A. Hattori

发表

Ubiquitin carboxyl‐terminal hydrolase L1 promotes hypoxia‐inducible factor 1‐dependent tumor cell malignancy in spheroid models

Senye Takahashi, H. Kakeya, H. Harada, 2019, Cancer Science.

Melanoma Cell Lines Leukemia / Lymphoma , Carcinoma , and Healthy Donors and in Aminopeptidases in EBV-B Cell Lines from Expression of Endoplasmic Reticulum and Patrizio

S. Ferracuti, Oliver Carroll, P. Endert, 2006 .

Expression of Endoplasmic Reticulum Aminopeptidases in EBV-B Cell Lines from Healthy Donors and in Leukemia/Lymphoma, Carcinoma, and Melanoma Cell Lines1

S. Ferracuti, P. van Endert, Oliver Carroll, 2006, The Journal of Immunology.

Expression of placental leucine aminopeptidase/oxytocinase in neuronal cells and its action on neuronal peptides.

S. Mizutani, M. Tsujimoto, N. Tsuruoka, 2001, European journal of biochemistry.

New insights into the importance of aminopeptidase A in hypertension

T. Murohara, S. Mizutani, Y. Numaguchi, 2007, Heart Failure Reviews.

Prediction and determination of the stereochemistry of the 1,3,5-trimethyl-substituted alkyl chain in verucopeptin, a microbial metabolite.

H. Kakeya, S. Nishimura, Y. Sakai, 2014, The Journal of organic chemistry.

Essential role of placental leucine aminopeptidase in gynecologic malignancy

S. Mizutani, F. Kikkawa, M. Tsujimoto, 2007, Expert opinion on therapeutic targets.

pH-sensitive DNA cleaving agents: in situ activation by ring contraction of benzo-fused cyclobutanols.

H. Kakeya, K. Takasu, Y. Takemoto, 2013, Chemical communications.

Distribution of Adipocyte-derived Leucine Aminopeptidase (A-LAP)/ER-aminopeptidase (ERAP)-1 in Human Uterine Endometrium

H. Ando, A. Iwase, S. Mizutani, 2004, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

Design, synthesis, and structure-activity relationships of 1-ethylpyrazole-3-carboxamide compounds as novel hypoxia-inducible factor (HIF)-1 inhibitors.

N. Fujii, S. Oishi, H. Kakeya, 2015, Bioorganic & medicinal chemistry.

Bone Morphogenetic Protein‐2 Promotes Survival and Differentiation of Striatal GABAergic Neurons in the Absence of Glial Cell Proliferation

M. Kohno, M. Tsujimoto, A. Hattori, 1999, Journal of neurochemistry.

Multiple NF‐Y‐binding CCAAT boxes are essential for transcriptional regulation of the human C7orf24 gene, a novel tumor‐associated gene

H. Kakeya, S. Kageyama, M. Ueda, 2011, The FEBS journal.

Regulation of the human leukocyte‐derived arginine aminopeptidase endoplasmic reticulum‐aminopeptidase 2 gene by interferon‐γ

S. Mizutani, M. Tsujimoto, T. Tanioka, 2005, The FEBS journal.

Physiological roles of M1 aminopeptidase family

M. Tsujimoto, A. Hattori, 2006 .

Involvement of the V2 receptor in vasopressin-stimulated translocation of placental leucine aminopeptidase/oxytocinase in renal cells.

S. Mizutani, M. Tsujimoto, Y. Natori, 2003, European journal of biochemistry.

Cutting Edge: Coding Single Nucleotide Polymorphisms of Endoplasmic Reticulum Aminopeptidase 1 Can Affect Antigenic Peptide Generation In Vitro by Influencing Basic Enzymatic Properties of the Enzyme

P. Voulgari, A. Drosos, M. Tsujimoto, 2011, The Journal of Immunology.

Enzymatic Properties of the Enzyme Generation In Vitro by Influencing Basic Aminopeptidase 1 Can Affect Antigenic Peptide Polymorphisms of Endoplasmic Reticulum Cutting Edge: Coding Single Nucleotide

A. Drosos, M. Tsujimoto, I. York, 2011 .

Basic Enzymatic Properties of the Enzyme Peptide Generation In Vitro by Influencing Aminopeptidase 1 Can Affect Antigenic Polymorphisms of Endoplasmic Reticulum Cutting Edge: Coding Single Nucleotide

P. Voulgari, A. Drosos, M. Tsujimoto, 2011 .

Physiological and pathophysiological roles of placental aminopeptidase in maternal sera: possible relation to preeclampsia and preterm delivery.

