidus, 2020, Environmental and molecular mutagenesis.

Spectrum of Pig-a mutations in T lymphocytes of rats treated with procarbazine

J. Bhalli, Mason G. Pearce, Javier R Revollo, 2017, Mutagenesis.

Manifestation of Pig-a mutant bone marrow erythroids and peripheral blood erythrocytes in mice treated with N-ethyl-N-nitrosourea: direct sequencing of Pig-a cDNA from bone marrow cells negative for GPI-anchored protein expression.

Vasily N Dobrovolsky, Robert H Heflich, R. Heflich, 2011, Mutation research.

Report on stage III Pig‐a mutation assays using N‐ethyl‐N‐nitrosourea – comparison with other in vivo genotoxicity endpoints

J. Shaddock, J. Bhalli, Mason G. Pearce, 2011, Environmental and molecular mutagenesis.

Evaluation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) mutagenicity using in vitro and in vivo Pig-a assays.

R. Mittelstaedt, H. Rosenfeldt, Yunan Tang, 2019, Mutation research. Genetic toxicology and environmental mutagenesis.

Continued progress in developing the Pig-a gene mutation assay.

S. Dertinger, R. Heflich, V. Dobrovolsky, 2015, Mutagenesis.

A statistical approach for analyzing data from the in vivo Pig-a gene mutation assay.

A. Sutter, S. Dertinger, M. Raschke, 2018, Mutation research. Genetic toxicology and environmental mutagenesis.

p53‐competent cells and p53‐deficient cells display different susceptibility to oxygen functionalized graphene cytotoxicity and genotoxicity

W. Ding, S. Morris, D. Casciano, 2017, Journal of applied toxicology : JAT.

In vivo genotoxicity assessment of acrylamide and glycidyl methacrylate.

W. Ding, Mason G. Pearce, L. P. McDaniel, 2016, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Sertraline, an antidepressant, induces apoptosis in hepatic cells through the mitogen-activated protein kinase pathway.

Lei Guo, N. Mei, Liqing Wan, 2013, Toxicological sciences : an official journal of the Society of Toxicology.

Development of an in vivo gene mutation assay using the endogenous Pig‐A gene: I. Flow cytometric detection of CD59‐negative peripheral red blood cells and CD48‐negative spleen T‐cells from the rat

Y. Katsuura, R. Heflich, V. Dobrovolsky, 2008, Environmental and molecular mutagenesis.

In vivo mutation in gene A of splenic lymphocytes from ΦX174 transgenic mice

J. Shaddock, R. Delongchamp, C. R. Valentine, 2004, Environmental and molecular mutagenesis.

Further development of the rat Pig‐a mutation assay: Measuring rat Pig‐a mutant bone marrow erythroids and a high throughput assay for mutant peripheral blood reticulocytes

M. Honma, Katsuyoshi Horibata, R. Heflich, 2011, Environmental and molecular mutagenesis.

Effect of chronic azathioprine treatment on germ‐line transmission of Hprt mutation in mice

R. Albertini, J. Shaddock, R. Heflich, 2007, Environmental and molecular mutagenesis.

Analysis of mutations in the Tk gene of Tk(+/-) mice treated as neonates with 3'-azido-3'-deoxythymidine (AZT).

R. Mittelstaedt, J. Shaddock, F. Beland, 2004, Mutation research.

Flow cytometric detection of Pig‐A mutant red blood cells using an erythroid‐specific antibody: Application of the method for evaluating the in vivo genotoxicity of methylphenidate in adolescent rats

M. Bishop, M. Manjanatha, D. Doerge, 2009, Environmental and molecular mutagenesis.

Evaluation of mutagenic mode of action in Big Blue mice fed methylphenidate for 24 weeks.

W. Slikker, M. Moore, S. Morris, 2009, Mutation research.

Pharmacokinetics, dose‐range, and mutagenicity studies of methylphenidate hydrochloride in B6C3F1 mice

J. Shaddock, M. Manjanatha, S. Shelton, 2008, Environmental and molecular mutagenesis.

Molecular analysis of GPI-anchor biosynthesis pathway genes in rat strains used for the Pig-a gene mutation assay.

R. Heflich, Javier R Revollo, V. Dobrovolsky, 2020, Mutation research.

Establishment of neural stem cells from fetal monkey brain for neurotoxicity testing

W. Slikker, J. Talpos, Cheng Wang, 2023, Experimental biology and medicine.

Analysis of mutation in the rat Pig‐a assay: II. Studies with bone marrow granulocytes

Mason G. Pearce, R. Heflich, D. Petibone, 2018, Environmental and molecular mutagenesis.

