R. Simmonds

发表

NF-κ B and its relevance to arthritis and inflammation

B. Foxwell, R. Simmonds, 2012 .

phospholipid binding and severe functional protein S deficiency Protein S Gla-domain mutations causing impaired Ca2+-induced

S. Rezende, D. Lane, J. Conard, 2013 .

Protein S Gla-domain mutations causing impaired Ca(2+)-induced phospholipid binding and severe functional protein S deficiency.

S. Rezende, D. Lane, J. Conard, 2002, Blood.

TLR Signalling and Adapter Utilization in Primary Human In vitro Differentiated Adipocytes

M. Feldmann, R. Simmonds, C. Brenner, 2012, Scandinavian journal of immunology.

Buruli Ulcer: a Review of the Current Knowledge

A. Ablordey, R. Phillips, K. Asiedu, 2018, Current Tropical Medicine Reports.

Mycolactone enhances the Ca leak from endoplasmic reticulum by trapping Sec61 translocons in a Ca permeable state

A. Cavalié, V. Helms, B. Hall, 2021 .

Mycolactone enhances the Ca2+ leak from endoplasmic reticulum by trapping Sec61 translocons in a Ca2+ permeable state

A. Cavalié, V. Helms, B. Hall, 2021, bioRxiv.

Inhibition of the SEC61 translocon by mycolactone induces a protective autophagic response controlled by EIF2S1-dependent translation that does not require ULK1 activity

N. Ktistakis, B. Hall, G. Pluschke, 2021, Autophagy.

Inhibition of Sec61-dependent translocation by mycolactone uncouples the integrated stress response from ER stress, driving cytotoxicity via translational activation of ATF4

J. Taunton, B. Hall, R. Wek, 2018, Cell Death & Disease.

Inhibition of Sec 61-dependent translocation by mycolactone 1 uncouples the integrated stress response from ER stress , driving 2 cytotoxicity via translational activation of ATF 4 3 4

J. Taunton, B. Hall, A. Willis, 2018 .

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1

Mark R. Marten, Erinna F. Lee, Dana L. Miller, 2021, Autophagy.

Inhibitors of TLR8 Reduce TNF Production from Human Rheumatoid Synovial Membrane Cultures1

M. Feldmann, F. Brennan, B. Foxwell, 2008, The Journal of Immunology.

Membrane Cultures from Human Rheumatoid Synovial Inhibitors of TLR8 Reduce TNF Production

M. Feldmann, F. Brennan, B. Foxwell, 2008 .

Structure of the Inhibited State of the Sec Translocon

P. Biggin, B. Hall, P. Mayerhofer, 2020, Molecular cell.

Aberrant stromal tissue factor localisation and mycolactone-driven vascular dysfunction, exacerbated by IL-1β, are linked to fibrin formation in Buruli ulcer lesions

B. Hall, G. Pluschke, L. T. Hsieh, 2022, PLoS pathogens.

Haemostatic Genetic Risk Factors in Arterial Thrombosis

S. Rezende, D. Lane, J. Hermida, 2001, Thrombosis and Haemostasis.

Mycolactone-Dependent Depletion of Endothelial Cell Thrombomodulin Is Strongly Associated with Fibrin Deposition in Buruli Ulcer Lesions

C. Esmon, B. Hall, Hua-Lin Wu, 2015, PLoS pathogens.

Ipomoeassin F Binds Sec61α to Inhibit Protein Translocation

James Inglese, S. High, C. Demangel, 2019, Journal of the American Chemical Society.

Coagulation, inflammation, and apoptosis: different roles for protein S and the protein S-C4b binding protein complex.

S. Rezende, D. Lane, R. Simmonds, 2004, Blood.

Structural and Functional Implications of the Intron/Exon Organization of the Human Endothelial Cell Protein C/Activated Protein C Receptor (EPCR) Gene: Comparison With the Structure of CD1/Major Histocompatibility Complex 1 and 2 Domains

D. Lane, Rachel E. Simmonds, David A. Lane, 1999, Blood.

Genetic and phenotypic analysis of a large (122-member) protein S-deficient kindred provides an explanation for the familial coexistence of type I and type III plasma phenotypes.

B. Dahlbäck, D. Lane, H. Ireland, 1997, Blood.

Signalling, inflammation and arthritis: NF-kappaB and its relevance to arthritis and inflammation.

B. Foxwell, R. Simmonds, 2008, Rheumatology.

Pleiotropic molecular effects of the Mycobacterium ulcerans virulence factor mycolactone underlying the cell death and immunosuppression seen in Buruli ulcer.

Rachel Simmonds, B. Hall, Belinda Hall, 2014, Biochemical Society transactions.

Recent advances: role of mycolactone in the pathogenesis and monitoring of Mycobacterium ulcerans infection/Buruli ulcer disease

F. Sarfo, R. Phillips, M. Wansbrough-Jones, 2015, Cellular microbiology.

The One That Got Away: How Macrophage-Derived IL-1β Escapes the Mycolactone-Dependent Sec61 Blockade in Buruli Ulcer

B. Hall, S. Sacre, L. T. Hsieh, 2022, Frontiers in Immunology.

Mycobacterium ulcerans and Buruli Ulcer

B. Hall, M. Benbow, L. Mosi, 2015 .

Mycolactone causes catastrophic Sec61-dependent loss of the endothelial glycocalyx and basement membrane: a new indirect mechanism driving tissue necrosis in Mycobacterium ulcerans infection