S. Mizutani, M. Tsujimoto, Hiroshi Kobayashi, 2009, Expert opinion on medical diagnostics.

Laeverin/Aminopeptidase Q, a Novel Bestatin-sensitive Leucine Aminopeptidase Belonging to the M1 Family of Aminopeptidases*

M. Tsujimoto, H. Fujiwara, M. Maeda, 2007, Journal of Biological Chemistry.

The oxytocinase subfamily of M1 aminopeptidases.

M. Tsujimoto, A. Hattori, 2005, Biochimica et biophysica acta.

Characterization of recombinant human adipocyte-derived leucine aminopeptidase expressed in Chinese hamster ovary cells.

S. Mizutani, M. Tsujimoto, N. Tsuruoka, 2000, Journal of biochemistry.

Expression of Adipocyte-Derived Leucine Aminopeptidase in Endometrial Cancer

H. Kajiyama, S. Mizutani, F. Kikkawa, 2003, Tumor Biology.

Tumor necrosis factor stimulates the synthesis and secretion of biologically active nerve growth factor in non-neuronal cells.

M. Kohno, Y. Chatani, M. Tsujimoto, 1993, The Journal of biological chemistry.

Tumor necrosis factor (TNF) stimulates the production of nerve growth factor in fibroblasts via the 55‐kDa type 1 TNF receptor

M. Kohno, A. Hattori, K. Hayashi, 1996, FEBS letters.

CD9 suppresses human extravillous trophoblast invasion.

I. Konishi, H. Fujiwara, Y. Araki, 2016, Placenta.

Distribution and Characterization of Specific Cellular Binding Proteins for Bone Morphogenetic Protein-2 (*)

M. Kohno, M. Tsujimoto, N. Tsuruoka, 1995, The Journal of Biological Chemistry.

Role of glutamine-169 in the substrate recognition of human aminopeptidase B.

M. Tsujimoto, A. Ohnishi, Y. Sakuma, 2014, Biochimica et biophysica acta.

Glutamine-181 is crucial in the enzymatic activity and substrate specificity of human endoplasmic-reticulum aminopeptidase-1.

M. Tsujimoto, H. Tanji, A. Hattori, 2008, The Biochemical journal.

Biochemical and enzymatic properties of the M1 family of aminopeptidases involved in the regulation of blood pressure

M. Tsujimoto, A. Hattori, M. Maruyama, 2008, Heart Failure Reviews.

Adipocyte-derived leucine aminopeptidase suppresses angiogenesis in human endometrial carcinoma via renin-angiotensin system.

H. Kajiyama, S. Mizutani, F. Kikkawa, 2003, Clinical cancer research : an official journal of the American Association for Cancer Research.

Exon 10 coding sequence is important for endoplasmic reticulum retention of endoplasmic reticulum aminopeptidase 1.

M. Tsujimoto, A. Hattori, Yoshikuni Goto, 2012, Biological & pharmaceutical bulletin.

Promoting Roles of Embryonic Signals in Embryo Implantation and Placentation in Cooperation with Endocrine and Immune Systems

K. Imakawa, H. Fujiwara, Y. Araki, 2020, International journal of molecular sciences.

Reduced activity of the hypertension‐associated Lys528Arg mutant of human adipocyte‐derived leucine aminopeptidase (A‐LAP)/ER‐aminopeptidase‐1

M. Tsujimoto, A. Hattori, Yoshikuni Goto, 2006, FEBS letters.

Structure and biological activity of 8-deoxyheronamide C from a marine-derived Streptomyces sp.: heronamides target saturated hydrocarbon chains in lipid membranes.