Detection of Pig-a Mutant Erythrocytes in the Peripheral Blood of Rats and Mice.

J. Bhalli, R. Heflich, V. Dobrovolsky, 2020, Methods in molecular biology.

Detection of Pig-a mutant erythrocytes in the peripheral blood of rats and mice.

J. Bhalli, R. Heflich, V. Dobrovolsky, 2014, Methods in molecular biology.

Pig‐a gene mutation database

J. Polli, S. Dertinger, Katsuyoshi Horibata, 2019, Environmental and molecular mutagenesis.

Monitoring humans for somatic mutation in the endogenous pig‐a gene using red blood cells

R. Heflich, R. Elespuru, V. Dobrovolsky, 2011, Environmental and molecular mutagenesis.

Pig‐a gene mutations in bone marrow granulocytes of procarbazine‐treated F344 rats

Mason G. Pearce, R. Heflich, Javier R Revollo, 2021, Environmental and molecular mutagenesis.

Confirmation of Pig-a mutation in flow cytometry-identified CD48-deficient T-lymphocytes from F344 rats.

R. Mittelstaedt, Mason G. Pearce, D. Petibone, 2015, Mutagenesis.

The role of autophagy in usnic acid-induced toxicity in hepatic cells.

Lei Guo, N. Mei, Yuanfeng Wu, 2014, Toxicological sciences : an official journal of the Society of Toxicology.

In Vivo Rat T-Lymphocyte Pig-a Assay: Detection and Expansion of Cells Deficient in the GPI-Anchored CD48 Surface Marker for Analysis of Mutation in the Endogenous Pig-a Gene.

R. Heflich, D. Petibone, Javier R Revollo, 2017, Methods in molecular biology.

Glycosylphosphatidylinositol (GPI) anchored protein deficiency serves as a reliable reporter of Pig‐a gene Mutation: Support from an in vitro assay based on L5178Y/Tk+/− cells and the CD90.2 antigen

J. Bemis, S. Dertinger, Javier R Revollo, 2018, Environmental and molecular mutagenesis.

PacBio sequencing detects genome‐wide ultra‐low‐frequency substitution mutations resulting from exposure to chemical mutagens

Javier R Revollo, V. Dobrovolsky, Jaime A Miranda, 2021, Environmental and molecular mutagenesis.

Unbiased whole genome detection of ultrarare off‐target mutations in genome‐edited cell populations by HiFi sequencing

Javier R Revollo, V. Dobrovolsky, P. McKinzie, 2023, Environmental and molecular mutagenesis.

Genome‐wide detection of ultralow‐frequency substitution mutations in cultures of mouse lymphoma L5178Y cells and Caenorhabditis elegans worms by PacBio sequencing

Jian Yan, Javier R Revollo, V. Dobrovolsky, 2022, Environmental and molecular mutagenesis.

Monitoring humans for somatic mutation in the endogenous pig‐a gene using red blood cells

R. Heflich, R. Elespuru, V. Dobrovolsky, 2011, Environmental and molecular mutagenesis.

Analysis of mutation in the rat Pig‐a assay: I) studies with bone marrow erythroid cells

Mason G. Pearce, Javier R Revollo, Dayton M Petibone, 2018, Environmental and molecular mutagenesis.

CD48‐deficient T‐lymphocytes from DMBA‐treated rats have de novo mutations in the endogenous Pig‐a gene

Mason G. Pearce, Javier R Revollo, V. Dobrovolsky, 2015, Environmental and molecular mutagenesis.

The in vivo Pig-a assay: A report of the International Workshop On Genotoxicity Testing (IWGT) Workgroup.

K. Witt, S. Dertinger, J. Tanir, 2015, Mutation research. Genetic toxicology and environmental mutagenesis.

Whole-genome high-fidelity sequencing: A novel approach to detecting and characterization of mutagenicity in vivo.

Javier R Revollo, V. Dobrovolsky, P. McKinzie, 2023, Mutation research. Genetic toxicology and environmental mutagenesis.

Manifestation and persistence of Pig‐a mutant red blood cells in C57BL/6 mice following single and split doses of N‐ethyl‐N‐nitrosourea

J. Bhalli, Mason G. Pearce, R. Heflich, 2011, Environmental and molecular mutagenesis.

On the use of the T-REx tetracycline-inducible gene expression system in vivo.

R. Heflich, V. Dobrovolsky, 2007, Biotechnology and bioengineering.