K. Nohara

发表

Constitutively active aryl hydrocarbon receptor expressed in T cells increases immunization-induced IFN-gamma production in mice but does not suppress T(h)2-cytokine production or antibody production.

C. Tohyama, Y. Fujii‐Kuriyama, Masayuki Yamamoto, 2009, International immunology.

Expression of constitutively-active aryl hydrocarbon receptor in T-cells enhances the down-regulation of CD62L, but does not alter expression of CD25 or suppress the allogeneic CTL response

Y. Fujii‐Kuriyama, N. Kerkvliet, Masayuki Yamamoto, 2009, Journal of immunotoxicology.

Differential susceptibilities of Holtzman and Sprague-Dawley rats to fetal death and placental dysfunction induced by 2,3,7,8-teterachlorodibenzo-p-dioxin (TCDD) despite the identical primary structure of the aryl hydrocarbon receptor.

C. Tohyama, K. Takeda, S. Ohsako, 2006, Toxicology and applied pharmacology.

Constitutive activation of the aryl hydrocarbon receptor in T-lineage cells induces thymus involution independently of the Fas/Fas ligand signaling pathway.

M. Kubo, Masayuki Yamamoto, R. Abe, 2006, International immunopharmacology.

T cell-derived IL-5 production is a sensitive target of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).

C. Tohyama, Xiaoqing Pan, K. Nohara, 2005, Chemosphere.

Constitutively Active Aryl Hydrocarbon Receptor Expressed Specifically in T-Lineage Cells Causes Thymus Involution and Suppresses the Immunization-Induced Increase in Splenocytes1

C. Tohyama, Y. Fujii‐Kuriyama, Masayuki Yamamoto, 2005, The Journal of Immunology.

Functional activation of arylhydrocarbon receptor (AhR) in primary T cells by 2,3,7,8-tetrachlorodibenzo-p-dioxin.

C. Tohyama, T. Baba, K. Nohara, 2003, Chemosphere.

TCDD exposure exacerbates atopic dermatitis-related inflammation in NC/Nga mice.

C. Tohyama, H. Fujimaki, K. Nohara, 2008, Toxicology letters.

Roles of CD4+ and CD8+ T Cells in Adjuvant Activity of Diesel Exhaust Particles in Mice

H. Fujimaki, H. Ushio, K. Nohara, 2001, International Archives of Allergy and Immunology.

A Method for Micro-Determination of Total Microcystin Content in Waterblooms of Cyanobacteria (Blue-Green Algae)

T. Sano, K. Kaya, F. Shiraishi, 1992 .

2-(7,13-Dihydroxy-2-trans-octadecenoylamino)ethanesulfonic acid (lipotaurine) as an intermediate of taurolipids biosynthesis.

K. Kaya, H. Ito, K. Nohara, 1990, Biochimica et biophysica acta.

Inhibition of neurite outgrowth and alteration of cytoskeletal gene expression by sodium arsenite.

R. Kurihara, F. Maekawa, Tetsuya Kobayashi, 2013, Neurotoxicology.

Organic Chemicals Adsorbed onto Diesel Exhaust Particles Directly Alter the Differentiation of Fetal Thymocytes Through Arylhydrocarbon Receptor but Not Oxidative Stress Responses

C. Tohyama, R. Peterson, H. Nagai, 2006, Journal of immunotoxicology.

Brain-derived neurotrophic factor in VMH as the causal factor for and therapeutic tool to treat visceral adiposity and hyperleptinemia in type 2 diabetic Goto–Kakizaki rats

K. Fujiwara, T. Yashiro, T. Yada, 2013, Front. Synaptic Neurosci..

Role of Environmental Chemical Insult in Neuronal Cell Death and Cytoskeleton Damage.

A. Tanoue, F. Maekawa, Kazuaki Nakamura, 2015, Biological & pharmaceutical bulletin.

Suppressive effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin on vascular remodeling that takes place in the normal labyrinth zone of rat placenta during late gestation.

