G. L. Grunewald

发表

Inhibition of neuronal uptake of 3H-biogenic amines into rat cerebral cortex by partially and fully saturated derivatives of imipramine and desipramine. The importance of the aromatic ring in adrenergic amines--part 3.

L. Eiden, C. Rutledge, J. A. Ruth, 1979, Biochemical pharmacology.

Pronounced pharmacological differences arising from minor structural changes in conformationally defined amphetamine analogues. Comparative evaluation of endo- and exo-2-amino- and endo- and exo-2-(methylamino)benzobicyclo[2.2.1]heptene and -benzobicylco[2.2.2]octene analogues. Conformationally defi

A. Hallett, C. Rutledge, J. A. Ruth, 1980, Journal of medicinal chemistry.

The remarkable substrate activity for phenylethanolamine N-methyltransferase of some conformationally defined phenylethylamines lacking a side-chain hydroxyl group. Conformationally defined adrenergic agents. 6.

G. L. Grunewald, M. Rafferty, 1982, Molecular pharmacology.

Importance of the aromatic ring in adrenergic amines. Nonaromatic analoques of phenylethanolamine as substrates for phenylethanolamine N-methyltransferase.

R. Borchardt, G. L. Grunewald, J. M. Grindel, 1975, Molecular pharmacology.

Application of the Goldilocks effect to the design of potent and selective inhibitors of phenylethanolamine N-methyltransferase: balancing pKa and steric effects in the optimization of 3-methyl-1,2,3,4-tetrahydroisoquinoline inhibitors by beta-fluorination.

Mitchell R Seim, G. L. Grunewald, Jian Lu, 2006, Journal of medicinal chemistry.

Inhibition of norepinephrine transport into synaptic vesicles by amphetamine analogs.

S. Knepper, C. Rutledge, G. L. Grunewald, 1988, The Journal of pharmacology and experimental therapeutics.

Carbon-13 nuclear magnetic resonance examination of benzonorbornene derivatives. Assignment of site of aromatic ring substitution in benzonorbornen-2-ones

G. L. Grunewald, T. Reitz, 1983 .

Time-dependent inactivation of human phenylethanolamine N-methyltransferase by 7-isothiocyanatotetrahydroisoquinoline.

M. McLeish, J. Caine, S. Thomson, 2009, Bioorganic & medicinal chemistry letters.

Exploring the active site of phenylethanolamine N-methyltransferase with 1,2,3,4-tetrahydrobenz[h]isoquinoline inhibitors.

Mitchell R Seim, Rachel C Regier, G. L. Grunewald, 2007, Bioorganic & medicinal chemistry.

Synthesis and evaluation of 3-trifluoromethyl-7-substituted-1,2,3, 4-tetrahydroisoquinolines as selective inhibitors of phenylethanolamine N-methyltransferase versus the alpha(2)-adrenoceptor.

G. L. Grunewald, T. Caldwell, K. R. Criscione, 1999, Journal of medicinal chemistry.

A reinvestigation of the taxol content of himalayan taxus wallichiana zucc. and a revision of the structure of brevifoliol.

R. Himes, G. Georg, L. Mitscher, 1993 .

The Chemistry of Barrelene. III. A Unique Photoisomerization to Semibullvalene

H. Zimmerman, G. L. Grunewald, 1966 .

Synthesis of 3‐alkyl‐8‐substituted‐ and 4‐hydroxy‐8‐substituted‐2,3,4,5‐tetrahydro‐1H‐2‐benzazepines

G. L. Grunewald, V. Dahanukar, 1994 .

Effects of a 3-alkyl-, 4-hydroxy- and/or 8-aromatic-substituent on the phenylethanolamine N-methyltransferase inhibitor potency and alpha2-adrenoceptor affinity of 2,3,4,5-tetrahydro-1H-2-benzazepines.

G. L. Grunewald, V. Dahanukar, K. R. Criscione, 2001, Bioorganic & medicinal chemistry.

Synthesis and Evaluation of 4-Fluoro-8-substituted-2,3,4,5-tetrahydro-1H-2-benzazapines as Selective Inhibitors of Phenylethanolamine N-Methyltransferase versus the α2-Adrenoceptor.

