R. Frötschl

发表

A systems pharmacology approach to improve drug therapy in NSCLC: establishing a CESAR network.

H. Fröhlich, W. Jäger, M. Michaelis, 2014, International journal of clinical pharmacology and therapeutics.

IWGT report on quantitative approaches to genotoxicity risk assessment II. Use of point-of-departure (PoD) metrics in defining acceptable exposure limits and assessing human risk.

J. T. Macgregor, D. Eastmond, P. White, 2015, Mutation research. Genetic toxicology and environmental mutagenesis.

Knowledge-based approach to identify key determinants of cisplatin sensitivity .

H. Fröhlich, M. Michaelis, J. Cinatl, 2017, International journal of clinical pharmacology and therapeutics.

Development and validation of a high-throughput transcriptomic biomarker to address 21st century genetic toxicology needs

Jiri Aubrecht, Andrew Williams, Carole L. Yauk, 2017, Proceedings of the National Academy of Sciences.

N-Nitrosodimethylamine-Contaminated Valsartan and the Risk of Cancer-A Longitudinal Cohort Study Based on German Health Insurance Data.

K. Broich, B. Haenisch, H. Schröder, 2021, Deutsches Arzteblatt international.

Induction of CYP1A by various benzimidazoles and its significance in administrative drug regulation.

J. Brockmöller, I. Roots, K. Ruckpaul, 1999, Drug metabolism reviews.

Integrated Genotoxicity Testing of three anti-infective drugs using the TGx-DDI transcriptomic biomarker and high-throughput CometChip® assay in TK6 cells

A. Fornace, C. Yauk, S. Pettit, 2022, Frontiers in Toxicology.

Purification of Antiviral Proteins with Ribosome-Inactivating Properties from Plants

G. Adam, R. Frötschl, K. Mundry, 1992 .

Inhibition of the PI3K but not the MEK/ERK pathway sensitizes human glioma cells to alkylating drugs

Christina Keksel, M. Timmer, N. Eckstein, 2018, Cancer Cell International.

Effects of chlorpromazine with and without UV irradiation on gene expression of HepG2 cells.

P. Kasper, G. Kaufmann, R. Frötschl, 2005, Mutation research.

Is sunitinib a Narrow Therapeutic Index Drug? - A systematic review and in vitro toxicology-analysis of Sunitinib vs. Imatinib in cells from different tissues.

N. Eckstein, B. Haas, R. Frötschl, 2016, Regulatory toxicology and pharmacology : RTP.

TGx-DDI, a Transcriptomic Biomarker for Genotoxicity Hazard Assessment of Pharmaceuticals and Environmental Chemicals

Jiri Aubrecht, Carole L. Yauk, Syril Pettit, 2019, Front. Big Data.

Key Players of Cisplatin Resistance: Towards a Systems Pharmacology Approach

H. Fröhlich, M. Michaelis, J. Cinatl, 2018, International journal of molecular sciences.

Cisplatin resistance in non-small cell lung cancer cells is associated with an abrogation of cisplatin-induced G2/M cell cycle arrest

M. Michaelis, J. Cinatl, U. Jaehde, 2017, PloS one.

Beet yellows closterovirus: complete genome structure and identification of a leader papain-like thiol protease.

E. Koonin, E. Maiss, J. Atabekov, 1994, Virology.

Polymorphisms of drug-metabolizing enzymes CYP2C9, CYP2C19, CYP2D6, CYP1A1, NAT2 and of P-glycoprotein in a Russian population

J. Brockmöller, I. Roots, I. Cascorbi, 2003, European Journal of Clinical Pharmacology.

Prediction of aryl hydrocarbon receptor-mediated enzyme induction of drugs and chemicals by mRNA quantification.

J. Brockmöller, I. Roots, R. Frötschl, 1998, Chemical research in toxicology.

IWGT report on quantitative approaches to genotoxicity risk assessment I. Methods and metrics for defining exposure-response relationships and points of departure (PoDs).

J. T. Macgregor, D. Eastmond, P. White, 2015, Mutation research. Genetic toxicology and environmental mutagenesis.

The rat bone marrow micronucleus test: Statistical considerations on historical negative control data

Roland Frötschl, Volker Harm, Rupert Kellner, 2019, Regulatory toxicology and pharmacology : RTP.

The EU Response to the Presence of Nitrosamine Impurities in Medicines

M. Weise, T. Girard, R. Whomsley, 2021, Frontiers in Medicine.

In vitro genotoxicity test approaches with better predictivity: summary of an IWGT workshop.

A. Elhajouji, J. van Benthem, R. Corvi, 2011, Mutation research.

Experiences with the in vivo and in vitro comet assay in regulatory testing.

R. Frötschl, 2015, Mutagenesis.

Studies on the function of antiviral plant proteins

G. Adam, R. Frötschl, M. Schönfelder, 1990 .

Time-matched analysis of DNA adduct formation and early gene expression as predictive tool for renal carcinogenesis in methylazoxymethanol acetate treated Eker rats

D. Dietrich, H. Ellinger-Ziegelbauer, J. Swenberg, 2017, Archives of Toxicology.

Genotoxicity Assessment in E-cigarette Consumers, Cigarette Smokers and Non-smokers- a pilot study

U. Deppenmeier, G. Johnson, C. Ziemann, 2022 .

Do Carcinogens Have a Threshold Dose? The Pros and Cons

J. Hengstler, Adam D. Thomas, B. Kaina, 2021, Regulatory Toxicology.

Next Generation Sequencing Workshop at the Royal Society of Medicine (London, May 2022): How genomics is on the path to modernizing Genetic Toxicology.

I. Martincorena, K. Witt, J. Kucab, 2023, Mutagenesis.

The In Vivo Comet Assay Test

Marie Z. Vasquez, R. Frötschl, 2016 .

NSCLC cells adapted to EGFR inhibition accumulate EGFR interacting proteins and down-regulate microRNA related to epithelial-mesenchymal transition.

H. Fröhlich, W. Jäger, M. Michaelis, 2014, International journal of clinical pharmacology and therapeutics.

Experiences with the in vivo and in vitro comet assay in regulatory testing.

R. Frötschl, 2015, Mutagenesis.

In vivo alkaline comet assay: Statistical considerations on historical negative and positive control data.

S. Pfuhler, Marie Z. Vasquez, R. Frötschl, 2024, Regulatory toxicology and pharmacology : RTP.