B. Hall, Y. Umrania, M. Deery, 2023, bioRxiv.

Clarification of the Risk for Venous Thrombosis Associated with Hereditary Protein S Deficiency by Investigation of a Large Kindred with a Characterized Gene Defect

B. Dahlbäck, P. García de Frutos, D. Lane, 1998, Annals of Internal Medicine.

Scientific and Standardization Committee Communication Protein S Deficiency: A Database of Mutations - FIRST UPDATE For the Plasma Coagulation Inhibitors Subcommittee of the Scientific and Standardization Committee of the International Society on Thrombosis and Haemostasis

F. Bernardi, Y. Espinosa-Parrilla, S. Rezende, 2000 .

and the protein S-C4b binding protein complex Coagulation, inflammation, and apoptosis: different roles for protein S

S. Rezende, D. Lane, R. Simmonds, 2013 .

Identification of 19 protein S gene mutations in patients with phenotypic protein S deficiency and thrombosis. Protein S Study Group.

D. Lane, H. Ireland, R. Simmonds, 1996, Blood.

Regulation of the human endothelial cell protein C receptor gene promoter by multiple Sp1 binding sites.

G. Follows, C. Bonifer, P. Cockerill, 2003, Blood.

Transient up-regulation of miR-155-3p by lipopolysaccharide in primary human monocyte-derived macrophages results in RISC incorporation but does not alter TNF expression

R. Simmonds, 2019, Wellcome open research.

Transient up-regulation of miR-155-3p by lipopolysaccharide in primary human monocyte-derived macrophages results in RISC incorporation but does not alter TNF expression.

R. Simmonds, 2019, Wellcome open research.

Molecular diversity and thrombotic risk in protein S deficiency: The PROSIT study

M. Margaglione, P. Bucciarelli, G. Castaman, 2005, Human mutation.

Genetic and Phenotypic Variability between Families with Hereditary Protein S Deficiency

B. Dahlbäck, M. Laffan, S. Rezende, 2002, Thrombosis and Haemostasis.

The Pathogenic Mechanism of the Mycobacterium ulcerans Virulence Factor, Mycolactone, Depends on Blockade of Protein Translocation into the ER

Michael McKenna, Anne E. Willis, S. High, 2014, PLoS pathogens.

Mycolactone Inhibits Monocyte Cytokine Production by a Posttranscriptional Mechanism1

B. Foxwell, P. Small, T. Smallie, 2009, The Journal of Immunology.

Mechanistic insights into the inhibition of Sec61-dependent co- and post-translational translocation by mycolactone

Michael McKenna, S. High, Rachel E. Simmonds, 2016, Journal of Cell Science.

Synthesis, Biological Evaluation and Docking Studies of Ring-Opened Analogues of Ipomoeassin F

S. High, V. Helms, B. Hall, 2022, Molecules.

Biology-directed and in silico -aided design liberates a potent, simplified and ipomoeassin-F-derived Sec61 inhibitor

S. High, V. Helms, B. Hall, 2022 .

The Endothelial Cell Protein C Receptor: A Candidate Genetic Risk Factor for Thrombosis

D. Lane, R. Simmonds, 2001, Thrombosis and Haemostasis.

Educating Students for the Collaborative Workplace: Facilitating Interdisciplinary Learning in Construction Courses

Andrew Milligan, Rachel Simmonds, Mark Wilson, 2017 .

Aberrant stromal tissue factor and mycolactone-driven vascular permeability, exacerbated by IL-1Î², orchestrate pathogenic fibrin formation in Buruli ulcer lesions

G. Pluschke, L. T. Hsieh, J. Ogbechi, 2021, medRxiv.

Protein S Gla-domain mutations causing impaired Ca 2 (cid:1) -induced phospholipid binding and severe functional protein S deﬁciency

S. Rezende, D. Lane, J. Conard, 2002 .

Inhibition of Sec61-dependent translocation by mycolactone uncouples the integrated stress response from ER stress, driving cytotoxicity via translational activation of ATF4

J. Taunton, B. Hall, R. Wek, 2018, Cell Death & Disease.

Mycolactone reveals the substrate-driven complexity of Sec61-dependent transmembrane protein biogenesis

S. High, Michael J. McKenna, R. Simmonds, 2017, Journal of Cell Science.

Deletion or replacement of the second EGF-like domain of protein S results in loss of APC cofactor activity.

M. Laffan, S. Rezende, D. Lane, 2003, Blood.

Efficient isolation of peptide ligands for the endothelial cell protein C receptor (EPCR) using candidate receptor phage display biopanning

Andrew H. Baker, S. J. White, D. Lane, 2005, Peptides.

MechanismProduction by a Posttranscriptional Mycolactone Inhibits Monocyte Cytokine

B. Foxwell, P. Small, T. Smallie, 2009 .

Structural and functional implications of the intron/exon organization of the human endothelial cell protein C/activated protein C receptor (EPCR) gene: comparison with the structure of CD1/major histocompatibility complex alpha1 and alpha2 domains.

D. Lane, D A Lane, R E Simmonds, 1999, Blood.

Mycolactone enhances the Ca2+ leak from endoplasmic reticulum by trapping Sec61 translocons in a Ca2+ permeable state

A. Cavalié, V. Helms, B. Hall, 2021, Biochemical Journal.

Rachel promoter by multiple Sp 1 binding sites Regulation of the human endothelial cell protein C receptor gene

G. Follows, C. Bonifer, P. Cockerill, 2003 .

The one that got away: how macrophagederived IL1beta escapes the mycolactonedependent Sec61 blockade in Buruli Ulcer

L. T. Hsieh, R. Simmonds, Belinda S. Hall, 2022 .