Thomas Näsström

Monoclonal antibodies selective for α‐synuclein oligomers/protofibrils recognize brain pathology in Lewy body disorders and α‐synuclein transgenic mice with the disease‐causing A30P mutation

L. Lannfelt, M. Ingelsson, H. Kalimo, 2013, Journal of neurochemistry.

Amyloid fibrils prepared using an acetylated and methyl amidated peptide model of the α-Synuclein NAC 71–82 amino acid stretch contain an additional cross-β structure also found in prion proteins

P. Andersson, C. Lejon, Thomas Näsström, 2019, Scientific Reports.

Gelsolin co-occurs with Lewy bodies in vivo and accelerates α-synuclein aggregation in vitro.

F. Nikolajeff, L. Lannfelt, M. Ingelsson, 2011, Biochemical and biophysical research communications.

The lipid peroxidation products 4-oxo-2-nonenal and 4-hydroxy-2-nonenal promote the formation of α-synuclein oligomers with distinct biochemical, morphological, and functional properties.

M. Ekberg, F. Nikolajeff, L. Lannfelt, 2011, Free radical biology & medicine.

Extracellular Alpha-Synuclein Oligomers Modulate Synaptic Transmission and Impair LTP Via NMDA-Receptor Activation

L. Lannfelt, M. Ingelsson, T. Outeiro, 2012, The Journal of Neuroscience.

Antibodies against Alpha-Synuclein Reduce Oligomerization in Living Cells

L. Lannfelt, M. Ingelsson, T. Outeiro, 2011, PloS one.

A Capped Peptide of the Aggregation Prone NAC 71–82 Amino Acid Stretch of α-Synuclein Folds into Soluble β-Sheet Oligomers at Low and Elevated Peptide Concentrations

Jörgen Ådén, P. Andersson, Thomas Näsström, 2020, International journal of molecular sciences.

Off-pathway α-synuclein oligomers seem to alter α-synuclein turnover in a cell model but lack seeding capability in vivo

F. Nikolajeff, L. Lannfelt, M. Ingelsson, 2013, Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis.

Synthetic NAC 71-82 Peptides Designed to Produce Fibrils with Different Protofilament Interface Contacts

D. Malyshev, Jörgen Ådén, P. Andersson, 2021, International journal of molecular sciences.