N. Matsumori, Y. Tsunematsu, H. Kakeya, 2014, Journal of the American Chemical Society.

Chemical tagging of a drug target using 5-sulfonyl tetrazole.

H. Kakeya, S. Nishimura, Y. Sakai, 2013, Bioorganic & medicinal chemistry letters.

Tumescenamide C, an antimicrobial cyclic lipodepsipeptide from Streptomyces sp.

Y. Tsunematsu, H. Kakeya, S. Nishimura, 2012 .

Molecular cloning of adipocyte-derived leucine aminopeptidase highly related to placental leucine aminopeptidase/oxytocinase.

S. Mizutani, M. Tsujimoto, A. Hattori, 1999, Journal of biochemistry.

Human Leukocyte-derived Arginine Aminopeptidase THE THIRD MEMBER OF THE OXYTOCINASE SUBFAMILY OF AMINOPEPTIDASES*

S. Mizutani, H. Nakayama, M. Tsujimoto, 2003 .

Expression, purification and enzymatic characterization of a recombinant human ubiquitin-specific protease 47.

H. Kakeya, A. Hattori, Y. Aoki, 2015, Journal of biochemistry.

Association of epigenetic alterations in the human C7orf24 gene with the aberrant gene expression in malignant cells.

H. Kakeya, A. Hattori, T. Yoshiki, 2013, Journal of biochemistry.

Structural Changes in the Glycosaminoglycan Chain of Rat Skin Decorin with Growth

M. Tsujimoto, M. Watanabe, Y. Nomura, 2003, The Journal of dermatology.

Laeverin/aminopeptidase Q induces trophoblast invasion during human early placentation.

I. Konishi, H. Fujiwara, A. Horie, 2012, Human reproduction.

Tumor necrosis factor is markedly synergistic with interleukin 1 and interferon‐γ in stimulating the production of nerve growth factor in fibroblasts

M. Kohno, M. Tsujimoto, Masahiro Sato, 1994, FEBS letters.

Hepatocyte growth factor rapidly induces the tyrosine phosphorylation of 41-kDa and 43-kDa proteins in mouse keratinocytes.

T. Nakamura, M. Kohno, Y. Chatani, 1992, Biochemical and biophysical research communications.

Expression of Placental Leucine Aminopeptidase and Adipocyte-Derived Leucine Aminopeptidase in Human Normal and Malignant Invasive Trophoblastic Cells

H. Kajiyama, S. Mizutani, F. Kikkawa, 2003, Laboratory Investigation.

The Arabidopsis aminopeptidase LAP2 regulates plant growth, leaf longevity and stress response.

R. Rakwal, M. Tsujimoto, T. Takabe, 2011, The New phytologist.

Immunoaffinity purification and characterization of native placental leucine aminopeptidase/oxytocinase from human placenta.

F. Kikkawa, T. Ito, M. Tsujimoto, 2000, Placenta.

Structure Elucidation of Verucopeptin, a HIF-1 Inhibitory Polyketide-Hexapeptide Hybrid Metabolite from an Actinomycete.

H. Kakeya, S. Nishimura, A. Hattori, 2015, Organic letters.

New insights into the role of aminopeptidases in the treatment for both preeclampsia and preterm labor

S. Mizutani, M. Tsujimoto, Hiroshi Kobayashi, 2013, Expert opinion on investigational drugs.

Endoplasmic reticulum aminopeptidase-1 mediates leukemia inhibitory factor-induced cell surface human leukocyte antigen-G expression in JEG-3 choriocarcinoma cells.

S. Mizutani, F. Kikkawa, A. Itakura, 2006, Endocrinology.

An IFN-γ–induced aminopeptidase in the ER, ERAP1, trims precursors to MHC class I–presented peptides

Akira Hattori, A. Goldberg, K. Rock, 2002, Nature Immunology.

