A. Cho

发表

Recent Advances in Oral Prodrug Discovery

A. Cho, 2006 .

Preparation and biological evaluation of 1'-cyano-2'-C-methyl pyrimidine nucleosides as HCV NS5B polymerase inhibitors.

M. Fenaux, A. Ray, Joy Y. Feng, 2014, Bioorganic & medicinal chemistry letters.

Sensitivity of Mitochondrial Transcription and Resistance of RNA Polymerase II Dependent Nuclear Transcription to Antiviral Ribonucleosides

J. Arnold, C. Cameron, A. Gnatt, 2012, PLoS pathogens.

Metabolism and Pharmacokinetics of the Anti-Hepatitis C Virus Nucleotide Prodrug GS-6620

D. Stefanidis, A. Ray, Yeojin Park, 2014, Antimicrobial Agents and Chemotherapy.

Inhibition of Hepatitis C Virus Replication by GS-6620, a Potent C-Nucleoside Monophosphate Prodrug

W. Zhong, M. Fenaux, K. Kitrinos, 2014, Antimicrobial Agents and Chemotherapy.

Synthesis and characterization of 1'-C-cyano-2'-fluoro-2'-C-methyl pyrimidine nucleosides as HCV polymerase inhibitors.

M. Fenaux, A. Ray, Joy Y. Feng, 2015, Bioorganic & medicinal chemistry letters.

Novel, potent, and orally bioavailable phosphinic acid inhibitors of the hepatitis C virus NS3 protease.

W. Delaney, Xiaowu Chen, M. Clarke, 2011, Bioorganic & medicinal chemistry letters.

Synthesis and antiviral activity of a series of 1′-substituted 4-aza-7,9-dideazaadenosine C-nucleosides

A. Ray, Joy Y. Feng, Lijun Zhang, 2012, Bioorganic & Medicinal Chemistry Letters.

Practical synthesis of 1′-substituted Tubercidin C-nucleoside analogs

C. Kim, Sammy Metobo, A. Cho, 2012 .

Relationships between structure, antibacterial activity, serum stability, pharmacokinetics and efficacy in 3-(heteroarylthio)cephems. Discovery of RWJ-333441 (MC-04,546).

M. Dudley, S. Hecker, T. Glinka, 2003, Bioorganic & medicinal chemistry.

Phosphonic acid-containing analogues of mycophenolic acid as inhibitors of IMPDH.

William A. Lee, Xiaohong Liu, James M. Chen, 2006, Bioorganic & medicinal chemistry letters.

Discovery of RWJ-54428 (MC-02,479), a new cephalosporin active against resistant gram-positive bacteria.

S. Hecker, T. Glinka, A. Cho, 2000, The Journal of antibiotics.

SAR studies of anti-MRSA non-zwitterionic 3-heteroarylthiocephems.

M. Dudley, S. Hecker, T. Glinka, 2000, The Journal of antibiotics.

Discovery of GS-9451: an acid inhibitor of the hepatitis C virus NS3/4A protease.

T. Appleby, W. Delaney, Ruby Z Cai, 2012, Bioorganic & medicinal chemistry letters.

Discovery of GS-9256: a novel phosphinic acid derived inhibitor of the hepatitis C virus NS3/4A protease with potent clinical activity.

W. Delaney, Ruby Z Cai, Xiaowu Chen, 2012, Bioorganic & medicinal chemistry letters.

Synthesis of 1′-C-Cyano Pyrimidine Nucleosides and Characterization as HCV Polymerase Inhibitors

A. Ray, T. Kirschberg, C. Kim, 2015, Nucleosides, nucleotides & nucleic acids.

Discovery of the first C-nucleoside HCV polymerase inhibitor (GS-6620) with demonstrated antiviral response in HCV infected patients.

W. Zhong, M. Fenaux, H. Ye, 2014, Journal of medicinal chemistry.

Discovery of a 2'-fluoro-2'-C-methyl C-nucleotide HCV polymerase inhibitor and a phosphoramidate prodrug with favorable properties.