C. Tohyama, S. Ohsako, R. Ishimura, 2006, Toxicological sciences : an official journal of the Society of Toxicology.

Gestational arsenite exposure augments hepatic tumors of C3H mice by promoting senescence in F1 and F2 offspring via different pathways.

K. Nohara, Takehiro Suzuki, Kazuyuki Okamura, 2020, Toxicology and applied pharmacology.

Augmenting effects of gestational arsenite exposure of C3H mice on the hepatic tumors of the F2 male offspring via the F1 male offspring

Y. Kondo, Takehiro Michikawa, Takaaki Ito, 2016, Journal of applied toxicology : JAT.

Arsenic Exposure and Reproductive Toxicity

K. Nohara, Takehiro Suzuki, Osamu Udagawa, 2018, Current Topics in Environmental Health and Preventive Medicine.

In vivo mutagenicity of arsenite in the livers of gpt delta transgenic mice.

T. Sano, T. Nohmi, Y. Aoki, 2014, Mutation research. Genetic toxicology and environmental mutagenesis.

Alterations of thymocyte development, thymic emigrants and peripheral T cell population in rats exposed to 2,3,7, 8-tetrachlorodibenzo-p-dioxin.

C. Tohyama, H. Fujimaki, M. Kijima, 2000, Toxicology.

Gangliosides involved in activation of rat T lineage cells.

H. Saji, H. Fujimaki, H. Ozawa, 1997, Biochimica et biophysica acta.

Inorganic arsenic exposure induces E2F‐dependent G0/G1 arrest via an increase in retinoblastoma family protein p130 in B‐cell lymphoma A20 cells

D. Miki, K. Nohara, Kazuyuki Okamura, 2013, Genes to cells : devoted to molecular & cellular mechanisms.

Exposure assessment of lead from food and airborne dusts and biomonitoring in pregnant mothers, their fetus and siblings in Karachi, Pakistan and Shimotsuke, Japan

Takahiko Yoshida, Yayoi Kobayashi, Takako Sakamoto, 2016, Reviews on environmental health.

Involvement of focal adhesion kinase in inhibition of motility of human breast cancer cells by sphingosine 1-phosphate.

S. Spiegel, Fang Wang, A. Olivera, 1999, Experimental cell research.

Effect of environmental pollutants on the production of pro-inflammatory cytokines by normal human dermal keratinocytes.

H. Fujimaki, H. Ushio, K. Nohara, 1999, Toxicology letters.

Inorganic arsenic exposure-induced premature senescence and senescence-associated secretory phenotype (SASP) in human hepatic stellate cells.

K. Nohara, Takehiro Suzuki, Kazuyuki Okamura, 2022, Toxicology and applied pharmacology.

Glycosphingolipid composition of MDA-MB-231 and MCF-7 human breast cancer cell lines

S. Spiegel, F. Wang, K. Nohara, 1998, Breast Cancer Research and Treatment.

Glycosphingolipids of rat T cells. Predominance of asialo-GM1 and GD1c.

H. Nakauchi, S. Spiegel, K. Nohara, 1994, Biochemistry.

Induction of the imbalance of helper T-cell functions in mice exposed to diesel exhaust.

H. Fujimaki, H. Ushio, K. Nohara, 2001, The Science of the total environment.

The effect of a methyl‐deficient diet on the global DNA methylation and the DNA methylation regulatory pathways

Yayoi Kobayashi, T. Sano, Hiroyuki Yanagisawa, 2015, Journal of applied toxicology : JAT.

Effects of maternal exposure to arsenic on social behavior and related gene expression in F2 male mice

Tin-Tin Win-Shwe, K. Nohara, Takehiro Suzuki, 2021, Environmental Health and Preventive Medicine.