G. L. Grunewald, T. Caldwell, Qifang Li, 2001 .

1,3-Dimethyl-7-substituted-1,2,3,4-tetrahydroisoquinolines as probes for the binding orientation of tetrahydroisoquinoline at the active site of phenylethanolamine N-methyltransferase.

G. L. Grunewald, T. Caldwell, K. R. Criscione, 1999, Bioorganic & medicinal chemistry.

Design and stereoselective synthesis of conformationally constrained analogues of Zimeldine

W. Cho, G. L. Grunewald, 1996 .

Principles of medicinal chemistry (Foye, William O., ed.)

G. L. Grunewald, 1976 .

Structure-Based Drug Design of Bisubstrate Inhibitors of Phenylethanolamine N-Methyltransferase Possessing Low Nanomolar Affinity at Both Substrate Binding Domains1.

M. McLeish, E. Scott, G. L. Grunewald, 2020, Journal of medicinal chemistry.

Synthesis of 4,5,6,7-tetrahydrothieno[3,2-c]pyridines and comparison with their isosteric 1,2,3,4-tetrahydroisoquinolines as inhibitors of phenylethanolamine N-methyltransferase.

Mitchell R Seim, G. L. Grunewald, K. R. Criscione, 2008, Bioorganic & medicinal chemistry.

Inhibitors of phenylethanolamine N-methyltransferase devoid of alpha2-adrenoceptor affinity.

Cosmas O. Okoro, G. L. Grunewald, Jian Lu, 2005, Bioorganic & medicinal chemistry letters.

Structural, mutagenic, and kinetic analysis of the binding of substrates and inhibitors of human phenylethanolamine N-methyltransferase.

Jennifer L. Martin, C. Gee, M. McLeish, 2005, Journal of medicinal chemistry.

A new procedure for regioselective synthesis of 8,9-dichloro-2,3,4,5-tetrahydro-1H-2-benzazepine (LY134046) and its 3-methyl analogue as inhibitors of phenylethanolamine N-methyltransferase (PNMT)†

G. L. Grunewald, V. Paradkar, Duane M. Stillions, 1991 .

Stereochemical aspects of phenylethanolamine analogues as substrates of phenylethanolamine N-methyltransferase.

G. L. Grunewald, Q. Ye, 1988, Journal of medicinal chemistry.

The oxetane conformational lock of paclitaxel: structural analysis of D-secopaclitaxel.

M. Hepperle, G. Georg, D. V. Vander Velde, 1999, Bioorganic & medicinal chemistry letters.

Hydrophobic collapse of taxol and taxotere solution conformations in mixtures of water and organic solvent

G. Georg, L. Mitscher, D. Velde, 1993 .

Synthesis of bridgehead hydroxyl-substituted benzobicyclo[3.2.1]octenes and -octadienes via an acyloin rearrangement in the benzobicyclo[2.2.2]octene ring system

D. Walters, G. L. Grunewald, T. R. Kroboth, 1978 .

Binding requirements of phenolic phenylethylamines in the benzonorbornene skeleton at the active site of phenylethanolamine N-methyltransferase.

G. L. Grunewald, T. Reitz, D. J. Sall, 1986, Journal of medicinal chemistry.

Conformationally defined adrenergic agents. 8. Synthesis of conformationally defined analogs of norfenfluramine. A highly stereospecific synthesis of amines from alcohols in the benzobicyclo[2.2.1]heptene system

M. Pleiss, W. Seibel, G. L. Grunewald, 1983 .

Comparison of the binding of 3-fluoromethyl-7-sulfonyl-1,2,3,4-tetrahydroisoquinolines with their isosteric sulfonamides to the active site of phenylethanolamine N-methyltransferase.

Christine L Gee, Jennifer L. Martin, C. Gee, 2006, Journal of medicinal chemistry.

Gas chromatographic quantitation of underivatized amines in the determination of their octanol-0.1 M sodium hydroxide partition coefficients by the shake-flask method.