Characterization of a recombinant soluble form of human placental leucine aminopeptidase/oxytocinase expressed in Chinese hamster ovary cells.

S Mizutani, S. Mizutani, M. Tsujimoto, 2000, European journal of biochemistry.

The effect of recombinant aminopeptidase A (APA) on hypertension in pregnant spontaneously hypertensive rats (SHRs).

T. Murohara, Y. Numaguchi, M. Tsujimoto, 2009, Early human development.

Substrate-dependent nitric oxide synthesis by secreted endoplasmic reticulum aminopeptidase 1 in macrophages.

K. Ogawa, M. Tsujimoto, A. Hattori, 2015, Journal of biochemistry.

Characterization of the Bone Morphogenetic Protein-2 as a Neurotrophic Factor

M. Kohno, M. Tsujimoto, M. Sato, 1996, The Journal of Biological Chemistry.

Cell Type-specific Modulation of Cell Growth by Transforming Growth Factor β1 Does Not Correlate with Mitogen-activated Protein Kinase Activation (*)

M. Kohno, Y. Chatani, Masahiro Sato, 1995, The Journal of Biological Chemistry.

Asparatic Acid 221 Is Critical in the Calcium-induced Modulation of the Enzymatic Activity of Human Aminopeptidase A*

S. Mizutani, M. Tsujimoto, A. Hattori, 2007, Journal of Biological Chemistry.

Enzymatic Properties of Human Aminopeptidase A

S. Mizutani, M. Tsujimoto, A. Hattori, 2006, Journal of Biological Chemistry.

Human Leukocyte-derived Arginine Aminopeptidase

S. Mizutani, H. Nakayama, M. Tsujimoto, 2003, Journal of Biological Chemistry.

Processing of antigenic peptides by aminopeptidases.

M. Tsujimoto, A. Hattori, 2004, Biological & pharmaceutical bulletin.

Secretion of Endoplasmic Reticulum Aminopeptidase 1 Is Involved in the Activation of Macrophages Induced by Lipopolysaccharide and Interferon-γ*

K. Ogawa, M. Tsujimoto, A. Hattori, 2011, The Journal of Biological Chemistry.

Genomic organization of the human adipocyte-derived leucine aminopeptidase gene and its relationship to the placental leucine aminopeptidase/oxytocinase gene.

K. Matsumoto, S. Mizutani, M. Tsujimoto, 2001, Journal of biochemistry.

Endoplasmic reticulum aminopeptidases: biochemistry, physiology and pathology.

M. Tsujimoto, A. Hattori, 2013, Journal of biochemistry.

Histidine 379 of Human Laeverin/Aminopeptidase Q, a Nonconserved Residue within the Exopeptidase Motif, Defines Its Distinctive Enzymatic Properties*

M. Tsujimoto, H. Inoue, H. Fujiwara, 2009, The Journal of Biological Chemistry.

Acute-phase protein-like properties of endoplasmic reticulum aminopeptidase 1

K. Ogawa, M. Tsujimoto, A. Hattori, 2018, Journal of biochemistry.

Isolation, Structure Elucidation, and Conformational Regulation of Myropeptins, Lipopeptides from the Fungus Myrothecium roridum.

Takehiro Suzuki, N. Dohmae, H. Kakeya, 2019, Organic letters.

Factors Regulating Human Extravillous Trophoblast Invasion: Chemokine-peptidase and CD9-integrin Systems.

K. Imakawa, Y. Maida, Y. Mizumoto, 2018, Current pharmaceutical biotechnology.

The effects of 5‐OP‐RU stereochemistry on its stability and MAIT‐MR1 axis

S. Yamasaki, H. Ohno, S. Oishi, 2020, Chembiochem : a European journal of chemical biology.

Chlorocatechelins A and B from Streptomyces sp.: new siderophores containing chlorinated catecholate groups and an acylguanidine structure.

M. Tsujimoto, H. Kakeya, S. Nishimura, 2014, Organic letters.

JB Review Endoplasmic reticulum aminopeptidases: biochemistry, physiology and pathology

M. Tsujimoto, A. Hattori, 2013 .

Stimulation of nerve growth factor synthesis/secretion in mouse astroglial cells by coenzymes.

