Hao Zhang

发表

Discovery of a Partial Glucokinase Activator Clinical Candidate: Diethyl ((3-(3-((5-(Azetidine-1-carbonyl)pyrazin-2-yl)oxy)-5-isopropoxybenzamido)-1H-pyrazol-1-yl)methyl)phosphonate (BMS-820132).

Steven A. Spronk, K. Behnia, J. Barrish, 2022, Journal of medicinal chemistry.

Synthesis, molecular modeling, and biological evaluation of cinnamic acid metronidazole ester derivatives as novel anticancer agents.

Chen Xu, Hai-Liang Zhu, Jing Zhao, 2010, Bioorganic & medicinal chemistry.

Design, synthesis and structure-activity relationships of azole acids as novel, potent dual PPAR alpha/gamma agonists.

Wei Wang, Jonathan Lippy, Arthur M Doweyko, 2009, Bioorganic & medicinal chemistry letters.

Synthesis and biological evaluation of novel pyrrolidine acid analogs as potent dual PPARα/γ agonists.

Weiqi Wang, A. Doweyko, T. Harrity, 2015, Bioorganic & medicinal chemistry letters.

Design and synthesis of N-[(4-methoxyphenoxy)carbonyl]-N-[[4-[2-(5- methyl-2-phenyl-4-oxazolyl)ethoxy]phenyl]methyl]glycine [Muraglitazar/BMS-298585], a novel peroxisome proliferator-activated receptor alpha/gamma dual agonist with efficacious glucose and lipid-lowering activities.

Weiqi Wang, A. Doweyko, W. Humphreys, 2005, Journal of medicinal chemistry.

Discovery of tertiary aminoacids as dual PPARα/γ agonists-I

Wei Wang, Wei Sun, Zhengping Ma, 2007 .

Plasma Stability-Dependent Circulation of Acyl Glucuronide Metabolites in Humans: How Circulating Metabolite Profiles of Muraglitazar and Peliglitazar Can Lead to Misleading Risk Assessment

W. Humphreys, Donglu Zhang, R. Ramanathan, 2011, Drug Metabolism and Disposition.

BIOTRANSFORMATION OF CARBON-14-LABELED MURAGLITAZAR IN MALE MICE: INTERSPECIES DIFFERENCE IN METABOLIC PATHWAYS LEADING TO UNIQUE METABOLITES

W. Humphreys, Donglu Zhang, Lifei Wang, 2006, Drug Metabolism and Disposition.

Overcoming Limitations in Decarboxylative Arylation via Ag-Ni Electrocatalysis.

Maximilian D Palkowitz, M. Poss, Simon Kolb, 2022, Journal of the American Chemical Society.

Muraglitazar, a novel dual (alpha/gamma) peroxisome proliferator-activated receptor activator, improves diabetes and other metabolic abnormalities and preserves beta-cell function in db/db mice.

R. Gregg, W. Fenderson, Wen-pin Yang, 2006, Diabetes.

Determination of the absolute configuration and solution conformation of a novel disubstituted pyrrolidine acid A by vibrational circular dichroism.

Y. Shu, Xiaolin Cao, L. Nafie, 2006, Chirality.

Tuning novel Cd(II) topology networks through choosing three neutral and zwitterionic N/O ‐donor ligands: Synthesis, structures, and fluorescence

Ling-bo Qu, Cheng-xing Cui, Hao Zhang, 2020 .

Discovery of an Oxycyclohexyl Acid Lysophosphatidic Acid Receptor 1 (LPA1) Antagonist BMS-986278 for the Treatment of Pulmonary Fibrotic Diseases.

C. Chu, S. Jusuf, Yanou Yang, 2021, Journal of medicinal chemistry.

Ligand-Promoted Borylation of C(sp(3))-H Bonds with Palladium(II) Catalysts.

jin-quan yu, P. Cheng, Heng Jiang, 2016, Angewandte Chemie.

Synthesis and biological evaluation of ticagrelor derivatives as novel antiplatelet agents.

Luyong Zhang, Jun O. Liu, Hongbin Sun, 2012, Bioorganic & medicinal chemistry letters.

Design, synthesis and biological evaluations of diverse Michael acceptor-based phenazine hybrid molecules as TrxR1 inhibitors.

Yuting Zheng, Y. Zhong, Jing Liu, 2021, Bioorganic chemistry.

Modulateurs de récepteurs gpr120 à base d'acide bicyclo [2.2.2]

P. Cheng, Hao Zhang, Shiwei Tao, 2014 .

A rapid, homogeneous, fluorescence polarization binding assay for peroxisome proliferator-activated receptors alpha and gamma using a fluorescein-tagged dual PPARα/γ activator

R. Seethala, Rajasree Golla, Zhengping Ma, 2007 .

Muraglitazar, a Novel Dual (α/γ) Peroxisome Proliferator–Activated Receptor Activator, Improves Diabetes and Other Metabolic Abnormalities and Preserves β-Cell Function in db/db Mice

Michael Cap, R. Gregg, W. Fenderson, 2006 .

Synthesis and structure-activity relationships of 2-aryl-4-oxazolylmethoxy benzylglycines and 2-aryl-4-thiazolylmethoxy benzylglycines as novel, potent PPARalpha selective activators- PPARalpha and PPARgamma selectivity modulation.

Daniel Meyers, Jonathan Lippy, Rongan Zhang, 2010, Bioorganic & medicinal chemistry letters.

Ligand-Promoted Borylation of C(sp(3))-H Bonds with Palladium(II) Catalysts.

jin-quan yu, Heng Jiang, Hao Zhang, 2016, Angewandte Chemie.

Plasma Stability-Dependent Circulation of Acyl Glucuronide Metabolites in Humans: How Circulating Metabolite Profiles of Muraglitazar and Peliglitazar Can Lead to Misleading Risk Assessment

W. Humphreys, Donglu Zhang, R. Ramanathan, 2011, Drug Metabolism and Disposition.