M. Pleiss, G. L. Grunewald, M. Rafferty, 1984, Journal of chromatography.

Synthesis and Biochemical Evaluation of 3-Fluoromethyl-1,2,3,4-tetrahydroisoquinolines as Selective Inhibitors of Phenylethanolamine N-Methyltransferase versus the α2-Adrenoceptor1

R. Borchardt, G. L. Grunewald, Wen Wang, 1999 .

Effect of ring size or an additional heteroatom on the potency and selectivity of bicyclic benzylamine-type inhibitors of phenylethanolamine N-methyltransferase.

G. L. Grunewald, V. Dahanukar, K. R. Criscione, 1996, Journal of medicinal chemistry.

3,7-Disubstituted-1,2,3,4-tetrahydroisoquinolines display remarkable potency and selectivity as inhibitors of phenylethanolamine N-methyltransferase versus the alpha2-adrenoceptor.

G L Grunewald, V H Dahanukar, B Teoh, 1999, Journal of medicinal chemistry.

Synthesis of α-hydroxyamides via the cyanosilylation of aromatic ketones☆

J. A. Finney, W. Brouillette, G. L. Grunewald, 1980 .

Mechanistic and exploratory organic photochemistry. XLIV. The barrelene to semibullvalene transformation. Correlation of excited-state potential energy surfaces with reactivity

R. Givens, H. Zimmerman, G. L. Grunewald, 1969 .

The Chemistry of Barrelene. II.1 A Remarkable Transformation to Naphthalene Derivatives

H. Zimmerman, G. L. Grunewald, 1964 .

Synthesis and physical properties of barrelene, a unique Moebius-like molecule

H. Zimmerman, G. L. Grunewald, M. Sherwin, 1969 .

Fenfluramine hydrochloride, (+-)-N-ethyl-m-(trifluoromethyl)amphetamine hydrochloride

M. Extine, G. L. Grunewald, M. W. Creese, 1981 .

CONFORMATIONALLY DEFINED ADRENERGIC AGENTS. 8. SYNTHESIS OF CONFORMATIONALLY DEFINED ANALOGS OF NORFENFLURAMINE. A HIGHLY STEREOSPECIFIC SYNTHESIS OF AMINES FROM ALCOHOLS IN THE BENZOBICYCLO(2.2.1)HEPTENE SYSTEM

M. Pleiss, W. Seibel, G. L. Grunewald, 1983 .

A liquid chromatographic assay for phenylethanolamine N-methyltransferase.

R. Borchardt, G. L. Grunewald, W. Vincek, 1977, Analytical biochemistry.

Molecular recognition of physiological substrate noradrenaline by the adrenaline-synthesizing enzyme PNMT and factors influencing its methyltransferase activity.

Munish Puri, Christine L Gee, Jennifer L. Martin, 2009, The Biochemical journal.

Role of epinephrine stimulation of CNS α1‐adrenoceptors in motor activity in mice

D. Quartermain, H. Rosengarten, E. Stone, 2003 .

Conformational preference for the binding of biaryl substrates and inhibitors to the active site of phenylethanolamine N-methyltransferase.

J. Monn, G. L. Grunewald, D. J. Sall, 1988, Journal of medicinal chemistry.

Conformationally restricted and conformationally defined tyramine analogues as inhibitors of phenylethanolamine N-methyltransferase.

G. L. Grunewald, Q. Ye, 1989, Journal of medicinal chemistry.

Crystallization of PNMT, the adrenaline-synthesizing enzyme, is critically dependent on a high protein concentration.

Jennifer L. Martin, M. McLeish, J. Begun, 2002, Acta crystallographica. Section D, Biological crystallography.

Fragment-based screening by X-ray crystallography, MS and isothermal titration calorimetry to identify PNMT (phenylethanolamine N-methyltransferase) inhibitors.

Hoan Vu, Sally-Ann Poulsen, Thomas E Prisinzano, 2010, The Biochemical journal.

Enzyme adaptation to inhibitor binding: a cryptic binding site in phenylethanolamine N-methyltransferase.

Christine L Gee, Jennifer L. Martin, C. Gee, 2007, Journal of medicinal chemistry.