Huiling Yang, T. Appleby, M. Fenaux, 2017, Bioorganic & medicinal chemistry letters.

Synthesis and antiviral activity of a series of 1′-substituted 4-aza-7,9-dideazaadenosine C-nucleosides

A. Ray, Joy Y. Feng, Lijun Zhang, 2012, Bioorganic & Medicinal Chemistry Letters.

Synthesis and characterization of 2'-C-Me branched C-nucleosides as HCV polymerase inhibitors.

A. Ray, Joy Y. Feng, D. Babusis, 2012, Bioorganic & medicinal chemistry letters.

Inhibition of Hepatitis C Virus Replication by GS-6620 , A Potent C-Nucleoside 1 Monophosphate Prodrug 2 3 Running Title : In Vitro Pharmacology of GS-6620 4 5

W. Zhong, M. Fenaux, G. Cheng, 2014 .

Nucleotide Prodrug Containing a Nonproteinogenic Amino Acid To Improve Oral Delivery of a Hepatitis C Virus Treatment

Huiling Yang, M. Fenaux, Neeraj Tirunagari, 2018, Antimicrobial Agents and Chemotherapy.

1 'substituted carbanucleoside analogues for antiviral treatment

Lijun Zhang, C. Kim, A. Cho, 2009 .

Evolution of HCV NS5B Nucleoside and Nucleotide Inhibitors

A. Cho, 2019, Topics in Medicinal Chemistry.

1 Non-proteinogenic Amino Acid Containing Nucleotide Prodrug to Improve Oral Delivery of a 1 Hepatitis C Virus Treatment 2

Huiling Yang, M. Fenaux, Neeraj Tirunagari, 2018 .

Quinazolinone-based fungal efflux pump inhibitors. Part 1: Discovery of an (N-methylpiperazine)-containing derivative with activity in clinically relevant Candida spp.

Rajeshwar Singh, N. Iqbal, M. Dudley, 2004, Bioorganic & medicinal chemistry letters.

Synthesis of 1-amino-2-vinylcyclopropane-1-phosphinates. Conversion of a phosphonate to phosphinates

M. Clarke, Anthony D. Casarez, C. Kim, 2012 .

MexAB-OprM specific efflux pump inhibitors in Pseudomonas aeruginosa. Part 3: Optimization of potency in the pyridopyrimidine series through the application of a pharmacophore model.

W. Watkins, K. Nakayama, K. Hoshino, 2004, Bioorganic & medicinal chemistry letters.

New anti-MRSA cephalosporins with a basic aminopyridine at the C-7 position.

M. Wang, S. Hecker, T. Glinka, 2001, Bioorganic & medicinal chemistry letters.

MexAB-OprM specific efflux pump inhibitors in Pseudomonas aeruginosa. Part 4: Addressing the problem of poor stability due to photoisomerization of an acrylic acid moiety.

W. Watkins, K. Nakayama, K. Hoshino, 2004, Bioorganic & medicinal chemistry letters.

Quinazolinone fungal efflux pump inhibitors. Part 3: (N-methyl)piperazine variants and pharmacokinetic optimization.

Rajeshwar Singh, N. Iqbal, M. Dudley, 2007, Bioorganic & medicinal chemistry letters.

Quinazolinone fungal efflux pump inhibitors. Part 2: In vitro structure-activity relationships of (N-methyl-piperazinyl)-containing derivatives.

Rajeshwar Singh, N. Iqbal, M. Dudley, 2004, Bioorganic & medicinal chemistry letters.

Indium-Mediated Organic Reactions in Aqueous Media

A. Cho, 2002 .

Phosphatase-triggered guest release from a cyclodextrin complex.

A. Eliseev, A. K. Yatsimirsky, A. Cho, 2000, Organic Letters.

Structural basis for RNA replication by the hepatitis C virus polymerase

M. Mcgrath, T. Appleby, S. Swaminathan, 2015, Science.

Composes de phosphonate therapeutiques

James M. Chen, Xiaowu Chen, C. Boojamra, 2004 .