Samuel Peña-Díaz

发表

High-Throughput Screening Methodology to Identify Alpha-Synuclein Aggregation Inhibitors

J. Sancho, S. Ventura, Jordi Pujols, 2017, International journal of molecular sciences.

Chemical Chaperones as Novel Drugs for Parkinson's Disease.

S. Ventura, I. Pallarès, Jordi Pujols, 2020, Trends in molecular medicine.

The small aromatic compound SynuClean-D inhibits the aggregation and seeded polymerization of multiple α-synuclein strains

S. Ventura, T. Outeiro, Jaime Santos, 2022, The Journal of biological chemistry.

Design, synthesis and structure-activity evaluation of novel 2-pyridone-based inhibitors of α-synuclein aggregation with potentially improved BBB permeability.

J. Sancho, S. Ventura, I. Pallarès, 2021, Bioorganic chemistry.

Discovery of Neuroprotective Agents Based on a 5-(4-Pyridinyl)-1,2,4-triazole Scaffold

S. Cuzzocrea, S. Ventura, R. Di Paola, 2022, ACS chemical neuroscience.

Development of Small Molecules Targeting α-Synuclein Aggregation: A Promising Strategy to Treat Parkinson’s Disease

S. Ventura, Samuel Peña-Díaz, J. García-Pardo, 2023, Pharmaceutics.

α-Helical peptidic scaffolds to target α-synuclein toxic species with nanomolar affinity

S. Ventura, I. Pallarès, P. Gracia, 2021, Nature Communications.

Small molecule inhibits α-synuclein aggregation, disrupts amyloid fibrils, and prevents degeneration of dopaminergic neurons

Salvador Ventura, Susanna Navarro, Ernest Giralt, 2018, Proceedings of the National Academy of Sciences.

Title : a-Helical peptidic scaffolds to target a-synuclein pathogenic species with high affinity and selectivity

S. Ventura, I. Pallarès, P. Gracia, 2021 .

DisProt in 2022: improved quality and accessibility of protein intrinsic disorder annotation

Silvio C. E. Tosatto, Cristina Marino Buslje, Konstantinos D. Tsirigos, 2021, Nucleic Acids Res..

AGGRESCAN3D: Toward the Prediction of the Aggregation Propensities of Protein Structures.

S. Ventura, Jordi Pujols, Samuel Peña-Díaz, 2018, Methods in molecular biology.

Inhibition of α-Synuclein Aggregation and Mature Fibril Disassembling With a Minimalistic Compound, ZPDm

X. Salvatella, J. Sancho, S. Ventura, 2020, Frontiers in Bioengineering and Biotechnology.

Rational design of small molecules able to inhibit α-synuclein amyloid aggregation for the treatment of Parkinson’s disease

S. Ventura, S. Vittorio, R. Gitto, 2020, Journal of enzyme inhibition and medicinal chemistry.

ZPD-2, a Small Compound That Inhibits α-Synuclein Amyloid Aggregation and Its Seeded Polymerization

X. Salvatella, J. Sancho, S. Ventura, 2019, Front. Mol. Neurosci..

One ring is sufficient to inhibit α-synuclein aggregation

S. Ventura, Samuel Peña-Díaz, 2021, Neural regeneration research.

Small molecules to target tau amyloid aggregation

S. Ventura, Samuel Peña-Díaz, Zoe Manglano-Artuñedo, 2023, Neural Regeneration Research.

Ligand-Based Discovery of a Small Molecule as Inhibitor of α-Synuclein Amyloid Formation

S. Ventura, R. Gitto, L. De Luca, 2022, International Journal of Molecular Sciences.

The small molecule ZPD-2 inhibits the aggregation and seeded polymerisation of C-terminally truncated α-Synuclein.

Samuel Peña-Díaz, Salvador Ventura, 2024, The FEBS journal.