Takumi Aoki

发表

Structure-activity relationship studies of 3-substituted pyrazoles as novel allosteric inhibitors of MALT1 protease.

Kazuyuki Tokumaru, A. Watanabe, Yohei Adachi, 2021, Bioorganic & medicinal chemistry letters.

Nrf2 Activators Attenuate the Progression of Nonalcoholic Steatohepatitis–Related Fibrosis in a Dietary Rat Model

M. Yamada, Y. Asaoka, H. Noda, 2013, Molecular Pharmacology.

Design and synthesis of novel p38α MAP kinase inhibitors: discovery of pyrazole-benzyl ureas bearing 2-molpholinopyrimidine moiety.

M. Ohno, Yoko Koga, H. Meguro, 2012, Bioorganic & medicinal chemistry letters.

Discovery of novel 7-membered cyclic amide derivatives that inhibit 11beta-hydroxysteroid dehydrogenase type 1.

S. Okazaki, Shuji Udagawa, Takumi Aoki, 2013, Bioorganic & medicinal chemistry letters.

Discovery of 1-oxa-4,9-diazaspiro[5.5]undecane-based trisubstituted urea derivatives as highly potent soluble epoxide hydrolase inhibitors and orally active drug candidates for treating of chronic kidney diseases.

M. Yamada, Y. Kato, H. Kigoshi, 2014, Bioorganic & medicinal chemistry letters.

Discovery of 2,8-diazaspiro[4.5]decane-based trisubstituted urea derivatives as highly potent soluble epoxide hydrolase inhibitors and orally active drug candidates for treating hypertension.

M. Yamada, Y. Kato, Takumi Aoki, 2013, Bioorganic & medicinal chemistry letters.

Structure-antitussive activity relationships of naltrindole derivatives. Identification of novel and potent antitussive agents.

J. Kamei, S. Ueno, H. Nagase, 2008, Journal of medicinal chemistry.

Design and synthesis of a metabolically stable and potent antitussive agent, a novel delta opioid receptor antagonist, TRK-851.

H. Ohno, S. Ueno, H. Nagase, 2008, Bioorganic & Medicinal Chemistry.

Discovery of orally bioavailable inhibitors of MALT1 with in vivo activity for psoriasis.

Kazuyuki Tokumaru, Yasufumi Goto, Takumi Aoki, 2023, Bioorganic & medicinal chemistry letters.

A Novel MitoNEET Ligand, TT01001, Improves Diabetes and Ameliorates Mitochondrial Function in db/db Mice

J. Hayashi, K. Nakada, M. Kainoh, 2015, The Journal of Pharmacology and Experimental Therapeutics.

Multiple binding modes of a small molecule to human Keap1 revealed by X-ray crystallography and molecular dynamics simulation

H. Naitow, N. Kunishima, Y. Matsuura, 2015, FEBS open bio.

A Novel MitoNEET Ligand, TT01001, Improves Diabetes and Ameliorates Mitochondrial Function in db/db Mice

J. Hayashi, K. Nakada, M. Kainoh, 2015, The Journal of Pharmacology and Experimental Therapeutics.