A. Hattori, K. Hayashi, M. Kohno, 1993, Biochemistry and molecular biology international.

Aminopeptidase Q/Laeverin

M. Tsujimoto, H. Fujiwara, A. Hattori, 2013 .

Involvement of Phenylalanine 297 in the Construction of the Substrate Pocket of Human Aminopeptidase B.

M. Tsujimoto, A. Ohnishi, A. Hattori, 2015, Biochemistry.

TLR-Mediated Secretion of Endoplasmic Reticulum Aminopeptidase 1 from Macrophages

K. Ogawa, M. Tsujimoto, A. Hattori, 2014, The Journal of Immunology.

Probing the S1 specificity pocket of the aminopeptidases that generate antigenic peptides.

G. Salvesen, D. Vourloumis, L. Swevers, 2011, The Biochemical journal.

Reciprocal Expression Patterns of Placental Leucine Aminopeptidase/Insulin-Regulated Aminopeptidase and Vasopressin in the Murine Brain

K. Ogawa, M. Tsujimoto, A. Hattori, 2020, Frontiers in Molecular Biosciences.

Enzymatic Properties of Human Aminopeptidase A: REGULATION OF ITS ENZYMATIC ACTIVITY BY CALCIUM AND ANGIOTENSIN IV

S. Mizutani, M. Tsujimoto, A. Hattori, 2006 .

Role of the Arabidopsis leucine aminopeptidase 2

R. Rakwal, M. Tsujimoto, T. Takabe, 2011, Plant signaling & behavior.

Ubiquitin carboxyl‐terminal hydrolase L1 promotes hypoxia‐inducible factor 1‐dependent tumor cell malignancy in spheroid models

Senye Takahashi, H. Kakeya, H. Harada, 2019, Cancer science.

Mitogen-induced tyrosine phosphorylation of 41 kDa and 43 kDa proteins. Potential role in integrating multiple mitogenic signalling pathways.

M. Kohno, Y. Chatani, A. Hattori, 1992, The Biochemical journal.

Spheroid formation induces chemokine production in trophoblast‐derived Swan71 cells

T. Daikoku, R. Yamazaki, Ayumi Matsuoka, 2023, American journal of reproductive immunology.

Isolation, structure elucidation, and total synthesis of tryptopeptins A and B, new TGF-β signaling modulators from Streptomyces sp.

N. Fujii, S. Oishi, Y. Tsunematsu, 2015, Organic Letters.

Isolation, Structure Elucidation, and Total Synthesis of Tryptopeptins A and B, New TGF‐β Signaling Modulators from Streptomyces sp.

N. Fujii, S. Oishi, Y. Tsunematsu, 2015 .

Enzymatic Properties of the Enzyme Peptide Generation In Vitro by Influencing Aminopeptidase 1 Can Affect Antigenic Polymorphisms of Endoplasmic Reticulum Cutting Edge : Coding Single Nucleotide Amalfitano

P. Voulgari, A. Drosos, M. Tsujimoto, 2011 .

Substrate-dependent nitric oxide synthesis by secreted endoplasmic reticulum aminopeptidase 1 in macrophages.

K. Ogawa, M. Tsujimoto, A. Hattori, 2015, Journal of biochemistry.

Macrophages Reticulum Aminopeptidase 1 from Tlr-mediated Secretion of Endoplasmic

K. Ogawa, M. Tsujimoto, A. Hattori, 2022 .

Design, synthesis, and target identification of new hypoxia-inducible factor 1 (HIF-1) inhibitors containing 1-alkyl-1H-pyrazole-3-carboxamide moiety.

S. Kojima, Takehiro Suzuki, N. Dohmae, 2021, Bioorganic & medicinal chemistry.

Expression, purification and enzymatic characterization of a recombinant human ubiquitin-specific protease 47.

H. Kakeya, A. Hattori, Y. Aoki, 2015, Journal of biochemistry.