Inhibitors of phenylethanolamine-N-methyltransferase. 2. Comparison of nonaromatic analogs of phenylethanolamines, 7,8-dichloro-1,2,3,4-tetrahydroisoquinoline (SKF-64139) and 2,3-dichloro-alpha-methylbenzylamine: effects on rat brain and adrenal catecholamine content and blood pressure.

R. Borchardt, R. Tessel, G. L. Grunewald, 1982, The Journal of pharmacology and experimental therapeutics.

Inhibitors of phenylethanolamine N-methyltransferase. 1. Effects of 2-cycloocytyl-2-hydroxyethylamine on rat brain and adrenal catecholamine content and blood pressure.

R. Borchardt, R. Tessel, G. L. Grunewald, 1982, The Journal of pharmacology and experimental therapeutics.

Enantiospecific synthesis of 3-fluoromethyl-, 3-hydroxymethyl-, and 3-chloromethyl-1,2,3,4-tetrahydroisoquinolines as selective inhibitors of phenylethanolamine N-methyltransferase versus the alpha(2)-adrenoceptor.

G. L. Grunewald, T. Caldwell, V. Dahanukar, 1999, Journal of medicinal chemistry.

Effects of phenylethanolamine N-methyltransferase inhibitors on rat brain catecholamine levels and body temperature.

R. Borchardt, R. Tessel, G. L. Grunewald, 1982, Research communications in chemical pathology and pharmacology.

Importance of the aromatic ring in adrenergic amines. 6. Nonaromatic analogues of phenylethanolamine as inhibitors of phenylethanolamine N-methyltransferase: role of pi-electronic and steric interactions.

R. Borchardt, G. L. Grunewald, D. P. Davis, 1981, Journal of medicinal chemistry.

Getting the adrenaline going: crystal structure of the adrenaline-synthesizing enzyme PNMT.

M. McLeish, J. Begun, J. Caine, 2001, Structure.

Comparative molecular field analysis (CoMFA) models of phenylethanolamine N-methyltransferase (PNMT) and the alpha2-adrenoceptor: the development of new, highly selective inhibitors of PNMT.

G. L. Grunewald, T. Caldwell, V. Dahanukar, 1999, Bioorganic & medicinal chemistry letters.

Exploring the active site of phenylethanolamine N-methyltransferase with 3-hydroxyethyl- and 3-hydroxypropyl-7-substituted-1,2,3,4-tetrahydroisoquinolines.

D. Bylund, F. A. Romero, Mitchell R Seim, 2005, Bioorganic & medicinal chemistry letters.

Use of transferred nuclear overhauser effects to determine the conformation of 1-(3,4-dichlorophenyl)-2-aminopropane when bound to the active site of phenylethanolamine N-methyltransferace (PNMT)

M. Palanki, D. Velde, G. L. Grunewald, 1992 .

Conformational preferences of dopamine analogues for inhibition of norepinephrine N-methyltransferase. Conformationally defined adrenergic agents.

M. Pleiss, G. L. Grunewald, M. Rafferty, 1982, Life sciences.

Substituted tetralins. I. Synthesis and analgesic activities of some 2-aminotetralins.

A. Martin, A. I. White, G. L. Grunewald, 1969, Journal of pharmaceutical sciences.

A COMPARATIVE MOLECULAR FIELD ANALYSIS DERIVED MODEL OF THE BINDING OF TAXOL ANALOGUES TO MICROTUBULES

G. L. Grunewald, Karl-Heinz A. Czaplinski, 1994 .

Conformational preferences in alkylbenzenes and aryl‐alkylamines: A comparative study using CAMSEQ, MM2 and molecular dynamics methods

G. L. Grunewald, H. Weintraub, M. W. Creese, 1988 .

Medicinal chemistry of (10) annulenes and related compounds. 1. 11-Azatricyclo(4.4.1.0 1,6 )undecane, 11-azatricyclo(4.4.1.0 1,6 )undeca-3,8-diene, and 11-azabicyclo(4.4.1)undeca-1,3,5,7,9-pentaene as antiviral agents.

