I. Komiya

发表

Polarized efflux of mono- and diacid metabolites of ME3229, an ester-type prodrug of a glycoprotein IIb/IIIa receptor antagonist, in rat small intestine.

Y. Sugiyama, N. Okudaira, I. Komiya, 2000, The Journal of pharmacology and experimental therapeutics.

A novel method to predict the elimination half-lives and the renal excretion mechanisms of cephalosporins.

I. Komiya, M. Nishio, T. Sakurai, 1984, Journal of pharmacobio-dynamics.

Toxicokinetic approach for evaluating respiratory depression effect of aminoglycoside antibiotics: Species differences in drug susceptibility

I. Komiya, T. Kuribayashi, N. Mitomi, 1993, Biopharmaceutics & drug disposition.

Absence of glucopenic inhibition of the insulin response to arginine at the onset of diabetes in BB/W rats

R. Unger, I. Komiya, 1988, Diabetologia.

Reduced beta-cell glucose transporter in new onset diabetic BB rats.

L. Orci, H. Lodish, B. Thorens, 1990, The Journal of clinical investigation.

Compensatory capabilities of islets of BB/Wor rats exposed to sustained hyperglycemia.

L. Orci, R. Unger, M. Kuwajima, 1990, Metabolism: clinical and experimental.

Urine flow-dependence and interspecies variation of the renal reabsorption of sulfanilamide.

I. Komiya, 1987, Journal of pharmacobio-dynamics.

Effects of hypoglycemia and prolonged fasting on insulin and glucagon gene expression. Studies with in situ hybridization.

R. Unger, T. Alam, L. Chen, 1989, The Journal of clinical investigation.

Loss of insulin response to glucose but not arginine during the development of autoimmune diabetes in BB/W rats: relationships to islet volume and glucose transport rate.

J. H. Johnson, T. Alam, I. Komiya, 1986, Proceedings of the National Academy of Sciences of the United States of America.

Molecular and cellular responses of islets during perturbations of glucose homeostasis determined by in situ hybridization histochemistry.

R. Unger, T. Alam, L. Chen, 1989, Proceedings of the National Academy of Sciences of the United States of America.

Effects ofHypoglycemia andProlonged Fasting onInsulin andGlucagon GeneExpression Studies withInSituHybridization

T. Alam, I. Komiya, M. Appel, 1989 .

In-vitro and in-vivo antimicrobial activities of a novel cephalosporin derivative, CP6162, possessing a dihydroxypyridone moiety at the C-3 side chain.

T. Matsumoto, S. Inouye, I. Komiya, 1991, The Journal of antimicrobial chemotherapy.

Synthesis and biological activity of (cyclopentenopyridinium) thiomethylcephalosporins.

S. Inouye, I. Komiya, T. Yoshida, 1990, The Journal of antibiotics.

[Experimental studies on absorption, excretion, distribution and metabolism of 3',4' dideoxykanamycin B. 1. Absorption, excretion, distribution and metabolism in rats].

K. Umemura, I. Komiya, T. Komai, 1973, The Japanese journal of antibiotics.

Physiological models are good tools to predict rat bioavailability of EF5154 prodrugs from in vitro intestinal parameters.

M. Nomoto, J. Morita, I. Komiya, 2009, Journal of pharmaceutical sciences.

Prediction of Cerebrospinal Fluid Concentrations of Quinolone Antibiotics in Humans Using Parameters for Penetration into Cerebrospinal Fluid of Animals

I. Komiya, Shigeki Shibasaki, 2005 .

A rapid enzyme immunoassay for measurement of HBK in blood.

N. Shimada, I. Komiya, T. Yokoshima, 1986, Journal of Immunoassay.

Mechanism of renal distribution of aminoglycoside antibotics.

K. Umemura, I. Komiya, A. Kamiya, 1980, Journal of Pharmacobio-Dynamics.

[Absorption, distribution, and excretion of arbekacin after intravenous and intramuscular administration in rats].

T. Matsumoto, I. Komiya, N. Mitomi, 1987, The Japanese journal of antibiotics.

Pharmacokinetics of dibekacin in rabbits and dogs.

K. Umemura, I. Komiya, S. Murata, 1981, Journal of pharmacobio-dynamics.

RENAL DISTRIBUTION AND PHARMACOKINETICS OF DIBEKACIN IN RABBITS WITH ASCENDING RENAL INFECTION

K. Umemura, I. Komiya, K. Miyauchi, 2011 .

Mode of protective action of fosfomycin against dibekacin-induced nephrotoxicity in the dehydrated rats.

Y. Yamada, I. Komiya, Y. Yuda, 1982, Journal of pharmacobio-dynamics.

Quantitative mechanistic studies in simultaneous fluid flow and intestinal absorption using steroids as model solutes

W. Higuchi, N. Ho, I. Komiya, 1980 .

Thyrotropin-induced acceleration of calcium efflux from mouse thyroid: evidence for inhibition by excess iodide.

K. Ichikawa, K. Hashizume, I. Komiya, 1984, Endocrinology.

Up-Regulation of Carnitine Transporters Helps Maintain Tissue Carnitine Levels in Carnitine Deficiency Induced by Pivalic Acid

Y. Sugiyama, N. Okudaira, I. Komiya, 2001, Pharmaceutical Research.

A study of the intestinal absorption of an ester-type prodrug, ME3229, in rats: active efflux transport as a cause of poor bioavailability of the active drug.

Y. Sugiyama, N. Okudaira, I. Komiya, 2000, The Journal of pharmacology and experimental therapeutics.

Pharmacokinetics of ME1207, a novel oral cephem antibiotic, in rats—Single oral administration studies using (Pivaloyloxymethyl-14C) ME1207—

K. Kawano, Y. Esumi, Takashi Matsumoto, 1992 .

Protective effect of fosfomycin on gentamicin-induced lipid peroxidation of rat renal tissue.

T. Horie, Kousei Ito, I. Komiya, 2004, Chemico-biological interactions.

Studies on the cytochrome P450 (CYP)-mediated metabolic properties of miocamycin: evaluation of the possibility of a metabolic intermediate complex formation with CYP, and identification of the human CYP isoforms.

H. Suzuki, I. Komiya, M. Kasahara, 2000, Drug metabolism and disposition: the biological fate of chemicals.

Acute toxicity and pharmacokinetics of dibekacin mice.

K. Umemura, I. Komiya, S. Murata, 1981, Journal of pharmacobio-dynamics.

Pharmacokinetics of dibekacin after intramuscular administration in man.

K. Umemura, I. Komiya, S. Chow, 1977, The Japanese journal of antibiotics.

Morphometric and functional studies of islets in diabetes-prone BB/W rats that are discordant for overt diabetes

L. Orci, R. Unger, A. Perrelet, 1989 .