Long-term arsenite exposure induces premature senescence in B cell lymphoma A20 cells

K. Nohara, Kazuyuki Okamura, 2016, Archives of Toxicology.

Hijiki seaweed consumption elevates levels of inorganic arsenic intake in Japanese children and pregnant women

Y. Nakagi, Takahiko Yoshida, Yayoi Kobayashi, 2019, Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment.

Search for the target genes involved in the suppression of antibody production by TCDD in C57BL/6 mice.

C. Tohyama, M. Kubo, R. Abe, 2005, International immunopharmacology.

Effect of di-n-octyl phthalate on fatty acid composition of phosphatidylcholine in Tetrahymena.

K. Kaya, K. Nohara, 1987, Chemico-biological interactions.

Late-onset increases in oxidative stress and other tumorigenic activities and tumors with a Ha-ras mutation in the liver of adult male C3H mice gestationally exposed to arsenic.

Takaaki Ito, N. Nishimura, M. Kobori, 2012, Toxicological sciences : an official journal of the Society of Toxicology.

Increase in incidence of hepatic tumors caused by oncogenic somatic mutation in mice maternally exposed to inorganic arsenic and the multigenerational and transgenerational effects of inorganic arsenic.

Shota Takumi, K. Nohara, Takehiro Suzuki, 2014, Nihon eiseigaku zasshi. Japanese journal of hygiene.

Global DNA methylation in the mouse liver is affected by methyl deficiency and arsenic in a sex-dependent manner

N. Nishimura, Yayoi Kobayashi, T. Sano, 2011, Archives of Toxicology.

In utero and Lactational Exposure to Acetamiprid Induces Abnormalities in Socio-Sexual and Anxiety-Related Behaviors of Male Mice

C. Tohyama, S. Nakayama, T. Isobe, 2016, Front. Neurosci..

Prenatal Exposure to Arsenic Impairs Behavioral Flexibility and Cortical Structure in Mice

M. Kakeyama, C. Tohyama, A. Tanoue, 2016, Front. Neurosci..

Dioxin receptor is a ligand-dependent E3 ubiquitin ligase

Y. Fujii‐Kuriyama, S. Kato, T. Chiba, 2007, Nature.

Effect of a single oral dose of 2,3,7,8-tetrachlorodibenzo-p-dioxin on immune function in male NC/Nga mice.

C. Tohyama, H. Fujimaki, M. Kijima, 2002, Toxicological sciences : an official journal of the Society of Toxicology.

Aryl hydrocarbon receptor negatively regulates dendritic cell immunogenicity via a kynurenine-dependent mechanism

Kazuya Masuda, Nam Trung Nguyen, Y. Fujii‐Kuriyama, 2010, Proceedings of the National Academy of Sciences.

Gestational arsenic exposure induces site-specific DNA hypomethylation in active retrotransposon subfamilies in offspring sperm in mice

K. Hata, K. Nakabayashi, Shigekatsu Suzuki, 2020, Epigenetics & chromatin.

Gestational arsenic exposure and paternal intergenerational epigenetic inheritance.

K. Nohara, Takehiro Suzuki, Kazuyuki Okamura, 2020, Toxicology and applied pharmacology.

Epigenetics as a mechanism linking developmental exposures to long-term toxicity.

R. Slama, Z. Herceg, M. Karagas, 2018, Environment international.

Effects of Developmental Arsenic Exposure on the Social Behavior and Related Gene Expression in C3H Adult Male Mice

Tin-Tin Win-Shwe, K. Nohara, M. Sein, 2019, International journal of environmental research and public health.