R. Bussell, S. Hays, G. L. Grunewald, 1972, Journal of medicinal chemistry.

Homoallylic amines related to zimeldine. A comparative study on neuronal serotonin and norepinephrine reuptake based on conformational analysis.

J. Bunce, T. Högberg, P. Ström, 1988, Journal of medicinal chemistry.

Conformational analysis of nisoxetine and fluoxetine, selective inhibitors of norepinephrine and serotonin reuptake: are conformational differences an explanation of neurotransmitter selectivity?

G. L. Grunewald, M. W. Creese, 1986, Drug design and delivery.

Examination of the role of the acidic hydrogen in imparting selectivity of 7-(aminosulfonyl)-1,2,3,4-tetrahydroisoquinoline (SK&F 29661) toward inhibition of phenylethanolamine N-methyltransferase vs the alpha 2-adrenoceptor.

G. L. Grunewald, T. Caldwell, V. Dahanukar, 1997, Journal of Medicinal Chemistry.

Phenylethanolamine N-methyltransferase kinetics: bovine versus recombinant human enzyme.

M. McLeish, G. L. Grunewald, K. R. Criscione, 2001, Bioorganic & medicinal chemistry letters.

Synthesis and anticonvulsant activity of some substituted lactams and amides.

W. Brouillette, G. L. Grunewald, 1984, Journal of medicinal chemistry.

Exploring the active site of phenylethanolamine N-methyltransferase: 3-alkyl-7-substituted-1,2,3,4-tetrahydroisoquinoline inhibitors.

F. A. Romero, G. L. Grunewald, K. R. Criscione, 2005, Bioorganic & medicinal chemistry.

Conformational and steric aspects of the inhibition of phenylethanolamine N-methyltransferase by benzylamines.

J. Monn, G. L. Grunewald, D. J. Sall, 1988, Journal of medicinal chemistry.

Ab initio and semi-empirical molecular orbital calculations on 1,6-methano[10]annulene☆☆☆★

R. Christoffersen, D. Spangler, G. L. Grunewald, 1975 .

Phenylethanolamine N-methyltransferase inhibition: re-evaluation of kinetic data.

M. McLeish, G. L. Grunewald, Qian Wu, 2004, Bioorganic & medicinal chemistry letters.

Inhibition of phenylethanolamine N-methyltransferase (PNMT) by aromatic hydroxy-substituted 1,2,3,4,-tetrahydroisoquinolines: further studies on the hydrophilic pocket of the aromatic ring binding region of the active site.

G. L. Grunewald, D. J. Sall, 1987, Journal of medicinal chemistry.

Mode of binding of methyl acceptor substrates to the adrenaline-synthesizing enzyme phenylethanolamine N-methyltransferase: implications for catalysis.

Christine L Gee, Jennifer L. Martin, C. Gee, 2005, Biochemistry.

Nanomolar inhibitors of CNS epinephrine biosynthesis: (R)-(+)-3-fluoromethyl-7-(N-substituted aminosulfonyl)-1,2,3,4-tetrahydroisoquinolines as potent and highly selective inhibitors of phenylethanolamine N-methyltransferase1.

F. A. Romero, G. L. Grunewald, K. R. Criscione, 2005, Journal of medicinal chemistry.

Inhibitors of phenylethanolamine N-methyltransferase that are predicted to penetrate the blood-brain barrier: design, synthesis, and evaluation of 3-fluoromethyl-7-(N-substituted aminosulfonyl)-1,2,3,4-tetrahydroisoquinolines that possess low affinity toward the alpha2-adrenoceptor.

F. A. Romero, M. McLeish, G. L. Grunewald, 2004, Journal of medicinal chemistry.

Recombinant Human PhenylethanolamineN-Methyltransferase: Overproduction inEscherichia coli,Purification, and Characterization

I. Macreadie, M. McLeish, J. Caine, 1996 .

Molecular recognition of sub-micromolar inhibitors by the epinephrine-synthesizing enzyme phenylethanolamine N-methyltransferase.

Jennifer L. Martin, J. Archbold, M. McLeish, 2004, Journal of medicinal chemistry.