Te-Hsien Lin

发表

Targeting Ubiquitin Proteasome Pathway with Traditional Chinese Medicine for Treatment of Spinocerebellar Ataxia Type 3.

Yih-Ru Wu, M. Cheng, C. Chen, 2019, The American journal of Chinese medicine.

Aqueous extract of Gardenia jasminoides targeting oxidative stress to reduce polyQ aggregation in cell models of spinocerebellar ataxia 3

Yih-Ru Wu, Kuo-Hsuan Chang, C. Chen, 2014, Neuropharmacology.

Novel compound VB-037 inhibits Aβ aggregation and promotes neurite outgrowth through enhancement of HSP27 and reduction of P38 and JNK-mediated inflammation in cell models for Alzheimer's disease

Guan-Chiun Lee, H. Hsieh-Li, Kuo-Hsuan Chang, 2019, Neurochemistry International.

Formulated Chinese Medicine Shaoyao Gancao Tang Reduces Tau Aggregation and Exerts Neuroprotection through Anti-Oxidation and Anti-Inflammation

Yih-Ru Wu, Kuo-Hsuan Chang, C. Chen, 2018, Oxidative medicine and cellular longevity.

Aqueous Extract of Paeonia lactiflora and Paeoniflorin as Aggregation Reducers Targeting Chaperones in Cell Models of Spinocerebellar Ataxia 3

Yih-Ru Wu, Kuo-Hsuan Chang, C. Chen, 2013, Evidence-based complementary and alternative medicine : eCAM.

The indole compound NC009–1 inhibits aggregation and promotes neurite outgrowth through enhancement of HSPB1 in SCA17 cells and ameliorates the behavioral deficits in SCA17 mice

Yih-Ru Wu, H. Hsieh-Li, Kuo-Hsuan Chang, 2018, Neurotoxicology.

Medicinal herbs Oenanthe javanica (Blume) DC., Casuarina equisetifolia L. and Sorghum bicolor (L.) Moench protect human cells from MPP+ damage via inducing FBXO7 expression.

Yih-Ru Wu, C. Chen, Ting-Shou Chen, 2016, Phytomedicine : international journal of phytotherapy and phytopharmacology.

The Potential of Indole/Indolylquinoline Compounds in Tau Misfolding Reduction by Enhancement of HSPB1

H. Fung, Yih-Ru Wu, H. Hsieh-Li, 2017, CNS neuroscience & therapeutics.

Novel TRKB agonists activate TRKB and downstream ERK and AKT signaling to protect Aβ-GFP SH-SY5Y cells against Aβ toxicity

H. Hsieh-Li, Kuo-Hsuan Chang, C. Chen, 2022, Aging.

The aqueous extract of Glycyrrhiza inflata can upregulate unfolded protein response-mediated chaperones to reduce tau misfolding in cell models of Alzheimer’s disease

Yih-Ru Wu, Kuo-Hsuan Chang, C. Chen, 2016, Drug design, development and therapy.

Aqueous extract of Glycyrrhiza inflata inhibits aggregation by upregulating PPARGC1A and NFE2L2-ARE pathways in cell models of spinocerebellar ataxia 3.

Yih-Ru Wu, M. Cheng, Hsiang-Yu Tang, 2014, Free radical biology & medicine.

Novel Synthetic Coumarin-Chalcone Derivative (E)-3-(3-(4-(Dimethylamino)Phenyl)Acryloyl)-4-Hydroxy-2H-Chromen-2-One Activates CREB-Mediated Neuroprotection in Aβ and Tau Cell Models of Alzheimer's Disease

H. Hsieh-Li, Kuo-Hsuan Chang, C. Chen, 2021, Oxidative medicine and cellular longevity.

Chinese Herbal Medicine Glycyrrhiza inflataReduces Aβ Aggregation and Exerts Neuroprotection through Anti-Oxidation and Anti-Inflammation.

Kuo-Hsuan Chang, C. Chen, G. Lee-Chen, 2018, The American journal of Chinese medicine.

Neuroprotective Action of Coumarin Derivatives through Activation of TRKB-CREB-BDNF Pathway and Reduction of Caspase Activity in Neuronal Cells Expressing Pro-Aggregated Tau Protein

Kuo-Hsuan Chang, C. Chen, G. Lee-Chen, 2022, International journal of molecular sciences.

Flavones 7,8-DHF, Quercetin, and Apigenin Against Tau Toxicity via Activation of TRKB Signaling in ΔK280 TauRD-DsRed SH-SY5Y Cells

H. Hsieh-Li, Kuo-Hsuan Chang, C. Chen, 2021, Frontiers in Aging Neuroscience.

New Synthetic 3-Benzoyl-5-Hydroxy-2H-Chromen-2-One (LM-031) Inhibits Polyglutamine Aggregation and Promotes Neurite Outgrowth through Enhancement of CREB, NRF2, and Reduction of AMPKα in SCA17 Cell Models

Yih-Ru Wu, Kuo-Hsuan Chang, C. Chen, 2020, Oxidative medicine and cellular longevity.

Pathomechanism characterization and potential therapeutics identification for SCA3 targeting neuroinflammation

Yih-Ru Wu, Kuo-Hsuan Chang, C. Chen, 2020, Aging.

Shaoyao Gancao Tang (SG-Tang), a formulated Chinese medicine, reduces aggregation and exerts neuroprotection in spinocerebellar ataxia type 17 (SCA17) cell and mouse models

Yih-Ru Wu, H. Hsieh-Li, Kuo-Hsuan Chang, 2019, Aging.

Indole and synthetic derivative activate chaperone expression to reduce polyQ aggregation in SCA17 neuronal cell and slice culture models

Chung-Hsin Wu, H. Hsieh-Li, Kuo-Hsuan Chang, 2014, Drug design, development and therapy.

Exploration of multi‐target effects of 3‐benzoyl‐5‐hydroxychromen‐2‐one in Alzheimer’s disease cell and mouse models

Yih-Ru Wu, Kuo-Hsuan Chang, C. Chen, 2020, Aging cell.

Virtual Screening and Testing of GSK-3 Inhibitors Using Human SH-SY5Y Cells Expressing Tau Folding Reporter and Mouse Hippocampal Primary Culture under Tau Cytotoxicity

Yih-Ru Wu, Guan-Chiun Lee, H. Hsieh-Li, 2022, Biomolecules & therapeutics.

Using ΔK280 TauRD Folding Reporter Cells to Screen TRKB Agonists as Alzheimer’s Disease Treatment Strategy

Kuo-Hsuan Chang, C. Chen, G. Lee-Chen, 2023, Biomolecules.

Novel Lactulose and Melibiose Targeting Autophagy to Reduce PolyQ Aggregation in Cell Models of Spinocerebellar Ataxia 3.

Jinn-Moon Yang, Yih-Ru Wu, Guan-Chiun Lee, 2016, CNS & neurological disorders drug targets.

The potential of synthetic indolylquinoline derivatives for Aβ aggregation reduction by chemical chaperone activity

Chung-Hsin Wu, H. Fung, Yi-Chun Chen, 2016, Neuropharmacology.

The potential of indole and a synthetic derivative for polyQ aggregation reduction by enhancement of the chaperone and autophagy systems.

Yih-Ru Wu, Kuo-Hsuan Chang, C. Chen, 2014, ACS Chemical Neuroscience.

The aqueous extract of Glycyrrhiza inflata can upregulate unfolded protein response-mediated chaperones to reduce tau misfolding in cell models of alzheimer’s disease

Yih-Ru Wu, Kuo-Hsuan Chang, C. Chen, 2016 .