Long‐term arsenic exposure induces histone H3 Lys9 dimethylation without altering DNA methylation in the promoter region of p16INK4a and down‐regulates its expression in the liver of mice

K. Nohara, Takehiro Suzuki, 2013, Journal of applied toxicology : JAT.

Genome‐wide analysis of DNA methylation changes induced by gestational arsenic exposure in liver tumors

T. Ushijima, S. Yamashita, T. Sano, 2013, Cancer science.

Diurnal expression of Dnmt3b mRNA in mouse liver is regulated by feeding and hepatic clockwork

S. Shimba, F. Maekawa, T. Sano, 2012, Epigenetics.

The DNA methylation profile of liver tumors in C3H mice and identification of differentially methylated regions involved in the regulation of tumorigenic genes

T. Kawai, S. Yamashita, T. Sakurai, 2018, BMC Cancer.

Aryl hydrocarbon receptor in combination with Stat1 regulates LPS-induced inflammatory responses

Y. Fujii‐Kuriyama, T. Naka, A. Kimura, 2009, The Journal of experimental medicine.

Induction of apoptosis in mouse thymocytes by cadmium.

M. Ishido, H. Fujimaki, K. Nohara, 2000, Toxicology letters.

Modulation of oestrogen receptor signalling by association with the activated dioxin receptor

C. Tohyama, P. Chambon, Y. Fujii‐Kuriyama, 2003, Nature.

A Methyl-Deficient Diet Modifies Early B Cell Development

A. Nobukiyo, H. Inoue, M. Kanno, 2012, Pathobiology.

A Constitutively Active Arylhydrocarbon Receptor Induces Growth Inhibition of Jurkat T Cells through Changes in the Expression of Genes Related to Apoptosis and Cell Cycle Arrest*

C. Tohyama, Y. Fujii‐Kuriyama, R. Peterson, 2004, Journal of Biological Chemistry.

Effects of sodium arsenite on neurite outgrowth and glutamate AMPA receptor expression in mouse cortical neurons.

L. Pellerin, T. Tsuboi, F. Maekawa, 2013, Neurotoxicology.

Potential differences in chitin synthesis ability cause different sensitivities to diflubenzuron among three strains of Daphnia magna.

Hiroshi Yamamoto, Haruna Watanabe, N. Nakajima, 2021, Aquatic toxicology.

Research on Health Effects of Environmental Chemicals — New Developments through Introduction of Epigenetics —

K. Nohara, 2011 .

Aryl hydrocarbon receptor regulates Stat1 activation and participates in the development of Th17 cells

Y. Fujii‐Kuriyama, T. Naka, A. Kimura, 2008, Proceedings of the National Academy of Sciences.

Tumor-augmenting effects of gestational arsenic exposure on F1 and F2 in mice

Junya Matsushita, Shota Takumi, K. Nohara, 2017, Genes and Environment.

Association between chronic arsenic exposure and the characteristic features of asthma.

Md Imam Hossain, N. Huda, Z. Saud, 2019, Chemosphere.

Aryl hydrocarbon receptor deficiency in T cells suppresses the development of collagen-induced arthritis

Y. Fujii‐Kuriyama, A. Kimura, T. Kishimoto, 2011, Proceedings of the National Academy of Sciences.

Chronic exposure to arsenic, LINE-1 hypomethylation, and blood pressure: a cross-sectional study in Bangladesh

Mashiur Rahman, Z. Saud, Md. Shofikul Islam, 2017, Environmental Health.

DNA methylation changes involved in the tumor increase in F2 males born to gestationally arsenite‐exposed F1 male mice

T. Kawai, K. Hata, T. Sano, 2019, Cancer science.

Identification by TCGA database search of five genes that are aberrantly expressed and involved in hepatocellular carcinoma potentially via DNA methylation changes

G. Ichihara, Junya Matsushita, K. Nohara, 2020, Environmental Health and Preventive Medicine.

Arsenite-induced thymus atrophy is mediated by cell cycle arrest: a characteristic downregulation of E2F-related genes revealed by a microarray approach.

C. Tohyama, S. Omura, K. Nohara, 2008, Toxicological sciences : an official journal of the Society of Toxicology.

Skewed differentiation of thymocytes toward CD8 T cells by 2,3,7,8-tetrachlorodibenzo-p-dioxin requires activation of the extracellular signal-related kinase pathway

C. Tohyama, S. Tsukumo, K. Nohara, 2002, Archives of Toxicology.

Comparison of the 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced CYP1A1 gene expression profile in lymphocytes from mice, rats, and humans: most potent induction in humans.

