Masayuki Ii

发表

TAK-242 selectively suppresses Toll-like receptor 4-signaling mediated by the intracellular domain.

T. Kawamoto, H. Kimura, Masayuki Ii, 2008, European journal of pharmacology.

A Novel Cyclohexene Derivative, Ethyl (6R)-6-[N-(2-Chloro-4-fluorophenyl)sulfamoyl]cyclohex-1-ene-1-carboxylate (TAK-242), Selectively Inhibits Toll-Like Receptor 4-Mediated Cytokine Production through Suppression of Intracellular Signaling

O. Hazeki, T. Seya, K. Hazeki, 2006, Molecular Pharmacology.

NF-κB-Inducing Kinase Regulates Selected Gene Expression in the Nod2 Signaling Pathway

D. Goeddel, Shuang Huang, R. Schreiber, 2006, Infection and Immunity.

Analysis of binding site for the novel small‐molecule TLR4 signal transduction inhibitor TAK‐242 and its therapeutic effect on mouse sepsis model

T. Kaisho, O. Hazeki, M. Yoshimatsu, 2009, British journal of pharmacology.

Discovery of novel and potent small-molecule inhibitors of NO and cytokine production as antisepsis agents: synthesis and biological activity of alkyl 6-(N-substituted sulfamoyl)cyclohex-1-ene-1-carboxylate.

M. Yamada, T. Ichikawa, Masayuki Ii, 2005, Journal of medicinal chemistry.

Combination of Imipenem and TAK-242, a Toll-Like Receptor 4 Signal Transduction Inhibitor, Improves Survival in a Murine Model of Polymicrobial Sepsis

Masayuki Ii, Y. Iizawa, T. Sha, 2011, Shock.

Novel cyclohexene derivatives as anti-sepsis agents: synthetic studies and inhibition of NO and cytokine production.

M. Yamada, T. Ichikawa, Masayuki Ii, 2008, Bioorganic & medicinal chemistry.

TAK-242 (Resatorvid), a Small-Molecule Inhibitor of Toll-Like Receptor (TLR) 4 Signaling, Binds Selectively to TLR4 and Interferes with Interactions between TLR4 and Its Adaptor Molecules

N. Tsuchimori, Tatsumi Matsumoto, Masayuki Ii, 2011, Molecular Pharmacology.

A randomized, double-blind, placebo-controlled trial of TAK-242 for the treatment of severe sepsis*

Jon Cohen, G. Bernard, J. Vincent, 2010, Critical care medicine.

Effect of Toll-like receptor 4 inhibitor on LPS-induced lung injury

J. Takeda, H. Seki, K. Fukunaga, 2010, Inflammation Research.

NF-kappa B-inducing kinase regulates selected gene expression in the Nod2 signaling pathway.

D. Goeddel, Shuang Huang, R. Schreiber, 2006, Infection and immunity.

Therapeutic effects of TAK-242, a novel selective Toll-like receptor 4 signal transduction inhibitor, in mouse endotoxin shock model.

Masayuki Ii, T. Kitazaki, Y. Iizawa, 2007, European journal of pharmacology.

Analysis of binding site for the novel small‐molecule TLR4 signal transduction inhibitor TAK‐242 and its therapeutic effect on mouse sepsis model

T. Kaisho, O. Hazeki, M. Yoshimatsu, 2009, British journal of pharmacology.