C. Tohyama, H. Toyoshiba, K. Nohara, 2006, Toxicology.

Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on T cell-derived cytokine production in ovalbumin (OVA)-immunized C57Bl/6 mice.

C. Tohyama, H. Sone, H. Fujimaki, 2002, Toxicology.

The mechanisms underlying sexual differentiation of behavior and physiology in mammals and birds: relative contributions of sex steroids and sex chromosomes

H. Ohki‐Hamazaki, F. Maekawa, K. Nohara, 2014, Front. Neurosci..

Ganglioside GM3 inhibits interleukin-3-dependent bone marrow-derived mast cell proliferation.

H. Fujimaki, K. Nohara, N. Katayama, 1995, International archives of allergy and immunology.

[Exploration of Epigenetic Changes and DNA Methylation Markers Associated with Liver Tumors Induced by Inorganic Arsenite Exposure in Mice].

K. Nohara, Takehiro Suzuki, 2015, Nihon eiseigaku zasshi. Japanese journal of hygiene.

Mechanism of TCDD-induced suppression of antibody production: effect on T cell-derived cytokine production in the primary immune reaction of mice.

C. Tohyama, H. Fujimaki, K. Nohara, 2002, Toxicological sciences : an official journal of the Society of Toxicology.

Suppressive effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on the high-affinity antibody response in C57BL/6 mice.

C. Tohyama, Yoshimasa Takahashi, H. Fujimaki, 2003, Toxicological sciences : an official journal of the Society of Toxicology.

Effect of low-dose 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on influenza A virus-induced mortality in mice.

C. Tohyama, R. Nagata, K. Nohara, 2002, Toxicology.

The effects of perinatal exposure to low doses of 2,3,7,8-tetrachlorodibenzo-p-dioxin on immune organs in rats.

C. Tohyama, J. Yonemoto, H. Fujimaki, 2000, Toxicology.

Results shown are the mean ^ s.d. We analysed data by one-way analysis of variance (ANOVA). Individual statistical differences were determined by Scheffe's multiple range comparison test.

C. Tohyama, P. Chambon, A. Krust, 2003 .

Gestational arsenic exposure induces anxiety-like behaviors in F1 female mice by dysregulation of neurological and immunological markers

Tin-Tin Win-Shwe, K. Nohara, Takehiro Suzuki, 2023, Environmental health and preventive medicine.

Oral exposure to lead for Japanese children and pregnant women, estimated using duplicate food portions and house dust analyses

Y. Nakagi, Takahiko Yoshida, Yayoi Kobayashi, 2019, Environmental Health and Preventive Medicine.

Comparison of immunotoxicity among tetrachloro-, pentachloro-, tetrabromo- and pentabromo-dibenzo-p-dioxins in mice.

C. Tohyama, H. Nagai, K. Nohara, 2009, Toxicology.

Evaluation of relative potencies of PCB126 and PCB169 for the immunotoxicities in ovalbumin (OVA)-immunized mice.

C. Tohyama, Xiaoqing Pan, Y. Miyabara, 2004, Toxicology.

Regulatory factors involved in species-specific modulation of arylhydrocarbon receptor (AhR)-dependent gene expression in humans and mice.

K. Nohara, Takehiro Suzuki, 2007, Journal of biochemistry.

Effects of sodium arsenite on neurite outgrowth and glutamate AMPA receptor expression in mouse cortical neurons.

L. Pellerin, T. Tsuboi, F. Maekawa, 2013, Neurotoxicology.

Long-term arsenite exposure induces premature senescence in B cell lymphoma A20 cells

K. Nohara, Kazuyuki Okamura, 2015, Archives of Toxicology.